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. Anticholinergiques and . .. Acb, Annexe, vol.2

, Revue de littérature sur l'épidémiologie des démences en France, Annexe, vol.3, p.190

, Annexe, vol.4

, Latitude et longitude des préfectures par département, Annexe, vol.5

. Francfort-sur-le-main, Il y côtoie notamment le psychiatre Emil Sioli (directeur de l'établissement) et le neurologue Franz Nissl (3). Ensemble, ils étudient l'anatomie normale et pathologique du cortex cérébral

, Il rencontre également Emil Kraepelin, qui devient un de ses mentors, Années à Munich, 1903.

, Il intègre son équipe de chercheurs au sein de la Clinique psychiatrique, où vont se côtoyer Alfons Maria Jakob, Alois Alzheimer suit Emil Kraepelin au Royal Psychiatric Hospital de Munich en, issue.3, p.1903

, il publie sa thèse d'université : Histologische Studien zur Differentialdiagnose der progressiven Paralyse, 1904.

, Il fonde l'école de neuropathologie de Munich et est nommé professeur assistant de psychiatrie au Ludwig Maximilian University en 1908, puis professeur de psychiatrie et directeur du Neurologic and Psychiatric Institute of the Silesian Friederich, Il devient membre de la société d'hygiène raciale, fondée en 1905 par, entre autres, p.1912

. Années-À-breslau, , pp.1912-1915

, Hospitalisé en février 1913, sa santé se détériore et il décède à l'âge de 51 ans des suites des complications rénales et cardiaques d'un rhumatisme articulaire aigu. Il est enterré au cimetière principal de Francfort, auprès de sa femme

, est admise à l'hôpital de Francfort le 25 novembre 1901, atteinte d'une démence. Elle est suivie par le Dr Alois Alzheimer jusqu'à sa mort. En raison du coût de l'hôpital de Francfort, Karl Deter, son mari, vol.3, 1906.

, Alois Alzheimer négocie le maintien à Francfort en échange de la possibilité de réaliser l'autopsie cérébrale à Munich après son décès

, Il décrit pour la première fois les symptômes de la dégénérescence corticale et l'analyse histologique du cerveau le 3 novembre 1906, lors de la 37 ème conférence des psychiatres allemands du Sud-Ouest à Tübingen (3). Les auditeurs ne posent pas de question, L'autopsie permet d'y découvrir les anomalies qui deviendront caractéristiques de la maladie : plaques amyloïdes et dégénérescence neurofibrillaire

, Bonfiglio en 1908, Perusini en 1909 qui réétudie le cerveau d'Auguste Deter) vont confirmer sa découverte, 1907.

C. Le-psychiatre-renommé and E. Kraepelin, , p.1910

, Solomon Carter Fuller a décrit un cas similaire à celui d, Auguste Deter en juin, issue.3, p.1906

, Oskar Fisher a décrit 12 cas en, p.1907

, Le cas Auguste Deter : une authentique maladie d'Alzheimer ?

, Dans les années 1990, des critiques sur le cas Auguste Deter ont été formulées ; une nouvelle analyse publiée en 1998 a confirmé qu'Auguste Deter a bien eu ce qui est maintenant appelé une maladie d'Alzheimer (14), Le deuxième cas de Johann F, 1911.

. «-alois-alzheimer--genwiki,

S. Marktbreit-am-main and «. Alzheimer-haus,

G. Cipriani, C. Dolciotti, L. Picchi, and U. Bonuccelli, Alzheimer and his disease: a brief history, Neurological Sciences, vol.32, pp.275-279, 2010.

G. Stertz and . Alzheimer, Alois » [archive], sur www.deutsche-biographie.de Neue Deutsche Biographie (NDB), vol.1, p.236, 1953.

G. Devi and W. Quitschke, Alois Alzheimer, neuroscientist (1864-1915), vol.13, pp.132-137

A. Alzheimer, Über die Ohrenschmalzdrüsen, p.1888

F. Nissl and A. Alzheimer, Histologische und histopathologische Arbeiten über die Grosshirnrinde mit besonderer Berücksichtigung der pathologischen Anatomie der Geisteskrankheiten, pp.1-1904

, « Histologische Studien zur Differentialdiagnose der progressiven Paralyse [Texte imprimé] / von Alois Alzheimer -Sudoc

N. Cartier-lacave and «. Alzheimer,

E. J. Engstrom, « Researching Dementia in Imperial Germany: Alois Alzheimer and the Economies of Psychiatric Practice, Culture, Medicine and Psychiatry, vol.31, pp.405-413, 2007.

M. B. Graeber, S. Kösel, R. Egensperger, and R. B. Banati, « Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis, Neurogenetics, vol.1, pp.73-80, 1997.

E. Kraepelin and E. Walter, Psychiatrie : ein Lehrbuch für Studierende und Ärzte

M. Goedert and . Oskar, Fischer and the study of dementia, Brain, vol.132, pp.1102-1111, 2016.

M. B. Graeber and P. Mehraein, Reanalysis of the first case of Alzheimer's disease, vol.249, pp.10-13, 1999.

, Univ. Rouen) détaillé ci-dessous. Les articles ont été explorés sur la base de leur titre, Nous avons effectué notre recherche sur MEDLINE, sans limite de période, en langue anglaise ou française. L'équation de recherche a été déterminée à l'aide du constructeur de requêtes bibliographiques médicales (CRBM

. And-(démence.mc[ter_msh]-or and . France, Alzheimer.mc[TER_MSH] OR démence frontotemporale.mc[TER_MSH] OR maladie à corps de lewy.mc[TER_MSH] OR démence vasculaire

, Les critères d'exclusion étaient les études sur population pré-sélectionnées (par exemple demandeurs d'allocation personnalisée pour l'autonomie), les résultats intermédiaires, les revues de littérature n'apportant pas de nouvelles données, Les articles concernant l'épidémiologie des démences pré-citées en population générale en France étaient inclus

, Notion de démence : o ("dementia

. Tw]-or-"dementia-alzheimer, AlzheimerType dementia (ATD)"[TW] OR "late onset alzheimer disease"[TW] OR "alzheimer type senile dementia, Alzheimer Diseases Familial (FAD)"[TW] OR "alzheimer disease early onset"[TW] OR "dementia Alzheimer-Type (ATD)

, UbiquitinPositive frontotemporal dementias"[TW] OR "Wilhelmsen-Lynch disease"[TW] OR "frontotemporal dementias Ubiquitin-Positive"[TW] OR "Disinhibition-DementiaParkinsonism-Amytrophy complices"[TW] OR "wilhelmsen lynch disease"[TW] OR "frontotemporal lobe dementias (FLDEM)"[TW] OR "diseases familial pick's"[TW] OR "FTLD with TDP-43 pathology"[TW] OR "frontotemporal dementia with parkinsonism"[TW] OR "dementia semantic"[TW] OR "hereditary dysphasic disinhibition dementia, complices Disinhibition-DementiaParkinsonism-Amyotrophy"[TW] OR "Ubiquitin-Positive frontotemporal dementia"[TW] OR "FTLD with TDP 43 pathology"[TW] OR "Disinhibition-Dementia-Parkinsonism-Amyotrophy complex"[TW] OR "dementias Ubiquitin-Positive frontotemporal

;. Tw]-or-"dementias-frontotemporal and . Tw]-or-"complex-disinhibition-dementiaparkinsonism-amyotrophy,

. Tw]-or-"lewy, lewy body type senile dementia

. Pierre,

, Traitements non-médicamenteux communs aux démences

, et adapter l'environnement à la perte d'autonomie et aux troubles cognitifs d'autre part. 1.1. Préserver l'autonomie et les fonctions cognitives Pour préserver l'autonomie, il est possible d'avoir recours à plusieurs partenaires, tels que les orthophonistes ou les kinésithérapeutes. L'orthophonie est par exemple utile en phase initiale de la dégénérescence lobaire fronto-temporale ; réhabilitation par an, organisées par les équipes spécialisées Alzheimer (ESA) en cas de troubles cognitifs légers à modérés. Ces équipes sont déployées en 2010 et attachées aux services de soins infirmiers à domicile (SSIAD), Dans les démences, les approches non pharmacologiques sont favorisées, pour tenter de préserver l'autonomie et les fonctions cognitives d'une part

, L'activité physique a montré un intérêt pour retarder l'apparition d'une démence, vol.536

, Adapter l'environnement

, tels que les infirmiers (délivrance de médicaments notamment), les auxiliaires de vie et autres aides à domicile (portage de repas, ménage, toilette, etc.), ou plus rarement les ergothérapeutes. Plusieurs études ont montré un intérêt thérapeutique de la musique et des activités ludiques contre l'agitation chez les patients déments [537] ; la musique, la peinture ou les activités ludiques ont également été associées à une diminution de douleur, Pour suppléer à la perte d'autonomie, nous pouvons également avoir recours à plusieurs partenaires

T. La-poupée,

, D'autres activités non-médicamenteuses sont testées dans les EHPAD : jardin thérapeutique, zoothérapie ou médiation animale

, Deux méta-analyses récentes se sont intéressées aux traitements non-médicamenteux dans la maladie d'Alzheimer en, et, 2015.

, Les traitements symptomatiques peuvent être utiles à certains stades des démences. La prescription de psychotropes (benzodiazépines, antipsychotiques, antidépresseurs, hypnotiques) doit être raisonnée, vol.341

, Alzheimer commercialisés en France : 3 inhibiteurs de l'acétylcholinestérase (donépézil, galantamine, rivastigmine) et un antagoniste du récepteur N-Méthyl-D-Aspartate (mémantine

, Ces médicaments ont été déremboursés par l'assurance maladie en France en août 2018 en raison d'un service médical rendu jugé insuffisant par la HAS

, Européens (sauf à Chypre et au Danemark pour le donépézil ; en Roumanie pour la rivastigmine ; en Lettonie, à Malte et en Pologne pour la mémantine), vol.555

. De, Nous présentons en Table 18 une synthèse originale de méta-analyses récentes sur plusieurs traitements proposés dans la maladie d'Alzheimer, vol.342