What are Biomarkers?, Curr Opin HIV AIDS, vol.5, issue.6, pp.463-466, 2011. ,
DOI : 10.1097/coh.0b013e32833ed177
, Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework, Biomarkers Definitions Working Group, vol.69, issue.3, pp.89-95, 2001.
Chemical Engineering of Self-Assembled Alzheimer ' s Peptide on a Silanized Silicon Surface, Langmuir, vol.30, issue.20, pp.5863-5872, 2014. ,
MicroRNA : a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer, Cancer Biol Med, vol.12, issue.4, pp.328-341, 2015. ,
Proteins are potent biomarkers to detect colon cancer progression, Saudi J. Biol. Sci, vol.24, issue.6, pp.1212-1221, 2017. ,
Clinical use of biomarkers in breast cancer : Updated guidelines from the European Group on Tumor Markers, Eur. J. Cancer, vol.75, pp.284-298, 2017. ,
A Review on the Clinical Utility of PSA in Cancer Prostate, Indian J Surg Oncol, vol.3, pp.120-129, 2012. ,
Strategies for discovering novel cancer biomarkers through utilization of emerging technologies, Nat Clin Pr. Oncol, vol.5, issue.10, pp.588-599, 2008. ,
Biomarker classification, validation, and what to look for in 2017 and beyond, BJU Int, vol.119, issue.5, pp.812-814, 2017. ,
Cancer biomarkers -Current perspectives, Rev. Artic. Indian J Med Res, vol.132, pp.129-149, 2010. ,
Biomarker detection technologies and future directions, Analyst, vol.141, issue.3, pp.740-755, 2016. ,
Efficiency of Anti-Stokes Fluorescence in Dyes, Nature, vol.131, pp.839-840, 1933. ,
Fundamentals of Fluorescence and Fluorescence Microscopy, Methods in Cell Biology, vol.114, pp.69-97, 2007. ,
, Cold Spring Harb Protoc, vol.2014, issue.10, pp.1042-1065, 2016.
Förster Theory, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.23-62, 2014. ,
Über quantenmechanische Energieübertragung zwischen atomaren Systemen, pp.207-243, 1928. ,
DOI : 10.1515/zpch-1929-0214
Transfer Mechanisms of Electronic Excitation, Discussions of the Faraday Society, pp.7-17, 1959. ,
Energy migration and fluorescence, Naturwissenschaften, vol.33, issue.6, pp.166-175, 1946. ,
How to Apply FRET : From Experimental Design to Data Analysis, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.105-163, 2014. ,
The renaissance of fluorescence resonance energy transfer, Nat Struct Biol, vol.7, issue.9, pp.730-734, 2000. ,
In Vitro FRET Sensing, Diagnostics, and Personalized Medicine, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.271-322, 2014. ,
Implementation of FRET Technologies for Studying the Folding and Conformational Changes in Biological Structures, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.357-396, 2014. ,
FRET-Based Cellular Sensing with Genetically Encoded Fluorescent Indicators, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.397-429, 2014. ,
Compact quantum dot-antibody conjugates for FRET immunoassays with subnanomolar detection limits, Nanoscale, vol.8, issue.21, pp.11275-11283, 2016. ,
URL : https://hal.archives-ouvertes.fr/cea-01851581
Protein folding studied by single-molecule FRET, Curr Opin Struct Biol, vol.18, issue.1, pp.16-26, 2008. ,
Intracellular bioconjugation of targeted proteins with semiconductor quantum dots, J. Am. Chem. Soc, vol.132, issue.17, pp.5975-5977, 2010. ,
Single-molecule techniques in biophysics : a review of the progress in methods and applications, Rep. Prog. Phys, vol.81, issue.2, 2018. ,
A Dance with Two Dragons : fluorophores photophysics in the context of FRET, 2017. ,
Single-Molecule Applications, FRET -Förster Resonance Energy Transfer From Theory to Applications, pp.323-356, 2014. ,
A Practical Guide to Single Molecule FRET, Nat. Methods, vol.5, issue.6, pp.507-516, 2008. ,
Chapter 2.3 -Homogeneous Immunoassays, The Immunoassay Handbook, pp.67-87, 2013. ,
Quantumdot-based Forster resonance energy transfer immunoassay for sensitive clinical diagnostics of low-volume serum samples, ACS Nano, vol.7, issue.8, pp.7411-7419, 2013. ,
Quantum Dot -Based FRET Immunoassay for HER2 Using Ultrasmall Affinity Proteins, Small, vol.14, issue.35, pp.1-5, 2018. ,
Energy Transfer with Semiconductor Quantum Dot Bioconjugates : A Versatile Platform for Biosensing , Energy Harvesting , and Other Developing Applications, Chem. Rev, vol.117, issue.2, pp.536-711, 2017. ,
On-chip detection of protein glycosylation based on energy transfer between nanoparticles, Biosens. Bioelectron, vol.24, issue.5, pp.1189-1194, 2009. ,
Time-Resolved FRET -Based Approach for Antibody Detection -A New Serodiagnostic Concept, PLoS One, vol.8, issue.5, 2013. ,
, Micro-and Nanoscale Immunoassay Systems, and Microarrays, pp.175-202, 2013.
A Gas Chromatographic Air Analyzer Fabricated, IEEE, vol.26, issue.12, pp.1880-1886, 1979. ,
The origins and the future of microfluidics, Nature, vol.442, pp.368-373, 2006. ,
Quantum Dot FRET-Based Probes in Thin Films Grown in Microfluidic Channels, J. Am. Chem. Soc, vol.132, issue.5, pp.1460-1461, 2010. ,
Protein -protein interaction analysis in single microfluidic droplets using FRET and fluorescence, Lab Chip, vol.13, issue.14, pp.2808-2822, 2013. ,
Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Micro fl uidics and Its Application to Endometriosis, J. Am. Chem. Soc, vol.135, issue.5, pp.1645-1648, 2013. ,
Toward a solid-phase nucleic acid hybridization assay within microfluidic channels using immobilized quantum dots as donors in fluorescence resonance energy transfer, Anal Bioanal Chem, vol.399, issue.1, pp.133-141, 2011. ,
On-Chip Transduction of Nucleic Acid Hybridization Using Spatial Profiles of Immobilized Quantum Dots and Fluorescence Resonance Energy Transfer, Anal Chem, vol.84, issue.1, pp.312-321, 2012. ,
On-Chip Multiplexed Solid-Phase Nucleic Acid Hybridization Assay Using Spatial Profiles of Immobilized Quantum Dots and Fluorescence Resonance Energy Transfer ( FRET ), Anal. Chim. Acta, vol.788, pp.148-57, 2013. ,
Optical Biosensors Based on Plasmonic Nanostructures : A Review, Proc. IEEE, vol.104, pp.2380-2408, 2016. ,
Chemical Functionalization of Plasmonic Surface Biosensors: A Tutorial Review on Issues, Strategies, and Costs, ACS Appl. Mater. Interfaces, vol.9, issue.35, pp.29394-29411, 2017. ,
Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology, Chem. Rev, vol.105, issue.4, pp.1103-1169, 2005. ,
Self-assembled monolayers in organic electronics, Chem. Soc. Rev, vol.46, issue.1, pp.40-71, 2017. ,
Formation and Structure of Self-Assembled Monolayers, Chem. Rev, vol.96, issue.4, pp.1533-1554, 1996. ,
Atomic layer deposition: medical and biological applications, Int. Mater. Rev, vol.58, issue.2, pp.113-129, 2013. ,
Design of Surface Modifications for Nanoscale Sensor Applications, Sensors, vol.15, issue.1, pp.1635-1675, 2015. ,
Surface Functionalization of Microfluidic Devices, Microsystems for Pharmatechnology Manipulation of Fluids, Particles, Droplets, and Cells, A. Dietzel, pp.59-97, 2016. ,
Status and prospects of Al2O3-based surface passivation schemes for silicon solar cells, J. Vac. Sci. Technol. A Vacuum, Surfaces, Film, vol.30, issue.4, pp.40802-40803, 2012. ,
Polymer surface modification by plasmas and photons, Surf. Sci. Rep, vol.24, issue.1-2, pp.1-54, 1996. ,
Surface modification for PDMS-based microfluidic devices, Electrophoresis, vol.33, issue.1, pp.89-104, 2012. ,
Organosilane deposition for microfluidic applications, Biomicrofluidics, vol.5, issue.3, pp.36501-36508, 2011. ,
Surface modification of poly ( dimethylsiloxane ) for microfluidic assay applications, Appl. Surf. Sci, vol.256, issue.8, pp.2524-2531, 2010. ,
Solution-Phase Surface Modification in Intact Poly (dimethylsiloxane) Microfluidic Channels, Anal. Chem, vol.78, issue.15, pp.5543-5551, 2006. ,
Coming of age: ten years of next-generation sequencing technologies, Nat Rev Genet, vol.17, issue.6, pp.333-351, 2016. ,
Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA, ACS Nano, vol.9, issue.11, pp.10598-10611, 2015. ,
The potential and challenges of nanopore sequencing, Nat. Biotechnol, vol.26, issue.10, pp.1146-1153, 2008. ,
Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore, Science, vol.274, issue.5294, pp.1859-66, 1996. ,
Unfoldase-mediated protein translocation through an ?-hemolysin nanopore, Nat. Biotechnol, vol.31, issue.3, pp.247-50, 2013. ,
Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA, Nano Today, vol.8, issue.1, pp.56-74, 2013. ,
Nanopore DNA sequencing with MspA, Proc. Natl. Acad. Sci. U. S. A, vol.107, issue.37, pp.16060-16065, 2010. ,
Continuous base identification for single-molecule nanopore DNA sequencing, Nat. Nanotechnol, vol.4, issue.4, pp.265-270, 2009. ,
Nanopore-based fourthgeneration DNA sequencing technology, Genomics, Proteomics Bioinforma, vol.13, issue.1, pp.4-16, 2015. ,
DNA Translocations through Solid-State Plasmonic Nanopores, Nano Lett, vol.14, issue.12, pp.6917-6925, 2014. ,
A draft map of the human proteome, Nature, vol.509, issue.7502, pp.575-581, 2014. ,
Mass-spectrometry-based draft of the human proteome, Nature, vol.509, issue.7502, pp.582-587, 2014. ,
Single-molecule protein sequencing through fi ngerprinting : computational assessment, Phys. Biol, vol.12, issue.5, p.55003, 2015. ,
Single-molecule peptide fingerprinting, vol.115, pp.3338-3343, 2018. ,
Assay of Plasma Insulin in Human Subjects by Immunological Methods, Nature, vol.184, issue.4699, pp.1648-1649, 1959. ,
The Immunoassay Handbook, 2013. ,
Six-Color TimeResolved Förster Resonance Energy Transfer for Ultrasensitive Multiplexed Biosensing, J. Am. Chem. Soc, vol.135, issue.3, pp.1102-1109, 2013. ,
Nanobodies and antibodies for duplexed EGFR/HER2 immunoassays using terbium-to-quantum dot FRET, Chem. Mater, vol.28, issue.22, pp.8256-8267, 2016. ,
Energy Transfer-Based Multiplexed Assay of Proteases by Using Gold Nanoparticle and Quantum Dot Conjugates on a Surface, Anal. Chem, vol.80, issue.12, pp.4634-4641, 2008. ,
Toward A Multiplexed Solid-Phase Nucleic Acid Hybridization Assay Using Quantum Dots as Donors in Fluorescence Resonance Energy Transfer, Anal. Chem, vol.81, issue.15, pp.4113-4120, 2009. ,
Highly Sensitive AluminumBased Biosensors using Tailorable Fano Resonances in Capped Nanostructures, Nat. Sci. reports, vol.7, issue.44104, pp.1-14, 2017. ,
Trends in Analytical Chemistry Aluminum-based localized surface plasmon resonance for biosensing, Trends Anal. Chem, vol.80, pp.486-494, 2016. ,
Aluminium plasmonics, J. Phys. D. Appl. Phys, vol.48, issue.18, p.184001, 2015. ,
Aluminum Nanoholes for Optical Biosensing, Biosensors, vol.5, issue.3, pp.417-431, 2015. ,
Matching Nanoantenna Field Confinement to FRET Distances Enhances Förster Energy Transfer Rates, Nano Lett, vol.15, issue.9, pp.6193-6201, 2015. ,
Fabrication of aluminium nanostructures for plasmonics, J. Phys. D. Appl. Phys, vol.48, issue.18, p.184002, 2015. ,
Aluminum for Plasmonics, ACS Nano, vol.8, issue.1, pp.834-840, 2014. ,
, Review Surface Modification, p.151
, Functionalization of Metal and Metal Oxide Nanoparticles by Organic Ligands, Monatshefte für Chemie -Chem. Mon, vol.139, issue.3, pp.183-195, 2008.
Functionalization of aluminum nanoparticles using a combination of aryl diazonium salt chemistry and iniferter method, J. Phys. Chem. C, vol.117, issue.49, pp.26000-26006, 2013. ,
Powerful Surface Chemistry Approach for the Grafting of Alkyl Multilayers on Aluminum Nanoparticles, Langmuir, vol.31, issue.22, pp.6092-6098, 2015. ,
Fluorescence near interfaces : The role of photonic mode density, J. Mod. Opt, vol.45, issue.4, pp.661-699, 1998. ,
Radiative Decay Engineering: Biophysical and Biomedical Applications, Anal Biochem, vol.298, issue.1, pp.1-24, 2001. ,
Plasmonic Enhancement of Molecular Fluorescence, Nano Lett, vol.7, issue.2, pp.496-501, 2007. ,
GaN Nanowire Functionalized with Atomic Layer Deposition Techniques for Enhanced Immobilization of Biomolecules, Langmuir, vol.26, issue.23, pp.18382-18391, 2010. ,
Distance-Dependent Metal-Enhanced Intrinsic Fluorescence of Proteins Using Polyelectrolyte Layer-by-Layer Assembly and Aluminum Nanoparticles, J. Phys. Chem. C, vol.116, issue.19, pp.10766-10773, 2012. ,
Enhancement and Quenching of Single-Molecule Fluorescence, Phys Rev Lett, vol.96, issue.11, p.113002, 2006. ,
Competition between Förster resonance energy transfer and donor photodynamics in plasmonic dimer nanoantennas, ACS Photonics, vol.3, issue.5, pp.895-903, 2016. ,
Approaching the limits of dielectric breakdown for SiO2 films deposited by plasma-enhanced atomic layer deposition, Acta Mater, vol.61, issue.20, pp.7660-7670, 2013. ,
Optimization of Silica Silanization by 3-Aminopropyltriethoxysilane, Langmuir, vol.22, issue.26, pp.11142-11147, 2006. ,
Structure of 3-Aminopropyltriethoxy silane on silicon oxide, J. Colloid Interface Sci, vol.147, issue.1, pp.103-118, 1991. ,
Chemical Improved surface plasmon resonance biosensing using silanized optical fibers, Sensors Actuators B Chem, vol.216, pp.518-526, 2015. ,
A new controlled concept of immune-sensing platform for specific detection of Alzheimer's biomarkers, Biosens. Bioelectron, vol.40, issue.1, pp.329-335, 2013. ,
Chemical Modifications of Au/ SiO 2 Template Substrates for Patterned Biofunctional Surfaces, Langmuir, vol.27, issue.2, pp.678-685, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00602936
A novel FRET-based optical fiber biosensor for rapid detection of Salmonella typhimurium, Biosens Bioelectron, vol.21, issue.7, pp.1283-1290, 2006. ,
Immobilization of Antibodies and Enzymes on Platforms for Biosensors and Diagnostics, Chem. Rev, vol.114, issue.21, pp.11083-11130, 2014. ,
Etude de l'adhésion de vésicules géantes et de cellules vivantes par nanoscopie de fluorescence, 2015. ,
A surface modification strategy on silicon nitride for developing biosensors, Anal. Biochem, vol.343, issue.2, pp.322-328, 2005. ,
Reaction of (3-Aminopropyl) dimethylethoxysilane with Amine Catalysts on Silica Surfaces, J. Colloid Interface Sci, vol.232, issue.2, pp.400-407, 2000. ,
Icy : an open bioimage informatics platform for extended reproducible research, Nat Methods, vol.9, issue.7, pp.690-696, 2012. ,
, Principles of Fluorescence Spectroscopy, 2010.
Integration of microcoils for on-chip immunosensors based on magnetic nanoparticles capture, Sens. Bio-Sensing Res, vol.13, pp.115-121, 2017. ,
Extended Nanofl uidic Immunochemical Reaction with Femtoliter Sample Volumes, Small, vol.10, issue.8, pp.1514-1522, 2014. ,
Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues, Analyst, vol.134, issue.10, pp.1191-1993, 2009. ,
Electroosmotic properties of microfluidic channels composed of poly ( dimethylsiloxane ), J. Chromatogr. B Biomed. Sci. Appl, vol.762, issue.2, pp.117-125, 2001. ,
Fabrication of Microfluidic Devices, Microsystems for Pharmatechnology Manipulation of Fluids, Particles, Droplets, and Cells, A. Dietzel, pp.23-57, 2016. ,
The autofluorescence of plastic materials and chips measured under laser irradiation, Lab Chip, vol.5, issue.12, pp.1348-1354, 2005. ,
, Hemocompatibility, Biocompatibility, p.153
, Inflammatory and in Vivo Studies of Primary Reference Materials Low-Density Polyethylene and Polydimethylsiloxane: A Review, J. Biomed. Mater. Res, vol.58, issue.5, pp.467-477, 2001.
Replication and Compression of Bulk and Surface Structures with Polydimethylsiloxane Elastomer, J. Chem. Educ, vol.75, issue.4, pp.537-541, 1999. ,
Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems, Biomed Microdevices, vol.7, issue.4, pp.281-293, 2005. ,
Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering, J. Micromechanics Microengineering, vol.24, issue.3, p.35017, 2014. ,
Use of Fluorescamine for the Spectrofluorimetric Investigation of Primary Amines on Silanized Glass and Indium Tin Oxidecoated Glass, Analyst, vol.120, issue.1, pp.175-178, 1995. ,
Radiometric and fluorimetric determination of aminosilanes and protein covalently bound to thermally pretreated glass substrates, Anal. Chim. Acta, vol.228, pp.107-116, 1990. ,
Multiplexed diagnostics and spectroscopic ruler applications with terbium to quantum dots FRET, Clinical and Biomedical Spectroscopy, vol.7368, pp.1-8, 2009. ,
Luminescent terbium complexes : Superior Förster resonance energy transfer donors for flexible and sensitive multiplexed biosensing, Coord. Chem. Rev, pp.125-138, 2014. ,
Influence of Luminescence Quantum Yield, Surface Coating, and Functionalization of Quantum Dots on the Sensitivity of TimeResolved FRET Bioassays, Appl. Mater. Interfaces, vol.5, issue.8, pp.2881-2892, 2013. ,
Recent developments in lanthanide-to-quantum dot FRET using time-gated fluorescence detection and photon upconversion, Trends Anal. Chem, vol.84, issue.A, pp.60-71, 2016. ,
Evaluating quantum dot performance in homogeneous FRET immunoassays for prostate specific antigen, Sensors (Switzerland), vol.16, issue.2, p.197, 2016. ,
Adsorption of Fluorescently Labeled Microbeads on PDMS Surfaces, SPIE Proceedings, vol.5718, pp.159-167, 2005. ,
Surface Modification of Poly(dimethylsiloxane) Using Ionic Complementary Peptides to Minimize Nonspecific Protein Adsorption, Langmuir, vol.31, issue.21, pp.5891-5898, 2015. ,
Restraining non-specific adsorption of protein using Parylene C-caulked polydimethylsiloxane, Biomicrofluidics, vol.10, issue.2, pp.24126-24137, 2016. ,
Förster Resonance Energy Transfer from Terbium Complexes to Quantum Dots for Multiplexed Homogeneous Immunoassays and Molecular Rulers, 2016. ,
Time-Gated Förster Resonance Energy Transfer Biosensors for Multiplexed Diagnostics of Epidermal Growth Factor Receptors and MicroRNAs, 2017. ,
Quantum dots and upconverting nanoparticles : Bioconjugation and time-resolved multiplexed FRET spectroscopy for cancer diagnostics, 2017. ,
URL : https://hal.archives-ouvertes.fr/tel-01548910
, Annexe B Exemples d'histogrammes d'intensité de fluorescence pour les différentes concentrations étudiées au chapitre III (0,25 mg/mL, 0,5 mg/mL et 1,0 mg/mL, p.161