Rôle de la connectivité intracorticale dans le traitement des informations sensorielles

Abstract : The sensory perception of the external world relies on the coordinated activity in space and time of cortical neurons. Primary sensory areas of mammals are organized in six layers.It has been suggested that sensory information is processed serially through the six layers of the cortex. Sensory information is supposed to propagate first through the layer IV, principal target of thalamic axonal projections. Cortical layers II/III then receive sensory information relayed by layer IV excitatory neurons. Finally, deep cortical layers V and VI are connected by layer II/III pyramidal cells. Layer V pyramidal neurons are the principal output of the neocortex.Recently, it has been shown that deep layer neurons receive direct thalamic inputs relaying sensory information. The role of the translaminar connectivity during sensory processing remains an opened question.I took the advantage of in utero electroporation to express photo-sensitive proteins specifically in layer II/III pyramidal cells of the mouse primary somatosensory cortex.By proceeding to extracellular recordings of cortical neurons of either anesthetized or awake mice, I have shown that the recruitment of layer II/III pyramidal neurons amplifies layer V neurons sensory responses. Moreover, the analysis of this amplification phenomenon as a function the sensory stimulation intensity suggests that translaminar connectivity can operate a gain modulation of the layer V pyramidal neurons.
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Michael Quiquempoix. Rôle de la connectivité intracorticale dans le traitement des informations sensorielles. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066181⟩. ⟨tel-02162632⟩

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