Transfert intergénérationnel de l'immunité chez le pigeon biset (Columba livia)

Abstract : Intergenerational transfer of immunity is a phenomenon which started to be studied 10 years ago. In vertebrates, it takes the form of a transfer of antibodies from mothers to juveniles. However, the ecological and evolutionary processes of transfer across several generations and the persistence of maternals antibodies in chicks remain poorly understood. This thesis focuses on the study of the mechanisms of maternal antibodies transfer over several generations and on how they impact the immune response and growth in juveniles. By using experimental approaches, I first show that the transfer of maternal antibody was affected by food availability in the environment. In addition, our results suggest that the persistence of maternal antibodies depends on the initial level of maternal antibodies present in the nestlings in the first days of life. Secondly, we studied the immune response and growth of juvenile by investigating how maternal antibodies may affect the resolution of the trade-off between these two physiological parameters. Finally, our results suggest that maternal antibodies would be a messenger of an epigenetic effect on immunty. Indeed, induced immune response in grand-mothers towards a pathogen has been found to stimulate the immune response of grand-children. My thesis emphasizes the importance of maternal transfer of immunity in the ecology and evolution of host-parasite.
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Ahmad Ismail. Transfert intergénérationnel de l'immunité chez le pigeon biset (Columba livia). Physiologie [q-bio.TO]. Université Pierre et Marie Curie - Paris VI, 2014. Français. ⟨NNT : 2014PA066371⟩. ⟨tel-02161705⟩

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