I. Scheme, 49: HPLC follow-up of the photolysis of a mono-acid bimane caged compound with

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7. , , vol.31

, CDCl 3 ): ? = 10.41 (s, 1 H), 8.06 (s, 1H)

J. , H) = 2.2 Hz, 1H) ppm

, CDCl 3 ): ? = 186, vol.9

H. Nmr, MHz, issue.400

, Hz, 1H), 7.63 (d, 3 J, vol.1

, 3-Dioxolan-2-yl)-N,N-dimethyl-4?-nitro, p.3

J. and H. , 56 (d, 3 J (H,H) = 8.4 Hz, 2H), 6.79 (d, 3 J (H,H) = 9, Hz, 1H), vol.7

, /z calcd: 315.13, m/z found: 315.05

, 4?-(Dimethylamino)-4-nitro

, CDCl 3 ): ? = 10.53 (s, 1H), vol.8, p.17

J. and H. )-=-8-hz,

J. and H. , Hz, 1H), vol.7

J. and H. , Hz, 2H), 3.03 (s, 6H) ppm

, + ) m/z calcd: 271.01, m/z

, /z calcd: 441.0703, m/z found

, 3-yl)ethyl-2-(3,4-dimethoxyphenyl)acetate (6)

, 450 mg, 1.02 mmol) was dissolved and 2-(3,4-dimethoxyphenyl)acetic acid (300 mg, 1.53 mmol) was added along with 4-dimethyl aminopyridine (DMAP) (7 mg, 0.051 mmol) under argon, vol.25

H. Nmr, MHz, vol.1, issue.400

J. and H. , Hz, issue.6

J. and H. ,

2. Hz, 38 (s, 1H), 7.23 (d, 3 J (H,H) = 9, Hz, vol.7, issue.6

J. and H. , Hz, 2H), 6.79 (d, 3 J (H,H) = 9, Hz, vol.2, issue.6

J. and H. , Hz, 1H) ppm. HMMS(ESI): [M + H] + (C 32 H 32 N 2 O 6 Br + ) m/z calcd: 619.1443, pp.619-1436

, The same procedure was followed for the synthesis of, vol.7

H. Nmr, 400 MHz, CDCl 3 ): ? = 8.08 (d, 3 J (H,H) = 8.4 Hz, 1H), vol.7

J. and H. ,

J. and H. Hz, , p.1

J. , H) = 15.2 Hz, 1H), 3.02 (s, 6H) ppm

. Hrms(esi,

, + ) m/z calcd: 647.2757, m/z found: 647, 2767.

, CDCl 3 ): ? = 8.08 (d, 3 J (H,H) = 9, vol.36

H. Nmr,

C. Nmr, MHz, vol.7, issue.100, p.31

H. Nmr, MHz, CDCl, vol.3, issue.400

C. Nmr, MHz, issue.100

, 210 mg, 0.47 mmol) was dissolved and 9 (306 mg, 0.71 mmol) was added along with N,N?-dimethylaminopyridine (DMAP) (7 mg, 0.026 mmol) under argon, vol.10

, CDCl 3 ): ? = 8.06 (d, 3 J (H,H) = 9

J. and H. ,

. Hz,

J. , H) = 13.6 Hz, 1H), 3.01 (s, 6H) ppm

. Ms(esi,

, + ) m/z calcd: 865.30, m/z found

, -yl)ethyl-2-(2-methoxyoctaethoxy) solvent was evaporated, and the residue was extracted with water and dichloromethane and dried over MgSO 4 . The solvent was evaporated under vacuum and the residue was purified over a silica gel column to afford the product 11 as reddish paste (36 mg, vol.30

H. Nmr, MHz, vol.1, issue.400

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