Activité pharmacologique de dérivés polyphénoliques isolés de Clusiaceae et de Calophyllaceae malaisiennes : effets régulateurs sur des marqueurs endothéliaux de l’inflammation et de l’immunité

Abstract : In order to identify new compounds preventing endothelial cells dysfunction and immunogenicity which are involved in the emergence of graft rejection, the secondary metabolites of different Clusiaceae and Calophyllaceae specious were investigated. Firstly 4DCM extracts originating from Malaysian Calophyllaceae specious were selected through a dereplication analysis combined with an anti-inflammatory screening. Then, the phytochemical study of the fruits extract of Mesualepidota allowed us to isolate 9 mammea coumarins, among which 7 represent 2 novel series, i.e. lepidotols and lepidotins. The phytochemical study of 2 different batches of Calophyllum tetrapterum leaves led to the isolation of distinct polyphenolic derivatives : polyprenylated acylphloroglucinols were identified in batch A, with the major compound, tetrapterone, as a new acid derivative, whilst chromanone acids were identified in batch B, including a new derivative named as tetrapteric acid. The same protocol applied to Mesuaassamica leave extract showed that cytotoxic fractions were rich in xanthones whereas anti-inflammatory fractions contained numerous mammea coumarins. Along with these phytochemical studies, a panel of polyphenols representative of the chemical classes generally identified in Clusiaceae and Calophyllaceae specious were evaluated for their effects on various endothelial markersof inflammation and immunity. Mammea coumarins and guttiferone J, a polyprenylated benzophenone, appeared to significantly inhibit the expression of VCAM-1 as well as that of HLA class II molecules, HLA-E and MICA.
Document type :
Theses
Complete list of metadatas

Cited literature [277 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02155239
Contributor : Abes Star <>
Submitted on : Thursday, June 13, 2019 - 2:09:12 PM
Last modification on : Friday, June 14, 2019 - 2:07:04 AM

File

these_ROUGER_STAR.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02155239, version 1

Citation

Caroline Rouger. Activité pharmacologique de dérivés polyphénoliques isolés de Clusiaceae et de Calophyllaceae malaisiennes : effets régulateurs sur des marqueurs endothéliaux de l’inflammation et de l’immunité. Médecine humaine et pathologie. Université d'Angers, 2015. Français. ⟨NNT : 2015ANGE0066⟩. ⟨tel-02155239⟩

Share

Metrics

Record views

88

Files downloads

62