, Malaria, The Lancet, vol.383, pp.723-735, 2014.
, World Heal, 2017.
, Malaria: Biology and Disease, vol.167, pp.610-624, 2016.
Malaria biology and disease pathogenesis: insights for new treatments, Nat. Med, vol.19, p.156, 2013. ,
Hemoglobin degradation, Curr. Top. Microbiol. Immunol, vol.295, pp.275-291, 2005. ,
The malaria digestive vacuole, Front. Biosci. Sch. Ed, vol.4, pp.1424-1448, 2012. ,
Haemozoin formation, Mol. Biochem. Parasitol, vol.157, pp.127-136, 2008. ,
Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury, Am. J. Respir. Cell Mol. Biol, vol.15, pp.9-19, 1996. ,
Innate inflammatory response to the malarial pigment hemozoin, Microbes Infect, vol.12, pp.889-899, 2010. ,
Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice, Malar. J, vol.11, pp.166-166, 2012. ,
Heme Detoxification in Malaria: A Target Rich Environment, Inorg. Chem, vol.17, pp.263-280, 2005. ,
Hemozoin and antimalarial drug discovery, Future Med. Chem, vol.5, pp.1437-1450, 2013. ,
Biological actions of Artemisinin: Insights from medicinal chemistry studies, Molecules, vol.15, pp.1378-97, 2010. ,
,
Heme-Artemisinin Adducts Are Crucial Mediators of the Ability of Artemisinin to Inhibit Heme Polymerization, Chem. Biol, vol.9, pp.321-332, 2002. ,
Detection, Characterization, and Screening of Heme-Binding Molecules by Mass Spectrometry for Malaria Drug Discovery, Anal. Chem, vol.84, pp.3324-3329, 2012. ,
A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds, PLOS ONE, vol.7, p.41006, 2012. ,
Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay, Comb. Chem. High Throughput Screen, vol.8, pp.63-79, 2005. ,
Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae), Fitoterapia, vol.118, pp.1-5, 2017. ,
URL : https://hal.archives-ouvertes.fr/mnhn-02047319
Antivascular and antiparasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae), Eur. J. Med. Chem, vol.93, pp.93-100, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01149551
Interaction of Chloroquine and Its Analogues with Heme: An Isothermal Titration Calorimetric Study, Biochem. Biophys. Res. Commun, vol.276, pp.1075-1079, 2000. ,
Interactions of Genistein and Related Isoflavones with Lipid Micelles, Langmuir, vol.22, pp.7175-7184, 2006. ,
, Structure?Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by, p.33
, Chem. Res. Toxicol, vol.23, pp.1921-1935, 2010.
, Inhibition of Plasmodium falciparum Fatty Acid Biosynthesis: Evaluation of FabG, FabZ, and FabI as Drug Targets for Flavonoids, 2006.
Phytochemical composition, antiparasitic and ?-glucosidase inhibition activities from Pelliciera rhizophorae, Chem. Cent. J, vol.9, p.53, 2015. ,
A broad analysis of resistance development in the malaria parasite, Nat. Commun, vol.7, p.11901, 2016. ,
Structure-Activity Relationship of Citrus Polymethoxylated Flavones and Their Inhibitory Effects on Aspergillus niger, J. Agric. Food Chem, vol.60, pp.4336-4341, 2012. ,
Structure-Activity Relationship of Flavonoids on Their Anti-Escherichia coli Activity and Inhibition of DNA Gyrase, J. Agric. Food Chem, vol.61, pp.8185-8190, 2013. ,
, Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia, vol.56, pp.4-28, 2016.
Myricetin and quercetin methyl ethers from Haplopappus integerrimus var. Punctatus, Phytochemistry, vol.20, pp.98561-98564, 1981. ,
DOI : 10.1016/s0031-9422(00)98561-3
Structure elucidation, conformational analysis and thermal effects on membrane bilayers of an antimicrobial myricetin ether derivative, J. Heterocycl. Chem, vol.38, pp.703-710, 2001. ,
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents, Eur. J. Med. Chem, vol.54, pp.952-958, 2012. ,
Synthesis of Benzopyran-Fused Flavone Derivatives via Microwave-Assisted Intramolecular C-H Activation, Synthesis, vol.50, pp.1610-1620, 2018. ,
Regioselective iodination of flavonoids by N-iodosuccinimide under neutral conditions, Tetrahedron Lett, vol.54, pp.6345-6348, 2013. ,
Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties, J. Nat. Prod, vol.79, pp.1808-1814, 2016. ,
Flavonoids from Potentilla parvifolia Fisch . and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro, Chem. Biodivers, vol.14, p.1600487, 2017. ,
Influence of flavonols and quercetin derivative compounds on MA-10 Leydig cells steroidogenic genes expressions, Toxicol. In Vitro, vol.44, pp.111-121, 2017. ,
Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities, Org. Biomol. Chem, vol.14, pp.3061-3068, 2016. ,
Hydroxylated Polymethoxyflavones and Methylated Flavonoids in Sweet Orange (Citrus sinensis) Peel, 2006. ,
5?-Hexamethoxyflavone from the Australian plant Eremophila debilis (Myoporaceae), Fitoterapia, vol.4, pp.90-92, 2018. ,
Human malaria parasites in continuous culture, Science, vol.193, pp.673-675, 1976. ,
Synchronization of Plasmodium falciparum erythrocytic stages in culture, J. Parasitol, vol.65, pp.418-420, 1979. ,
Antiplasmodial activity of selected ,
, Nat. Commun, 2015.
, Proc. Natl. Acad. Sci, p.2080, 2016.
, Antimicrob. Agents Chemother, vol.38, pp.1854-1858, 1994.
, Angew. Chem. Int. Ed, vol.38, pp.2580-2582, 1999.
, Biochem. Pharmacol, vol.48, pp.569-573, 1994.
, Angew. Chem. Int. Ed, vol.40, pp.1954-1957, 2001.
, Bioorg. Med. Chem. Lett, vol.13, pp.1645-1647, 2003.
,
, Angew. Chem. Int. Ed, vol.46, pp.6278-6283, 2007.
, J. Med. Chem, vol.38, pp.2273-2275, 1995.
, J. Med. Chem, vol.54, pp.6443-6455, 2011.
, Trends Parasitol, vol.32, pp.682-696, 2016.
, Biochem. Pharmacol, vol.46, pp.336-339, 1993.
, Proc. Natl. Acad. Sci. U. S. A, p.13676, 2005.
, Pan, Mol. Biochem. Parasitol, vol.49, pp.181-189, 1991.
, Mol. Biochem. Parasitol, vol.63, pp.121-128, 1994.
, Malar. Prog. Probl. Plans Genomic Era, vol.32, pp.1655-1660, 2002.
, J. Med. Chem, vol.47, pp.2945-2964, 2004.
, Trans. R. Soc. Trop. Med. Hyg, vol.81, pp.710-714, 1987.
, Biol. Med, vol.22, pp.1283-1288, 1997.
, Pharm. Res, vol.10, pp.662-666, 1993.
, ChemMedChem, vol.2, pp.1448-1463, 2007.
, J. Chromatogr. B, vol.876, pp.54-60, 2008.
, Bioanalysis, issue.5, 2013.
, Drug Metab. Dispos, p.313, 1998.
, Antimicrob. Agents Chemother, vol.47, pp.3795-3798, 2003.
,
, Angew. Chem. Int. Ed, vol.45, pp.2082-2088, 2006.
, J. Med. Chem, vol.42, pp.5487-5493, 1999.
, Am. J. Trop. Med. Hyg, vol.49, pp.485-491, 1993.
, J. Chem. Soc. Perkin Trans. 2, pp.2089-2092, 1999.
, Angew. Chem. Int. Ed, vol.44, pp.2060-2063, 2005.
, J. Nat. Prod, vol.62, pp.54-58, 1999.
, J. Med. Chem, vol.38, pp.5045-5050, 1995.
, Org. Lett, vol.10, pp.5461-5464, 2008.
, Phytochem. Rev, vol.15, pp.1093-1114, 2016.
, Front. Biosci. Sch. Ed, vol.4, pp.1424-1448, 2012.
, Biochem. Pharmacol, vol.77, pp.322-336, 2009.
, Angew. Chem. Int. Ed, vol.43, pp.1381-1385, 2004.
, J. Med. Chem, vol.36, pp.4264-4275, 1993.
, T. J. REFERENCES, vol.14
The Structural Diversity and Promise of Antiparasitic 15 Marine Invertebrate-Derived Small Molecules, Chem. Biotechnol. -Pharm. Biotechnol, vol.16, issue.6, pp.808-818, 2010. ,
Molecular Networking as a Dereplication 2 Strategy, J. Nat. Prod, vol.76, issue.9, pp.1686-1699, 2013. ,
Comparing Similar Spectra: From Similarity Index 4 to Spectral Contrast Angle, J. Am. Soc. Mass Spectrom, vol.13, issue.1, pp.85-88, 2002. ,
, Characterization of 6 Noncovalent Complexes of Antimalarial Agents of the Artemisinin-Type and FE
, Heme by Electrospray Mass Spectrometry and Collisional Activation Tandem Mass
, Am. Soc. Mass Spectrom, vol.15, issue.8, pp.1181-1190, 2004.
,
, Intraerythrocytic Malarial Parasites. 2. Altered Vacuolar 11 Volume Regulation in Drug Resistant Malaria, Biochemistry (Mosc.), vol.12, issue.41, pp.12411-12423, 2006.
The pH of the Digestive Vacuole of Plasmodium 14 falciparum Is Not Associated with Chloroquine Resistance, J. Cell Sci, vol.119, issue.6, p.1016, 2006. ,
The Malaria Digestive Vacuole, Front. Biosci ,
, , vol.4, pp.1424-1448, 2012.
The Plasmodium Digestive Vacuole: Metabolic 19 Headquarters and Choice Drug Target, Parasitol. Today, vol.11, issue.8, pp.294-297, 1995. ,
Human Malaria Parasites in Continuous Culture, Science, vol.1, issue.4254, pp.673-675, 1976. ,
Synchronization of Plasmodium falciparum Erythrocytic 3 Stages in Culture, J. Parasitol, vol.65, issue.3, pp.418-420, 1979. ,
,
Antiprotozoal 6 Activity of Medicinal Plants Used by Iquitos-Nauta ,
, J. Ethnopharmacol, vol.210, pp.372-385, 2018.
Selective 9 Inhibition of PfA-M1, over PfA-M17, by an Amino-Benzosuberone Derivative Blocks 10 Malaria Parasites Development in vitro and in vivo, Malar. J, vol.2017, issue.1, p.382 ,
Cell Biology of Heme, Am. J. Med. Sci, vol.318, issue.4, pp.241-256, 1999. ,
Nitric Oxide Synthase Is a Cytochrome P-450 Type 13 Hemoprotein, Biochemistry (Mosc.), issue.29, pp.6627-6631, 1992. ,
Growth of Large Hematin Crystals in 15 Biomimetic Solutions, Cryst. Growth Des, vol.14, issue.5, pp.2123-2127, 2014. ,
Hematin 17 Crystallization from Aqueous and Organic Solvents, J. Chem. Phys, vol.2013, issue.12, p.121911 ,
Increase on the Initial 20 Soluble Heme Levels in Acidic Conditions Is an Important Mechanism for Spontaneous 21 ,
, Heme Crystallization in vitro, PLOS ONE, vol.2010, issue.9, p.12694
Lipid or Aqueous Medium for 1 Hematin Crystallization? CrystEngComm, vol.17, pp.7790-7800, 2015. ,
Als-Nielsen, 3 J.; Leiserowitz, L. Aligned Hemozoin Crystals in Curved Clusters in Malarial Red Blood 4 Cells Revealed by Nanoprobe X-Ray Fe Fluorescence and Diffraction, Proc. Natl. Acad ,
, , vol.109, pp.11184-11187, 2012.
,
, Digestive Vacuole Membrane in Plasmodium falciparum, Proc. Natl. Acad. Sci. 2012, vol.9, pp.11188-11193
, J. Haemozoin Formation. Mol. Biochem. Parasitol, vol.157, issue.2, pp.127-136, 2008.
Recent Advances in Understanding the Mechanism of Hemozoin (Malaria 12 Pigment) Formation, J. Inorg. Biochem, vol.102, issue.5, pp.1288-1299, 2008. ,
Octanol-Water Partition Coefficients: Fundamentals and Physical 14 Chemistry, vol.2, 1997. ,
Mechanisms of Hematin 16 Crystallization and Inhibition by the Antimalarial Drug Chloroquine, Proc. Natl. Acad ,
, , vol.112, pp.4946-4951, 2015.
Simple 19 Colorimetric Inhibition Assay of Heme Crystallization for High-Throughput Screening, p.20 ,
, Antimalarial Compounds. Antimicrob. Agents Chemother, vol.51, issue.1, pp.350-353, 2007.
,
, Preprocessing To Enhance Molecular Networking Reliability, Anal. Chem, 2017.
Comprehensive Analytical Chemistry Volume XXXVIII: Countercurrent 24 Chromatography -The Support-Free Liquid Stationary Phase ,
, Parasite Mitochondria as a Target of Chemotherapy: Inhibitory Effect of, vol.26, p.27
, Licochalcone A on the Plasmodium falciparum Respiratory Chain, vol.28, pp.46-54, 2005.
Biological Evaluation of Phytoconstituents from 31 Polygonum hydropiper, Nat. Prod. Res, vol.30, issue.17, pp.2053-2057 ,
DOI : 10.1080/14786419.2016.1269094
Specific Interaction of Chalcone-Protein: 33 Cardamonin Binding Site II on the Human Serum Albumin Molecule, Biopolymers, vol.34, issue.1, pp.48-57, 2005. ,
The Chemistry of Chalcones and Related Compounds, vol.36, 1981. ,
Chalcone: A Privileged 38 Structure in Medicinal Chemistry, Chem. Rev, vol.2017, issue.12, pp.7762-7810 ,
2'-Hydroxymatteucinol, a New 10 C-Methyl Flavanone Derivative from Matteccia orientalis; Potent Hypoglycemic 11 Activity in Streptozotocin (STZ)-Induced Diabetic Rat, Chem. Pharm. Bull, vol.12, issue.10, pp.1790-1795, 1993. ,
,
, Antihyperglycaemic Flavonoids from Syzygium samarangense (Blume) Merr. and 15 Perry, Phytother. Res, vol.19, issue.3, pp.246-251, 2005.
Biological Evaluation of Phytoconstituents from 18 Polygonum hydropiper, Nat. Prod. Res, vol.17, issue.17, pp.2053-2057 ,
Phenolic Compounds from the Rhizomes of Alpinia 20 speciosa, Phytochemistry, vol.20, issue.11, pp.2503-2506, 1981. ,
Three Flavanones from Leaves of Eucalyptus sieberi ,
DOI : 10.1071/ch9720449
URL : http://www.publish.csiro.au/ch/pdf/ch9720449
, , vol.25, pp.449-451, 1972.
A ?-Hydroxychalcone from Leptospermum scoparium, Planta Med, vol.59, issue.3, pp.269-271, 2007. ,
Constituents from 26 Limonia crenulata, J. Asian Nat. Prod. Res, vol.3, issue.4, pp.299-311, 2001. ,
Constituents of Pleiospermium alatum: 28 Alatamide and N-Benzoyltyramine Methyl Ether, Aust. J. Chem, vol.28, issue.2, pp.457-460, 1975. ,
, Controlling the C, vol.3
, C(sp2) Axial Conformation in the Enantioselective Friedel-Crafts-Type Alkylation of ?-31 Naphthols with Inden-1-Ones, Org. Lett, vol.19, issue.24, pp.6692-6695, 2017.
Thiol-Olefin Cooxidation Reaction. 6. A New Convenient 33 Route to 1-Substituted Indenes. Indenone as Dienophile in Diels-Alder Reactions ,
, , vol.43, pp.1835-1837, 1978.
Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II, Spec. Issue Mem. Edw. Stiefel, vol.101, pp.1739-1747, 2007. ,
Evaluating antidisease immunity to malaria and implications for vaccine design, Immunology, vol.153, pp.423-434, 2018. ,
,
Combination of Bioautography with HPTLC-MS/NMR: A Fast identification of acetylcholinesterase inhibitors from Galbanum, Phytochem. Anal, vol.24, pp.395-400, 2013. ,
Host-parasite interactions that guide red blood cell invasion by malaria parasites, Curr. Opin. Hematol, vol.22, pp.220-226, 2015. ,
A mass spectrometric journey into protein and proteome research, J. Am. Soc. Mass Spectrom, vol.14, pp.289-296, 2003. ,
Are public-private partnerships the solution to tackle neglected tropical diseases? A systematic review of the literature, Health Policy, vol.121, pp.745-754, 2017. ,
Integration of Molecular Networking and In-Silico MS/MS fragmentation for natural products dereplication, Anal. Chem, vol.88, pp.3317-3323, 2016. ,
Sobre a origem e dispersão das leishmanioses cutânea e mucosa com base em fontes históricas pré e pós-colombianas, Hist Cienc Saude-Manguinhos, vol.10, pp.853-882, 2003. ,
Mode of action of methoprene in affecting female reproduction in the African malaria mosquito, Anopheles gambiae, Pest Manag. Sci, vol.66, pp.936-943, 2010. ,
Malaria gametocytogenesis. Mol, Biochem. Parasitol, vol.172, pp.57-65, 2010. ,
Spectral networks: a new approach to de novo discovery of protein sequences and posttranslational modifications, BioTechniques, vol.42, pp.687-695, 2007. ,
Protein identification by spectral networks analysis, Proc. Natl. Acad. Sci, vol.104, p.6140, 2007. ,
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.990-995, 2002. ,
Management of trypanosomiasis and leishmaniasis, Br. Med. Bull, vol.104, pp.175-196, 2012. ,
Haem polymerization in malaria, Nature, vol.378, 1995. ,
Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation: Grand Rounds at University of California, San Francisco Medical Center, J. Gen. Intern. Med, vol.23, pp.854-859, 2008. ,
, , 2002.
Methoxylated flavones: occurrence, importance, biosynthesis, Phytochem. Rev, vol.15, pp.363-390, 2016. ,
Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus, J. Nat. Prod, vol.53, pp.867-874, 1990. ,
, The effect of malaria control on Plasmodium falciparum in Africa between, vol.526, p.207, 2000.
Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: Its application to Artemisia annua constituents, Life Sci, vol.70, pp.1447-1450, 2002. ,
Accelerated dereplication of natural products, supported by reference libraries, Chim. Int. J. Chem, vol.61, pp.332-338, 2007. ,
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic, Nat. Med, vol.23, 2017. ,
New sesquiterpenes and acetylenes from Athanasia and Pentzia species, Phytochemistry, vol.17, issue.00, pp.94650-94658, 1978. ,
Zwei neue sesquiterpen-lactone aus lidbeckia pectinata berg. und pentzia elegans DC, Tetrahedron Lett, vol.13, pp.621-624, 1972. ,
, , pp.84393-84401
Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets, Chem. Biodivers, vol.3, pp.622-634, 2006. ,
?-Lactones as privileged structures for the activesite labeling of versatile bacterial enzyme classes, Angew. Chem. Int. Ed, vol.47, pp.4600-4603, 2008. ,
Pharmacognosie, Phytochimie, Plantes médicinales, 2016. ,
Human African trypanosomiasis, The Lancet, vol.390, pp.31510-31516, 2017. ,
Two decades of ethnobotanical research in southern Ecuador and northern Peru, Ethnobiol. Conserv, pp.1-50, 2014. ,
,
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis, Sci. Rep, vol.3, 2013. ,
Apuntes de Medicina Tradicional: la racionalizacion de lo irracional, vol.1, 1993. ,
Frontal affinity chromatography?Mass Spectrometry useful for characterization of new ligands for GPR17 receptor, J. Med. Chem, vol.53, pp.3489-3501, 2010. ,
Dereplication of natural products using GC-TOF Mass Spectrometry: Improved metabolite identification by spectral deconvolution ratio analysis, Front. Mol. Biosci, vol.3, 2016. ,
, CDC, 2018.
, CDC, 2013. Parasites -Leishmaniasis: Epidemiology & Risk Factors
, CDC, 2012. Parasites -African Trypanosomiasis: Epidemiology & Risk Factors
Drug Resistance in Leishmaniasis, J. Glob. Infect. Dis, vol.2, pp.167-176, 2010. ,
Chagas disease drug discovery: Toward a new era, J. Biomol. Screen, vol.20, pp.22-35, 2014. ,
Applying mass spectrometry to study non-covalent biomolecule complexes, Mass Spectrom. Rev, vol.35, pp.48-70, 2015. ,
Chemical components and cardiovascular activities of Valeriana spp, Evid. Based Complement. Alternat. Med, vol.11, 2015. ,
Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury, Am. J. Respir. Cell Mol. Biol, vol.15, pp.9-19, 1996. ,
Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum, Proc. Natl. Acad. Sci. 110, 5392, 2013. ,
Optical, Electric and Magnetic Properties of Molecules: A Review of the Work of, 1997. ,
NMRbot: Python scripts enable high-throughput data collection on current Bruker BioSpin NMR spectrometers, Metabolomics, vol.9, pp.558-563, 2013. ,
Treatment of drug-resistant malaria in man, Bull. World Health Organ, vol.50, pp.243-249, 1974. ,
Manson's Tropical Diseases, Twenty-first, 2003. ,
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum, Nature, vol.480, 2011. ,
Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors, MedChemComm, vol.2, pp.590-595, 2011. ,
Cutaneous Leishmaniasis: Recent developments in diagnosis and management, Am. J. Clin. Dermatol, vol.16, pp.99-109, 2015. ,
Ethnobotanical study of medicinal plants used by the Andean people of Canta, J. Ethnopharmacol, vol.111, pp.284-294, 2007. ,
Ritual and medicinal plants of the Ese'ejas of the Amazonian rainforest (Madre de Dios, Perú), J. Ethnopharmacol, vol.52, pp.1390-1396, 1996. ,
Alternative to chemotherapy-The unmet demand against, Leishmaniasis. Front. Immunol, vol.8, p.1779, 2017. ,
Drugs for Neglected Diseases Initiave: about Chagas Disease, 2017. ,
Artemisinin Resistance in Plasmodium falciparum Malaria, N. Engl. J. Med, vol.361, pp.455-467, 2009. ,
Spectral deconvolution for Gas Chromatography Mass SpectrometryBased metabolomics: Current status and future perspectives, Comput. Struct. Biotechnol. J, vol.4, 2013. ,
Use of tropical rainforests by native Amazonians, BioScience, vol.40, pp.652-659, 1990. ,
PfCRT and its role in antimalarial drug resistance, Trends Parasitol, vol.28, pp.504-514, 2012. ,
Artemisinins target the SERCA of Plasmodium falciparum, Nature, vol.424, p.957, 2003. ,
Haemozoin formation. Mol, Biochem. Parasitol, vol.157, pp.127-136, 2008. ,
Identification and Characterization of Falcilysin, a Metallopeptidase Involved in Hemoglobin Catabolism within the Malaria Parasite Plasmodium falciparum, J. Biol. Chem, vol.274, pp.32411-32417, 1999. ,
Experimentally induced blood stage malaria infection as a tool for clinical research, Trends Parasitol, vol.28, pp.515-521, 2012. ,
Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group, J. Ethnopharmacol, vol.114, pp.254-259, 2007. ,
,
Flavonoids: biosynthesis, biological functions, and biotechnological applications, Front. Plant Sci, vol.3, 2012. ,
Electrospray ionization for mass spectrometry of large biomolecules, Science, vol.246, 1989. ,
Electrospray wings for molecular elephants (Nobel Lecture), Angew. Chem. Int. Ed, vol.42, pp.3871-3894, 2003. ,
Structure and function of enzymes involved in the biosynthesis of phenylpropanoids, Plant Struct. Biol, vol.46, pp.356-370, 2008. ,
Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: Assembly of 26.4 Million structures (110.9 Million Stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery, J. Chem. Inf. Model, vol.47, pp.342-353, 2007. ,
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs, Life Sci, vol.74, pp.1957-1972, 2004. ,
Involvement of lipids in ferriprotoporphyrin IX polymerization in malaria, Biochim. Biophys. Acta BBA -Mol. Basis Dis, vol.1454, pp.31-37, 1999. ,
Antimalarial drug discovery -approaches and progress towards new medicines, Nat. Rev. Microbiol, vol.11, 2013. ,
Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents, Pharmacol. Ther, vol.79, pp.55-87, 1998. ,
, , pp.12-18
Hemozoin and antimalarial drug discovery, Future Med. Chem, vol.5, pp.1437-1450, 2013. ,
Revisiting previously investigated plants: A Molecular Networking-Based study of Geissospermum laeve, J. Nat. Prod, vol.80, pp.1007-1014, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02105819
Hemoglobin metabolism in the malaria parasite Plasmodium falciparum, Annu. Rev. Microbiol, vol.51, pp.97-123, 1997. ,
The use of high-performance liquid chromatography and diode array detection in fungal chemotaxonomy based on profiles of secondary metabolites, Bot. J. Linn. Soc, vol.99, pp.81-95, 1989. ,
The relation of Plasmodium berghei and Plasmodium knowlesi to their respective red-cell hosts, Trans. R. Soc. Trop. Med. Hyg, vol.50, pp.90076-90077, 1956. ,
Dereplication: racing to speed up the natural products discovery process, Nat. Prod. Rep, vol.32, pp.779-810, 2015. ,
, Pentzia monodiana Maire, 2018.
, gbif, 2018b. gbif.org
Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics, Malar. J, vol.13, p.38, 2014. ,
Leishmaniasis in humans: drug or vaccine therapy?, Drug Des. Devel. Ther, vol.12, pp.25-40, 2018. ,
Microfractionation revisited: A 1536 well high resolution screening assay, Anal. Chem, vol.81, pp.5460-5466, 2009. ,
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria, Biochemistry, vol.45, pp.12411-12423, 2006. ,
Hemoglobin degradation, Curr. Top. Microbiol. Immunol, vol.295, pp.275-291, 2005. ,
Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle, Proc. Natl. Acad. Sci, vol.87, 1990. ,
Bioautography with TLC-MS/NMR for rapid discovery of anti-tuberculosis lead compounds from natural sources, ACS Infect. Dis, vol.2, pp.294-301, 2016. ,
Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS, Phytochem. Anal, vol.17, pp.102-106, 2005. ,
Chapter 8 -Interfacial Phenomena, in: Developing Solid Oral Dosage Forms, pp.225-252, 2017. ,
Mass Spectrometry for proteomics, Curr. Opin. Chem. Biol, vol.12, pp.483-490, 2008. ,
Detection and Assay of Antitumor Antibiotics, Antitumor Antibiotics, pp.69-76, 1978. ,
X-Hitting: An algorithm for novelty detection and dereplication by UV spectra of complex mixtures of natural products, Anal. Chem, vol.77, pp.6805-6817, 2005. ,
Ethnobotany and ethnopharmacology-Interdisciplinary links with the historical sciences, J. Ethnopharmacol, vol.107, pp.157-160, 2006. ,
Plasmodium falciparum: sacrificing membrane to grow crystals?, Trends Parasitol, vol.19, pp.11-20, 2003. ,
Defining the structure and stability of macromolecular assemblies in solution: the re-emergence of analytical ultracentrifugation as a practical tool, Structure, vol.4, pp.42-43, 1996. ,
Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry, J. R. Soc. Interface, vol.9, 2012. ,
Some transfusion-induced parasitic infections in Zambia, J. Hyg. Epidemiol. Microbiol. Immunol, vol.23, pp.436-444, 1979. ,
Crystallization of synthetic haemozoin, 2010. ,
, Dalton Trans, vol.39, pp.1235-1244
Non-Covalent Interactions, Theoretical and Computational Chemistry Series, 2009. ,
Organic Chemistry, Second Edition, 2004. ,
Interrogation of Noncovalent Complexes by ESI-MS: A Powerful Platform for High Throughput Drug Discovery, Mass Spectrometry in Medicinal Chemistry, pp.321-338, 2007. ,
,
Applications of ESI-MS in drug discovery: interrogation of noncovalent complexes, Nat. Rev. Drug Discov, vol.5, 2006. ,
Approaches to automating the dereplication of bioactive natural products-The key step in high throughput screening of bioactive materials from natural sources, J. Biomol. Screen, vol.2, pp.145-152, 1997. ,
Strategy in the search for new lead compounds and drugs from plants, Chimia, vol.59, pp.291-294, 2005. ,
The global burden of disease study 2010: Interpretation and implications for the neglected tropical diseases, PLoS Negl. Trop. Dis, vol.8, 2014. ,
, Ionic Bonding, Crystals, and Intermolecular Forces, pp.47-66, 2016.
DOI : 10.1016/b978-0-12-804697-5.00004-x
Exploiting the complementarity between dereplication and domputer-assisted structure elucidation for the chemical profiling of natural cosmetic ingredients: Tephrosia purpurea as a case study, J. Nat. Prod, vol.78, pp.1609-1617, 2015. ,
Identification of natural metabolites in mixture: A pattern recognition strategy based on 13C NMR, Anal. Chem, vol.86, pp.2955-2962, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01968799
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?, Phytochem. Rev, vol.16, pp.55-95, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01904964
Aromatic interactions, J. Chem. Soc. Perkin Trans, vol.2, pp.651-669, 2001. ,
The nature of .pi.-.pi. interactions, J. Am. Chem. Soc, vol.112, pp.5525-5534, 1990. ,
KAE609 (Cipargamin), a enw Spiroindolone agent for the treatment of malaria: Evaluation of the absorption, distribution, metabolism, and excretion of a single oral 300-mg dose of [ 14 C]KAE609 in healthy male Subjects, Drug Metab. Dispos, vol.44, p.672, 2016. ,
High-Throughput Screening and prediction model building for novel hemozoin inhibitors using physicochemical properties, Antimicrob. Agents Chemother, vol.61, pp.1607-1623, 2017. ,
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products, J. Chromatogr. A, vol.872, pp.1292-1295, 2000. ,
Determination of d-myo-1,2,6-inositol trisphosphate by ion-pair reversed-phase liquid chromatography with post-column ligand exchange and fluorescence detection, 1990. ,
, J. Chromatogr. A, vol.499, pp.97006-97013
Specific ring stacking interaction on the tryptophan-7-methylguanine system: comparative crystallographic studies of indole derivatives-7-methylguanine base, nucleoside, and nucleotide complexes, J. Am. Chem. Soc, vol.110, pp.2286-2294, 1988. ,
Chapter 2 -Glycoglycerolipids, New Comprehensive Biochemistry, pp.60021-60027, 1985. ,
DOI : 10.1016/s0167-7306(08)60021-6
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7, Proc. Natl. Acad. Sci, vol.113, 2016. ,
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions, Proc. Natl. Acad. Sci, vol.110, 2013. ,
Intermolecular and Surface Forces, Third Edition, 2011. ,
SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium, Proc. Natl. Acad. Sci. 111, E5455, 2014. ,
Purification and analysis of 4-aminopteroylglutamic acid-2-C14 (aminopterin) by chromatography and bioautography, Anal. Chem, vol.26, pp.1856-1856, 1954. ,
An ethnobotanical study of the traditional medicine of the Mestizo people of Suni Miraño, J. Ethnopharmacol, vol.53, pp.1437-1444, 1996. ,
Espiritus incorporados: therapeutic plants and animals in the Amazonian Mestizo folklore, J. Ethnobiol, vol.8, pp.141-148, 1988. ,
Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.11184-11187, 2012. ,
Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography, Sci. Rep, vol.7, 2017. ,
Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum, Proc. Natl. Acad. Sci, vol.109, pp.11188-11193, 2012. ,
Digestive vacuole membrane in Plasmodium falciparum-Infected erythrocytes: relevance to templated nucleation of hemozoin, Langmuir, vol.29, pp.14595-14602, 2013. ,
Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons, Anal. Chem, vol.60, pp.2299-2301, 1988. ,
,
Cytochrome b Mutations That Modify the Ubiquinol-binding pocket of the Cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae, J. Biol. Chem, vol.280, pp.17142-17148, 2005. ,
Hematin crystallization from aqueous and organic solvents, J. Chem. Phys, vol.139, p.121911, 2013. ,
Methylation of flavonoids: Chemical structures, bioactivities, progress and perspectives for biotechnological production, Enzyme Microb. Technol, vol.86, pp.103-116, 2016. ,
On the role of London dispersion forces in biomolecular structure determination, J. Phys. Chem. B, vol.115, pp.8038-8046, 2011. ,
,
Advances in mass spectrometry-based postcolumn bioaffinity profiling of mixtures, Anal. Bioanal. Chem, vol.399, pp.2655-2668, 2011. ,
Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins, Mol. Biochem. Parasitol, vol.119, pp.427-430, 2002. ,
, Infectious Diseases, pp.1345-1372, 2017.
Management of medicinally useful plants by European migrants in South America, J. Ethnopharmacol, vol.172, pp.347-355, 2015. ,
Trepanation procedures/outcomes: Comparison of Prehistoric Peru with other ancient, medieval, and American civil war cranial surgery, World Neurosurg, vol.114, pp.245-251, 2018. ,
,
Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis, J. Ethnopharmacol, vol.106, pp.390-402, 2006. ,
Biodiversity and Traditional Knowledge, 2002. ,
Measuring protein-protein interactions, Curr. Opin. Struct. Biol, vol.8, pp.80019-80024, 1998. ,
UV-Guided isolation of Verrucines A and B, novel quinazolines from Penicillium verrucosum structurally related to Anacine from Penicillium aurantiogriseum, J. Nat. Prod, vol.62, pp.1578-1580, 1999. ,
,
UV-guided screening of benzodiazepine producing species in Penicillium, Biochem. Syst. Ecol, vol.28, pp.881-886, 2000. ,
UV-Guided isolation of Alantrypinone, a novel Penicillium alkaloid, J. Nat. Prod, vol.61, pp.1154-1157, 1998. ,
Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV spectra, combined with structural determination by NMR spectroscopy, J. Nat. Prod, vol.68, pp.871-874, 2005. ,
Mass spectrometry as a versatile ancillary technique for the rapid in situ identification of lichen metabolites directly from TLC plates, The Lichenologist, vol.49, pp.507-520, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01617558
Substances, relationships and the omnipresence of the body: an overview of Ashéninka ethnomedicine (Western Amazonia), J. Ethnobiol. Ethnomedicine, vol.2, pp.49-49, 2006. ,
Sixty medicinal plants from the Peruvian Amazon: Ecology, ethnomedicine and bioactivity, J. Nat. Prod, vol.63, pp.1596-1597, 2000. ,
Biological actions of Artemisinin: Insights from medicinal chemistry studies, Molecules, vol.15, pp.1378-97, 2010. ,
The occurrence of tricin and its derivatives in plants, Green Chem, vol.18, pp.1439-1454, 2016. ,
Antifungal cyclopentenediones from Piper coruscans, J. Am. Chem. Soc, vol.126, pp.6872-6873, 2004. ,
Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer, Drug Metab. Rev, vol.42, pp.590-611, 2010. ,
,
Novel mutations on the ace-1 gene of the malaria vector Anopheles albimanus provide evidence for balancing selection in an area of high insecticide resistance in Peru, Malar. J, vol.14, 2015. ,
The unknown risk of vertical transmission in sleeping sickness -a literature review, PLoS Negl. Trop. Dis, vol.4, 2010. ,
Bioactive Compounds from Plants Used in Peruvian Traditional Medicine, Nat. Prod. Commun, vol.11, pp.315-337, 2016. ,
Studying noncovalent protein complexes by electrospray ionization mass spectrometry, Mass Spectrom. Rev, vol.16, pp.1-23, 1997. ,
Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials, Biochem. J, vol.339, pp.363-370, 1999. ,
The healing practices of a peruvian shaman, J. Ethnopharmacol, vol.11, pp.90035-90042, 1984. ,
Ayahuasca Visions, North Atlantic Books, 1991. ,
Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography, RDPA, vol.48, pp.238-246, 2007. ,
Two new species of Asteraceae (tribe Anthemideae, subtribe Pentziinae) from the Cape Floristic Region of South Africa. South Afr, J. Bot, vol.76, pp.279-284, 2010. ,
A taxonomic revision of Pentzia (Asteraceae, Anthemideae) I: the P. incana group in southern Africa, including the description of the new species P. oppositifolia Magee. South Afr, J. Bot, vol.79, pp.148-158, 2012. ,
,
Twenty years of gas phase structural biology, Structure, vol.21, pp.1541-1550, 2013. ,
Preconquest Peruvian neurosurgeons: a study of Inca and pre-Columbian trephination and the art of medicine in ancient Peru, Neurosurgery, vol.47, pp.940-950, 2000. ,
Rethinking the term "pi-stacking, Chem. Sci, vol.3, pp.2191-2201, 2012. ,
DOI : 10.1039/c2sc20045g
URL : https://repositories.lib.utexas.edu/bitstream/2152/41033/1/2012_Martinez.pdf
Uncovering the molecular mode of action of the antimalarial drug Atovaquone using a bacterial system, J. Biol. Chem, vol.280, pp.27458-27465, 2005. ,
Determinants of disease phenotype in trypanosomatid parasites, Trends Parasitol, vol.30, pp.342-349, 2014. ,
Targeting Plasmodium PI(4)K to eliminate malaria, Nature, vol.504, p.248, 2013. ,
Activated oxygen mediates the antimalarial activity of qinghaosu, Prog. Clin. Biol. Res, vol.313, pp.95-104, 1989. ,
Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes, Proc. Natl. Acad. Sci. 108, 18796, 2011. ,
Malaria pathogenesis, Science, vol.264, 1878. ,
DOI : 10.1126/science.8009217
The Resistance Factor to Plasmodium vivax in Blacks -the Duffy blood group genotype, FyFy. N. Engl. J. Med, vol.295, pp.302-304, 1976. ,
, Mapa de Leishmaniosis por distritos Perú, 2017.
, Boletín Epidemiológico del Perú, 2017.
, Casos de malaria por departamentos Perú, 2016.
, Boletín epidemiológico del Perú 2016: Ministerio de salud del Perú, 2016.
, Situación epidemiológica de la leishmaniasis en el Perú, I semestre, 2015.
Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes, Science, vol.347, pp.985-988, 2015. ,
Hotspots: Earth's Biologically Richest and Most Endangered Terrestrial Ecoregions, J. Mammal, vol.83, pp.630-633, 2002. ,
The preparation and development of cellular membrane affinity chromatography columns, Nat. Protoc, vol.4, pp.197-205, 2009. ,
,
Le métissage dans l'histoire de l'Amérique latine, Fayard, 1971. ,
Medicinal plant use in two Andean communities located at different altitudes in the Bolívar Province, Peru. J. Ethnopharmacol, vol.145, pp.450-464, 2013. ,
Antimalarial drugs: modes of action and mechanisms of parasite resistance, Future Microbiol, vol.5, pp.1857-1873, 2010. ,
Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery, Anal. Chem, vol.84, pp.3324-3329, 2012. ,
Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach, Sci. Rep, vol.6, 2016. ,
Identification of essential histidine residues involved in heme binding and hemozoin formation in heme detoxification protein from Plasmodium falciparum, p.6137, 2014. ,
A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria, J. Antimicrob. Chemother, vol.60, pp.929-936, 2007. ,
,
, Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes, vol.347, 2015.
Natural products as sources of new drugs from 1981 to, J. Nat. Prod, vol.79, pp.629-661, 2014. ,
Dereplication of microbial natural products by LC-DAD-TOFMS, J. Nat. Prod, vol.74, pp.2338-2348, 2011. ,
DOI : 10.1021/np200254t
URL : http://orbit.dtu.dk/en/publications/dereplication-of-microbial-natural-products-by-lcdadtofms(4f83f4f1-5c17-41d0-8954-9816b36c998c).html
Flavonoids: a review of probable mechanisms of action and potential applications, Am. J. Clin. Nutr, vol.74, pp.418-425, 2001. ,
Enzyme inhibitor discovery by activity-based protein profiling, Annu. Rev. Biochem, vol.83, pp.341-377, 2014. ,
DOI : 10.1146/annurev-biochem-060713-035708
, The Nobel Prize in Physiology or Medicine, 2015.
Antiviral activity of diterpene esters on Chikungunya virus and HIV replication, J. Nat. Prod, vol.78, pp.1277-1283, 2015. ,
DOI : 10.1021/acs.jnatprod.5b00073
URL : https://hal.archives-ouvertes.fr/hal-01297516
Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy, Trends Parasitol, vol.21, pp.292-298, 2005. ,
,
Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium, Trends Parasitol, vol.21, pp.334-339, 2005. ,
Ta'ta', Huayani: Perception of leishmaniasis and evaluation of medicinal plants used by the Chayahuita in Peru. Part II, J. Ethnopharmacol, vol.126, pp.149-158, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-01087667
Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III, J. Ethnopharmacol, vol.137, pp.875-879, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00684617
Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon), J. Ethnopharmacol, vol.146, pp.127-153, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00816594
Dereplication of depsides from the lichen Pseudevernia furfuracea by centrifugal partition chromatography combined to 13C nuclear magnetic resonance pattern recognition, Anal. Chim. Acta, vol.846, pp.60-67, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01968801
Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine, Proc. Natl. Acad. Sci. U. S. A, vol.112, pp.4946-4951, 2015. ,
Molecular mechanisms of hematin crystallization from organic solvent, Cryst. Growth Des, vol.15, pp.5535-5542, 2015. ,
Antimalarials inhibit hematin crystallization by unique drug-surface site interactions, Proc. Natl. Acad. Sci. U. S. A, vol.114, pp.7531-7536, 2017. ,
Growth of large hematin crystals in biomimetic solutions, Cryst. Growth Des, vol.14, pp.2123-2127, 2014. ,
The Plasmodium digestive vacuole: Metabolic headquarters and choice Drug target, Parasitol. Today, vol.11, issue.95, pp.80042-80047, 1995. ,
The Molecular mechanism of action of artemisinin-the debate continues, Molecules, vol.15, 2010. ,
Theoretical concepts of online liquid chromatographic-biochemical detection systems II. Detection systems based on labelled affinity proteins, J. Chromatogr. A, vol.787, pp.37-46, 1997. ,
Theoretical concepts of on-line liquid chromatographic-biochemical detection systems I. Detection systems based on labelled ligands, J. Chromatogr. A, vol.787, pp.646-654, 1997. ,
The structure of malaria pigment [beta]-haematin, Nature, vol.404, pp.307-310, 2000. ,
,
The nature of the chemical bond. II. The one-electron bond and the threeelectron bond, J. Am. Chem. Soc, vol.53, pp.3225-3237, 1931. ,
,
Clinical spectrum of Leishmaniasis, Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am, vol.22, pp.1-13, 1996. ,
Malaria: Principles and practice of malariology (vols 1 and 2), Parasitol. Today, vol.5, 1989. ,
, Malaria. Nat. Rev. Dis. Primer, vol.3, p.17051, 2017.
The useful plants of Tambopata, Peru: I. Statistical hypotheses tests with a new quantitative technique, Econ. Bot, vol.47, pp.15-32, 1993. ,
Comparative bioautography of vitamin B12 and related growth factors using Euglena gracilis and Lactobacillus leichmannii, Proc. Soc. Exp. Biol. Med. Soc. Exp. Biol. Med. N. Y. N, vol.75, pp.511-515, 1950. ,
The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization, Biochem. J, vol.402, pp.197-204, 2007. ,
The evolution of drug-resistant malaria, Trans. R. Soc. Trop. Med. Hyg, vol.103, pp.11-14, 2009. ,
, Biophysical Principles, pp.53-62, 2017.
Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays, Nat. Prod. Rep, vol.30, pp.546-564, 2013. ,
First domino radical cyclisation/Smiles rearrangement combination, Chem. Commun, vol.48, pp.2442-2444, 2012. ,
Apical membrane antigen 1: a malaria vaccine candidate in review, Trends Parasitol, vol.24, pp.74-84, 2008. ,
Las ramas floridas del bosque, experiencias en el manejo de plantas medicinales amazónicas. Intituto de Investigaciones de la Amazonia Peruana, 2007. ,
Interactions non-covalentes et propriétés physico-chimiques de petits systèmes biologiques : approches théoriques. Ecole polytechnique, 2014. ,
The antimalarial drug artemisinin alkylates heme in infected mice, Proc. Natl. Acad. Sci. U. S. A, vol.102, 2005. ,
Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin, Angew. Chem. Int. Ed, vol.40, pp.1954-1957, 2001. ,
Characterization of the First Covalent Adduct between Artemisinin and a Heme Model, J. Am. Chem. Soc, vol.119, pp.5968-5969, 1997. ,
Quinine, malaria and the quest for a cure that changed the world, 2003. ,
Possible cases of sexual and congenital transmission of sleeping sickness, The Lancet, vol.363, pp.15345-15352, 2004. ,
PfCRT mediated drug transport in malarial parasites, Biochemistry, vol.50, pp.163-171, 2011. ,
The major yolk protein Vitellogenin interferes with the anti-Plasmodium response in the malaria mosquito Anopheles gambiae, PLOS Biol, vol.8, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00707257
Cysteine proteases of malaria parasites: Targets for chemotherapy, Curr. Pharm. Des, vol.8, pp.1659-1672, 2002. ,
Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment, QSAR and Historical Developments, pp.1-46, 2015. ,
Intracellular phagotrophy by malaria parasites: an electron microscope study of Plasmodium lophurae, J. Protozool, vol.4, pp.190-199, 1957. ,
Ecological bases of Amuesha agriculture, Peruvian Upper Amazon, Adv Ecom Bot, vol.7, pp.189-212, 1989. ,
Identification of ?-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity, Int. J. Parasitol. Drugs Drug Resist, vol.4, pp.316-325, 2014. ,
Recent updates and perspectives on leishmaniasis, J. Infect. Dev. Ctries, vol.9, 2015. ,
Screening of natural products extracts for the presence of phosphodiesterase inhibitors using liquid chromatography coupled online to parallel biochemical detection and chemical characterization, J. Biomol. Screen, vol.8, pp.421-429, 2003. ,
Target identification and mechanism of action in chemical biology and drug discovery, Nat. Chem. Biol, vol.9, 2013. ,
Histoire du métissage, de La Martinière, 2003. ,
High resolution screening of plant natural product extracts for estrogen receptor a and f3 binding activity using an online HPLC-MS Biochemical detection system, J. Biomol. Screen, vol.6, pp.291-303, 2001. ,
,
L'indispensable de chimie organique, 1998. ,
,
Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages, Mol. Nutr. Food Res, vol.52, pp.427-438, 2008. ,
Synthesis of coruscanones A and B, metabolites of Piper coruscans, and related compounds, Russ. Chem. Bull, vol.59, pp.81-90, 2010. ,
Coupling HPLC to on-line, post-column (bio)chemical assays for high-resolution screening of bioactive compounds from complex mixtures, TrAC Trends Anal. Chem, vol.28, pp.865-877, 2009. ,
Probing noncovalent structural features of proteins by mass spectrometry, Mass Spectrom. Rev, vol.13, pp.411-429, 1994. ,
,
Gas Chromatography and Mass Spectrometry: Chapter 1 -Introduction and History, Gas Chromatography and Mass Spectrometry, 2011. ,
, , pp.2-13
Profiling enzyme activities In vivo using click chemistry methods, Chem. Biol, vol.11, pp.535-546, 2004. ,
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs, Int. J. Parasitol. Drugs Drug Resist, vol.5, pp.149-162, 2015. ,
Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.13275-13280, 2011. ,
,
Treatment and Prevention of Malaria -Antimalarial Drug Chemistry, Action and Use, 2012. ,
Plasmodium hemozoin formation mediated by histidine-rich proteins, Science, vol.271, 1996. ,
Drug resistance in Indian visceral leishmaniasis, Trop. Med. Int. Health, vol.6, pp.849-854, 2002. ,
Mechanisms of artemisinin resistance in Plasmodium falciparum malaria, ? Anti-Infect. New Technol, vol.42, pp.46-54, 2018. ,
,
Nature et Médecine: Les plantes qui guérissent, National Geographic, 2000. ,
Nuevo Compendio de la Historia del Perú, 2013. ,
Cyclic Tetrapyrrolic Photosensitisers from the leaves of Phaeanthus ophthalmicus, Chem. Cent. J, vol.5, pp.32-32, 2011. ,
Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay, Comb. Chem. High Throughput Screen, vol.8, pp.63-79, 2005. ,
,
, Tropicos.org, 2018.
Leishmania: Origin, evolution and future since the Precambrian, FEMS Immunol. Med. Microbiol, vol.54, pp.158-166, 2008. ,
,
The candidate antimalarial drug MMV665909 causes oxygendependent mRNA mistranslation and synergizes with quinoline-derived antimalarials, 2017. ,
Rapid detection and identification of angiotensin-converting enzyme inhibitors by online liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry. 19th Montreux Symp, Liq. Chromatogr. -Mass Spectrom. Supercrit. Fluid Chromatogr. -Mass Spectrom. Capill. Electrophor. -Mass Spectrom. Tandem Mass Spectrom, vol.61, pp.45-58, 2003. ,
An ethnobotanical survey of medicinal plants in the southeastern Karoo, South Africa. South Afr. J. Bot, vol.74, pp.696-704, 2008. ,
Antiprotozoal activity of medicinal plants used by Iquitos-Nauta, 2018. ,
, J. Ethnopharmacol, vol.210, pp.372-385
A new phthalide derivative from Peperomia nivalis, Nat. Prod. Res, vol.31, pp.138-142, 2017. ,
Lipid or aqueous medium for hematin crystallization, CrystEngComm, vol.17, pp.7790-7800, 2015. ,
,
The Antifolates, Hematol. Oncol. Clin. North Am, vol.26, p.629, 2012. ,
Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparum invasion of erythrocytes, Cell Host Microbe, vol.20, pp.60-71, 2016. ,
Polyfunctional DNA intercalating agents, Med. Res. Rev, vol.6, pp.275-340, 1986. ,
Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption, Mol. Pharm, vol.4, pp.826-832, 2007. ,
,
Noncovalent intermolecular forces in polycrystalline and amorphous saccharides in the far infrared, Chem. Phys, vol.288, pp.261-268, 2003. ,
Comparing similar spectra: from similarity index to spectral contrast angle, J. Am. Soc. Mass Spectrom, vol.13, pp.85-88, 2002. ,
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nat. Commun, vol.6, 2015. ,
, Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking, vol.34, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01371824
Advanced activity-based protein profiling application strategies for drug development, Front. Pharmacol, vol.9, 2018. ,
The relationship of physicochemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids, Malar. J, vol.2, 2003. ,
Role of medicines in malaria control and elimination, Drug Dev. Res, vol.71, pp.4-11, 2010. ,
Epigenetic roulette in blood stream Plasmodium: Gambling on sex, PLOS Pathog, vol.12, 2016. ,
Introduction to Mass Spectrometry Instrumentation, Applications and Strategies for Data Interpretation, Fourth Edition, 2007. ,
Epidemiología y clínica de las leishmaniosis tegumentarias en el Perú, Rev Perú Med Exp Salud Publica, vol.2, p.39, 1943. ,
Malaria medicines: a glass half full?, Nat. Rev. Drug Discov, vol.14, 2015. ,
Structure, bioactivity, and synthesis of methylated flavonoids, Ann. N. Y. Acad. Sci, vol.1398, pp.120-129, 2017. ,
Does remoteness from urban centres Influence plant diversity in homegardens and swidden fields?: A case study from the Matsiguenka in the Amazonian rain forest of Peru, Agrofor. Syst, vol.65, pp.241-251, 2005. ,
,
Spiroindolone KAE609 for Falciparum and Vivax Malaria, N. Engl. J. Med, vol.371, pp.403-410, 2014. ,
, Leishmaniasis: Epidemiological situation, WHO, 2018.
,
, Neglected tropical diseases, WHO, 2017.
, Trypanosomiase humaine africaine (maladie du sommeil), WHO, 2017.
, Maladie de Chagas (trypanosomiase américaine), WHO, 2017.
, World malaria report 2017, World Health Organization, WHO, 2017.
, Global Technical Strategy for Malaria, WHO, 2015.
Current developments in activity-based protein profiling, Bioconjug. Chem, vol.25, pp.1181-1191, 2014. ,
,
Dereplication of natural products using minimal NMR data inputs, Org. Biomol. Chem, vol.13, pp.9957-9962, 2015. ,
The range and shielding of dipole-dipole interactions in phospholipid bilayers, Biophys. J, vol.87, pp.2433-2445, 2004. ,
,
Bioautography of biotin and certain related compounds, Proc. Soc. Exp. Biol. Med. Soc. Exp. Biol. Med. N. Y. N, vol.86, pp.480-483, 1954. ,
Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines, J. Hematol. Oncol.J Hematol Oncol, vol.4, pp.52-52, 2011. ,
The malaria digestive vacuole, Front. Biosci. Sch. Ed, vol.4, pp.1424-1448, 2012. ,
Molecular Networking as a dereplication strategy, J. Nat. Prod, vol.76, pp.1686-1699, 2013. ,
Glaucolides, fulvenoguaianolides and other sesquiterpene lactones from Pentzia species, Phytochemistry, vol.29, pp.189-194, 1990. ,
, , pp.89035-89043
, , vol.407, 2014.
, Antimicrob. Agents Chemother, vol.58, pp.1586-1595
Basigin is a druggable target for host-oriented antimalarial interventions, J. Exp. Med, vol.212, pp.1145-1151, 2015. ,
Comparative evaluation of three methods based on high-performance liquid chromatography analysis combined with a 2,2?-diphenyl-1-picrylhydrazyl assay for the rapid screening of antioxidants from Pueraria lobata flowers, Anal. Bioanal. Chem, vol.402, pp.2965-2976, 2012. ,
,
Design, synthesis and evaluation of a novel ?-? stacking nano-intercalator as an antitumor agent, MedChemComm, vol.7, pp.247-257, 2016. ,
Lead optimization of imidazopyrazines: A new class of antimalarial with activity on Plasmodium liver stages, ACS Med. Chem. Lett, vol.5, pp.947-950, 2014. ,
,