Thrombosis modeling in blood coated medical devices

Abstract : Thrombosis, which is the formation of a blood clot (thrombus) in the vascular system, is one of the major issues of blood-coated medical devices. To reduce thrombosis risk in this type of devices, computational fluid dynamics has been used. Up to date, bio-material surfaces used in blood coated devices initiate blood coagulation through the contact activation system. This system has not been considered in models dedicated to devices, even though its importance in thrombosis has been recently highlighted. The objective of this thesis is to introduce device-triggered coagulation reactions in the modeling of device-related thrombosis.A novel reduced kinetic model including the contact activation system is proposed. The model correctly captures thrombin formation in physiological and prothrombin deficient platelet-poor-plasma. The reduced set of reactions is then included in a platelet-based model for thrombus formation considering platelet activation by thrombin. This approach is used to study thrombus formation in an academic configuration.
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Rodrigo Mendez Rojano. Thrombosis modeling in blood coated medical devices. General Mathematics [math.GM]. Université Montpellier, 2018. English. ⟨NNT : 2018MONTS088⟩. ⟨tel-02152653⟩

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