R. J. Advani, H. R. Bae, J. B. Bock, D. S. Chao, Y. C. Doung et al., Seven novel mammalian SNARE proteins localize to distinct membrane compartments, Journal of Biological Chemistry, vol.273, pp.10317-10324, 1998.

K. Aghajani, S. Keerthivasan, Y. Yu, and F. Gounari, Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells, Genesis, vol.50, pp.908-913, 2012.

E. Aguado, S. Richelme, S. Nuñez-cruz, A. Miazek, A. Mura et al., Induction of T helper type 2 immunity by a point mutation in the LAT adaptor, Science, vol.296, pp.2036-2040, 2002.

R. S. Ajioka and J. Kaplan, Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors, Proc. Natl. Acad. Sci. U.S.A, vol.83, pp.6445-6449, 1986.

B. Alarcón, B. Alarcón, D. Mestre, D. Mestre, N. Martínez-martín et al., The immunological synapse: a cause or consequence of T-cell receptor triggering?, Immunology, vol.133, pp.420-425, 2011.

P. Alberts, R. Rudge, I. Hinners, A. Muzerelle, S. Martinez-arca et al., Cross talk between tetanus neurotoxininsensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion, Mol. Biol. Cell, vol.14, pp.4207-4220, 2003.

A. Alloatti, F. Kotsias, A. Pauwels, J. Carpier, M. Jouve et al., Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens, Immunity, vol.43, pp.1087-1100, 2015.

M. Amessou, A. Fradagrada, T. Falguières, J. M. Lord, D. C. Smith et al., Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins, J. Cell. Sci, vol.120, pp.1457-1468, 2007.

A. H. Andreotti, P. L. Schwartzberg, R. E. Joseph, and L. J. Berg, T-cell signaling regulated by the Tec family kinase, Itk, vol.2, pp.2287-002287, 2010.

L. Andrés-delgado, O. M. Antón, R. Madrid, J. A. Byrne, and M. A. Alonso, Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes, Blood, vol.116, pp.5919-5929, 2010.

C. Antony, C. Cibert, G. Geraud, A. S. Maria, B. Maro et al., The Small GtpBinding Protein Rab6p Is Distributed From Medial Golgi to the Trans-Golgi Network as Determined by a Confocal Microscopic Approach, J. Cell. Sci, vol.103, pp.785-796, 1992.

O. Antón, A. Batista, J. Millán, L. Andrés-delgado, R. Puertollano et al., An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes, J. Exp. Med, vol.205, pp.3201-3213, 2008.

R. M. Arantes and N. W. Andrews, A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons, J. Neurosci, vol.26, pp.4630-4637, 2006.

M. N. Artyomov, M. Lis, S. Devadas, M. M. Davis, and A. K. Chakraborty, CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery, Proc. Natl. Acad. Sci. U.S.A, vol.107, pp.16916-16921, 2010.

B. B. Au-yeung, H. J. Melichar, J. O. Ross, D. A. Cheng, J. Zikherman et al., Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development, Nat. Immunol, vol.15, pp.687-694, 2014.

P. A. Baeuerle and D. Baltimore, Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor, Cell, vol.53, pp.90382-90382, 1988.

P. A. Baeuerle and D. Baltimore, I kappa B: a specific inhibitor of the NF-kappa B transcription factor, Science, vol.242, pp.540-546, 1988.

S. R. Bailey, M. H. Nelson, R. A. Himes, Z. Li, S. Mehrotra et al., Th17 Cells in Cancer: The Ultimate Identity Crisis, Front Immunol, vol.5, 0200.

L. Balagopalan, B. A. Ashwell, K. M. Bernot, I. O. Akpan, N. Quasba et al., Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation, Proc. Natl. Acad. Sci. U.S.A, vol.108, pp.2885-2890, 2011.

L. Balagopalan, V. A. Barr, R. L. Kortum, A. K. Park, and L. E. Samelson, Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling, J. Immunol, vol.190, pp.3849-3853, 2013.

M. Barda-saad, A. Braiman, R. Titerence, S. C. Bunnell, V. A. Barr et al., Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton, Nat. Immunol, vol.6, pp.80-89, 2005.

M. Barda-saad, N. Shirasu, M. H. Pauker, N. Hassan, O. Perl et al., Cooperative interactions at the SLP-76 complex are critical for actin polymerization, EMBO J, vol.29, pp.2315-2328, 2010.

S. Bardin, S. Miserey-lenkei, I. Hurbain, D. Garcia-castillo, G. Raposo et al., Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts, Biol. Cell, vol.107, pp.427-439, 2015.

F. A. Barr, A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins, Curr. Biol, vol.9, pp.381-384, 1999.

C. Basquin, V. Malardé, P. Mellor, D. H. Anderson, V. Meas-yedid et al., The signalling factor PI3K is a specific regulator of the clathrinindependent dynamin-dependent endocytosis of IL-2 receptors, J. Cell. Sci, vol.126, pp.1099-1108, 2013.

C. Basquin, M. Trichet, H. Vihinen, V. Malardé, T. Lagache et al., Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptor, EMBO J, vol.34, pp.2147-2161, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01202886

R. Basu, B. M. Whitlock, J. Husson, A. Le-floc'h, W. Jin et al., Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing, Cell, vol.165, pp.100-110, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01317871

A. Batista, J. Millan, M. Mittelbrunn, F. Sanchez-madrid, and M. A. Alonso, Recruitment of Transferrin Receptor to Immunological Synapse in Response to TCR Engagement, The Journal of Immunology, vol.172, pp.6709-6714, 2004.

C. Benzing, J. Rossy, and K. Gaus, Do signalling endosomes play a role in T cell activation?, FEBS J, vol.280, pp.5164-5176, 2013.

F. Bertrand, M. Esquerré, A. Petit, M. Rodrigues, S. Duchez et al., Activation of the ancestral polarity regulator protein kinase C zeta at the immunological synapse drives polarization of Th cell secretory machinery toward APCs, J. Immunol, vol.185, pp.2887-2894, 2010.

M. Y. Bilal and J. C. Houtman, GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-?1 Activation and Cytokine Production, Front Immunol, vol.6, p.141, 2015.

N. Blanchard, V. Di-bartolo, and C. Hivroz, In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern, Immunity, vol.17, pp.389-399, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00138115

N. J. Boerth, J. J. Sadler, D. E. Bauer, J. L. Clements, S. M. Gheith et al., Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling, J. Exp. Med, vol.192, pp.1047-1058, 2000.

G. Bonello, N. Blanchard, M. C. Montoya, E. Aguado, C. Langlet et al., Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment, J. Cell. Sci, vol.117, pp.1009-1016, 2004.

J. S. Bonifacino and J. H. Hurley, Retromer. Curr. Opin. Cell Biol, vol.20, pp.427-436, 2008.

J. S. Bonifacino and R. Rojas, Retrograde transport from endosomes to the trans-Golgi network, Nat. Rev. Mol. Cell Biol, vol.7, pp.568-579, 2006.

J. S. Bonifacino and R. Rojas, Retrograde transport from endosomes to the trans-Golgi network, Nat. Rev. Mol. Cell Biol, vol.7, pp.568-579, 2006.

J. Bouchet, I. Del-río-iñiguez, R. Lasserre, S. Agüera-gonzalez, C. Cuche et al., Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation, EMBO J, vol.35, pp.1160-1174, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01370720

J. Bouchet, M. W. Mccaffrey, A. Graziani, and A. Alcover, The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry. Small GTPases 1-6, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01371033

A. L. Brass, D. M. Dykxhoorn, Y. Benita, N. Yan, A. Engelman et al., Identification of host proteins required for HIV infection through a functional genomic screen, Science, vol.319, pp.921-926, 2008.

V. Braun, V. Braun, V. Fraisier, V. Fraisier, G. Raposo et al., TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages, EMBO J, vol.23, pp.4166-4176, 2004.

C. Brignatz, A. Restouin, G. Bonello, D. Olive, and Y. Collette, Evidences for ubiquitination and intracellular trafficking of LAT, the linker of activated T cells, Biochim. Biophys. Acta, vol.1746, pp.108-115, 2005.

V. Briken, D. Lankar, and C. Bonnerot, New evidence for two MHC class II-restricted antigen presentation pathways by overexpression of a small G protein, The Journal of Immunology, vol.159, pp.4653-4658, 1997.

C. Brossard, V. Feuillet, A. Schmitt, C. Randriamampita, M. Romao et al., Multifocal structure of the T cell -dendritic cell synapse, Eur. J. Immunol, vol.35, pp.1741-1753, 2005.

R. J. Brownlie and R. Zamoyska, T cell receptor signalling networks: branched, diversified and bounded, Nat. Rev. Immunol, vol.13, pp.257-269, 2013.

N. Bufi, M. Saitakis, S. Dogniaux, O. Buschinger, A. Bohineust et al., Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation, Biophys. J, vol.108, pp.2181-2190, 2015.

M. V. Bujny, V. Popoff, L. Johannes, and P. J. Cullen, The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network, J. Cell. Sci, vol.120, pp.2010-2021, 2007.

S. C. Bunnell, D. I. Hong, J. R. Kardon, T. Yamazaki, C. J. Mcglade et al., T cell receptor ligation induces the formation of dynamically regulated signaling assemblies, J. Cell Biol, vol.158, pp.1263-1275, 2002.

C. G. Burd, Physiology and pathology of endosome-to-Golgi retrograde sorting, Traffic, vol.12, pp.948-955, 2011.

A. Burgo, A. Burgo, A. M. Casano, A. M. Casano, A. Kuster et al., Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain, J. Biol. Chem, vol.288, pp.11960-11972, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02177558

A. Burgo, V. Proux-gillardeaux, V. Proux-gillardeaux, E. Sotirakis, E. Sotirakis et al., A Molecular Network for the Transport of the TI-VAMP/VAMP7 Vesicles from Cell Center to Periphery, Dev Cell, vol.23, pp.166-180, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00764157

A. Burgo, E. Sotirakis, M. Simmler, M. Simmler, A. Verraes et al., Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth, EMBO Rep, vol.10, pp.1117-1124, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00441596

J. R. Burgoyne, D. J. Haeussler, V. Kumar, Y. Ji, D. R. Pimental et al., Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis, FASEB J, vol.26, pp.832-841, 2012.

A. S. Burguete, T. D. Fenn, A. T. Brunger, and S. R. Pfeffer, Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185, Cell, vol.132, pp.286-298, 2008.

G. Campi, R. Varma, and M. L. Dustin, Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling, J. Exp. Med, vol.202, pp.1031-1036, 2005.

J. Carlton, M. Bujny, B. J. Peter, V. M. Oorschot, A. Rutherford et al., Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides, Curr. Biol, vol.14, pp.1791-1800, 2004.

K. S. Carroll, J. Hanna, I. Simon, J. Krise, P. Barbero et al., Role of Rab9 GTPase in facilitating receptor recruitment by TIP47, Science, vol.292, pp.1373-1376, 2001.

C. Cauvin, M. Rosendale, N. Gupta-rossi, M. Rocancourt, P. Larraufie et al., Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes, Curr. Biol, vol.26, pp.120-128, 2016.

M. Cebecauer, J. Humpolí?ková, and J. Rossy, Advanced imaging of cellular signaling events, Meth. Enzymol, vol.505, pp.273-289, 2012.

S. Cemerski, J. Das, E. Giurisato, M. A. Markiewicz, P. M. Allen et al., The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality, Immunity, vol.29, pp.414-422, 2008.

J. Cerveira, J. Begum, R. Di-marco-barros, A. G. Van-der-veen, and A. Filby, An imaging flow cytometry-based approach to measuring the spatiotemporal calcium mobilisation in activated T cells, J. Immunol. Methods, vol.423, pp.120-130, 2015.

M. Chaineau, L. Danglot, V. Proux-gillardeaux, and T. Galli, Role of HRB in clathrin-dependent endocytosis, Journal of Biological Chemistry, vol.283, pp.34365-34373, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00326921

A. K. Chakraborty and A. Weiss, Insights into the initiation of TCR signaling, Nat. Immunol, vol.15, pp.798-807, 2014.

A. C. Chan, M. Dalton, R. Johnson, G. H. Kong, T. Wang et al., Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function, EMBO J, vol.14, pp.2499-2508, 1995.

A. C. Chan, B. A. Irving, J. D. Fraser, and A. Weiss, The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein, Proc. Natl. Acad. Sci. U.S.A, vol.88, pp.9166-9170, 1991.

A. C. Chan, M. Iwashima, C. W. Turck, and A. Weiss, ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain, Cell, vol.71, pp.649-662, 1992.

J. T. Chang, V. R. Palanivel, I. Kinjyo, F. Schambach, A. M. Intlekofer et al., Asymmetric T lymphocyte division in the initiation of adaptive immune responses, Science, vol.315, pp.1687-1691, 2007.

V. T. Chang, R. A. Fernandes, K. A. Ganzinger, S. F. Lee, C. Siebold et al., Initiation of T cell signaling by CD45 segregation at 'close contacts', Nat. Immunol, vol.17, pp.574-582, 2016.

K. Chemin, A. Bohineust, S. Dogniaux, M. Tourret, S. Guégan et al., Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity, J. Immunol, vol.189, pp.2159-2168, 2012.

D. Chen, J. R. Guo, and W. A. Gahl, rab GTPases expressed in human melanoma cells, Biochim. Biophys. Acta, vol.1355, pp.1-6, 1997.

L. Chen and D. B. Flies, Molecular mechanisms of T cell co-stimulation and co-inhibition, Nat. Rev. Immunol, vol.13, pp.227-242, 2013.

Y. A. Chen and R. H. Scheller, Snare-mediated membrane fusion, Nat. Rev. Mol. Cell Biol, vol.2, pp.98-106, 2001.

J. Chevallier, C. Koop, A. Srivastava, R. J. Petrie, N. Lamarche-vane et al., Rab35 regulates neurite outgrowth and cell shape, FEBS Lett, vol.583, pp.1096-1101, 2009.

S. Chevrier, C. Genton, B. Malissen, M. Malissen, and H. Acha-orbea, Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells, Front Immunol, vol.3, p.27, 2012.

K. Choudhuri, D. Wiseman, M. H. Brown, K. Gould, and P. A. Van-der-merwe, T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand, Nature, vol.436, pp.578-582, 2005.

C. W. Chow, M. Rincón, and R. J. Davis, Requirement for transcription factor NFAT in interleukin-2 expression, Mol. Cell. Biol, vol.19, pp.2300-2307, 1999.

M. I. Chuck, M. Zhu, S. Shen, and W. Zhang, The role of the LAT-PLC-gamma1 interaction in T regulatory cell function, J. Immunol, vol.184, pp.2476-2486, 2010.

T. Chum, D. Glatzová, Z. Kví?alová, J. Malínský, T. Brdicka et al., The role of palmitoylation and transmembrane domain in sorting of transmembrane adaptor proteins, J. Cell. Sci, vol.129, pp.95-107, 2016.

J. Combs, S. J. Kim, S. Tan, L. A. Ligon, E. L. Holzbaur et al., Recruitment of dynein to the Jurkat immunological synapse, Proc. Natl. Acad. Sci. U.S.A, vol.103, pp.14883-14888, 2006.

W. A. Comrie, A. Babich, and J. K. Burkhardt, F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse, J. Cell Biol, vol.208, pp.475-491, 2015.

W. A. Comrie, S. Li, S. Boyle, and J. K. Burkhardt, The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility, J. Cell Biol, vol.208, pp.457-473, 2015.

E. Conibear and N. G. Davis, Palmitoylation and depalmitoylation dynamics at a glance, J. Cell. Sci, vol.123, pp.4007-4010, 2010.

S. Cordoba, K. Choudhuri, H. Zhang, M. Bridge, A. B. Basat et al., The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor, Blood, vol.121, pp.4295-4302, 2013.

M. Côte, M. M. Ménager, A. Burgess, N. Mahlaoui, C. Picard et al., Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells, J. Clin. Invest, vol.119, pp.3765-3773, 2009.

L. Danglot, M. Chaineau, M. Dahan, M. Gendron, N. Boggetto et al., Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling, J. Cell. Sci, vol.123, pp.723-735, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00486387

L. Danglot, K. Zylbersztejn, M. Petkovic, M. Gauberti, H. Meziane et al., Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice, J. Neurosci, vol.32, pp.1962-1968, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00786430

M. A. Daniels, E. Teixeiro, J. Gill, B. Hausmann, D. Roubaty et al., Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling, Nature, vol.444, pp.724-729, 2006.

E. Daro, P. Van-der-sluijs, T. Galli, and I. Mellman, Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling, Proc. Natl. Acad. Sci. U.S.A, vol.93, pp.9559-9564, 1996.

V. Das, B. Nal, A. Dujeancourt, M. I. Thoulouze, T. Galli et al., Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse: Involvement of SNARE complexes, Immunity, vol.20, pp.106-108, 2004.
URL : https://hal.archives-ouvertes.fr/pasteur-00137478

F. Daste, T. Galli, and D. Tareste, Structure and function of longin SNAREs, J. Cell. Sci, vol.128, pp.4263-4272, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01336646

S. J. Davis and P. A. Van-der-merwe, The kinetic-segregation model: TCR triggering and beyond, Nat. Immunol, vol.7, pp.803-809, 2006.

G. De-saint-basile, G. Ménasché, and A. Fischer, Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules, Nat. Rev. Immunol, vol.10, pp.568-579, 2010.

G. De-vreede, J. D. Schoenfeld, S. L. Windler, H. Morrison, H. Lu et al., The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization, Development, vol.141, pp.2796-2802, 2014.

M. Deguchi-tawarada, E. Inoue, E. Takao-rikitsu, M. Inoue, T. Ohtsuka et al., CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST, Genes Cells, vol.9, pp.15-23, 2004.

S. Deindl, T. A. Kadlecek, T. Brdicka, X. Cao, A. Weiss et al., Structural basis for the inhibition of tyrosine kinase activity of ZAP-70, Cell, vol.129, pp.735-746, 2007.

E. Del-nery, S. Miserey-lenkei, T. Falguières, C. Nizak, L. Johannes et al., Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking, Traffic, vol.7, pp.394-407, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00565201

M. K. Dennis, C. Delevoye, A. Acosta-ruiz, I. Hurbain, M. Romao et al., BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers, J. Cell Biol, vol.214, pp.293-308, 2016.

M. C. Derby, Z. Z. Lieu, D. Brown, J. L. Stow, B. Goud et al., The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure, Traffic, vol.8, pp.758-773, 2007.

D. Deretic, Post-Golgi trafficking of rhodopsin in retinal photoreceptors, Eye (Lond), vol.12, pp.526-530, 1998.

D. Deretic and D. S. Papermaster, Rab6 is associated with a compartment that transports rhodopsin from the trans-Golgi to the site of rod outer segment disk formation in frog retinal photoreceptors, J. Cell. Sci, vol.106, pp.803-813, 1993.

E. Derivery, C. Sousa, J. J. Gautier, B. Lombard, D. Loew et al., The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex, Dev Cell, vol.17, pp.712-723, 2009.

D. Bartolo, V. Mège, D. Germain, V. Pelosi, M. Dufour et al., Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling, Journal of Biological Chemistry, vol.274, pp.6285-6294, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00138130

D. Bartolo, V. Montagne, B. Salek, M. Jungwirth, B. Carrette et al., A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76, J. Exp. Med, vol.204, pp.681-691, 2007.
URL : https://hal.archives-ouvertes.fr/pasteur-01372621

J. Dietrich, J. Kastrup, B. L. Nielsen, N. Odum, and C. Geisler, Regulation and function of the CD3 gamma DxxxLL motif: A binding site for adaptor protein-1 and adaptor protein-2 in vitro, J Cell Biol, vol.138, pp.271-281, 1997.

E. Díaz and S. R. Pfeffer, TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking, Cell, vol.93, pp.433-443, 1998.

S. Dong, B. Corre, E. Foulon, E. Dufour, A. Veillette et al., T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2, J. Exp. Med, vol.203, pp.2509-2518, 2006.
URL : https://hal.archives-ouvertes.fr/pasteur-00162042

A. D. Douglass and R. D. Vale, Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells, Cell, vol.121, pp.937-950, 2005.

R. Dressel, R. Dressel, L. Elsner, L. Elsner, P. Novota et al., The exocytosis of lytic granules is impaired in Vti1b-or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation, J. Immunol, vol.185, pp.1005-1014, 2010.

J. R. Duncan and S. Kornfeld, Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus, J Cell Biol, vol.106, pp.617-628, 1988.

P. Duplay, M. Thome, F. Hervé, and O. Acuto, p56lck interacts via its src homology 2 domain with the ZAP-70 kinase, J. Exp. Med, vol.179, pp.1163-1172, 1994.

M. L. Dustin and D. R. Colman, Neural and immunological synaptic relations, Science, vol.298, pp.785-789, 2002.

M. L. Dustin and D. Depoil, New insights into the T cell synapse from single molecule techniques, Nat. Rev. Immunol, vol.11, pp.672-684, 2011.

A. Echard, F. Jollivet, O. Martinez, J. J. Lacapere, A. Rousselet et al., Interaction of a Golgi-associated kinesin-like protein with Rab6, Science, vol.279, pp.580-585, 1998.

A. Echard, F. Opdam, H. De-leeuw, F. Jollivet, P. Savelkoul et al., Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms, Mol. Biol. Cell, vol.11, pp.3819-3833, 2000.

L. I. Ehrlich, P. J. Ebert, M. F. Krummel, A. Weiss, and M. M. Davis, Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation, Immunity, vol.17, pp.809-822, 2002.

F. Facchetti, J. K. Chan, W. Zhang, A. Tironi, M. Chilosi et al., Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions, Am. J. Pathol, vol.154, issue.10, pp.65356-65360, 1999.

C. M. Fader, M. O. Aguilera, and M. I. Colombo, ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner, autophagy, vol.8, pp.12-27, 2012.

C. M. Fader, D. G. Sánchez, D. G. Sánchez, M. B. Mestre, M. B. Mestre et al., TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways, Biochim. Biophys. Acta, vol.1793, pp.1901-1916, 2009.

B. Favier, N. J. Burroughs, L. Wedderburn, and S. Valitutti, TCR dynamics on the surface of living T cells, Int. Immunol, vol.13, pp.1525-1532, 2001.

N. Fehrenbacher, D. Bar-sagi, and M. Philips, Ras/MAPK signaling from endomembranes, Mol Oncol, vol.3, pp.297-307, 2009.

J. Feldmann, I. Callebaut, G. Raposo, S. Certain, D. Bacq et al., Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3), Cell, vol.115, pp.461-473, 2003.

H. Fernandes, E. Franklin, F. Jollivet, K. Bliedtner, and A. R. Khan, Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1, PLoS ONE, vol.7, 2012.

S. Feske, Calcium signalling in lymphocyte activation and disease, Nat. Rev. Immunol, vol.7, pp.690-702, 2007.

F. Filippini, V. Rossi, T. Galli, A. Budillon, M. D'urso et al., Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain, Trends Biochem. Sci, vol.26, pp.407-409, 2001.

T. S. Finco, T. Kadlecek, W. G. Zhang, L. E. Samelson, and A. Weiss, LAT is required for TCRmediated activation of PLC gamma 1 and the Ras pathway, Immunity, vol.9, pp.617-626, 1998.

F. Finetti, S. R. Paccani, M. G. Riparbelli, E. Giacomello, G. Perinetti et al., Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse, Nat. Cell Biol, vol.11, pp.1332-1339, 2009.

F. Finetti, L. Patrussi, D. Galgano, C. Cassioli, G. Perinetti et al., The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse, J. Cell. Sci, vol.128, pp.2541-2552, 2015.

F. Finetti, L. Patrussi, G. Masi, A. Onnis, D. Galgano et al., Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system, J. Cell. Sci, vol.127, pp.1924-1937, 2014.

A. Fischer, C. Picard, K. Chemin, S. Dogniaux, F. Le-deist et al., ZAP70: a master regulator of adaptive immunity, vol.32, pp.107-116, 2010.

J. A. Follit, R. A. Tuft, K. E. Fogarty, and G. J. Pazour, The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly, Mol. Biol. Cell, vol.17, pp.3781-3792, 2006.

R. D. Fontijn, B. Goud, A. Echard, F. Jollivet, J. Van-marle et al., The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis, Mol. Cell. Biol, vol.21, pp.2944-2955, 2001.

C. L. Freeman, G. Hesketh, and M. N. Seaman, RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation, J. Cell. Sci, vol.127, pp.2053-2070, 2014.

G. Fu, J. Casas, S. Rigaud, V. Rybakin, F. Lambolez et al., Themis sets the signal threshold for positive and negative selection in T-cell development, Nature, vol.504, pp.441-445, 2013.

G. Fu, J. Casas, S. Rigaud, V. Rybakin, F. Lambolez et al., Themis sets the signal threshold for positive and negative selection in T-cell development, Nature, vol.504, pp.441-445, 2013.

G. Fu, S. Vallée, V. Rybakin, M. V. Mcguire, J. Ampudia et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling, Nat. Immunol, vol.10, pp.848-856, 2009.

M. Fukuda, Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP, Traffic, vol.17, pp.709-719, 2016.

D. M. Fuller, M. Zhu, S. Koonpaew, M. I. Nelson, and W. Zhang, The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity, J. Immunol, vol.189, pp.4005-4013, 2012.

T. Galli, T. Chilcote, O. Mundigl, T. Binz, H. Niemann et al., Tetanus Toxin-Mediated Cleavage of Cellubrevin Impairs Exocytosis of Transferrin Receptor-Containing Vesicles in Cho Cells, J. Cell Biol, vol.125, pp.1015-1024, 1994.

T. Galli, A. Zahraoui, V. V. Vaidyanathan, G. Raposo, J. M. Tian et al., A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells, Mol. Biol. Cell, vol.9, pp.1437-1448, 1998.

J. L. Gallop and H. T. Mcmahon, BAR domains and membrane curvature: bringing your curves to the BAR, Biochem. Soc. Symp, pp.223-231, 2005.

T. Galvez, J. Gilleron, M. Zerial, and G. A. O'sullivan, SnapShot: Mammalian Rab proteins in endocytic trafficking, Cell, vol.151, pp.234-234, 2012.

I. G. Ganley, E. Espinosa, and S. R. Pfeffer, A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells, J. Cell Biol, vol.180, pp.159-172, 2008.

X. Gao, S. Nagawa, G. Wang, and Z. Yang, Cell polarity signaling: focus on polar auxin transport, Mol Plant, vol.1, pp.899-909, 2008.

C. Genton, Y. Wang, S. Izui, B. Malissen, G. Delsol et al., The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity, The Journal of Immunology, vol.177, pp.2285-2293, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00165594

H. J. Geuze, W. Stoorvogel, G. J. Strous, J. W. Slot, J. E. Bleekemolen et al., Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles, J Cell Biol, vol.107, pp.2491-2501, 1988.

A. Gérard, A. E. Mertens, R. A. Van-der-kammen, and J. G. Collard, The Par polarity complex regulates Rap1-and chemokine-induced T cell polarization, J. Cell Biol, vol.176, pp.863-875, 2007.

R. N. Ghosh, W. G. Mallet, T. T. Soe, T. E. Mcgraw, and F. R. Maxfield, An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells, J Cell Biol, vol.142, pp.923-936, 1998.

A. K. Gillingham, R. Sinka, I. L. Torres, K. S. Lilley, and S. Munro, Toward a comprehensive map of the effectors of rab GTPases, Dev Cell, vol.31, pp.358-373, 2014.

M. A. Goldsmith, P. F. Dazin, and A. Weiss, At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor, Proc. Natl. Acad. Sci. U.S.A, vol.85, pp.8613-8617, 1988.

M. A. Goldsmith and A. Weiss, Generation and analysis of a T-lymphocyte somatic mutant for studying molecular aspects of signal transduction by the antigen receptor, Ann. N. Y. Acad. Sci, vol.546, pp.91-103, 1988.

M. A. Goldsmith and A. Weiss, Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor, Proc. Natl. Acad. Sci. U.S.A, vol.84, pp.6879-6883, 1987.

T. S. Gomez and D. D. Billadeau, A FAM21-containing WASH complex regulates retromer-dependent sorting, Dev Cell, vol.17, pp.699-711, 2009.

N. K. Gonatas, A. Steiber, S. U. Kim, D. I. Graham, and S. Avrameas, Internalization of neuronal plasma membrane ricin receptors into the Golgi apparatus, Experimental Cell Research, vol.94, pp.426-431, 1975.

J. S. Goodwin, K. R. Drake, C. Rogers, L. Wright, J. Lippincott-schwartz et al., Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway, J Cell Biol, vol.170, pp.261-272, 2005.

M. M. Gorska and R. Alam, A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia, Blood, vol.119, pp.1399-1406, 2012.

M. M. Gorska, Q. Liang, Z. Karim, and R. Alam, Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation, J. Immunol, vol.183, pp.1675-1684, 2009.

M. M. Gorska, S. J. Stafford, O. Cen, S. Sur, and R. Alam, Unc119, a novel activator of Lck/Fyn, is essential for T cell activation, J. Exp. Med, vol.199, pp.369-379, 2004.

B. Goud, A. Zahraoui, A. Tavitian, and J. Saraste, Small GTP-binding protein associated with Golgi cisternae, Nature, vol.345, pp.553-556, 1990.

A. Grakoui, S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw et al., The immunological synapse: a molecular machine controlling T cell activation, Science, vol.285, pp.221-227, 1999.

A. Grassart, A. Dujeancourt, P. B. Lazarow, A. Dautry-varsat, and N. Sauvonnet, Clathrinindependent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2, EMBO Rep, vol.9, pp.356-362, 2008.
URL : https://hal.archives-ouvertes.fr/pasteur-00332556

C. T. Griffin, J. Trejo, and T. Magnuson, Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2, Proc. Natl. Acad. Sci. U.S.A, vol.102, pp.15173-15177, 2005.

I. Grigoriev, D. Splinter, N. Keijzer, P. S. Wulf, J. Demmers et al., Rab6 regulates transport and targeting of exocytotic carriers, Dev Cell, vol.13, pp.305-314, 2007.

I. Grigoriev, K. L. Yu, E. Martinez-sanchez, A. Serra-marques, I. Smal et al., Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers, Curr. Biol, vol.21, pp.967-974, 2011.

I. Grigoriev, K. L. Yu, E. Martinez-sanchez, A. Serra-marques, I. Smal et al., Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers, Curr. Biol, vol.21, pp.967-974, 2011.

S. L. Gupton and F. B. Gertler, Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis, Dev Cell, vol.18, pp.725-736, 2010.

C. S. Guy, K. M. Vignali, J. Temirov, M. L. Bettini, A. E. Overacre et al., Distinct TCR signaling pathways drive proliferation and cytokine production in T cells, Nat. Immunol, vol.14, pp.262-270, 2013.

E. K. Haddad, X. F. Wu, J. A. Hammer, and P. A. Henkart, Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice, J. Cell Biol, vol.152, pp.835-841, 2001.

A. R. Hamad, S. M. O'herrin, M. S. Lebowitz, A. Srikrishnan, J. Bieler et al., Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor, J. Exp. Med, vol.188, pp.1633-1640, 1998.

M. E. Harbour, S. Y. Breusegem, R. Antrobus, C. Freeman, E. Reid et al., The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics, J. Cell. Sci, vol.123, pp.3703-3717, 2010.

A. Harding and J. F. Hancock, Ras nanoclusters: combining digital and analog signaling, Cell Cycle, vol.7, pp.127-134, 2008.

M. J. Harriff, E. Karamooz, A. Burr, W. F. Grant, E. T. Canfield et al., Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells, PLoS Pathog, vol.12, 2016.

G. L. Hayes, F. C. Brown, A. K. Haas, R. M. Nottingham, F. A. Barr et al., Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi, Mol. Biol. Cell, vol.20, pp.209-217, 2009.

S. M. Hedrick, D. I. Cohen, E. A. Nielsen, and M. M. Davis, Isolation of cDNA clones encoding T cellspecific membrane-associated proteins, Journal of immunology, 1950.

M. L. Hermiston, Z. Xu, and A. Weiss, CD45: a critical regulator of signaling thresholds in immune cells, Annu. Rev. Immunol, vol.21, pp.107-137, 2003.

G. G. Hesketh, I. Pérez-dorado, L. P. Jackson, L. Wartosch, I. B. Schäfer et al., VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface, Dev Cell, vol.29, pp.591-606, 2014.

E. Hill, N. Clarke, and F. A. Barr, The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis, EMBO J, vol.19, pp.5711-5719, 2000.

C. Hivroz and M. Saitakis, Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse, Front Immunol, vol.7, p.46, 2016.

K. A. Hogquist, T. A. Baldwin, and S. C. Jameson, Central tolerance: learning self-control in the thymus, Nat. Rev. Immunol, vol.5, pp.772-782, 2005.

O. Holt, E. Kanno, G. Bossi, S. Booth, T. Daniele et al., Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse, Traffic, vol.9, pp.446-457, 2008.

F. J. Houghton, P. L. Chew, S. Lodeho, B. Goud, and P. A. Gleeson, The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1, Cell, vol.138, pp.787-794, 2009.

J. C. Houtman, H. Yamaguchi, M. Barda-saad, A. Braiman, B. Bowden et al., Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1, Nat. Struct. Mol. Biol, vol.13, pp.798-805, 2006.

J. Huang, M. Brameshuber, X. Zeng, J. Xie, Q. Li et al., A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells, Immunity, vol.39, pp.846-857, 2013.

W. Y. Huang, Q. Yan, W. Lin, J. K. Chung, S. D. Hansen et al., Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS, Proc. Natl. Acad. Sci. U.S.A, vol.113, pp.8218-8223, 2016.

M. Hundt, Y. Harada, L. De-giorgio, N. Tanimura, W. Zhang et al., PalmitoylationDependent Plasma Membrane Transport but Lipid Raft-Independent Signaling by Linker for Activation of T Cells, J. Immunol, vol.183, pp.1685-1694, 2009.

M. Hundt, H. Tabata, M. Jeon, K. Hayashi, Y. Tanaka et al., Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect, Immunity, vol.24, pp.513-522, 2006.

J. B. Hurov, T. S. Stappenbeck, C. M. Zmasek, L. S. White, S. H. Ranganath et al., Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase, Mol. Cell. Biol, vol.21, pp.3206-3219, 2001.

J. B. Hurov, J. L. Watkins, and H. Piwnica-worms, Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity, Curr. Biol, vol.14, pp.736-741, 2004.

M. Huse, Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond, Front Immunol, vol.3, 2012.

M. Huse, B. F. Lillemeier, M. S. Kuhns, D. S. Chen, and M. M. Davis, T cells use two directionally distinct pathways for cytokine secretion, Nat. Immunol, vol.7, pp.247-255, 2006.

J. Husson, K. Chemin, A. Bohineust, C. Hivroz, and N. Henry, Force Generation upon T Cell Receptor Engagement, PLoS ONE, vol.6, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02106682

T. Imamura, J. Huang, I. Usui, H. Satoh, J. Bever et al., Insulin-Induced GLUT4 Translocation Involves Protein Kinase C--Mediated Functional Coupling between Rab4 and the Motor Protein Kinesin, Mol. Cell. Biol, vol.23, pp.4892-4900, 2003.

T. Itoh and P. De-camilli, BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature, Biochim. Biophys. Acta, vol.1761, pp.897-912, 2006.

I. Janoueix-lerosey, F. Jollivet, J. Camonis, P. N. Marche, and B. Goud, Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6, Journal of Biological Chemistry, vol.270, pp.14801-14808, 1995.

M. R. Jenkins, A. Tsun, J. C. Stinchcombe, and G. M. Griffiths, The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse, Immunity, vol.31, pp.621-631, 2009.

K. Jeong, H. Kwon, J. Lee, D. Jang, E. M. Hwang et al., Rab6-mediated retrograde transport regulates inner nuclear membrane targeting of caveolin-2 in response to insulin, Traffic, vol.13, pp.1218-1233, 2012.

D. Jia, T. S. Gomez, D. D. Billadeau, and M. K. Rosen, Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer, Mol. Biol. Cell, vol.23, pp.2352-2361, 2012.

Y. Jiang and H. Cheng, Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes, Leuk. Res, vol.31, pp.541-545, 2007.

J. Jing, J. R. Junutula, C. Wu, J. Burden, H. Matern et al., FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network, Mol. Biol. Cell, vol.21, pp.3041-3053, 2010.

L. Johannes and V. Popoff, Tracing the retrograde route in protein trafficking, Cell, vol.135, pp.1175-1187, 2008.

L. Johannes and M. Shafaq-zadah, SNAP-tagging the retrograde route, Methods Cell Biol, vol.118, pp.139-155, 2013.

L. Johannes and C. Wunder, Retrograde transport: two (or more) roads diverged in an endosomal tree?, Traffic, vol.12, pp.956-962, 2011.

L. Johannes and C. Wunder, The SNXy flavours of endosomal sorting, Nat. Cell Biol, vol.13, pp.884-886, 2011.

H. L. Johns, C. Gonzalez-lopez, C. L. Sayers, M. Hollinshead, and G. Elliott, Rab6 dependent postGolgi trafficking of HSV1 envelope proteins to sites of virus envelopment, Traffic, vol.15, pp.157-178, 2014.

S. M. Jones, J. R. Crosby, J. Salamero, and K. E. Howell, A Cytosolic Complex of P62 and Rab6 Associates with Tgn38/41 and Is Involved in Budding of Exocytic Vesicles From the Trans-Golgi Network, J. Cell Biol, vol.122, pp.775-788, 1993.

S. M. Jones and K. E. Howell, Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN, J. Cell Biol, vol.139, pp.339-349, 1997.

M. B. Jordan, D. Hildeman, J. Kappler, and P. Marrack, An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder, Blood, vol.104, pp.735-743, 2004.

I. Jordens, M. Fernandez-borja, M. Marsman, S. Dusseljee, L. Janssen et al., The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors, Curr. Biol, vol.11, pp.1680-1685, 2001.

H. Jung, K. H. Song, J. T. Chang, and J. Doh, Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays, PLoS ONE, vol.9, 2014.

A. Kabanova, F. Sanseviero, V. Candi, A. Gamberucci, A. Gozzetti et al., Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release, Cell Rep, vol.15, pp.9-18, 2016.

Y. Kaizuka, A. D. Douglass, S. Vardhana, M. L. Dustin, and R. D. Vale, The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells, J. Cell Biol, vol.185, pp.521-534, 2009.

Y. Kaizuka, A. D. Douglass, R. Varma, M. L. Dustin, and R. D. Vale, Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells, Proc. Natl. Acad. Sci. U.S.A, vol.104, pp.20296-20301, 2007.

T. Kakinuma, H. Ichikawa, Y. Tsukada, T. Nakamura, and B. Toh, Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery, Experimental Cell Research, vol.298, pp.388-398, 2004.

A. Karniguian, A. Zahraoui, and A. Tavitian, Identification of Small Gtp-Binding Rab Proteins in Human Platelets -Thrombin-Induced Phosphorylation of Rab3b, Rab6, and Rab8 Proteins, Proc. Natl. Acad. Sci. U.S.A, vol.90, pp.7647-7651, 1993.

L. Karnitz, S. L. Sutor, T. Torigoe, J. C. Reed, M. P. Bell et al., Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line, Mol. Cell. Biol, vol.12, pp.4521-4530, 1992.

B. Keller, I. Zaidman, O. S. Yousefi, D. Hershkovitz, J. Stein et al., Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT, J. Exp. Med, vol.213, pp.1185-1199, 2016.

H. M. Kent, H. M. Kent, P. R. Evans, I. B. Schäfer, S. R. Gray et al., Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex, Dev Cell, vol.22, pp.979-988, 2012.

J. M. Kim, J. P. Rasmussen, and A. Y. Rudensky, Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice, Nat. Immunol, vol.8, pp.191-197, 2006.

K. H. Kirsch, M. M. Georgescu, T. Shishido, W. Y. Langdon, R. B. Birge et al., The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction, Journal of Biological Chemistry, vol.276, pp.4957-4963, 2001.

K. Klinkert and A. Echard, Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond, Traffic, 2016.

K. Klinkert, M. Rocancourt, A. Houdusse, and A. Echard, Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening, Nat Commun, vol.7, p.11166, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01301777

H. Kobayashi, K. Etoh, N. Ohbayashi, and M. Fukuda, Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth, Biol Open, vol.3, pp.803-814, 2014.

S. Koonpaew, S. Shen, L. Flowers, and W. Zhang, LAT-mediated signaling in CD4+CD25+ regulatory T cell development, J. Exp. Med, vol.203, pp.119-129, 2006.

G. A. Koretzky, F. Abtahian, and M. A. Silverman, SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond, Nat. Rev. Immunol, vol.6, pp.67-78, 2006.

R. L. Kortum, L. Balagopalan, C. P. Alexander, J. Garcia, J. M. Pinski et al., The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo, Sci Signal, vol.6, pp.99-99, 2013.

R. L. Kortum, A. K. Rouquette-jazdanian, M. Miyaji, R. K. Merrill, E. Markegard et al., A phospholipase C-?1-independent, RasGRP1-ERKdependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice, J. Immunol, vol.190, pp.147-158, 2013.

M. F. Krummel and I. Macara, Maintenance and modulation of T cell polarity, Nat. Immunol, vol.7, pp.1143-1149, 2006.

K. Krzewski, A. Gil-krzewska, J. Watts, J. N. Stern, and J. L. Strominger, VAMP4-and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells, Eur. J. Immunol, vol.41, pp.3323-3329, 2011.

J. R. Kuhn and M. Poenie, Dynamic polarization of the microtubule cytoskeleton during CTLMediated killing, Immunity, vol.16, pp.111-121, 2002.

M. R. Kuhné, J. Lin, D. Yablonski, M. N. Mollenauer, L. I. Ehrlich et al., Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domaincontaining leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization, The Journal of Immunology, vol.171, pp.860-866, 2003.

N. Kunii, Y. Zhao, S. Jiang, X. Liu, J. Scholler et al., Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation, vol.24, pp.27-37, 2013.

A. Kupfer, T. R. Mosmann, and H. Kupfer, Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells, Proc. Natl. Acad. Sci. U.S.A, vol.88, pp.775-779, 1991.

M. Kurowska, N. Goudin, N. T. Nehme, M. Court, J. Garin et al., Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex, Blood, vol.119, pp.3879-3889, 2012.
URL : https://hal.archives-ouvertes.fr/hal-02084704

. La-roche, M. De, Y. Asano, and G. M. Griffiths, Origins of the cytolytic synapse, Nat. Rev. Immunol, vol.16, pp.421-432, 2016.

. La-roche, M. De, A. T. Ritter, K. L. Angus, C. Dinsmore et al., Hedgehog signaling controls T cell killing at the immunological synapse, Science, vol.342, pp.1247-1250, 2013.

P. Larghi, D. J. Williamson, J. Carpier, S. Dogniaux, K. Chemin et al., VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites, vol.14, pp.723-731, 2013.

R. Lasserre, S. Charrin, C. Cuche, A. Danckaert, M. Thoulouze et al., Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse, EMBO J, vol.29, pp.2301-2314, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00593159

R. Lasserre, C. Cuche, R. Blecher-gonen, E. Libman, E. Biquand et al., Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation, J. Cell Biol, vol.195, pp.839-853, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00646203

K. Lee, A. R. Dinner, C. Tu, G. Campi, S. Raychaudhuri et al., The immunological synapse balances T cell receptor signaling and degradation, Science, vol.302, pp.1218-1222, 2003.

K. Lee, A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen et al., T cell receptor signaling precedes immunological synapse formation, Science, vol.295, pp.1539-1542, 2002.

P. L. Lee, M. B. Ohlson, and S. R. Pfeffer, Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering, vol.4, p.917, 2015.

R. Lesourne, S. Uehara, J. Lee, K. Song, L. Li et al., Themis, a T cell-specific protein important for late thymocyte development, Nat. Immunol, vol.10, pp.840-847, 2009.

I. Levental, D. Lingwood, M. Grzybek, U. Coskun, and K. Simons, Palmitoylation regulates raft affinity for the majority of integral raft proteins, Proc. Natl. Acad. Sci. U.S.A, vol.107, pp.22050-22054, 2010.

H. Li, A. Llera, E. L. Malchiodi, and R. A. Mariuzza, The structural basis of T cell activation by superantigens, Annu. Rev. Immunol, vol.17, pp.435-466, 1999.

Q. Li, A. R. Dinner, S. Qi, D. J. Irvine, J. B. Huppa et al., CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse, Nat. Immunol, vol.5, pp.791-799, 2004.

Y. Liang, M. Cucchetti, R. Roncagalli, T. Yokosuka, A. Malzac et al., The lymphoid lineagespecific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells, Nat. Immunol, vol.14, pp.858-866, 2013.

Z. Z. Lieu, M. C. Derby, R. D. Teasdale, C. Hart, P. Gunn et al., The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network, Mol. Biol. Cell, vol.18, pp.4979-4991, 2007.

H. Liewen, I. Meinhold-heerlein, V. Oliveira, R. Schwarzenbacher, G. Luo et al., Characterization of the human GARP (Golgi associated retrograde protein) complex, Experimental Cell Research, vol.306, pp.24-34, 2005.

B. F. Lillemeier, M. A. Mörtelmaier, M. B. Forstner, J. B. Huppa, J. T. Groves et al., TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation, Nat. Immunol, vol.11, pp.90-96, 2010.

B. F. Lillemeier, J. R. Pfeiffer, Z. Surviladze, B. S. Wilson, and M. M. Davis, Plasma membraneassociated proteins are clustered into islands attached to the cytoskeleton, Proc. Natl. Acad. Sci. U.S.A, vol.103, pp.18992-18997, 2006.

J. Lin, K. K. Hou, H. Piwnica-worms, and A. S. Shaw, The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization, J. Immunol, vol.183, pp.1215-1221, 2009.

J. Lin and A. Weiss, Identification of the minimal tyrosine residues required for linker for activation of T cell function, Journal of Biological Chemistry, vol.276, pp.29588-29595, 2001.

A. J. Lindsay, F. Jollivet, C. P. Horgan, A. R. Khan, G. Raposo et al., Identification and characterization of multiple novel Rab-myosin Va interactions, Mol. Biol. Cell, vol.24, pp.3420-3434, 2013.

D. Liu, Y. T. Bryceson, T. Meckel, G. Vasiliver-shamis, M. L. Dustin et al., Integrindependent organization and bidirectional vesicular traffic at cytotoxic immune synapses, Immunity, vol.31, pp.99-109, 2009.

H. Liu, M. Rhodes, D. L. Wiest, and D. A. Vignali, On the dynamics of TCR:CD3 complex cell surface expression and downmodulation, Immunity, vol.13, pp.665-675, 2000.

S. K. Liu, N. Fang, G. A. Koretzky, and C. J. Mcglade, The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors, Curr. Biol, vol.9, pp.67-75, 1999.

X. Liu, T. M. Kapoor, J. K. Chen, and M. Huse, Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II, Proc. Natl. Acad. Sci. U.S.A, vol.110, pp.11976-11981, 2013.

M. Llewelyn, S. Sriskandan, N. Terrazzini, J. Cohen, and D. M. Altmann, The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength, Int. Immunol, vol.18, pp.1433-1441, 2006.

J. G. Lock, L. A. Hammond, F. Houghton, P. A. Gleeson, and J. L. Stow, E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97, Traffic, vol.6, pp.1142-1156, 2005.

S. K. Loftus, D. M. Larson, L. L. Baxter, A. Antonellis, Y. Chen et al., Mutation of melanosome protein RAB38 in chocolate mice, Proc. Natl. Acad. Sci. U.S.A, vol.99, pp.4471-4476, 2002.

D. Lombardi, T. Soldati, M. A. Riederer, Y. Goda, M. Zerial et al., Rab9 Functions in Transport Between Late Endosomes and the Trans Golgi Network, EMBO J, vol.12, pp.677-682, 1993.

L. S. Loo, L. Hwang, Y. M. Ong, H. S. Tay, C. Wang et al., A role for endobrevin/VAMP8 in CTL lytic granule exocytosis, Eur. J. Immunol, vol.39, pp.3520-3528, 2009.

J. Lou, J. Rossy, Q. Deng, S. V. Pageon, and K. Gaus, New Insights into How Trafficking Regulates T Cell Receptor Signaling, Front Cell Dev Biol, vol.4, p.77, 2016.

B. Lowin-kropf, V. S. Shapiro, and A. Weiss, Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism, J. Cell Biol, vol.140, pp.861-871, 1998.

M. J. Ludford-menting, J. Oliaro, F. Sacirbegovic, E. T. Cheah, N. Pedersen et al., A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation, Immunity, vol.22, pp.737-748, 2005.

I. G. Macara, Parsing the polarity code, Nat. Rev. Mol. Cell Biol, vol.5, pp.220-231, 2004.

A. Mai, S. Veltel, T. Pellinen, A. Padzik, E. Coffey et al., Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration, J Cell Biol, vol.194, pp.291-306, 2011.

R. A. Maldonado, D. J. Irvine, R. Schreiber, and L. H. Glimcher, A role for the immunological synapse in lineage commitment of CD4 lymphocytes, Nature, vol.431, pp.527-532, 2004.

R. A. Maldonado, M. A. Soriano, L. C. Perdomo, K. Sigrist, D. J. Irvine et al., Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse, J. Exp. Med, vol.206, pp.877-892, 2009.

B. Malissen, E. Aguado, and M. Malissen, Role of the LAT adaptor in T-cell development and Th2 differentiation, Adv. Immunol, vol.87, pp.1-25, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00079112

B. Malissen, C. Grégoire, M. Malissen, and R. Roncagalli, Integrative biology of T cell activation, Nat. Immunol, vol.15, pp.790-797, 2014.

F. Mallard, C. Antony, D. Tenza, J. Salamero, B. Goud et al., Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of shiga toxin Bfragment transport, J. Cell Biol, vol.143, pp.973-990, 1998.

F. Mallard, B. L. Tang, T. Galli, D. Tenza, A. Saint-pol et al., Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform, J. Cell Biol, vol.156, pp.653-664, 2002.

J. N. Mandl, J. N. Mandl, J. P. Monteiro, J. P. Monteiro, N. Vrisekoop et al., T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens, Immunity, 2013.

B. N. Manz, B. L. Jackson, R. S. Petit, M. L. Dustin, and J. Groves, T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters, Proc. Natl. Acad. Sci. U.S.A, vol.108, pp.9089-9094, 2011.

K. Marek-bukowiec, E. Aguado, and A. Miazek, Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription, Genes Immun, vol.17, pp.313-320, 2016.

M. R. Marshall, V. Pattu, M. Halimani, M. Maier-peuschel, M. Müller et al., VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity, J. Cell Biol, vol.210, pp.135-151, 2015.

O. Martinez, A. Schmidt, J. Salamero, B. Hoflack, M. Roa et al., The Small GtpBinding Protein Rab6 Functions in Intra-Golgi Transport, J Cell Biol, vol.127, pp.1575-1588, 1994.

S. Martinez-arca, P. Alberts, A. Zahraoui, D. Louvard, and T. Galli, Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth, J Cell Biol, vol.149, pp.889-899, 2000.

S. Martinez-arca, S. Coco, G. Mainguy, U. Schenk, P. Alberts et al., A common exocytotic mechanism mediates axonal and dendritic outgrowth, J. Neurosci, vol.21, pp.3830-3838, 2001.

S. Martinez-arca, S. Martinez-arca, R. Rudge, R. Rudge, M. Vacca et al., A dual mechanism controlling the localization and function of exocytic v-SNAREs, Proc. Natl. Acad. Sci. U.S.A, vol.100, pp.9011-9016, 2003.

S. Martinez-arca, R. Rudge, M. Vacca, G. Raposo, J. Camonis et al., A dual mechanism controlling the localization and function of exocytic v-SNAREs, Proc. Natl. Acad. Sci. U.S.A, vol.100, pp.9011-9016, 2003.

N. B. Martín-cófreces, F. Baixauli, M. J. López, D. Gil, A. Monjas et al., End-binding protein 1 controls signal propagation from the T cell receptor, EMBO J, vol.31, pp.4140-4152, 2012.

N. B. Martín-cófreces, F. Baixauli, and F. Sanchez-madrid, Immune synapse: conductor of orchestrated organelle movement, Trends Cell Biol, vol.24, pp.61-72, 2014.

N. B. Martín-cófreces, J. Robles-valero, J. R. Cabrero, M. Mittelbrunn, M. Gordón-alonso et al., MTOC translocation modulates IS formation and controls sustained T cell signaling, J. Cell Biol, vol.182, pp.951-962, 2008.

N. Martínez-martín, E. Fernández-arenas, S. Cemerski, P. Delgado, M. Turner et al., T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis, Immunity, vol.35, pp.208-222, 2011.

S. Matsuda, Y. Miwa, Y. Hirata, A. Minowa, J. Tanaka et al., Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT, EMBO J, vol.23, pp.2577-2585, 2004.

M. Matsuto, F. Kano, and M. Murata, Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport, Biochim. Biophys. Acta, vol.1853, pp.2592-2609, 2015.

T. Mayer, N. Touchot, and Z. Elazar, Transport between cis and medial Golgi cisternae requires the function of the Ras-related protein Rab6, Journal of Biological Chemistry, vol.271, pp.16097-16103, 1996.

C. Mccarl, C. Picard, S. Khalil, T. Kawasaki, J. Röther et al., ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia, J. Allergy Clin. Immunol, vol.124, pp.1311-1318, 2009.

I. J. Mcgough, F. Steinberg, D. Jia, P. A. Barbuti, K. J. Mcmillan et al., Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation, Curr. Biol, vol.24, pp.1670-1676, 2014.

H. T. Mcmahon, Y. A. Ushkaryov, L. Edelmann, E. Link, T. Binz et al., Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein, Nature, vol.364, pp.346-349, 1993.

L. Mcneill, R. J. Salmond, J. C. Cooper, C. K. Carret, R. L. Cassady-cain et al., The Differential Regulation of Lck Kinase Phosphorylation Sites by CD45 Is Critical for T Cell Receptor Signaling Responses, Immunity, vol.27, pp.425-437, 2007.

C. Meyer, D. Zizioli, S. Lausmann, E. L. Eskelinen, J. Hamann et al., mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors, EMBO J, vol.19, pp.2193-2203, 2000.

M. M. Ménager, G. Ménasché, M. Romao, P. Knapnougel, C. Ho et al., Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4, Nat. Immunol, vol.8, pp.257-267, 2007.

G. Ménasché, M. M. Ménager, J. M. Lefebvre, E. Deutsch, R. Athman et al., A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion, Blood, vol.112, pp.5052-5062, 2008.

G. Ménasché, E. Pastural, J. Feldmann, S. Certain, F. Ersoy et al., Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome, Nat. Genet, vol.25, pp.173-176, 2000.

M. Micaroni, A. C. Stanley, T. Khromykh, J. Venturato, C. X. Wong et al., Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages, PLoS ONE, vol.8, 2013.

M. Mingueneau, R. Roncagalli, C. Grégoire, A. Kissenpfennig, A. Miazek et al., Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor, Immunity, vol.31, pp.197-208, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00432068

S. Miserey-lenkei, G. Chalancon, S. Bardin, E. Formstecher, B. Goud et al., Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex, Nat. Cell Biol, vol.12, pp.645-654, 2010.

S. Miserey-lenkei, F. Waharte, A. Boulet, M. Cuif, D. Tenza et al., Rab6-interacting protein 1 links Rab6 and Rab11 function, vol.8, pp.1385-1403, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00195227

S. Monier, F. Jollivet, I. Janoueix-lerosey, L. Johannes, and B. Goud, Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport, Traffic, vol.3, pp.289-297, 2002.

C. R. Monks, B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer, Three-dimensional segregation of supramolecular activation clusters in T cells, Nature, vol.395, pp.82-86, 1998.

C. R. Monks, H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer, Selective modulation of protein kinase C-theta during T-cell activation, Nature, vol.385, pp.83-86, 1997.

L. Montanaro, S. Sperti, and F. Stirpe, Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin, Biochem. J, vol.136, pp.677-683, 1973.

A. Mor and M. R. Philips, Compartmentalized Ras/MAPK signaling, Annu. Rev. Immunol, vol.24, pp.771-800, 2006.

H. D. Moreau, F. Lemaître, E. Terriac, G. Azar, M. Piel et al., Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo, Immunity, vol.37, pp.351-363, 2012.

K. Moreau, B. Ravikumar, M. Renna, C. Puri, and D. C. Rubinsztein, Autophagosome precursor maturation requires homotypic fusion, Cell, vol.146, pp.303-317, 2011.

A. Motley, N. A. Bright, M. N. Seaman, and M. S. Robinson, Clathrin-mediated endocytosis in AP-2-depleted cells, J Cell Biol, vol.162, pp.909-918, 2003.

A. Muhammad, I. Flores, H. Zhang, R. Yu, A. Staniszewski et al., Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation, Proc. Natl. Acad. Sci. U.S.A, vol.105, pp.7327-7332, 2008.

A. J. Müller, O. Filipe-santos, G. Eberl, T. Aebischer, G. F. Späth et al., CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation, Immunity, vol.37, pp.147-157, 2012.

R. Neef, C. Preisinger, J. Sutcliffe, R. Kopajtich, E. A. Nigg et al., Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis, J Cell Biol, vol.162, pp.863-875, 2003.

M. Neeft, M. Wieffer, A. S. De-jong, G. Negroiu, C. H. Metz et al., Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells, Mol. Biol. Cell, vol.16, pp.731-741, 2005.

M. S. Nielsen, C. Gustafsen, P. Madsen, J. R. Nyengaard, G. Hermey et al., Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA, Mol. Cell. Biol, vol.27, pp.6842-6851, 2007.

K. Nika, C. Soldani, M. Salek, W. Paster, A. Gray et al., Constitutively active Lck kinase in T cells drives antigen receptor signal transduction, Immunity, vol.32, pp.766-777, 2010.

M. A. Norcross, A synaptic basis for T-lymphocyte activation, Ann. Immunol. (Paris), vol.135, pp.113-134, 1984.

S. F. Nothwehr, S. A. Ha, and P. Bruinsma, Sorting of yeast membrane proteins into an endosometo-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p, J Cell Biol, vol.151, pp.297-310, 2000.

N. Ohbayashi, A. Yatsu, K. Tamura, and M. Fukuda, The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes, Mol. Biol. Cell, vol.23, pp.669-678, 2012.

A. Onnis, F. Finetti, and C. T. Baldari, Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set, Front Immunol, vol.7, p.50, 2016.

A. Onnis, F. Finetti, L. Patrussi, M. Gottardo, C. Cassioli et al., The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis, Cell Death Differ, vol.22, pp.1687-1699, 2015.

F. Opdam, A. Echard, H. Croes, J. Van-den-hurk, R. A. Van-de-vorstenbosch et al., The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus, J. Cell. Sci, vol.113, pp.2725-2735, 2000.

D. G. Osborne, J. T. Piotrowski, C. J. Dick, J. Zhang, and D. D. Billadeau, SNX17 affects T cell activation by regulating TCR and integrin recycling, J. Immunol, vol.194, pp.4555-4566, 2015.

E. H. Palacios and A. Weiss, Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation, Oncogene, vol.23, pp.7990-8000, 2004.

W. Paster, C. Brockmeyer, G. Fu, P. C. Simister, B. De-wet et al., GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development, J. Immunol, vol.190, pp.3749-3756, 2013.

G. Patino-lopez, X. Dong, K. Ben-aissa, K. M. Bernot, T. Itoh et al., Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation, Journal of Biological Chemistry, vol.283, 2008.

S. Paul and B. C. Schaefer, A new look at T cell receptor signaling to nuclear factor-?B, Trends Immunol, vol.34, pp.269-281, 2013.

F. J. Pérez-victoria and J. S. Bonifacino, Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network, Mol. Cell. Biol, vol.29, pp.5251-5263, 2009.

F. J. Pérez-victoria, G. A. Mardones, and J. S. Bonifacino, Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes, Mol. Biol. Cell, vol.19, pp.2350-2362, 2008.

S. R. Pfeffer, Entry at the trans-face of the Golgi, Cold Spring Harb Perspect Biol, vol.3, 2011.

C. Picard, C. Mccarl, A. Papolos, S. Khalil, K. Lüthy et al., STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity, N. Engl. J. Med, vol.360, 1971.

J. T. Piotrowski, T. S. Gomez, R. A. Schoon, A. K. Mangalam, and D. D. Billadeau, WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function, Mol. Cell. Biol, vol.33, pp.958-973, 2013.

S. M. Pocha, T. Wassmer, C. Niehage, B. Hoflack, and E. Knust, Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs, Curr. Biol, vol.21, pp.1111-1117, 2011.

V. Popoff, G. A. Mardones, S. Bai, V. Chambon, D. Tenza et al., Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes, Traffic, vol.10, pp.1868-1880, 2009.

V. Popoff, G. A. Mardones, D. Tenza, R. Rojas, C. Lamaze et al., The retromer complex and clathrin define an early endosomal retrograde exit site, J. Cell. Sci, vol.120, pp.2022-2031, 2007.

A. M. Powelka, J. Sun, J. Li, M. Gao, L. M. Shaw et al., Stimulationdependent recycling of integrin beta1 regulated by ARF6 and Rab11, Traffic, vol.5, pp.20-36, 2004.

P. R. Pryor, L. Jackson, S. R. Gray, M. A. Edeling, A. Thompson et al., Molecular Basis for the Sorting of the SNARE VAMP7 into Endocytic Clathrin-Coated Vesicles by the ArfGAP Hrb, Cell, vol.134, pp.817-827, 2008.

P. R. Pryor, B. M. Mullock, N. A. Bright, M. R. Lindsay, S. R. Gray et al., Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events, EMBO Rep, vol.5, pp.590-595, 2004.

M. A. Purbhoo, H. Liu, S. Oddos, D. M. Owen, M. A. Neil et al., Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse, Sci Signal, vol.3, pp.36-36, 2010.

E. J. Quann, X. Liu, G. Altan-bonnet, and M. Huse, A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells, Nat. Immunol, vol.12, pp.647-654, 2011.

E. J. Quann, E. Merino, T. Furuta, and M. Huse, Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells, Nat. Immunol, vol.10, pp.627-635, 2009.

G. Racchetti, A. Lorusso, C. Schulte, D. Gavello, V. Carabelli et al., Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome, J. Cell. Sci, vol.123, pp.165-170, 2010.

J. Rahajeng, S. S. Giridharan, B. Cai, N. Naslavsky, and S. Caplan, MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a, Traffic, vol.13, pp.82-93, 2012.

V. K. Randhawa, F. S. Thong, D. Y. Lim, D. Li, R. R. Garg et al., Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using Nethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP, Mol. Biol. Cell, vol.15, pp.5565-5573, 2004.

S. K. Rao, C. Huynh, V. Proux-gillardeaux, T. Galli, and N. W. Andrews, Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis, Journal of Biological Chemistry, vol.279, pp.20471-20479, 2004.

S. K. Rao, S. K. Rao, C. Huynh, C. Huynh, V. Proux-gillardeaux et al., Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis, J. Biol. Chem, vol.279, pp.20471-20479, 2004.

E. Real, S. Faure, E. Donnadieu, and J. Delon, Cutting edge: Atypical PKCs regulate T lymphocyte polarity and scanning behavior, The Journal of Immunology, vol.179, pp.5649-5652, 2007.
DOI : 10.4049/jimmunol.179.9.5649

URL : http://www.jimmunol.org/content/jimmunol/179/9/5649.full.pdf

R. Recacha, A. Boulet, F. Jollivet, S. Monier, A. Houdusse et al., Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain, Structure, vol.17, pp.21-30, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00355625

J. V. Reddy, A. S. Burguete, K. Sridevi, I. G. Ganley, R. M. Nottingham et al., A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling, Mol. Biol. Cell, vol.17, pp.4353-4363, 2006.

M. A. Riederer, T. Soldati, A. D. Shapiro, J. Lin, and S. R. Pfeffer, Lysosome Biogenesis Requires Rab9 Function and Receptor Recycling From Endosomes to the Trans-Golgi Network, J Cell Biol, vol.125, pp.573-582, 1994.
DOI : 10.1083/jcb.125.3.573

URL : http://jcb.rupress.org/content/125/3/573.full.pdf

M. Rincón, R. A. Flavell, and R. J. Davis, Signal transduction by MAP kinases in T lymphocytes, Oncogene, vol.20, pp.2490-2497, 2001.

M. Roa, V. Cornet, C. Z. Yang, and B. Goud, The small GTP-binding protein rab6p is redistributed in the cytosol by brefeldin A, J. Cell. Sci, vol.106, pp.789-802, 1993.

J. M. Robertson, P. E. Jensen, and B. D. Evavold, DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323-339 Epitope, The Journal of Immunology, vol.164, pp.4706-4712, 2000.

A. B. Rodriguez-peña, J. Gomez-rodriguez, R. L. Kortum, D. C. Palmer, Z. Yu et al., Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules, Gene Ther, vol.22, pp.781-792, 2015.

R. Rojas, S. Kametaka, C. R. Haft, and J. S. Bonifacino, Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors, Mol. Cell. Biol, vol.27, pp.1112-1124, 2007.

R. Roncagalli, S. Hauri, F. Fiore, Y. Liang, Z. Chen et al., Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub, Nat. Immunol, vol.15, pp.384-392, 2014.

V. Rossi, D. K. Banfield, M. Vacca, L. E. Dietrich, C. Ungermann et al., Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators, Trends Biochem. Sci, vol.29, pp.682-688, 2004.

J. Rossy, D. M. Owen, D. J. Williamson, Z. Yang, and K. Gaus, Conformational states of the kinase Lck regulate clustering in early T cell signaling, Nat. Immunol, vol.14, pp.82-89, 2013.

J. Rossy, S. V. Pageon, D. M. Davis, and K. Gaus, Super-resolution microscopy of the immunological synapse, Curr. Opin. Immunol, vol.25, pp.307-312, 2013.

E. V. Rothenberg, J. E. Moore, and M. A. Yui, Launching the T-cell-lineage developmental programme, Nat. Rev. Immunol, vol.8, pp.9-21, 2008.

A. K. Rouquette-jazdanian, C. L. Sommers, R. L. Kortum, D. K. Morrison, and L. E. Samelson, LATIndependent Erk Activation via Bam32-PLC-γ1-Pak1 Complexes: GTPase-Independent Pak1 Activation, Molecular Cell, vol.48, pp.298-312, 2012.
DOI : 10.1016/j.molcel.2012.08.011

URL : https://doi.org/10.1016/j.molcel.2012.08.011

D. A. Sahlender, P. Kozik, S. E. Miller, A. A. Peden, and M. S. Robinson, Uncoupling the Functions of CALM in VAMP Sorting and Clathrin-Coated Pit Formation, PLoS ONE, vol.8, 2013.

A. Saint-pol, B. Yélamos, M. Amessou, I. G. Mills, M. Dugast et al., Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes, Dev Cell, vol.6, pp.525-538, 2004.

S. Saitoh, R. Arudchandran, T. S. Manetz, W. Zhang, C. L. Sommers et al., LAT is essential for Fc(epsilon)RI-mediated mast cell activation, Immunity, vol.12, pp.525-535, 2000.

A. Salmerón, A. Borroto, M. Fresno, M. J. Crumpton, S. C. Ley et al., Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain, The Journal of Immunology, vol.154, pp.1675-1683, 1995.

L. E. Sander, S. P. Frank, S. Bolat, U. Blank, T. Galli et al., Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells, Eur. J. Immunol, vol.38, pp.855-863, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00786407

C. J. Sanderson and A. M. Glauert, Mechanism of T-Cell Mediated Cytotoxicity .6. T-Cell Projections and Their Role in Target-Cell Killing, Immunology, vol.36, pp.119-129, 1979.

K. Sandvig, O. Garred, K. Prydz, J. V. Kozlov, S. H. Hansen et al., Retrograde Transport of Endocytosed Shiga Toxin to the Endoplasmic-Reticulum, Nature, vol.358, pp.510-512, 1992.

W. W. Schamel, I. Arechaga, R. M. Risueño, H. M. Van-santen, P. Cabezas et al., Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response, J. Exp. Med, vol.202, pp.493-503, 2005.

I. B. Schäfer, I. B. Schäfer, G. G. Hesketh, G. G. Hesketh, N. A. Bright et al., The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation, Nat. Struct. Mol. Biol, 2012.

J. Schindelin, I. Arganda-carreras, E. Frise, V. Kaynig, M. Longair et al., Fiji: an open-source platform for biological-image analysis, Nat. Methods, vol.9, pp.676-682, 2012.

M. A. Schlager, L. C. Kapitein, I. Grigoriev, G. M. Burzynski, P. S. Wulf et al., Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis, EMBO J, vol.29, pp.1637-1651, 2010.

C. Schmedt, K. Saijo, T. Niidome, R. Kühn, S. Aizawa et al., Csk controls antigen receptor-mediated development and selection of T-lineage cells, Nature, vol.394, pp.901-904, 1998.

C. Schmedt and A. Tarakhovsky, Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk), J. Exp. Med, vol.193, pp.815-826, 2001.

J. Schmoranzer, J. P. Fawcett, M. Segura, S. Tan, R. B. Vallee et al., Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration, Curr. Biol, vol.19, pp.1065-1074, 2009.

U. Schneider, H. U. Schwenk, and G. Bornkamm, Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma, Int. J. Cancer, vol.19, pp.621-626, 1977.

J. R. Schoenborn, Y. X. Tan, C. Zhang, K. M. Shokat, and A. Weiss, Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling, Sci Signal, vol.4, pp.59-59, 2011.

M. N. Seaman, Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval, J. Cell. Sci, vol.120, pp.2378-2389, 2007.

M. N. Seaman, Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer, J Cell Biol, vol.165, pp.111-122, 2004.

J. P. Secrist, L. A. Burns, L. Karnitz, G. A. Koretzky, and R. T. Abraham, Stimulatory Effects of the Protein Tyrosine Phosphatase Inhibitor, Pervanadate, on T-Cell Activation Events, Journal of Biological Chemistry, vol.268, pp.5886-5893, 1993.

P. Sengupta, P. Satpute-krishnan, A. Y. Seo, D. T. Burnette, G. H. Patterson et al., ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization, Proc. Natl. Acad. Sci. U.S.A, vol.112, pp.6752-61, 2015.

F. E. Sepulveda, F. Debeurme, G. Ménasché, M. Kurowska, M. Côte et al., Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11, Blood, vol.121, pp.595-603, 2013.

M. Shafaq-zadah, C. S. Gomes-santos, S. Bardin, P. Maiuri, M. Maurin et al., Persistent cell migration and adhesion rely on retrograde transport of ?1 integrin, Nat. Cell Biol, 2015.

X. Shan, M. J. Czar, S. C. Bunnell, P. Liu, Y. Liu et al., Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation, Mol. Cell. Biol, vol.20, pp.6945-6957, 2000.

S. Shen, S. Shen, M. I. Chuck, M. I. Chuck, M. Zhu et al., The importance of LAT in the activation, homeostasis, and regulatory function of T cells, J. Biol. Chem, vol.285, pp.35393-35405, 2010.

S. Shen, M. Zhu, J. Lau, M. Chuck, and W. Zhang, The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage, J. Immunol, vol.182, pp.5596-5604, 2009.

E. Sherman, V. Barr, S. Manley, G. Patterson, L. Balagopalan et al., Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor, Immunity, vol.35, pp.705-720, 2011.

S. Shibata, T. Kawanai, T. Hara, A. Yamamoto, T. Chaya et al., ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles, J. Cell. Sci, vol.129, pp.3620-3634, 2016.

K. L. Singleton, M. Gosh, R. D. Dandekar, B. B. Au-yeung, O. Ksionda et al., Itk Controls the Spatiotemporal Organization of T Cell Activation, Sci Signal, vol.4, 2011.

K. L. Singleton, K. T. Roybal, Y. Sun, G. Fu, N. R. Gascoigne et al., Spatiotemporal patterning during T cell activation is highly diverse, Sci Signal, vol.2, pp.15-15, 2009.

R. Sinka, A. K. Gillingham, V. Kondylis, and S. Munro, Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins, J. Cell Biol, vol.183, pp.607-615, 2008.

J. W. Slot and H. J. Geuze, Cryosectioning and immunolabeling, Nat. Protocols, vol.2, pp.2480-2491, 2007.

S. A. Small and S. Gandy, Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis, Neuron, vol.52, pp.15-31, 2006.

S. A. Small, K. Kent, A. Pierce, C. Leung, M. S. Kang et al., Model-guided microarray implicates the retromer complex in Alzheimer's disease, Ann. Neurol, vol.58, pp.909-919, 2005.

J. A. Smith, J. Y. Tso, M. R. Clark, M. S. Cole, and J. A. Bluestone, Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy, J. Exp. Med, vol.185, pp.1413-1422, 1997.

H. Soares, R. Henriques, M. Sachse, L. Ventimiglia, M. A. Alonso et al., Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse, J. Exp. Med, vol.210, pp.2415-2433, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01371057

H. Soares, R. Lasserre, and A. Alcover, Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses, Immunol. Rev, vol.256, pp.118-132, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01371059

C. L. Sommers, J. Lee, K. L. Steiner, J. M. Gurson, C. L. Depersis et al., Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection, J. Exp. Med, vol.201, pp.1125-1134, 2005.

C. L. Sommers, C. Park, J. Lee, C. Feng, C. L. Fuller et al., A LAT mutation that inhibits T cell development yet induces lymphoproliferation, Science, vol.296, pp.2040-2043, 2002.

A. C. Souza, F. S. Machado, M. R. Celes, G. Faria, L. B. Rocha et al., Mitochondrial damage as an early event of monensin-induced cell injury in cultured fibroblasts L929, J Vet Med A Physiol Pathol Clin Med, vol.52, pp.230-237, 2005.

A. I. Sperling, J. R. Sedy, N. Manjunath, A. Kupfer, B. Ardman et al., TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site, The Journal of Immunology, vol.161, pp.6459-6462, 1998.

Z. Stadt, U. Rohr, J. Seifert, W. Koch, F. Grieve et al., Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11, Am. J. Hum. Genet, vol.85, pp.482-492, 2009.

K. K. Stanley and K. E. Howell, TGN38/41: a molecule on the move, Trends Cell Biol, vol.3, pp.252-255, 1993.

T. Starr, Y. Sun, N. Wilkins, and B. Storrie, Rab33b and Rab6 are functionally overlapping regulators of Golgi homeostasis and trafficking, Traffic, vol.11, pp.626-636, 2010.

C. Steenblock, T. Heckel, C. Czupalla, A. I. Santo, C. Niehage et al., The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts, Journal of Biological Chemistry, vol.289, pp.18347-18359, 2014.

H. Stenmark, Rab GTPases as coordinators of vesicle traffic, Nat. Rev. Mol. Cell Biol, vol.10, pp.513-525, 2009.

J. C. Stinchcombe, D. C. Barral, E. H. Mules, S. Booth, A. N. Hume et al., Rab27a is required for regulated secretion in cytotoxic T lymphocytes, J. Cell Biol, vol.152, pp.825-833, 2001.

J. C. Stinchcombe, G. Bossi, S. Booth, and G. M. Griffiths, The immunological synapse of CTL contains a secretory domain and membrane bridges, Immunity, vol.15, pp.751-761, 2001.

J. C. Stinchcombe and G. M. Griffiths, Communication, the centrosome and the immunological synapse, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.369, 2014.

J. C. Stinchcombe, E. Majorovits, G. Bossi, S. Fuller, and G. M. Griffiths, Centrosome polarization delivers secretory granules to the immunological synapse, Nature, vol.443, pp.462-465, 2006.

J. C. Stinchcombe, L. O. Randzavola, K. L. Angus, J. M. Mantell, P. Verkade et al., Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis, Curr. Biol, vol.25, pp.3239-3244, 2015.

D. B. Straus and A. Weiss, Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor, Cell, vol.70, pp.585-593, 1992.

M. Strom, A. N. Hume, A. K. Tarafder, E. Barkagianni, and M. C. Seabra, A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport, Journal of Biological Chemistry, vol.277, 2002.

X. Su, J. A. Ditlev, E. Hui, W. Xing, S. Banjade et al., Phase separation of signaling molecules promotes T cell receptor signal transduction, Science, vol.352, pp.595-599, 2016.

L. Summers-deluca and J. L. Gommerman, Fine-tuning of dendritic cell biology by the TNF superfamily, Nat. Rev. Immunol, vol.12, pp.339-351, 2012.

C. M. Szalinski, A. Labilloy, J. R. Bruns, and O. A. Weisz, VAMP7 modulates ciliary biogenesis in kidney cells, PLoS ONE, vol.9, p.86425, 2014.

G. Tai, L. Lu, L. Johannes, and W. Hong, Functional analysis of Arl1 and golgin-97 in endosometo-TGN transport using recombinant Shiga toxin B fragment, Meth. Enzymol, vol.404, pp.442-453, 2005.

K. Tamura, N. Ohbayashi, K. Ishibashi, and M. Fukuda, Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes, J. Biol. Chem, vol.286, pp.7507-7521, 2011.

K. Tamura, N. Ohbayashi, Y. Maruta, E. Kanno, T. Itoh et al., Varp Is a Novel Rab32/38-binding Protein That Regulates Tyrp1 Trafficking in Melanocytes, Mol. Biol. Cell, vol.20, pp.2900-2908, 2009.

N. Tanimura, S. Saitoh, S. Kawano, A. Kosugi, and K. Miyake, Palmitoylation of LAT contributes to its subcellular localization and stability, Biochem. Biophys. Res. Commun, vol.341, pp.1177-1183, 2006.

M. Thome and J. Tschopp, TCR-induced NF-?B activation: a crucial role for Carma1, Bcl10 and MALT1, Trends Immunol, vol.24, pp.419-424, 2003.

J. L. Thompson, O. Mignen, and T. J. Shuttleworth, The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition, Journal of Biological Chemistry, vol.284, pp.6620-6626, 2009.

M. Tourret, S. Guégan, K. Chemin, S. Dogniaux, F. Miro et al., T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells, J. Immunol, vol.185, pp.6809-6818, 2010.

A. Tsun, I. Qureshi, J. C. Stinchcombe, M. R. Jenkins, . Roche et al., Centrosome docking at the immunological synapse is controlled by Lck signaling, J. Cell Biol, vol.192, pp.663-674, 2011.

H. Ueda, M. K. Morphew, J. R. Mcintosh, and M. M. Davis, CD4+ T-cell synapses involve multiple distinct stages, Proc. Natl. Acad. Sci. U.S.A, vol.108, pp.17099-17104, 2011.

M. Uhlig, W. Passlack, and J. Eckel, Functional role of Rab11 in GLUT4 trafficking in cardiomyocytes, Mol. Cell. Endocrinol, vol.235, pp.1-9, 2005.

A. Utskarpen, H. H. Slagsvold, A. B. Dyve, S. S. Skånland, and K. Sandvig, SNX1 and SNX2 mediate retrograde transport of Shiga toxin, Biochem. Biophys. Res. Commun, vol.358, pp.566-570, 2007.

A. Utskarpen, H. H. Slagsvold, T. Iversen, S. Wälchli, and K. Sandvig, Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A, Traffic, vol.7, pp.663-672, 2006.

C. Valente, R. Polishchuk, and M. A. De-matteis, Rab6 and myosin II at the cutting edge of membrane fission, Nat. Cell Biol, vol.12, pp.635-638, 2010.

N. S. Van-oers, N. Killeen, and A. Weiss, Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes, J. Exp. Med, vol.183, pp.1053-1062, 1996.

N. Van-panhuys, F. Klauschen, and R. N. Germain, T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo, Immunity, vol.41, pp.63-74, 2014.

S. Vardhana, K. Choudhuri, R. Varma, and M. L. Dustin, Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster, Immunity, vol.32, pp.531-540, 2010.

G. Varga, N. Nippe, S. Balkow, T. Peters, M. K. Wild et al., LFA-1 contributes to signal I of T-cell activation and to the production of T(h)1 cytokines, J. Invest. Dermatol, vol.130, pp.1005-1012, 2010.

R. Varma, G. Campi, T. Yokosuka, T. Saito, and M. L. Dustin, T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster, Immunity, vol.25, pp.117-127, 2006.

A. Veillette, M. A. Bookman, E. M. Horak, L. E. Samelson, and J. B. Bolen, Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck, Nature, vol.338, pp.257-259, 1989.

S. I. Vieira, S. Rebelo, H. Esselmann, J. Wiltfang, J. Lah et al., , 2010.

, Mol Neurodegener, vol.5, p.40

D. A. Vignali, L. W. Collison, and C. J. Workman, How regulatory T cells work, Nat. Rev. Immunol, vol.8, pp.523-532, 2008.

O. I. Vivar, G. Masi, J. Carpier, J. G. Magalhaes, D. Galgano et al., IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo, Proc. Natl. Acad. Sci. U.S.A, 2015.

S. Vivona, C. W. Liu, P. Strop, V. Rossi, F. Filippini et al., The longin SNARE VAMP7/TI-VAMP adopts a closed conformation, J. Biol. Chem, vol.285, pp.17965-17973, 2010.

S. Waguri, F. Dewitte, R. Le-borgne, Y. Rouillé, Y. Uchiyama et al., Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells, Mol. Biol. Cell, vol.14, pp.142-155, 2003.

Y. Wakana, J. Van-galen, F. Meissner, M. Scarpa, R. S. Polishchuk et al., A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface, EMBO J, vol.31, pp.3976-3990, 2012.

F. Wang, H. Zhang, X. Zhang, Y. Wang, F. Ren et al., Varp interacts with Rab38 and functions as its potential effector, Biochem. Biophys. Res. Commun, vol.372, pp.162-167, 2008.

H. Wang, T. A. Kadlecek, B. B. Au-yeung, H. E. Goodfellow, L. Hsu et al., ZAP-70: an essential kinase in T-cell signaling, vol.2, pp.2279-002279, 2010.

Y. Wang, A. Kissenpfennig, M. Mingueneau, S. Richelme, P. Perrin et al., Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells, The Journal of Immunology, vol.180, pp.1565-1575, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00294270

B. Wanschers, R. Van-de-vorstenbosch, M. Wijers, B. Wieringa, S. M. King et al., Rab6 family proteins interact with the dynein light chain protein DYNLRB1, Cell Motil. Cytoskeleton, vol.65, pp.183-196, 2008.

T. Wassmer, N. Attar, M. V. Bujny, J. Oakley, C. J. Traer et al., A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer, J. Cell. Sci, vol.120, pp.45-54, 2007.

T. Wassmer, N. Attar, M. Harterink, J. R. Van-weering, C. J. Traer et al., The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network, Dev Cell, vol.17, pp.110-122, 2009.

J. L. Watkins, K. T. Lewandowski, S. E. Meek, P. Storz, A. Toker et al., Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association, Proc. Natl. Acad. Sci. U.S.A, vol.105, pp.18378-18383, 2008.

R. Weil, K. Schwamborn, A. Alcover, C. Bessia, V. Di-bartolo et al., Induction of the NFkappa B cascade by recruitment of the scaffold molecule NEMO to the T cell receptor, Immunity, vol.18, pp.13-26, 2003.

A. Weiss, Discovering the TCR -Chain by Subtraction, The Journal of Immunology, vol.175, 2005.

T. Welz, J. Wellbourne-wood, and E. Kerkhoff, Orchestration of cell surface proteins by Rab11, Trends Cell Biol, vol.24, pp.407-415, 2014.

J. White, L. Johannes, F. Mallard, A. Girod, S. Grill et al., Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells, J Cell Biol, vol.147, pp.743-759, 1999.

M. Wilcke, L. Johannes, T. Galli, V. Mayau, B. Goud et al., Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network, J. Cell Biol, vol.151, pp.1207-1220, 2000.

D. Williams and J. E. Pessin, Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes, J. Cell Biol, vol.180, pp.375-387, 2008.

D. J. Williamson, D. M. Owen, J. Rossy, A. Magenau, M. Wehrmann et al., Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events, Nat. Immunol, vol.12, pp.655-662, 2011.

B. S. Wilson, J. R. Pfeiffer, Z. Surviladze, E. A. Gaudet, and J. M. Oliver, High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT, J. Cell Biol, vol.154, pp.645-658, 2001.

S. M. Wilson, R. Yip, D. A. Swing, T. N. O'sullivan, Y. Zhang et al., A mutation in Rab27a causes the vesicle transport defects observed in ashen mice, Proc. Natl. Acad. Sci. U.S.A, vol.97, pp.7933-7938, 2000.

L. Wooldridge, . Van-den, H. A. Berg, M. Glick, E. Gostick et al., Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface, Journal of Biological Chemistry, vol.280, pp.27491-27501, 2005.

C. Wulfing and M. M. Davis, A receptor/cytoskeletal movement triggered by costimulation during T cell activation, Science, vol.282, pp.2266-2269, 1998.

S. Yamasaki, K. Nishida, M. Sakuma, D. Berry, C. J. Mcglade et al., Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells, Mol. Cell. Biol, vol.23, pp.2515-2529, 2003.

Y. Yanagi, Y. Yoshikai, K. Leggett, S. P. Clark, I. Aleksander et al., A human T cellspecific cDNA clone encodes a protein having extensive homology to immunoglobulin chains, Nature, vol.308, pp.145-149, 1984.

C. Yang, C. D. Hojer, M. Zhou, X. Wu, A. Wuster et al., Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease, Cell, vol.164, pp.141-155, 2016.

X. Yang, Y. Zhang, S. Li, C. Liu, Z. Jin et al., Rab21 attenuates EGFmediated MAPK signaling through enhancing EGFR internalization and degradation, Biochem. Biophys. Res. Commun, vol.421, pp.651-657, 2012.

T. Yasuda, K. Bundo, A. Hino, K. Honda, A. Inoue et al., Dok-1 and Dok-2 are negative regulators of T cell receptor signaling, Int. Immunol, vol.19, pp.487-495, 2007.

J. Yi, X. Wu, A. H. Chung, J. K. Chen, T. M. Kapoor et al., Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage, J. Cell Biol, vol.202, pp.779-792, 2013.

T. Yokosuka, W. Kobayashi, K. Sakata-sogawa, M. Takamatsu, A. Hashimoto-tane et al., Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation, Immunity, vol.29, pp.589-601, 2008.

T. Yokosuka, K. Sakata-sogawa, W. Kobayashi, M. Hiroshima, A. Hashimoto-tane et al., Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76, Nat. Immunol, vol.6, pp.1253-1262, 2005.

I. A. Yudushkin and R. D. Vale, Imaging T-cell receptor activation reveals accumulation of tyrosinephosphorylated CD3? in the endosomal compartment, Proc. Natl. Acad. Sci. U.S.A, vol.107, pp.22128-22133, 2010.

A. Zahraoui, N. Touchot, P. Chardin, and A. Tavitian, The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion, Journal of Biological Chemistry, vol.264, pp.12394-12401, 1989.

D. Zhang, J. Dubey, S. P. Koushika, and C. Rongo, RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans, PLoS ONE, vol.11, 2016.

W. Zhang, J. Sloan-lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson, LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation, Cell, vol.92, pp.83-92, 1998.

W. Zhang, C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. Dejarnette et al., Essential role of LAT in T cell development, Immunity, vol.10, pp.323-332, 1999.

W. Zhang, R. P. Trible, M. Zhu, S. K. Liu, C. J. Mcglade et al., Association of Grb2, Gads, and Phospholipase C-1 with Phosphorylated LAT Tyrosine Residues: EFFECT OF LAT TYROSINE MUTATIONS ON T CELL ANTIGEN RECEPTOR-MEDIATED SIGNALING, Journal of Biological Chemistry, vol.275, pp.23355-23361, 2000.

W. G. Zhang, R. P. Trible, and L. E. Samelson, LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation, Immunity, vol.9, pp.239-246, 1998.

X. Zhang, X. He, X. Fu, and Z. Chang, Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics, J. Cell. Sci, vol.119, pp.1053-1062, 2006.

B. Zhou, Y. Wu, and X. Lin, Retromer regulates apical-basal polarity through recycling Crumbs, Dev. Biol, vol.360, pp.87-95, 2011.

M. Zhu, E. Janssen, and W. Zhang, Minimal Requirement of Tyrosine Residues of Linker for Activation of T Cells in TCR Signaling and Thymocyte Development, The Journal of Immunology, vol.170, pp.325-333, 2003.

Q. Zou, J. Jin, Y. Xiao, H. Hu, X. Zhou et al., T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi, J. Exp. Med, vol.212, pp.1323-1336, 2015.

L. Analyse-de,