Potentialisation des chimiothérapies dans le traitement du glioblastome : étude des transporteurs ABC et ouverture de la barrière hémato-encéphalique par ultrasons

Abstract : Glioblastoma (GBM) is the most frequent and severe brain cancer for adults. Its dark prognosis in partly due to the resistance of these tumors to chemotherapies. One of the main causes of these resistances is the incapacity of chemotherapies to enter the brain from the blood circulation because of the bloodbrain barrier (BBB), a specificity of cerebral blood vessels. By the injection of microbubbles and the delivery of ultrasound into the brain, it is possible to open this BBB to allow chemotherapies to enter the brain. We have showed that the chemotherapeutic agent carboplatin gained efficacy when it was injectedafter this procedure. GBM can also exhibit resistance to chemotherapies by genetic mechanisms intrinsic to the tumor. We studied the expression and the impact on prognosis for GBM patients of the genes of the ABC transporters family, which member ABCA13 appeared important.
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Antonin Drean. Potentialisation des chimiothérapies dans le traitement du glioblastome : étude des transporteurs ABC et ouverture de la barrière hémato-encéphalique par ultrasons. Biotechnologies. Université Paris-Saclay, 2018. Français. ⟨NNT : 2018SACLS110⟩. ⟨tel-02145219⟩

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