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, Kcl 10 mM, DTT 1 mM, NP-40 0.1%), incubated 10 min on ice followed by centrifugation (5 minutes, Nuclei were resuspended in nuclear lysis buffer (Hepes pH 7.9 50 mM, NaCl 140 mM, EDTA 1 mM, Triton X100 1%, Na-deoxycholate 0.1%, SDS 0.5%), and sonicated on bioruptor to, 2000.

I. I. Pol and . Milliport, or 5 µg of IgG. Antibody-beads, pp.4-1572

, NaCl 140 mM, EDTA 1 mM, Triton X100 1%)

, Immunoprecipitates were washed three times with IP buffer, one time with wash buffer (Tris pH 8 20 mM, LiCl 250 mM, EDTA 1 mM, NP-40 0.5%, Na-deoxycholate 0.5%), and two times with elution buffer

, mM) and RnaseA (0.3 µg/µL) and incubating whole night at 65°C. The proteins were digested by adding Proteinase K (0.2 µg/µL) and incubating 4 hours at 37°C. Finally, DNA was purified with phenol-chloroform, Chromatin was then reverse cross-linked by adding NaCl

G. Gtg, A. Gga-aga, C. Ga, and . At, We analyzed the ChIP data by real-time qPCR. The primers used are as followed : negative control region (intergenic region)

C. Gga, . Gct, T. Tca-tg, and . Tt,

A. Ltr, . Caa, C. Tac-ttc, T. Gat, C. Tss et al.,