D. Bouvard, A. Aszodi, G. Kostka, M. R. Block, C. Albige?-s-rizo et al., Defective osteoblast function in ICAP-1-deficient mice, Development, vol.134, pp.2615-2625, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00166116

M. Brunner, A. Millon-fre?millonfre?millon, G. Chevalier, I. A. Nakchbandi, D. Mosher et al., Osteoblast mineralization requires {beta}1 integrin/ICAP-1-dependent fibronectin deposition, J. Cell Biol, vol.194, pp.307-322, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00610020

K. Burridge and E. S. Wittchen, The tension mounts: stress fibers as forcegenerating mechanotransducers, J. Cell Biol, vol.200, pp.9-19, 2013.

L. Carvallo, R. Mun-?-oz, F. Bustos, N. Escobedo, H. Carrasco et al., Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4, J. Biol. Chem, vol.285, pp.29546-29555, 2010.

D. D. Chang, B. Q. Hoang, J. Liu, and T. A. Springer, Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin, J. Biol. Chem, vol.277, pp.8140-8145, 2002.

C. Chen, T. Tao, C. Wen, W. He, Y. Qiao et al., myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism, J. Biol. Chem, vol.289, pp.28478-28488, 2014.

L. E. Crose, T. L. Hilder, N. Sciaky, and G. L. Johnson, Cerebral cavernous malformation 2 protein promotes Smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells, J. Biol. Chem, vol.284, pp.13301-13305, 2009.

S. Degani, F. Balzac, M. Brancaccio, S. Guazzone, S. F. Retta et al., The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading, J. Cell Biol, vol.156, pp.377-387, 2002.

D. E. Discher, P. Janmey, and Y. L. Wang, Tissue cells feel and respond to the stiffness of their substrate, Science, vol.310, pp.1139-1143, 2005.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, Matrix elasticity directs stem cell lineage specification, Cell, vol.126, pp.677-689, 2006.

E. Faurobert, C. Rome, J. Lisowska, . Manet-dupe?, S. Dupe? et al., CCM1-ICAP-1 complex controls ?1 integrin-dependent endothelial contractility and fibronectin remodeling, J. Cell Biol, vol.202, pp.545-561, 2013.

C. Gally, F. Wissler, H. Zahreddine, S. Quintin, F. Landmann et al., Myosin II regulation during C. elegans embryonic elongation: LET-502/ ROCK, MRCK-1 and PAK-1, three kinases with different roles, Development, vol.136, pp.3109-3119, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00420802

T. L. Hilder, M. H. Malone, S. Bencharit, J. Colicelli, T. A. Haystead et al., Proteomic identification of the cerebral cavernous malformation signaling complex, J. Proteome Res, vol.6, pp.4343-4355, 2007.

C. Huang, Z. Rajfur, N. Yousefi, Z. Chen, K. Jacobson et al., Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration, Nat. Cell Biol, vol.11, pp.624-630, 2009.

A. Je?gouje?gou, M. Carlier, and G. Romet-lemonne, Formin mDia1 senses and generates mechanical forces on actin filaments, Nat. Commun, vol.4, p.1883, 2013.

G. Jiang, A. H. Huang, Y. Cai, M. Tanase, and M. P. Sheetz, Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha, Biophys. J, vol.90, pp.1804-1809, 2006.

T. Leung, X. Chen, I. Tan, E. Manser, and L. Lim, Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization, Mol. Cell. Biol, vol.18, pp.130-140, 1998.

W. Liu, K. M. Draheim, R. Zhang, D. A. Calderwood, and T. J. Boggon, Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation, Mol. Cell, vol.49, pp.719-729, 2013.

K. Lu, X. Yin, T. Weng, S. Xi, L. Li et al., Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1, Nat. Cell Biol, vol.10, pp.994-1002, 2008.

K. Lu, P. Li, M. Zhang, G. Xing, X. Li et al., Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection, J. Biol. Chem, vol.286, pp.16861-16870, 2011.

A. Millon-fre?millonfre?millon, D. Bouvard, A. Grichine, . Manet-dupe?, S. Dupe? et al., Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity, J. Cell Biol, vol.180, pp.427-441, 2008.

E. Montanez, S. Ussar, M. Schifferer, M. Bo-?-sl, R. Zent et al., Kindlin-2 controls bidirectional signaling of integrins, Genes Dev, vol.22, pp.1325-1330, 2008.

S. W. Moore, P. Roca-cusachs, and M. P. Sheetz, Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing, Dev. Cell, vol.19, pp.194-206, 2010.

J. M. Peter, A. Bele?nbele?n, R. Jacco-van, M. W. Yvonne, G. Dirk et al., Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane, J. Cell. Physiol, vol.208, pp.620-628, 2006.

M. Raab, J. Swift, P. C. Dingal, P. Shah, J. Shin et al., Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain, J. Cell Biol, vol.199, pp.669-683, 2012.

E. Sahai, R. Garcia-medina, J. Pouysse?gurpouysse?gur, and E. Vial, Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility, J. Cell Biol, vol.176, pp.35-42, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00320762

A. Schaefer, M. Nethe, and P. L. Hordijk, Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration, Biochem. J, vol.442, pp.13-25, 2012.

Y. Su, C. Gao, Y. Liu, S. Guo, A. Wang et al., Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7, Mol. Cell. Biol, vol.33, pp.1546-1560, 2013.

S. Torrino, O. Visvikis, A. Doye, L. Boyer, C. Stefani et al., The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1, Dev. Cell, vol.21, pp.959-965, 2011.

G. Totsukawa, Y. Yamakita, S. Yamashiro, D. J. Hartshorne, Y. Sasaki et al., Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts, J. Cell Biol, vol.150, pp.797-806, 2000.

G. Totsukawa, Y. Wu, Y. Sasaki, D. J. Hartshorne, Y. Yamakita et al., Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts, J. Cell Biol, vol.164, pp.427-439, 2004.

Q. Tseng, I. Wang, E. Duchemin-pelletier, A. Azioune, N. Carpi et al., A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels, Lab. Chip, vol.11, pp.2231-2240, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00611335

M. Unbekandt and M. F. Olson, The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer, J. Mol. Med, vol.92, pp.217-225, 2014.

O. Visvikis, P. Lore?-s, L. Boyer, P. Chardin, E. Lemichez et al., Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process, FEBS J, vol.275, pp.386-396, 2008.

H. Wang, Y. Zhang, B. Ozdamar, A. A. Ogunjimi, E. Alexandrova et al., Regulation of cell polarity and protrusion formation by targeting RhoA for degradation, Science, vol.302, pp.1775-1779, 2003.

H. Wang, A. A. Ogunjimi, Y. Zhang, B. Ozdamar, R. Bose et al., Degradation of RhoA by Smurf1 ubiquitin ligase, Methods Enzymol, vol.406, pp.437-447, 2006.

S. Wilkinson, H. F. Paterson, and C. J. Marshall, Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion, Nat. Cell Biol, vol.7, pp.255-261, 2005.

F. Ye, A. K. Snider, and M. H. Ginsberg, Talin and kindlin: the one-two punch in integrin activation, Front. Med, vol.8, pp.6-16, 2014.

H. Zhu, P. Kavsak, S. Abdollah, J. L. Wrana, and G. H. Thomsen, A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation, Nature, vol.400, pp.687-693, 1999.

M. Abercrombie, J. E. Heaysman, and S. M. Pegrum, The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella, Exp. Cell Res, vol.67, pp.359-367, 1971.

A. , Integrin Endosomal Signalling Suppresses Anoikis, 2015.

S. M. Albelda, S. A. Mette, D. E. Elder, R. M. Stewart, L. Damjanovich et al., Integrin Distribution in Malignant Melanoma: Association of the ? 3 Subunit with Tumor Progression, Cancer Res, vol.50, pp.6757-6764, 1990.

C. Albiges-rizo, O. Destaing, B. Fourcade, E. Planus, and M. R. Block, Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions, J. Cell Sci, vol.122, pp.3037-3049, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00410924

K. Alessandri, B. R. Sarangi, V. V. Gurchenkov, B. Sinha, T. R. Kiessling et al., Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro, Proc. Natl. Acad. Sci, vol.110, pp.14843-14848, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-01356886

R. Alon and M. L. Dustin, Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells, Immunity, vol.26, pp.17-27, 2007.

B. Alvarez, P. J. Stroeken, M. J. Edel, and E. Roos, Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions, J. Cell. Physiol, vol.214, pp.474-482, 2008.

N. J. Anthis and I. D. Campbell, The tail of integrin activation, Trends Biochem. Sci, vol.36, pp.191-198, 2011.

A. Arjonen, J. Alanko, S. Veltel, and J. Ivaska, Distinct recycling of active and Traffic, vol.13, pp.610-635, 2012.

A. I. Bachir, J. Zareno, K. Moissoglu, E. F. Plow, E. Gratton et al., Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions, Curr. Biol, vol.24, pp.1845-1853, 2014.

C. Ballestrem, B. Hinz, B. A. Imhof, and B. Wehrle-haller, Marching at the front and dragging behind: Differential ? V3-integrin turnover regulates focal adhesion behavior, J. Cell Biol, vol.155, pp.1319-1332, 2001.

C. Ballestrem, B. Hinz, B. A. Imhof, and B. Wehrle-haller, Marching at the = 144 = front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior, J. Cell Biol, vol.155, pp.1319-1351, 2001.

M. Barczyk, S. Carracedo, and D. Gullberg, Integrins. Cell Tissue Res, vol.339, pp.269-280, 2010.

S. Béraud-dufour, R. Gautier, C. Albiges-rizo, P. Chardin, and E. Faurobert, Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1, FEBS J, vol.274, pp.5518-5532, 2007.

J. Bereiter-hahn, Mechanics of crawling cells, Med. Eng. Phys, vol.27, pp.743-753, 2005.

M. E. Berginski and S. M. Gomez, The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics, 1000.

L. Beyec, J. , R. Xu, S. Lee, C. M. Nelson et al., Cell shape regulates global histone acetylation in human mammary epithelial cells, Exp. Cell Res, vol.313, pp.3066-3075, 2007.

M. Bharadwaj, N. Strohmeyer, G. P. Colo, J. Helenius, N. Beerenwinkel et al., integrins to strengthen adhesion to fibronectin, Nat. Commun, vol.8, p.14348

L. Blanchoin, R. Boujemaa-paterski, C. Sykes, and J. Plastino, Actin dynamics, architecture, and mechanics in cell motility, Physiol. Rev, vol.94, pp.235-63, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00943523

M. Boissan, G. Montagnac, Q. Shen, L. Griparic, J. Guitton et al., Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling, Science, vol.344, pp.1510-1515, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01074739

G. G. Borisy and T. M. Svitkina, Actin machinery: Pushing the envelope, Curr. Opin. Cell Biol, vol.12, pp.104-112, 2000.

A. Bouin, A. Kyumurkov, M. Régent-kloeckner, A. Ribba, E. Faurobert et al.,

I. Fournier, S. Bourrin-reynard, C. Manet-dupé, M. Oddou, E. Balland et al., Correction: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2, J. Cell Sci, vol.130, pp.1195-1195, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02063871

A. Bouin, A. Kyurmurkov, and M. Régent-kloeckner,

I. Fournier, S. Bourrin-reynard, C. Manet-dupé, M. Oddou, E. Balland et al., ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-balance, J. Cell Sci, vol.130, pp.626-636, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02063875

D. Bouvard, A. Aszodi, G. Kostka, M. R. Block, C. Albigès-rizo et al., Defective osteoblast function in ICAP-1-deficient mice, Development, vol.134, pp.2615-2640, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00166116

D. Bouvard and M. R. Block, Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha, Biochem Biophys Res Commun, vol.252, pp.99592-99596, 1998.

D. Bouvard, L. Vignoud, S. Dupe-manet, N. Abed, H. N. Fournier et al., Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1, J. Biol. Chem, vol.278, pp.6567-6574, 2003.

R. E. Bridgewater, J. C. Norman, and P. T. Caswell, Integrin trafficking at a glance, J. Cell Sci, vol.125, pp.3695-3701, 2012.

J. Brinckmann, Collagens at a glance, Top. Curr. Chem, vol.247, pp.1-6, 2005.

C. M. Brown, B. Hebert, D. L. Kolin, J. Zareno, L. Whitmore et al., Probing the integrin-actin linkage using high-resolution protein velocity mapping, J. Cell Sci, vol.119, pp.5204-5214, 2006.

M. Brunner, A. Millon-fremillon, G. Chevalier, I. A. Nakchbandi, D. Mosher et al., Osteoblast mineralization requires {beta}1 integrin/ICAP-1-dependent fibronectin deposition, J Cell Biol, vol.194, pp.307-322, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00610020

M. Brunner, A. Millon-frémillon, G. Chevalier, I. Nakchbandi, D. Mosher et al., Osteoblast mineralization -1-dependent fibronectin deposition, J. Cell Biol, vol.194, pp.307-322, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00610020

A. Buguin, P. Chavrier, B. Ladoux, O. Du-roure, A. Saez et al., , 2005.

, Med Sci, vol.21, pp.765-767

X. R. Bustelo, V. Sauzeau, and I. M. Berenjeno, GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo, BioEssays, vol.29, pp.356-370, 2007.

D. T. Butcher, T. Alliston, and V. M. Weaver, A tense situation: forcing tumour = 146 = progression, Nat. Rev. Cancer, vol.9, pp.108-122, 2009.

J. P. Butler, I. M. Tolic-norrelykke, B. Fabry, and J. J. Fredberg, Traction fields, moments, and strain energy that cells exert on their surroundings, AJP Cell Physiol, vol.282, pp.595-605, 2002.

A. Byron, M. R. Morgan, and M. J. Humphries, Adhesion signalling complexes, Curr. Biol, vol.20, 2010.

C. W. Cairo, R. Mirchev, and D. E. Golan, Cytoskeletal Regulation Couples LFA-1 Conformational Changes to Receptor Lateral Mobility and Clustering, Immunity, vol.25, pp.297-308, 2006.

D. A. Calderwood, Y. Fujioka, J. M. Pereda, B. Garca-a-alvarez, T. Nakamoto et al., Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.2272-2277, 2003.

L. Carvallo, R. Muñoz, F. Bustos, N. Escobedo, H. Carrasco et al., Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4, J. Biol. Chem, vol.285, pp.29546-55, 2010.

P. Caswell and J. Norman, Endocytic transport of integrins during cell migration and invasion, Trends Cell Biol, vol.18, pp.257-263, 2008.

P. T. Caswell, M. Chan, A. J. Lindsay, M. W. Mccaffrey, D. Boettiger et al., Rab-coupling protein coordinates recycling of51 integrin and EGFR1 to promote cell migration in 3D microenvironments, J. Cell Biol, vol.183, pp.143-155, 2008.

P. T. Caswell, S. Vadrevu, and J. C. Norman, Integrins: masters and slaves of endocytic transport, Nat. Rev. Mol. Cell Biol, vol.10, pp.843-853, 2009.

E. A. Cavalcanti-adam, T. Volberg, A. Micoulet, H. Kessler, B. Geiger et al., Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands, Biophys. J, vol.92, pp.2964-74, 2007.

M. Cebecauer, M. Spitaler, A. Sergé, and A. I. Magee, Signalling complexes and clusters: functional advantages and methodological hurdles, J. Cell Sci, vol.123, pp.309-320, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00502965

B. P. Ceresa and S. L. Schmid, Regulation of signal transduction by endocytosis, Curr. Opin. Cell Biol, vol.12, pp.204-214, 2000.

M. Chalfie, Neurosensory mechanotransduction, Nat. Rev. Mol. Cell Biol. =, vol.147, pp.44-52, 2009.

M. W. Chan, B. Hinz, and C. A. Mcculloch, Mechanical Induction of Gene Expression in Connective Tissue Cells, vol.98, pp.179-205, 2010.

D. D. Chang, C. Wong, H. Smith, and J. Liu, ICAPcytoplasmic domain-associated protein, J. Cell Biol, vol.138, pp.1149-1157, 1997.

W. Chao and J. Kunz, Focal adhesion disassembly requires clathrindependent endocytosis of integrins, FEBS Lett, vol.583, pp.1337-1380, 2009.

G. Charras and E. Paluch, Blebs lead the way: how to migrate without lamellipodia, Nat. Rev. Mol. Cell Biol, vol.9, pp.730-736, 2008.

P. W. Chen, R. Luo, X. Jian, and P. A. Randazzo, The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that, J. Biol. Chem, vol.289, pp.30237-30248, 2014.

M. Chiquet, L. Gelman, R. Lutz, and S. Maier, From mechanotransduction to extracellular matrix gene expression in fibroblasts, Biochim. Biophys. ActaMol. Cell Res, vol.1793, pp.911-920, 2009.

A. Cho, V. M. Howell, and E. K. Colvin, The Extracellular Matrix in Epithelial Ovarian Cancer -A Piece of a Puzzle, Front. Oncol, vol.5, pp.1-16, 2015.

C. K. Choi, M. Vicente-manzanares, J. Zareno, L. A. Whitmore, A. Mogilner et al., Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner, Nat. Cell Biol, vol.10, pp.1039-50, 2008.

M. Chrzanowska-wodnicka and K. Burridge, Rho-stimulated contractility drives the formation of stress fibers and focal adhesions, J. Cell Biol, vol.133, pp.1403-1415, 1996.

O. Collin, S. Na, F. Chowdhury, M. Hong, M. E. Shin et al., Self-Organized Podosomes Are Dynamic Mechanosensors, Curr. Biol, vol.18, pp.1288-1294, 2008.

H. Colognato and P. D. Yurchenco, Form and function: The laminin family of heterotrimers, Dev. Dyn, vol.218, pp.213-234, 2000.

T. R. Cox and J. T. Erler, Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer, Dis. Model. Mech, vol.4, 2011.

V. Dammai, K. R. B.-adryan, T. Lavenburg, and . Hsu, Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development, Genes Dev, vol.17, pp.2812-2824, 2003.

E. H. Danen, P. Sonneveld, C. Brakebusch, R. Fässler, and A. Sonnenberg, The fibronectin--GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis, J. Cell Biol, vol.159, pp.1071-1086, 2002.

M. Dembo, D. C. Torney, K. Saxman, and D. Hammer, The reaction-limited kinetics of membrane-to-surface adhesion and detachment, Proc. R. Soc. London. Ser. B, vol.234, pp.55-83, 1988.

C. F. Deroanne, C. M. Lapiere, and B. V. Nusgens, In vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrixcytoskeleton, Cardiovasc. Res, vol.49, pp.647-658, 2001.

S. J. Desgrosellier and A. D. Cheresh, Integrins in cancer: biological implications and therapeutic opportunities, Nat. Rev. Cancer, vol.10, pp.9-22, 2010.

N. Desprat, W. Supatto, P. A. Pouille, E. Beaurepaire, and E. Farge, Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos, Dev. Cell, vol.15, pp.470-477, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00324225

O. Destaing, E. Planus, D. Bouvard, C. Oddou, C. Badowski et al., AlbigesRegulator of Invadosome Organization and Function, Mol. Biol. Cell, vol.21, pp.4108-4119
DOI : 10.1091/mbc.e10-07-0580
URL : http://europepmc.org/articles/pmc2993740?pdf=render

B. Diagouraga, A. Grichine, A. Fertin, J. Wang, S. Khochbin et al., Motor-driven marginal band coiling promotes cell shape change during platelet activation, J. Cell Biol, vol.204, pp.177-185, 2014.
DOI : 10.1083/jcb.201306085
URL : https://hal.archives-ouvertes.fr/hal-01002792

D. E. Discher, L. Smith, S. Cho, M. Colasurdo, A. J. García et al., Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer, Annu. Rev. Biophys, vol.46, pp.295-315, 2017.

, = 149 =

H. G. Doebereiner, B. J. Dubin-thaler, G. Giannone, H. S. Xenias, M. P. Sheetz et al., Dynamic Phase Transitions in Cell Spreading, Phys. Rev. Lett, vol.93, p.108105, 2004.

G. J. Doherty, M. K. Ahlund, M. T. Howes, B. Moren, R. G. Parton et al., The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading, Mol. Biol. Cell, vol.22, pp.4380-4389, 2011.

P. T. Domain, D. D. Chang, B. Q. Hoang, J. Liu, and T. Springer, Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin, J. Biol. Chem, vol.277, pp.8140-8145, 2002.

A. D. Doyle, F. W. Wang, K. Matsumoto, and K. M. Yamada, One-dimensional topography underlies three-dimensional fibrillar cell migration, SUPP MAT. J. Cell Biol, vol.184, pp.481-90, 2009.
DOI : 10.1083/jcb.200810041
URL : http://jcb.rupress.org/content/184/4/481.full.pdf

A. D. Doyle and K. M. Yamada, Sensing tension, Nature, vol.466, pp.5-6, 2010.

J. Du, X. Chen, X. Liang, G. Zhang, J. Xu et al., Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity, Proc. Natl. Acad. Sci, vol.108, pp.9466-9471, 2011.

A. D. Dubash, M. M. Menold, T. Samson, E. Boulter, R. García-mata et al., Chapter 1 Focal Adhesions: New Angles on an Old Structure, Int. Rev. Cell Mol. Biol, vol.277, pp.1-65, 2009.
DOI : 10.1016/s1937-6448(09)77001-7

B. J. Dubin-thaler, G. Giannone, H. Döbereiner, and M. P. Sheetz, Nanometer Analysis of Cell Spreading on Matrix-Coated Surfaces Reveals Two Distinct Cell States and STEPs, Biophys. J, vol.86, pp.74246-74246, 2004.

N. G. Dulyaninova, V. N. Malashkevich, S. C. Almo, and A. R. Bresnick, Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation, Biochemistry, vol.44, pp.6867-6876, 2005.
DOI : 10.1021/bi0500776

S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti et al., Role of YAP/TAZ in mechanotransduction, Nature, vol.474, pp.179-183, 2011.

J. C. Effler, Y. S. Kee, J. M. Berk, M. N. Tran, P. A. Iglesias et al., Mitosis-Specific Mechanosensing and Contractile-Protein Redistribution Control Cell Shape, Curr. Biol, vol.16, pp.1962-1967, 2006.
DOI : 10.1016/j.cub.2006.08.027
URL : https://doi.org/10.1016/j.cub.2006.08.027

U. S. Eggert, T. J. Mitchison, and C. M. Field, Animal cytokinesis: from parts list to mechanisms, Annu. Rev. Biochem, vol.75, pp.543-566, 2006.
DOI : 10.1146/annurev.biochem.74.082803.133425

A. Elosegui-artola, E. Bazellières, M. D. Allen, I. Andreu, R. Oria et al., Rigidity sensing and adaptation through regulation of integrin types, Nat. Mater, vol.13, pp.631-638, 2014.

J. Emsley, C. G. Knight, R. W. Farndale, M. J. Barnes, and R. C. Liddington, Structural basis of collagen recognition by integrin alpha2beta1, Cell, vol.101, pp.47-56, 2000.

A. Engler, L. Bacakova, C. Newman, A. Hategan, M. Griffin et al., Substrate compliance versus ligand density in cell on gel response, Biophys. J, vol.86, issue.1, pp.617-628, 2004.

A. J. Engler, F. Rehfeldt, S. Sen, and D. E. Discher, Microtissue Elasticity: Measurements by Atomic Force Microscopy and Its Influence on Cell Differentiation, Methods Cell Biol, vol.83, pp.521-545, 2007.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, Matrix Elasticity Directs Stem Cell Lineage Specification. Cell, vol.126, pp.677-689, 2006.

E. Engvall and E. Ruoslahti, Binding of soluble form of fibroblast surface protein, fibronectin, to collagen, Int. J. cancer, vol.20, pp.1-5, 1977.

T. Enomoto, Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade, Cell Struct. Funct, vol.21, pp.317-326, 1996.

R. D. Evans, V. C. Perkins, A. Henry, P. E. Stephens, M. K. Robinson et al., A tumor-associated1 integrin mutation that abrogates epithelial differentiation control, Mol. Biol. Cell, vol.160, pp.2869-2881, 2003.

E. J. Ezratty, C. Bertaux, E. E. Marcantonio, and G. G. Gundersen, Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells, J. Cell Biol, vol.187, pp.733-780, 2009.
DOI : 10.1083/jcb.200904054
URL : http://jcb.rupress.org/content/187/5/733.full.pdf

E. J. Ezratty, M. Partridge, and G. G. Gundersen, Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase, Nat. Cell Biol, vol.7, pp.581-590, 2005.
DOI : 10.1038/ncb1262

S. Fereol, R. Fodil, V. M. Laurent, M. Balland, B. Louis et al., Prestress and adhesion site dynamics control cell = 151 = sensitivity to extracellular stiffness, Biophys. J, vol.96, pp.2009-2022, 2009.

E. Faurobert and C. Albiges-rizo, Recent insights into cerebral cavernous malformations: A complex jigsaw puzzle under construction, FEBS J, vol.277, pp.1084-1096, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00544895

E. Faurobert, C. Rome, J. Lisowska, S. Manet-dupé, G. Boulday et al., CCM1-ICAP-1 complex controls -dependent endothelial contractility and fibronectin remodeling, J. Cell Biol, vol.202, pp.545-61, 2013.
DOI : 10.1084/jem.2109oia28

J. P. Ferguson, S. D. Huber, N. M. Willy, E. Aygün, S. Goker et al., Mechanoregulation of clathrin-mediated endocytosis, J. Cell Sci. jcs, 2017.
DOI : 10.1242/jcs.205930
URL : http://jcs.biologists.org/content/joces/130/21/3631.full.pdf

L. Fourel, A. Valat, E. Faurobert, R. Guillot, I. Bourrin-reynard et al., Albiges--mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner, J. Cell Biol, vol.212, pp.693-706

H. N. Fournier, C. Albiges-rizo, and M. R. Block, New insights into Nm23 control of cell adhesion and migration, J Bioenerg Biomembr, vol.35, pp.81-87, 2003.

H. N. Fournier, S. Dupé-manet, D. Bouvard, M. L. Lacombe, C. Marie et al., Integrin cytoplasmic domain-associated protein --H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement, J. Biol. Chem, vol.277, pp.20895-20902, 2002.

S. I. Fraley, Y. Feng, R. Krishnamurthy, D. Kim, A. Celedon et al., A distinctive role for focal adhesion proteins in threedimensional cell motility, Nat. Cell Biol, vol.12, pp.598-604, 2010.

N. De-franceschi, A. Arjonen, N. Elkhatib, K. Denessiouk, A. G. Wrobel et al., Selective integrin -chain and AP2, 2016.

, Nat. Struct. Mol. Biol, vol.23, pp.172-179

C. Frantz, K. M. Stewart, and V. M. Weaver, The extracellular matrix at a = 152 = glance, J. Cell Sci, vol.123, pp.4195-4200, 2010.

P. Friedl and K. Wolf, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat. Rev. Cancer, vol.3, pp.362-74, 2003.

J. C. Friedland, M. H. Lee, and D. Boettiger, Mechanically activated integrin switch controls alpha5beta1 function, Science, vol.323, pp.642-644, 2009.

S. M. Frisch and H. Francis, Disruption of epithelial cell-matrix interactions induces apoptosis, J. Cell Biol, vol.124, pp.619-626, 1994.

K. T. Furukawa, K. Yamashita, N. Sakurai, and S. Ohno, The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin, Cell Rep, vol.20, pp.1435-1447, 2017.

Y. Gao and M. L. Kilfoil, Accurate detection and complete tracking of large populations of features in three dimensions, Opt. Express, vol.17, p.4685, 2009.

A. J. García, J. E. Schwarzbauer, and D. Boettiger, Distinct activation states of show differential binding to RGD and synergy domains of fibronectin, Biochemistry, vol.41, pp.9063-9069, 2002.

B. S. Gardiner, K. K. Wong, G. R. Joldes, A. J. Rich, C. W. Tan et al., Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components, PLoS Comput. Biol, vol.11, 2015.

N. C. Gauthier, O. M. Rossier, A. Mathur, J. C. Hone, and M. P. Sheetz, Plasma Membrane Area Increases with Spread Area by Exocytosis of a GPI-anchord Protein Compartment, Mol. Biol. Cell, vol.20, pp.3261-3272, 2009.

B. Geiger and A. Bershadsky, Assembly and mechanosensory function of focal contacts, Curr. Opin. Cell Biol, vol.13, pp.255-261, 2001.

B. Geiger, A. Bershadsky, R. Pankov, and K. M. Yamada, Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk, Nat. Rev. Mol. Cell Biol, vol.2, pp.793-805, 2001.

C. M. Ghajar, H. Peinado, H. Mori, I. R. Matei, K. J. Evason et al., The perivascular niche regulates breast tumour dormancy, Nat. Cell Biol, vol.15, pp.807-817, 2013.

G. Giannone, B. J. Dubin-thaler, H. G. Döbereiner, N. Kieffer, A. R. Bresnick et al., Periodic lamellipodial contractions correlate with rearward actin waves, Cell, vol.116, pp.431-443, 2004.

, = 153 =

G. Giannone, B. J. Dubin-thaler, O. Rossier, Y. Cai, O. Chaga et al., Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation. Cell, vol.128, pp.561-575, 2007.

G. Giannone, R. M. Mege, and O. Thoumine, Multi-level molecular clutches in motile cell processes, Trends Cell Biol, vol.19, pp.475-486, 2009.

A. Glading, J. Han, R. A. Stockton, and M. H. Ginsberg, KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell-cell junctions, J. Cell Biol, vol.179, pp.247-254, 2007.

C. Grashoff, B. D. Hoffman, M. D. Brenner, R. Zhou, M. Parsons et al., Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics, Nature, vol.466, pp.263-269, 2010.

J. T. Groves and J. Kuriyan, Molecular mechanisms in signal transduction at the membrane, Nat. Struct. Mol. Biol, vol.17, pp.659-65, 2010.

W. Guo and F. G. Giancotti, Integrin signalling during tumour progression, Nat. Rev. Mol. Cell Biol, vol.5, pp.816-826, 2004.

S. L. Gupton and C. M. Waterman-storer, Spatiotemporal Feedback between Actomyosin and Focal-Adhesion Systems Optimizes Rapid Cell Migration, Cell, vol.125, pp.1361-1374, 2006.

K. Hamasaki, T. Mimura, H. Furuya, N. Morino, T. Yamazaki et al., Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK, Biochem. Biophys. Res. Commun, vol.212, pp.544-549, 1995.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: The next generation, Cell, vol.144, pp.646-674, 2011.

J. N. Heck, S. M. Ponik, M. G. Garcia-mendoza, C. A. Pehlke, D. R. Inman et al., Microtubules regulate GEF-H1 in response to extracellular matrix stiffness, Mol. Biol. Cell, vol.23, pp.2583-2592, 2012.

H. Fournier, S. Dupe-manet, D. Bouvard, F. L. , S. F. Simona-degani et al., Nuclear Translocation of Integrin Cytoplasmic Domainassociated Protein 1 Stimulates Cellular Proliferation, Mol. Biol. Cell, vol.16, pp.1-13, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00171321

T. Hodge and M. J. Cope, A myosin family tree, J. Cell Sci, vol.113, pp.3353-3354, 2000.

E. R. Horton, A. Byron, J. A. Askari, D. H. Ng, A. Millon-frémillon et al., Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly, Nat. Cell Biol, vol.17, pp.1577-1587, 2015.

P. Hotulainen, P. Lappalainen, X. Wang, P. Hotulainen, P. Lappalainen et al., J. Cell Biol, vol.173, pp.383-94, 2006.

P. Hsieh, R. Segal, and L. B. Chen, Studies of fibronectin matrices in living cells with fluoresceinated gelatin, J. Cell Biol, vol.87, pp.14-22, 1980.

X. Hu, C. Jing, X. Xu, N. Nakazawa, V. W. Cornish et al., Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy, Nano Lett, vol.16, pp.4062-4068, 2016.

J. D. Humphries, A. Byron, M. D. Bass, S. E. Craig, J. W. Pinney et al., Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6, Sci. Signal, vol.2, p.51, 2009.

, = 155 =

J. D. Humphries, A. Byron, and M. J. Humphries, Integrin ligands at a glance, J. Cell Sci, vol.119, pp.3901-3903, 2006.

S. Huveneers and J. De-rooij, Mechanosensitive systems at the cadherin-Factin interface, J. Cell Sci, vol.126, pp.403-413, 2013.

R. O. Hynes, Integrins: Bidirectional, allosteric signaling machines, Cell, vol.110, pp.971-977, 2002.

R. O. Hynes, The extracellular matrix: not just pretty fibrils, Science, vol.326, pp.1216-1219, 2009.

T. Ikeda, NDP kinase 7 is a conserved microtubule-binding protein preferentially expressed in ciliated cells, Cell Struct. Funct, vol.35, pp.23-30, 2010.

D. E. Ingber, The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering?, Cell, vol.75, issue.93, p.90612, 1993.

D. E. Ingber, Tensegrity II. How structural networks influence cellular information processing networks, J. Cell Sci, vol.116, pp.1397-408, 2003.

D. E. Ingber, Tensegrity I. Cell structure and hierarchical systems biology, J. Cell Sci, vol.116, pp.1157-1173, 2003.

G. Jacquemet, D. M. Green, R. E. Bridgewater, A. Kriegsheim, M. J. Humphries et al., Rcp-driven and promotes rhoa activity via the racgap1-iqgap1 complex, J. Cell Biol, vol.202, pp.917-935, 2013.

P. A. Janmey and C. A. Mcculloch, Cell mechanics: integrating cell responses to mechanical stimuli, Annu. Rev. Biomed. Eng, vol.9, pp.1-34, 2007.

G. Jiang, G. Giannone, D. R. Critchley, E. Fukumoto, and M. P. Sheetz, Twopiconewton slip bond between fibronectin and the cytoskeleton depends on talin, Nature, vol.424, pp.334-337, 2003.

P. Kanchanawong, G. Shtengel, A. M. Pasapera, E. B. Ramko, M. W. Davidson et al., Nanoscale architecture of integrin-based cell adhesions, Nature, vol.468, pp.580-584, 2010.

R. N. Kaplan, R. D. Riba, S. Zacharoulis, A. H. Bramley, L. Vincent et al., VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche, Nature, vol.438, pp.820-827, 2005.

M. Karakozova, Arginylation of -Actin Regulates Actin Cytoskeleton and Cell Motility. Science (80-. ), vol.313, pp.192-196, 2006.

P. Keely, L. Parise, R. Juliano, E. A. Clark, J. S. Brugge et al.,

. Schlaepfer,

J. E. Assoian, M. A. Meredith, S. Schwartz, and . Miyamoto, Integrins and GTPases in tumour cell growth, motility and invasion, Trends Cell Biol, vol.8, issue.97, pp.1219-1220, 1998.

T. Kiema, Y. Lad, P. Jiang, C. L. Oxley, M. Baldassarre et al., The molecular basis of filamin binding to integrins and competition with talin, Mol. Cell, vol.21, pp.337-347, 2006.

S. Kim, H. Takahashi, W. Lin, P. Descargues, S. Grivennikov et al., Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis, Nature, vol.457, pp.102-106, 2009.

T. H. Kim, N. Monsefi, J. H. Song, A. Kriegsheim, D. Vandamme et al., Network-based identification of feedback modules that control RhoA activity and cell migration, J. Mol. Cell Biol, vol.7, pp.242-252, 2015.

T. Kinashi, Intracellular signalling controlling integrin activation in lymphocytes, Nat. Rev. Immunol, vol.5, pp.546-559, 2005.
DOI : 10.1038/nri1646

C. Kirkpatrick and S. B. Selleck, Heparan sulfate proteoglycans at a glance, J. Cell Sci, vol.120, pp.1829-1832, 2007.
DOI : 10.1242/jcs.03432
URL : http://jcs.biologists.org/content/120/11/1829.full.pdf

B. Klapholz and N. H. Brown, Talin -the master of integrin adhesions, J. Cell Sci, vol.130, pp.2435-2446, 2017.

E. A. Klein, L. Yin, D. Kothapalli, P. Castagnino, F. J. Byfield et al., Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening, Curr. Biol, vol.19, pp.1511-1518, 2009.

T. Kobayashi and M. Sokabe, Sensing substrate rigidity by mechanosensitive = 157 = ion channels with stress fibers and focal adhesions, Curr. Opin. Cell Biol, vol.22, pp.669-676, 2010.

A. Kren, V. Baeriswyl, F. Lehembre, C. Wunderlin, K. Strittmatter et al., Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function, EMBO J, vol.26, pp.2832-2874, 2007.

K. S. Krishnan, R. Rikhy, S. Rao, M. Shivalkar, M. Mosko et al., Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling, Neuron, vol.30, pp.197-210, 2001.

E. Kubow, H. A. Kristopher, K. E. Kubow, A. R. Horwitz, H. A. Kubow et al., Reducing background fluorescence reveals adhesion in 3D matrices, Nat Cell Biol, vol.13, pp.3-7, 2011.

J. Kuo, X. Han, C. Hsiao, J. R. Yates, and C. M. Waterman, Analysis of the myosin-II--Pix in negative regulation of focal adhesion maturation, Nat. Cell Biol, vol.13, pp.383-393, 2011.

R. Lakshminarayan, C. Wunder, U. Becken, M. T. Howes, C. Benzing et al., Galectin-3 drives glycosphingolipiddependent biogenesis of clathrin-independent carriers, Nat. Cell Biol, vol.16, pp.595-606, 2014.

T. Lämmermann, B. L. Bader, S. J. Monkley, T. Worbs, R. Wedlich-söldner et al., Rapid leukocyte migration by integrin-independent flowing and squeezing, Nature, vol.453, pp.51-56, 2008.

C. Leduc, S. Si, J. Gautier, M. Soto-ribeiro, B. Wehrle-haller et al., A highly specific gold nanoprobe for live-cell single-molecule imaging, Nano Lett, vol.13, pp.1489-1494, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796925

J. O. Lee, P. Rieu, M. Arnaout, and R. Liddington, Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18), Cell, vol.80, pp.631-638, 1995.

S. Lee and S. Kumar, Actomyosin stress fiber mechanosensing in 2D and 3D. F1000Research, vol.5, p.2261, 2016.

K. R. Legate and R. Fässler, Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails, J. Cell Sci, vol.122, pp.187-98, 2009.
DOI : 10.1242/jcs.041624
URL : http://jcs.biologists.org/content/122/2/187.full.pdf

M. Leiss, K. Beckmann, A. Girós, M. Costell, and R. Fässler, The role of integrin = 158 = binding sites in fibronectin matrix assembly in vivo, Curr. Opin. Cell Biol, vol.20, pp.502-507, 2008.

Z. Li, X. Guo, S. Matsushita, and J. Guan, Differentiation of cardiospherederived cells into a mature cardiac lineage using biodegradable poly(Nisopropylacrylamide) hydrogels, Biomaterials, vol.32, pp.3220-3232, 2011.

Z. H. Li and A. R. Bresnick, The S100A4 metastasis factor regulates cellular motility via a direct interaction with myosin-IIA, Cancer Res, vol.66, pp.5173-5180, 2006.

A. D. Lieber, S. Yehudai-resheff, E. L. Barnhart, J. A. Theriot, and K. Keren, Membrane tension in rapidly moving cells is determined by cytoskeletal forces, Curr. Biol, vol.23, pp.1409-1417, 2013.
DOI : 10.1016/j.cub.2013.05.063
URL : https://doi.org/10.1016/j.cub.2013.05.063

J. Liu, Y. Wang, W. I. Goh, H. Goh, M. A. Baird et al., Talin determines the nanoscale architecture of focal adhesions, Proc. Natl. Acad. Sci, vol.112, 2015.
DOI : 10.1073/pnas.1512025112
URL : https://www.pnas.org/content/pnas/112/35/E4864.full.pdf

W. Liu, K. M. Draheim, R. Zhang, D. A. Calderwood, and T. J. Boggon, Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation, Mol. Cell, vol.49, pp.719-729, 2013.

C. M. Lo, H. B. Wang, M. Dembo, and Y. L. Wang, Cell movement is guided by the rigidity of the substrate, Biophys. J, vol.79, pp.76279-76284, 2000.

S. H. Lo, Q. C. Yu, L. Degenstein, L. B. Chen, and E. Fuchs, Progressive kidney degeneration in mice lacking tensin, J. Cell Biol, vol.136, pp.1349-1361, 1997.

H. Lv, L. Li, M. Sun, Y. Zhang, L. Chen et al., Mechanism of regulation of stem cell differentiation by matrix stiffness, Stem Cell Res. Ther, vol.6, p.103, 2015.

M. Machacek, L. Hodgson, C. Welch, H. Elliott, O. Pertz et al., Coordination of Rho GTPase activities during cell protrusion, Nature, vol.461, pp.99-103, 2009.

C. D. Madsen and N. Sidenius, The interaction between urokinase receptor and vitronectin in cell adhesion and signalling, Eur. J. Cell Biol, vol.87, pp.617-629, 2008.

I. Malanchi, A. Santamaria-martinez, E. Susanto, H. Peng, H. Lehr et al., Abstract SY28-02: Interactions between cancer stem cells and their niche govern metastatic colonization, Cancer Res, vol.72, 2012.

, = 159 =

A. J. Maniotis, C. S. Chen, and D. E. Ingber, Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure, Proc. Natl. Acad. Sci. U. S. A, vol.94, pp.849-54, 1997.

C. Margadant, H. N. Monsuur, J. C. Norman, and A. Sonnenberg, Mechanisms of integrin activation and trafficking, Curr. Opin. Cell Biol, vol.23, pp.607-621, 2011.

A. C. Martin, M. Kaschube, and E. F. Wieschaus, Pulsed contractions of an actin-myosin network drive apical constriction, Nature, vol.457, pp.495-504, 2009.

B. D. Matthews, D. R. Overby, R. Mannix, and D. E. Ingber, Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels, J. Cell Sci, vol.119, pp.508-526, 2006.

C. J. Mccleverty, D. C. Lin, and R. C. Liddington, Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions, Protein Sci, vol.16, pp.1223-1232, 2007.

H. T. Mcmahon and E. Boucrot, Molecular mechanism and physiological functions of clathrin-mediated endocytosis, Nat Rev Mol Cell Biol, vol.12, pp.517-533, 2011.

I. Mellman and Y. Yarden, Endocytosis and cancer, Cold Spring Harb. Perspect. Biol, vol.5, p.16949, 2013.

K. E. Michael, D. W. Dumbauld, K. L. Burns, S. K. Hanks, and A. J. García, Focal adhesion kinase modulates cell adhesion strengthening via integrin activation, facilitates cancer cell invasion through enhanced contractile forces. J. Cell Sci, vol.20, pp.369-383, 2009.

C. G. Miller, G. Budoff, J. L. Prenner, and J. E. Schwarzbauer, Minireview: Fibronectin in retinal disease, Exp. Biol. Med, vol.242, pp.1-7, 2017.

A. Millon-frémillon, D. Bouvard, A. Grichine, S. Manet-dupé, M. R. Block et al., Cell adaptive response to extracellular matrix density is controlled by ICAP-1--integrin affinity, J. Cell Biol, vol.180, pp.427-441, 2008.

A. Millon-frémillon, M. Brunner, N. Abed, E. Collomb, A. S. Ribba et al., Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain, 2013.

, J. Biol. Chem, vol.288, pp.20248-20260

R. Milloud, O. Destaing, R. De-mets, I. Bourrin-reynard, C. Oddou et al., Albigès-regulate cellular forces by phosphorylation of its distal NPXY site, Biol. Cell, vol.109, pp.127-137

T. J. Mitchison, G. T. Charras, and L. Mahadevan, Implications of a poroelastic cytoplasm for the dynamics of animal cell shape, Semin. Cell Dev. Biol, vol.19, pp.215-223, 2008.

M. Miyamoto, S. Iwashita, S. Yamaguchi, and Y. Ono, Role of nm23 in the regulation of cell shape and migration via Rho family GTPase signals, Mol. Cell. Biochem, vol.329, pp.175-179, 2009.

A. Mogilner and K. Keren, The Shape of Motile Cells, Curr. Biol, vol.19, 2009.

C. Monge, J. Almodóvar, T. Boudou, and C. Picart, Spatio-temporal control of LbL films for biomedical applications: From 2D to 3D, Adv. Healthc. Mater, vol.4, pp.811-830, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01545114

E. Montanez, S. Ussar, M. Schifferer, M. Bösl, R. Zent et al., Kindlin-2 controls bidirectional signaling of integrins, Genes Dev, vol.22, pp.1325-1355, 2008.

S. W. Moore, P. Roca-cusachs, and M. P. Sheetz, Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing, Dev. Cell, vol.19, pp.194-206, 2010.

E. M. Morse, N. N. Brahme, and D. A. Calderwood, Integrin cytoplasmic tail interactions, Biochemistry, vol.53, pp.810-820, 2014.

J. K. Mouw, G. Ou, and V. M. Weaver, Extracellular matrix assembly: a multiscale deconstruction, Nat. Rev. Mol. Cell Biol, vol.15, pp.771-785, 2014.

S. R. Mulay, J. Desai, S. V. Kumar, J. N. Eberhard, D. Thomasova et al., Blebs lead the way: how to migrate without lamellipodia, Nat. Commun, vol.7, p.10274, 2016.

P. A. Muller, P. T. Caswell, B. Doyle, M. P. Iwanicki, E. H. Tan et al., Mutant p53 Drives Invasion by Promoting Integrin Recycling, vol.139, pp.1327-1341, 2009.

R. D. Mullins, J. Heuser, and T. D. Pollard, The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments, Proc. Natl. Acad. Sci. U. S. A, vol.95, pp.6181-6186, 1998.

M. Murrell, P. W. Oakes, M. Lenz, and M. L. Gardel, Forcing cells into shape: the mechanics of actomyosin contractility, Nat. Rev. Mol. Cell Biol, vol.16, pp.486-498, 2015.

A. Naba, K. R. Clauser, S. Hoersch, H. Liu, S. A. Carr et al., The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices, Mol. Cell. Proteomics, vol.11, 2012.

G. Nallamothu, J. A. Woolworth, V. Dammai, and T. Hsu, Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion, Mol. Cell. Biol, vol.28, pp.1964-73, 2008.

P. Naumanen, P. Lappalainen, and P. Hotulainen, Mechanisms of actin stress fibre assembly, Journal of Microscopy, pp.446-454, 2008.

C. M. Nelson, R. P. Jean, J. L. Tan, W. F. Liu, N. J. Sniadecki et al., Emergent patterns of growth controlled by multicellular form and mechanics, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.11594-11603, 2005.

D. H. Ng, J. D. Humphries, A. Byron, A. Millon-frémillon, and M. J. Humphries, Microtubule-dependent modulation of adhesion complex composition, PLoS One, vol.9, pp.1-24, 2014.

T. Nishimura and K. Kaibuchi, Numb Controls Integrin Endocytosis for Directional Cell Migration with aPKC and PAR-3, Dev. Cell, vol.13, pp.15-28, 2007.

P. W. Oakes, D. C. Patel, N. A. Morin, D. P. Zitterbart, B. Fabry et al., Neutrophil morphology and migration are affected by substrate elasticity, Blood, vol.114, pp.1387-1395, 2009.

M. Ochsner, M. Textor, V. Vogel, and M. L. Smith, Dimensionality controls cytoskeleton assembly and metabolism of fibroblast cells in response to rigidity and shape, PLoS One, vol.5, 2010.

T. Oskarsson, S. Acharyya, X. H. Zhang, S. Vanharanta, S. F. Tavazoie et al., Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs, Nat. Med, vol.17, pp.867-874, 2011.

C. L. Oxley, N. J. Anthis, E. D. Lowe, I. Vakonakis, I. D. Campbell et al., An integrin phosphorylation switch: The effect of phosphorylation on Dok1 and talin binding, J. Biol. Chem, vol.283, pp.5420-5426, 2008.

E. Paluch, C. Sykes, J. Prost, and M. Bornens, Dynamic modes of the cortical actomyosin gel during cell locomotion and division, Trends Cell Biol, vol.16, pp.5-10, 2006.

R. Pankov, E. Cukierman, B. Z. Katz, K. Matsumoto, D. C. Lin et al., Integrin dynamics and matrix assembly: Tensindependent translocation of fibrillogenesis, J. Cell Biol, vol.148, pp.1075-1090, 2000.

R. Pankov and K. M. Yamada, Fibronectin at a glance, J. Cell Sci, vol.115, pp.3861-3863, 2002.

M. Parri and P. Chiarugi, Rac and Rho GTPases in cancer cell motility control, Cell Commun. Signal, vol.8, p.23, 2010.

J. T. Parsons, A. R. Horwitz, and M. Schwartz, Cell adhesion: integrating cytoskeletal dynamics and cellular tension, Nat. Rev. Mol. Cell Biol, vol.11, pp.633-643, 2010.

M. J. Paszek, C. C. Dufort, O. Rossier, R. Bainer, J. K. Mouw et al., The cancer glycocalyx mechanically primes integrin-mediated growth and survival, Nature, vol.511, pp.319-325, 2014.

M. J. Paszek, N. Zahir, K. R. Johnson, J. N. Lakins, G. I. Rozenberg et al., Tensional homeostasis and the malignant phenotype, Cancer Cell, vol.8, pp.241-254, 2005.

N. R. Paul, J. L. Allen, A. Chapman, M. Morlan-mairal, E. Zindy et al., Hurlstone, -independent cancer cell invasion via the formin FHOD3, J. Cell Biol, vol.210, pp.1013-1031

R. J. Pelham and Y. L. Wang, Cell locomotion and focal adhesions are regulated by the mechanical properties of the substrate, Biol. Bull, vol.194, pp.348-350, 1998.

S. R. Peyton and A. J. Putnam, Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion, J. Cell. Physiol, vol.204, pp.198-209, 2005.

A. Pietras, A. M. Katz, E. J. Ekström, B. Wee, J. J. Halliday et al., Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth, Cell Stem Cell, vol.14, pp.357-369, 2014.

S. V. Plotnikov, A. M. Pasapera, B. Sabass, and C. M. Waterman, Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration, Cell, vol.151, pp.1513-1527, 2012.

T. D. Pollard, Actin and actin-binding proteins, Cold Spring Harb. Perspect. Biol, vol.8, 2016.

T. D. Pollard and G. G. Borisy, Cellular motility driven by assembly and disassembly of actin filaments, Cell, vol.112, p.120, 2003.

B. Psaila and D. Lyden, The metastatic niche: adapting the foreign soil, Nat. Rev. Cancer, vol.9, pp.285-293, 2009.

E. Puklin-faucher and M. P. Sheetz, The mechanical integrin cycle, J. Cell Sci, vol.122, pp.179-186, 2009.

M. Régent, E. Planus, A. P. Bouin, D. Bouvard, M. Brunner et al., Albiges-Rizo. signaling in the control of cell adhesion and adhesive strength, Eur. J. Cell Biol, vol.90, pp.261-269

X. D. Ren, W. B. Kiosses, and M. A. Schwartz, Regulation of the small GTPbinding protein Rho by cell adhesion and the cytoskeleton, EMBO J, vol.18, pp.578-585, 1999.

J. Renkawitz, K. Schumann, M. Weber, T. Lämmermann, H. Pflicke et al., Adaptive force transmission in amoeboid cell migration, Nat. Cell Biol, vol.11, pp.1438-1443, 2009.

M. Renz, C. Otten, E. Faurobert, F. Rudolph, Y. Zhu et al., Regul-Klf2-mediated angiogenesis by CCM proteins, Dev. Cell, vol.32, pp.181-90, 2015.

N. E. Reticker-flynn, D. F. Malta, M. M. Winslow, J. M. Lamar, M. J. Xu et al., A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis, Nat. Commun, vol.3, p.1122, 2012.

A. J. Ridley, M. A. Schwartz, K. Burridge, R. A. Firtel, M. H. Ginsberg et al., Cell migration: integrating signals from front to back, Science, vol.302, pp.1704-1713, 2003.

K. Riento and A. J. Ridley, Rocks: multifunctional kinases in cell behaviour, Nat. Rev. Mol. Cell Biol, vol.4, pp.446-456, 2003.

A. Del-rio, R. Perez-jimenez, R. Liu, P. Roca-cusachs, J. M. Fernandez et al., Stretching single talin rod molecules activates vinculin binding, Science, vol.323, pp.638-641, 2009.

D. Riveline, E. Zamir, N. Q. Balaban, U. S. Schwarz, T. Ishizaki et al., Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism, J. Cell Biol, vol.153, pp.1175-1185, 2001.

J. Robertson, G. Jacquemet, A. Byron, M. C. Jones, S. Warwood et al., Defining the phosphoadhesome through the phosphoproteomic analysis of integrin signalling, Nat. Commun, vol.6, p.6265, 2015.

P. Roca-cusachs, N. C. Gauthier, A. Rio, and M. P. Sheetz, Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.16245-16250, 2009.

P. Roca-cusachs, E. Rio, N. C. Puklin-faucher, N. Gauthier, M. P. Biais et al., Integrin-dependent force transmission to the extracellular matrix by -actinin triggers adhesion maturation, Proc. Natl. Acad. Sci, vol.110, 2013.

O. Rossier and G. Giannone, The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking, Exp. Cell Res, vol.343, pp.28-34, 2016.

O. Rossier, V. Octeau, J. Sibarita, C. Leduc, B. Tessier et al., organizations inside focal adhesions, Nat. Cell Biol, vol.14, pp.1057-1067
URL : https://hal.archives-ouvertes.fr/hal-00909235

K. Rottner, A. Hall, and J. V. Small, Interplay between Rac and Rho in the control of substrate contact dynamics, Curr. Biol, vol.9, pp.80286-80289, 1999.

V. Ruprecht, P. Monzo, A. Ravasio, Z. Yue, E. Makhija et al., , vol.165

V. Shivashankar, V. Studer, C. Albiges-rizo, and V. Viasnoff, How cells respond to environmental cues -insights from bio-functionalized substrates, J. Cell Sci, vol.130, pp.51-61, 2017.

B. Sabass, M. L. Gardel, C. M. Waterman, and U. S. Schwarz, High resolution traction force microscopy based on experimental and computational advances, Biophys. J, vol.94, pp.207-220, 2008.

A. Saez, A. Buguin, P. Silberzan, and B. Ladoux, Is the Mechanical Activity of Epithelial Cells Controlled by Deformations or Forces?, Biophys. J, vol.89, pp.52-54, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00188263

E. Sahai, R. Garcia-medina, J. Pouyssegur, and E. Vial, Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility, J Cell Biol, vol.176, pp.35-42, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00320762

K. Salaita, P. M. Nair, R. S. Petit, R. M. Neve, D. Das et al., Restriction of receptor movement alters cellular response: physical force sensing by EphA2, Science, vol.327, pp.1380-1385, 2010.

Y. Sawada and M. P. Sheetz, Force transduction by Triton cytoskeletons, J. Cell Biol, vol.156, pp.609-615, 2002.

Y. Sawada, M. Tamada, B. J. Dubin-thaler, O. Cherniavskaya, R. Sakai et al., Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas, Cell, vol.127, pp.1015-1026, 2006.

T. M. Scales and M. Parsons, Spatial and temporal regulation of integrin signalling during cell migration, Curr. Opin. Cell Biol, vol.23, pp.562-568, 2011.

A. Schaefer, M. Nethe, and P. L. Hordijk, Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration, Biochem. J, vol.442, pp.13-25, 2012.

H. B. Schiller, C. C. Friedel, C. Boulegue, and R. Fässler, Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins, EMBO Rep, vol.12, pp.259-266, 2011.

H. B. Schiller, M. Hermann, J. Polleux, T. Vignaud, S. Zanivan et al., -class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments, Nat. Cell Biol, vol.15, pp.625-661

, =, vol.166

J. Schindelin, I. Arganda-carreras, E. Frise, V. Kaynig, M. Longair et al., Fiji: An open source platform for biological image analysis, Nat. Methods, vol.9, pp.676-682, 2012.

M. A. Schwartz, Integrins and extracellular matrix in mechanotransduction, Cold Spring Harb. Perspect. Biol, vol.2, 2010.

U. S. Schwarz, N. Q. Balaban, D. Riveline, A. Bershadsky, B. Geiger et al., Calculation of Forces at Focal Adhesions from Elastic Substrate Data: The Effect of Localized Force and the Need for Regularization, Biophys. J, vol.83, pp.1380-1394, 2002.

G. Scita and P. P. Di-fiore, The endocytic matrix, Nature, vol.463, pp.464-473, 2010.

I. Serebriiskii, J. Estojak, G. Sonoda, J. R. Testa, and E. Golemis, Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22, Oncogene, vol.15, pp.1043-1049, 1997.

V. P. Sharma, D. Entenberg, and J. Condeelis, High-Resolution Live-Cell Imaging and Time-Lapse Microscopy of Invadopodium Dynamics and Tracking Analysis, Methods in molecular biology, pp.343-357, 2013.

S. J. Shattil, C. Kim, and M. H. Ginsberg, The final steps of integrin activation: the end game, Nat. Rev. Mol. Cell Biol, vol.11, pp.288-300, 2010.

M. P. Sheetz, Cell control by membrane-cytoskeleton adhesion, Nat. Rev. Mol. Cell Biol, vol.2, pp.392-396, 2001.

M. P. Sheetz, J. E. Sable, and H. G. Döbereiner, Continuous membranecytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics, Annu Rev Biophys Biomol Struct, vol.35, pp.417-434, 2006.

F. Shi and J. Sottile, Caveolin-1-dependent 1 integrin endocytosis is a critical regulator of fibronectin turnover, J. Cell Sci, vol.121, pp.2360-2371, 2008.

F. Shi and J. Sottile, Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover, J. Cell Sci, vol.121, pp.2360-71, 2008.

A. C. Shibata, T. K. Fujiwara, L. Chen, K. G. Suzuki, Y. Ishikawa et al., Archipelago = 167 = architecture of the focal adhesion: Membrane molecules freely enter and exit from the focal adhesion zone, Cytoskeleton, vol.69, pp.380-392, 2012.

H. Shroff, C. G. Galbraith, J. A. Galbraith, H. White, J. Gillette et al., Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes, Proc. Natl. Acad. Sci, vol.104, pp.20308-20313, 2007.

L. Smith, S. Cho, and D. E. Discher, Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo, Semin. Cell Dev. Biol, 2017.

S. Stehbens and T. Wittmann, Targeting and transport: how microtubules control focal adhesion dynamics, J. Cell Biol, vol.198, pp.481-490, 2012.
DOI : 10.1083/jcb.201206050
URL : http://jcb.rupress.org/content/198/4/481.full.pdf

S. J. Stehbens, M. Paszek, H. Pemble, A. Ettinger, S. Gierke et al., CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover, Nat. Cell Biol, vol.16, pp.561-573, 2014.
DOI : 10.1038/ncb2975
URL : http://europepmc.org/articles/pmc4108447?pdf=render

P. J. Stroeken, B. Alvarez, J. Van-rheenen, Y. M. Wijnands, D. Geerts et al., Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane, J. Cell. Physiol, vol.208, pp.620-628, 2006.

K. M. Stroka and H. Aranda-espinoza, Neutrophils display biphasic relationship between migration and substrate stiffness, Cell Motil. Cytoskeleton, vol.66, pp.328-341, 2009.
DOI : 10.1002/cm.20363

E. Tabdanov, N. Borghi, F. Brochard-wyart, S. Dufour, and J. P. Thiery, Role of E-cadherin in membrane-cortex interaction probed by nanotube extrusion, Biophys. J, vol.96, pp.2457-2465, 2009.

J. Takagi, B. M. Petre, T. Walz, and T. A. Springer, Global conformational earrangements in integrin extracellular domains in outside-in and inside-out signaling, Cell, vol.110, pp.599-611, 2002.

J. Takagi, K. Strokovich, T. A. Springer, and T. Walz, Structure of integrin in complex with fibronectin, EMBO J, vol.22, pp.4607-4615, 2003.

I. Takahashi, K. Onodera, Y. Sasano, I. Mizoguchi, J. Bae et al., Effect of stretching on gene expression of beta1 integrin and focal adhesion kinase and on chondrogenesis through cell-extracellular matrix interactions, Eur. J. Cell Biol, vol.82, pp.182-192, 2003.

H. Takala, E. Nurminen, S. M. Nurmi, M. Aatonen, T. Strandin et al., 22 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding, Blood, vol.112, pp.1853-1862, 2008.

J. W. Tamkun, D. W. Desimone, D. Fonda, R. S. Patel, C. Buck et al., Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin, Cell, vol.46, pp.271-282, 1986.

C. Tang, R. Yang, T. Huang, S. Liu, and W. Fu, Enhancement of fibronectin fibrillogenesis and bone formation by basic fibroblast growth factor via protein kinase C-dependent pathway in rat osteoblasts, Mol. Pharmacol, vol.66, pp.440-449, 2004.

A. Teckchandani, N. Toida, J. Goodchild, C. Henderson, J. Watts et al., Quantitative proteomics identifies a Dab2/integrin module regulating cell migration, J. Cell Biol, vol.186, pp.99-111, 2009.

M. Thery and M. Bornens, Cell shape and cell division, Curr Opin Cell Biol, vol.18, pp.648-657, 2006.

R. W. Tilghman, C. R. Cowan, J. D. Mih, Y. Koryakina, D. Gioeli et al., Matrix rigidity regulates cancer cell growth and cellular phenotype, PLoS One, vol.5, 2010.
DOI : 10.1371/journal.pone.0012905
URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012905&type=printable

A. Tomar and D. D. Schlaepfer, Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility, Curr. Opin. Cell Biol, vol.21, pp.676-683, 2009.

J. R. Tse and A. J. Engler, Preparation of hydrogel substrates with tunable mechanical properties, Curr. Protoc. Cell Biol, 2010.

T. A. Ulrich, E. M. De-juan, S. Pardo, and . Kumar, The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells, Cancer Res, vol.69, pp.4167-4174, 2009.

P. Upla, V. Marjomäki, P. Kankaanpaa, J. Ivaska, T. Hyypiä et al., Clustering Induces a Lateral Redistribution of 2 1 Integrin from Membrane Rafts to Caveolae and Subsequent Protein Kinase C-dependent Internalization, Mol. Biol. Cell, vol.15, pp.625-636, 2004.

D. Valdembri and G. Serini, Regulation of adhesion site dynamics by integrin traffic, Curr. Opin. Cell Biol, vol.24, pp.582-591, 2012.

M. Vicente-manzanares, J. Zareno, L. Whitmore, C. K. Choi, and A. F. Horwitz, Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells, J. Cell Biol, vol.176, pp.573-580, 2007.

W. N. De-vries, A. Evsikov, B. E. Haac, K. S. Fancher, A. E. Holbrook et al., Maternal beta-catenin and E-cadherin in mouse development, Development, vol.131, pp.4435-4445, 2004.

H. Wang, Y. Zhang, B. Ozdamar, A. A. Ogunjimi, E. Alexandrova et al., Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation, vol.302, pp.1775-1779, 2003.

H. B. Wang, M. Dembo, S. K. Hanks, and Y. Wang, Focal adhesion kinase is involved in mechanosensing during fibroblast migration, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.11295-300, 2001.

H. B. Wang, M. Dembo, Y. L. Wang, S. Ghassemi, G. Meacci et al., Substrate flexibility regulates growth and apoptosis of normal but not transformed cells, Am. J. Physiol. Cell Physiol, vol.279, pp.1345-50, 2013.

N. Wang, J. D. Tytell, and D. E. Ingber, Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus, Nat. Rev. Mol. Cell Biol, vol.10, pp.75-82, 2009.

D. J. Webb, K. Donais, L. A. Whitmore, S. M. Thomas, C. E. Turner et al., FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly, Nat. Cell Biol, vol.6, pp.154-161, 2004.

D. J. Webb, J. T. Parsons, and A. F. Horwitz, Adhesion assembly, disassembly and turnover in migrating cells -over and over and over again, Nat. Cell Biol, vol.4, 2002.

B. Wehrle-haller, v3 and pathways dictate downstream Rho kinase signaling to regulate persistent cell migration, Curr. Opin. Cell Biol, vol.24, pp.515-525, 2012.

G. Von-wichert, G. Jiang, A. Kostic, K. De, J. Vos et al., RPTPalpha acts as a transducer of mechanical force on alphav/beta3-integrincytoskeleton linkages, J. Cell Biol, vol.161, pp.143-53, 2003.

D. Wirtz, K. Konstantopoulos, and P. C. Searson, The physics of cancer: the role of physical interactions and mechanical forces in metastasis, Nat. Rev. Cancer, vol.11, pp.512-522, 2011.

P. W. Wiseman, C. M. Brown, D. J. Webb, B. Hebert, N. L. Johnson et al., Spatial mapping of integrin interactions and dynamics during cell migration by image correlation microscopy, J. Cell Sci, vol.117, pp.5521-5534, 2004.

D. C. Worth, K. Hodivala-dilke, S. D. Robinson, S. J. King, P. E. Morton et al., v3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration, J. Cell Biol, vol.189, pp.369-383

C. Wu, A. J. Fields, B. A. Kapteijn, and J. A. Mcdonald, The role of alpha 4 beta 1 integrin in cell motility and fibronectin matrix assembly, J. Cell Sci, vol.108, pp.821-830, 1995.

C. Xie, J. Zhu, X. Chen, L. Mi, N. Nishida et al., Structure of an integrin with an alphaI domain, complement receptor type 4, EMBO J, vol.29, pp.666-79, 2010.

J. Xiong, Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3. Science (80-. ), vol.294, pp.339-345, 2001.

J. Xiong, T. Stehle, R. Zhang, A. Joachimiak, M. Frech et al., Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand, Science, vol.296, pp.151-155, 2002.

D. Yamazaki, S. Kurisu, and T. Takenawa, Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates, Oncogene, vol.28, pp.1570-1583, 2009.

C. C. Yap and B. Winckler, Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development, Front. Cell. Neurosci, vol.9, 2015.

F. Ye, G. Hu, D. Taylor, B. Ratnikov, A. A. Bobkov et al., Recreation of the terminal events in physiological integrin activation, J. Cell Biol, vol.188, pp.157-173, 2010.

F. Ye, A. K. Snider, and M. H. Ginsberg, Talin and kindlin: the one-two punch in integrin activation, Front. Med, vol.8, pp.6-16, 2014.

T. Yeung, P. C. Georges, L. Flanagan, B. Marg, M. Ortiz et al., Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion, Cell Motil. Cytoskeleton, vol.60, pp.24-34, 2005.

C. Yu, N. B. Rafiq, F. Cao, Y. Zhou, A. Krishnasamy et al., Integrinbeta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nat. Commun, vol.6, p.8672, 2015.

E. C. Yusko and C. L. Asbury, Force is a signal that cells cannot ignore, Mol. Biol. Cell, vol.25, pp.3717-3742, 2014.

N. Zaari, P. Rajagopalan, S. K. Kim, A. J. Engler, and J. Y. Wong, Photopolymerization in microfluidic gradient generators: Microscale control of substrate compliance to manipulate cell response, Adv. Mater, vol.16, pp.2133-2137, 2004.

R. Zaidel-bar and B. Geiger, The switchable integrin adhesome, J. Cell Sci, vol.123, pp.1385-1388, 2010.

R. Zaidel-bar, S. Itzkovitz, A. Ma'ayan, R. Iyengar, and B. Geiger, Functional atlas of the integrin adhesome, Nat. Cell Biol, vol.9, pp.858-867, 2007.

E. Zamir, B. Z. Katz, S. Aota, K. M. Yamada, B. Geiger et al., Molecular diversity of cell-matrix adhesions, J. Cell Sci, vol.112, issue.pt11, pp.1655-1669, 1999.

E. Zamir, M. Katz, Y. Posen, N. Erez, K. M. Yamada et al., Dynamics and segregation of cellmatrix adhesions in cultured fibroblasts, Nat. Cell Biol, vol.2, pp.191-197, 2000.

E. Zamir, M. Katz, Y. Posen, N. Erez, K. M. Yamada et al., Dynamics and segregation of cellmatrix adhesions in cultured fibroblasts, Nat. Cell Biol, vol.2, pp.191-196, 2000.

J. S. Zawistowski, I. G. Serebriiskii, M. F. Lee, E. Golemis, and D. Marchuk, = 172 = KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis, Hum. Mol. Genet, vol.11, pp.389-396, 2002.

H. Zhang, F. Landmann, H. Zahreddine, D. Rodriguez, M. Koch et al., A tension-induced mechanotransduction pathway promotes epithelial morphogenesis, Nature, vol.471, pp.99-103, 2011.

J. Zhang, R. E. Clatterbuck, D. Rigamonti, D. D. Chang, and H. C. Dietz, Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation, Hum. Mol. Genet, vol.10, pp.2953-2960, 2001.

X. A. Zhang and M. E. Hemler, Interaction of the integrin domain with ICAP-1 protein, J. Biol. Chem, vol.274, pp.11-19, 1999.

X. A. Zhang and M. E. Hemler, Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein, J. Biol. Chem, vol.274, pp.11-20, 1999.

X. Zhang, G. Jiang, Y. Cai, S. J. Monkley, D. R. Critchley et al., Talin depletion reveals independence of initial cell spreading from integrin activation and traction, Nat. Cell Biol, vol.10, pp.1062-1068, 2008.

C. Zhong, M. Chrzanowska-wodnicka, J. Brown, A. Shaub, A. M. Belkin et al., Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly, J. Cell Biol, vol.141, pp.539-551, 1998.

J. Zhu, T. B.-h.-luo, C. Xiao, N. Zhang, T. A. Nishida et al., Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces, Mol. Cell, vol.32, pp.849-61, 2008.

J. Zhu, B. H. Luo, T. Xiao, C. Zhang, N. Nishida et al., Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces, Mol. Cell, vol.32, pp.849-861, 2008.

O. Zschenker, T. Streichert, S. Hehlgans, and N. Cordes, Genome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair, PLoS One, vol.7, 2012.