Modeling Mucosal Cell-Associated HIV Type 1 Transmission in Vitro, 2014. ,
DOI : 10.1093/infdis/jiu537
URL : http://europepmc.org/articles/pmc4303080?pdf=render
, , 2010.
, Targeting Trojan Horse leukocytes for HIV prevention, AIDS, vol.24, pp.163-187
HIV-1 vaginal transmission: cell-free or cell-associated virus?, Am J Reprod Immunol, vol.71, pp.589-599, 2014. ,
Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface, J. Immunol, vol.185, pp.7026-7036, 2010. ,
Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection, AIDS, vol.30, pp.1197-1208, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01274885
Binding of LFA-1 (CD11a) to intercellular adhesion molecule, vol.3, 2002. ,
, CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells, J Virol, vol.76, pp.32-40
R5 HIV-1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5, EMBO Mol Med, vol.5, pp.776-794, 2013. ,
Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer, J Immunol, vol.176, pp.5627-5636, 2006. ,
DOI : 10.4049/jimmunol.176.9.5627
URL : http://www.jimmunol.org/content/jimmunol/176/9/5627.full.pdf
Role of semen in HIV-1 transmission: inhibitor or facilitator?, Am J Reprod Immunol, vol.65, pp.292-301, 2010. ,
Role of semen in modulating the female genital tract microenvironment--implications for HIV transmission, Am J Reprod Immunol, vol.71, pp.564-574, 2014. ,
Influence of common mucosal co-factors on HIV infection in the female genital tract, Am. J. Reprod. Immunol, vol.71, pp.543-554, 2014. ,
Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells, Fertil. Steril, vol.69, pp.309-317, 1998. ,
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides, Antivir. Res, vol.74, pp.111-124, 2007. ,
Nitric oxide is an antiadhesive molecule for leukocytes, New Horiz, vol.3, pp.93-104, 1995. ,
Critical Review: Immunomodulation by Seminal Factors and Implications for Male-to-Female HIV-1 Transmission, J. Acquir. Immune Defic. Syndr, vol.69, pp.131-137, 2015. ,
Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus, J. Virol, vol.87, pp.13589-13597, 2013. ,
Human Semen or Seminal Plasma Does Not Enhance HIV-1BaL Ex Vivo Infection of Human Colonic Explants, AIDS Res. Hum. Retroviruses, vol.34, pp.459-466, 2018. ,
DOI : 10.1089/aid.2017.0118
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934974
Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia, J. Exp. Med, vol.198, pp.999-1010, 2003. ,
Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma, AIDS, vol.26, pp.785-796, 2012. ,
URL : https://hal.archives-ouvertes.fr/ujm-00749507
HIV binding, penetration, and primary infection in human cervicovaginal tissue, Proc Natl Acad Sci U S A, vol.102, pp.11504-11509, 2005. ,
DOI : 10.1073/pnas.0500848102
URL : http://www.pnas.org/content/102/32/11504.full.pdf
Mechanisms of HIV/SIV mucosal transmission, AIDS-Res-HumRetroviruses, vol.10, pp.1305-2229, 1994. ,
New model for studying the migration of immune cells into intestinal epithelial cell monolayers, Cytotechnology, vol.43, pp.57-64, 2003. ,
Zinc reduces epithelial barrier compromise induced by human seminal plasma, PLoS One, vol.12, 2017. ,
DOI : 10.1371/journal.pone.0170306
URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170306&type=printable
Seminal plasma induces programmed cell death in cultured peripheral blood mononuclear cells, AIDS Res Hum Retroviruses, vol.18, pp.797-803, 2002. ,
Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction, J. Clin. Invest, vol.88, pp.1605-1612, 1991. ,
Estimating per-act HIV transmission risk: a systematic review, AIDS, vol.28, pp.1509-1519, 2014. ,
Depletion of CD4 + T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy, 2009. ,
T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen, J Infect Dis, vol.176, pp.960-968, 1997. ,
Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue, Mediators Inflamm, p.7650260, 2016. ,
Seminal plasma protects human spermatozoa and pathogenic yeasts from capture by dendritic cells, Hum. Reprod, vol.26, pp.987-999, 2011. ,
Semen clusterin is a novel DC-SIGN ligand, J Immunol, vol.187, pp.5299-5309, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00871196
Human seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN, J. Virol, vol.81, pp.13723-13734, 2007. ,
The role of semen in sexual transmission of HIV: beyond a carrier for virus particles, Microbes Infect, vol.13, pp.977-982, 2011. ,
Infection of macaques after vaginal exposure to cellassociated simian immunodeficiency virus, J Infect Dis, vol.202, pp.337-344, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00657429
Inhibiting sexual transmission of HIV-1 infection, Nat Rev Microbiol, vol.1, pp.25-34, 2003. ,
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes, Virology, vol.391, pp.203-211, 2009. ,
Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia, J Virol, vol.86, pp.2556-2570, 2011. ,
Immunohistologic characterization and quantitation of leukocyte subpopulations in human semen, Fertil Steril, vol.49, pp.497-504, 1988. ,
HIV-1 Efficient Entry in Inner Foreskin Is Mediated by Elevated CCL5/RANTES that Recruits T Cells and Fuels Conjugate Formation with Langerhans Cells, Modeling Mucosal Cell-Associated HIV Type 1 Transmission in Vitro, vol.7, 2011. ,
Cell-associated HIV mucosal transmission: the neglected pathway, J Infect Dis, vol.210, pp.606-614, 2014. ,
, , 2010.
, Targeting Trojan Horse leukocytes for HIV prevention, AIDS, vol.24, pp.163-187
Semen CD4(+) T Cells and Macrophages Are Productively Infected at All Stages of SIV infection in Macaques, PLoS Pathog, vol.9, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00955292
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract, J Exp Med, vol.200, pp.749-759, 2004. ,
Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection, AIDS, vol.30, pp.1197-1208, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01274885
A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group, N. Engl. J. Med, vol.337, pp.1485-1490, 1997. ,
Binding of LFA-1 (CD11a) to intercellular adhesion molecule, vol.3, 2002. ,
, CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells, J Virol, vol.76, pp.32-40
Macrophage polarization and HIV-1 infection, J. Leukoc. Biol, vol.87, pp.599-608, 2010. ,
DOI : 10.1189/jlb.1009673
Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer, J Immunol, vol.176, pp.5627-5636, 2006. ,
DOI : 10.4049/jimmunol.176.9.5627
URL : http://www.jimmunol.org/content/jimmunol/176/9/5627.full.pdf
HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages, J. Immunol, vol.188, pp.3620-3627, 2012. ,
DOI : 10.4049/jimmunol.1101593
URL : http://www.jimmunol.org/content/188/8/3620.full.pdf
Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas, Clin. Exp. Immunol, vol.126, pp.397-402, 2001. ,
Role of semen in modulating the female genital tract microenvironment--implications for HIV transmission, Am J Reprod Immunol, vol.71, pp.564-574, 2014. ,
Dendritic cells in semen of infertile men: association with sperm quality and inflammatory status of the epididymis, Fertil Steril, vol.101, pp.70-77, 2014. ,
In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level, Virology, vol.515, pp.1-10, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01663650
Number, distribution pattern, and identification of macrophages in the testes of infertile men, Fertil Steril, vol.78, pp.298-306, 2002. ,
HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy, AIDS, vol.31, pp.35-48, 2017. ,
DOI : 10.1097/qad.0000000000001309
URL : http://europepmc.org/articles/pmc5131694?pdf=render
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides, Antivir. Res, vol.74, pp.111-124, 2007. ,
Origins of HIV-infected leukocytes and virions in semen, J, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01121761
Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs, J. Virol, vol.92, 2018. ,
DOI : 10.1128/jvi.00133-18
URL : https://hal-univ-rennes1.archives-ouvertes.fr/hal-01795804/file/Houzet_Seminal%20Simian%20Immunodeficiency.pdf
HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse, J Exp Med, vol.199, pp.283-293, 2004. ,
DOI : 10.1084/jem.20030648
URL : http://jem.rupress.org/content/199/2/283.full.pdf
Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus, J. Virol, vol.87, pp.13589-13597, 2013. ,
Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma, AIDS, vol.26, pp.785-796, 2012. ,
URL : https://hal.archives-ouvertes.fr/ujm-00749507
The semen microbiome and its relationship with local immunology and viral load in HIV infection, PLoS Pathog, vol.10, p.1004262, 2014. ,
DOI : 10.1371/journal.ppat.1004262
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004262&type=printable
Selective transmission of CCR5-utilizing HIV-1: the "gatekeeper" problem resolved?, Nat. Rev. Microbiol, vol.4, pp.312-317, 2006. ,
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection, Nature, vol.434, pp.1093-1097, 2005. ,
Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy, PLoS One, vol.10, 2015. ,
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells, AIDS Res. Ther, vol.15, p.7, 2018. ,
Phenotypic classification of human CD4+ T cell subsets and their differentiation, Int. Immunol, vol.20, pp.1189-1199, 2008. ,
DOI : 10.1093/intimm/dxn075
URL : https://academic.oup.com/intimm/article-pdf/20/9/1189/1933624/dxn075.pdf
Seminal plasma induces programmed cell death in cultured peripheral blood mononuclear cells, AIDS Res Hum Retroviruses, vol.18, pp.797-803, 2002. ,
DOI : 10.1089/08892220260139549
Depletion of CD4 + T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy, 2009. ,
Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses, J. Virol, vol.83, pp.6234-6246, 2009. ,
DOI : 10.1128/jvi.00282-09
URL : https://hal.archives-ouvertes.fr/pasteur-00458065
Infection of macaques after vaginal exposure to cellassociated simian immunodeficiency virus, J Infect Dis, vol.202, pp.337-344, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00657429
The characterisation of non-sperm cells in the ejaculates of fertile men using transmission electron microscopy, Andrologia, vol.21, pp.319-333, 1989. ,
HIV infection of the male genital tract--consequences for sexual transmission and reproduction, Int J Androl, vol.33, pp.98-108, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00516571
Infection of semen-producing organs by HIV and role in virus dissemination, Med Sci, vol.26, pp.861-868, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00669524
Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia, J Virol, vol.86, pp.2556-2570, 2011. ,
DOI : 10.1128/jvi.06578-11
URL : https://jvi.asm.org/content/86/5/2556.full.pdf
Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection, J Virol, vol.74, pp.11001-11007, 2000. ,
The biologic significance of white blood cells in semen, Fertil. Steril, vol.63, pp.1143-1157, 1995. ,
Chemokine Receptors and Leukocyte Trafficking in the Mucosal Immune System, Immunol. Res, vol.29, pp.283-292, 2004. ,
DOI : 10.1385/ir:29:1-3:283
Identification and function analysis of macrophages subsets in chronically inflamed human epididymis. References Abner, J. Infect. Dis, vol.192, issue.9, pp.1545-1556, 2005. ,
HIV-1-infected blood mononuclear cells form an integrin-and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer, Mol. Biol. Cell, vol.16, issue.9, pp.4267-4279, 2005. ,
DOI : 10.1091/mbc.e05-03-0192
URL : http://europepmc.org/articles/pmc1196336?pdf=render
HIV infection and immune defense of the penis, Am. J. Reprod. Immunol, vol.65, issue.3, pp.220-229, 2011. ,
Targeting Trojan Horse leukocytes for HIV prevention, AIDS, vol.24, issue.2, pp.163-187, 2010. ,
Three-dimensional culture models for human viral diseases and antiviral drug development, Antivir. Res, vol.71, issue.2-3, pp.96-107, 2006. ,
Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells, J. Virol, vol.85, issue.24, pp.13443-13447, 2011. ,
Cell-free human immunodeficiency virus type 1 transcytosis through primary genital epithelial cells, J. Virol, vol.81, issue.1, pp.395-405, 2007. ,
Organotypic raft cultures and the study of the natural history of papillomavirus, Papillomavirus research: from natural history to vaccines and beyond, pp.145-173, 2006. ,
Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier, Nat. Med, vol.3, issue.1, pp.42-47, 1997. ,
Entry of viruses through the epithelial barrier: pathogenic trickery, Nat. Rev. Mol. Cell Biol, vol.4, issue.1, pp.57-68, 2003. ,
Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM, Immunity, vol.9, issue.2, pp.277-287, 1998. ,
Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells, AIDS, vol.21, issue.1, pp.13-22, 2007. ,
Early events in HIV transmission through a human reconstructed vaginal mucosa, AIDS, vol.22, issue.11, pp.1257-1266, 2008. ,
HIV and mucosal barrier interactions: consequences for transmission and pathogenesis, Curr. Opin. Immunol, vol.36, pp.22-30, 2015. ,
Comparison of the effect of semen from HIV-infected and uninfected men on CD4 + T-cell infection, AIDS, vol.30, issue.8, pp.1197-1208, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01274885
Binding of LFA-1 (CD11a) to intercellular adhesion molecule, vol.3, 2002. ,
, ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells, J. Virol, vol.76, issue.1, pp.32-40
R5 HIV-1 envelope attracts, J. Frouard et al. Virology, vol.515, pp.1-10, 2013. ,
, dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5, EMBO Mol. Med, vol.5, issue.5, pp.776-794
Intestinal intraepithelial lymphocytes, Gastroenterol. Clin. North Am, vol.20, issue.3, pp.549-576, 1991. ,
Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer, J. Immunol, vol.176, issue.9, pp.5627-5636, 2006. ,
Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract, Nat. Med, vol.6, issue.4, pp.475-479, 2000. ,
Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture, Antimicrob. Agents Chemother, vol.51, issue.5, pp.1770-1779, 2007. ,
Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo, Am. J. Pathol, vol.179, issue.5, pp.2397-2408, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00626549
Animal and human mucosal tissue models to study HIV biomedical interventions: can we predict success?, J. Int. AIDS Soc, vol.18, p.20301, 2015. ,
Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation, PLoS One, vol.9, issue.7, p.102585, 2014. ,
Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures, Off. Genes Dev, vol.6, issue.7, pp.1131-1142, 1992. ,
Role of semen in modulating the female genital tract microenvironment-implications for HIV transmission, Am. J. Reprod. Immunol, vol.71, issue.6, pp.564-574, 2014. ,
Role of semen in HIV-1 transmission: inhibitor or facilitator?, Am. J. Reprod. Immunol, vol.65, issue.3, pp.292-301, 2010. ,
Functional diversity of human vaginal APC subsets in directing T-cell responses, Mucosal Immunol, vol.6, issue.3, pp.626-638, 2013. ,
HIV-1 infection of human penile explant tissue and protection by candidate microbicides, AIDS, vol.23, issue.3, pp.319-328, 2009. ,
Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor, Antimicrob. Agents Chemother, vol.53, issue.2, pp.487-495, 2009. ,
Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides, AIDS, vol.20, issue.9, pp.1237-1245, 2006. ,
Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue, Virology, vol.369, issue.1, pp.55-68, 2007. ,
3D bioprinting in regenerative medicine and tissue engineering, Med. Sci, issue.1, pp.52-59, 2017. ,
The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages, Mucosal Immunol, vol.6, issue.4, pp.776-786, 2013. ,
Within 1h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates, Mucosal Immunol, vol.3, issue.5, pp.506-522, 2010. ,
Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides, J. Virol, vol.74, issue.12, pp.5577-5586, 2000. ,
Reverse transcriptase inhibitors as potential colorectal microbicides, Antimicrob. Agents Chemother, vol.53, issue.5, pp.1797-1807, 2009. ,
Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants, AIDS, vol.25, issue.16, pp.1971-1979, 2011. ,
Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1, Immunity, vol.26, issue.2, pp.257-270, 2007. ,
Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells, J. Virol, vol.75, issue.11, pp.5370-5374, 2001. ,
Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture, PLoS One, vol.6, issue.7, p.22638, 2011. ,
Origins of HIV-infected leukocytes and virions in semen, J. Infect. Dis, vol.210, issue.3, pp.622-630, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01121761
Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tract, J. Virol, vol.71, issue.5, pp.3498-3506, 1997. ,
Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells, J. Virol, vol.74, issue.13, pp.6087-6095, 2000. ,
Colonic macrophage polarization in homeostasis, inflammation, and cancer, Am. J. Physiol. Gastrointest. Liver Physiol, vol.311, issue.1, pp.59-73, 2016. ,
Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1, Methods, vol.55, issue.2, pp.114-121, 2011. ,
Efficiency of cell-free and cell-associated virus in mucosal transmission of human immunodeficiency virus type 1 and simian immunodeficiency virus, J. Virol, vol.87, issue.24, pp.13589-13597, 2013. ,
Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma, AIDS, vol.26, issue.7, pp.785-796, 2012. ,
URL : https://hal.archives-ouvertes.fr/ujm-00749507
Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo, Retrovirology, vol.5, issue.1, p.119, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00354718
Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection, Biol. Reprod, vol.77, issue.6, pp.1049-1059, 2007. ,
HIV binding, penetration, and primary infection in human cervicovaginal tissue, Proc. Natl. Acad. Sci. USA, vol.102, issue.32, pp.11504-11509, 2005. ,
Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells, Blood, vol.120, issue.3, pp.572-580, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01372479
Detection of simian immunodeficiency virus in semen, urethra, and male reproductive organs during efficient highly active antiretroviral therapy, J. Virol, vol.89, issue.11, pp.5772-5787, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01139816
Replication and interaction of herpes simplex virus and human papillomavirus in differentiating host epithelial tissue, Virology, vol.315, issue.1, pp.43-55, 2003. ,
Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation, Science, vol.257, issue.5072, pp.971-973, 1992. ,
T cell-tropic simian immunodeficiency virus (SIV) and simianhuman immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV, J. Infect. Dis, vol.179, issue.3, pp.413-417, 1999. ,
Zinc reduces epithelial barrier compromise induced by human seminal plasma, Semen-derived amyloid fibrils drastically enhance HIV infection, vol.12, pp.1059-1071, 2007. ,
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation, PLoS Pathog, vol.6, issue.4, p.1000852, 2010. ,
HIV-1 gp120 induces TLR2-and TLR4-mediated innate immune activation in human female genital epithelium, J. Immunol, vol.191, issue.8, pp.4246-4258, 2013. ,
Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women, Antivir. Res, vol.81, issue.2, pp.103-112, 2009. ,
Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection, Cell. Mol. Immunol, vol.11, issue.5, pp.410-427, 2014. ,
Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture, Am. J. Pathol, vol.161, issue.3, pp.867-873, 2002. ,
Antigenpresenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages, AIDS Res. Hum. Retrovir, vol.30, issue.3, pp.241-249, 2014. ,
Innate and acquired immunity in the human penile urethra, J. Reprod. Immunol, vol.88, issue.2, pp.219-227, 2011. ,
Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone, Biol. Reprod, vol.73, issue.6, pp.1253-1263, 2005. ,
Cultivated vaginal microbiomes alter HIV-1 infection and antiretroviral efficacy in colonized epithelial, 2014. ,
, Virology, vol.515, pp.1-10, 2018.
Rapid dissemination of SIV follows multisite entry after rectal inoculation, PLoS One, vol.6, issue.5, p.19493, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00636297
Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection, J. Virol, vol.88, issue.13, pp.7221-7234, 2014. ,
Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract, Mucosal Immunol, vol.7, issue.6, pp.1375-1385, 2014. ,
Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV, Mucosal Immunol, vol.10, issue.2, pp.531-544, 2017. ,
Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses, Mucosal Immunol, vol.4, issue.6, pp.671-681, 2011. ,
Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro, Am. J. Pathol, vol.169, issue.6, pp.2094-2103, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00653727
HIV-1 sexual transmission: early events of HIV-1 infection of human cervicovaginal tissue in an optimized ex vivo model, Mucosal Immunol, vol.3, issue.3, pp.280-290, 2010. ,
Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle, Mucosal Immunol, vol.6, issue.6, pp.1081-1090, 2013. ,
Semen clusterin is a novel DC-SIGN ligand, J. Immunol, vol.187, issue.10, pp.5299-5309, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00871196
Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virus, J. Infect. Dis, vol.202, issue.3, pp.337-344, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00657429
Inhibiting sexual transmission of HIV-1 infection, Nat. Rev. Microbiol, vol.1, issue.1, pp.25-34, 2003. ,
GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium, J. Immunol, vol.184, issue.7, pp.3648-3655, 2010. ,
Vaginal myeloid dendritic cells transmit founder HIV-1, J. Virol, vol.88, issue.13, pp.7683-7688, 2014. ,
Interactions between HIV-1 and mucosal cells in the female reproductive tract, Am. J. Reprod. Immunol, vol.71, issue.6, pp.608-617, 2014. ,
Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection, J. Virol, vol.83, issue.7, pp.3258-3267, 2009. ,
DOI : 10.1128/jvi.01796-08
URL : https://jvi.asm.org/content/83/7/3258.full.pdf
HIV-1 infection of Langerhans cells in a reconstructed vaginal mucosa, J. Infect. Dis, vol.190, issue.2, pp.227-235, 2004. ,
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells, Science, vol.348, issue.6241, p.8205, 2015. ,
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes, Virology, vol.391, issue.2, pp.203-211, 2009. ,
gp340 promotes transcytosis of human immunodeficiency virus type 1 in genital tract-derived cell lines and primary endocervical tissue, J. Virol, vol.83, issue.17, pp.8596-8603, 2009. ,
, , p.5, 2016.
CD4 T cells resident in the genital mucosa with lymphoid trafficking potential, J. Immunol, vol.197, issue.1, pp.368-376 ,
Distribution of immune cells in the human cervix and implications for HIV transmission, Am. J. Reprod. Immunol, vol.71, issue.3, pp.252-264, 2014. ,
Should probiotics be tested on ex vivo organ culture models?, Gut Microbes, vol.3, issue.5, pp.442-448, 2012. ,
DOI : 10.4161/gmic.20885
URL : https://www.tandfonline.com/doi/pdf/10.4161/gmic.20885?needAccess=true
Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia, J. Virol, vol.86, issue.5, pp.2556-2570, 2011. ,
DOI : 10.1128/jvi.06578-11
URL : https://jvi.asm.org/content/86/5/2556.full.pdf
Infection and replication of herpes simplex virus type 1 in an organotypic epithelial culture system, Virology, vol.230, issue.2, pp.236-243, 1997. ,
, Virology, vol.515, pp.1-10, 2018.
Prostasomes: extracellular vesicles from the prostate, REPRODUCTION, vol.147, pp.1-14, 2014. ,
DOI : 10.1530/rep-13-0358
URL : https://rep.bioscientifica.com/downloadpdf/journals/rep/147/1/R1.pdf
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women, vol.329, pp.1168-1174 ,
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women, vol.329, pp.1168-1174, 2010. ,
Cellcell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies, PLoS Pathog, vol.8, 2012. ,
DOI : 10.1371/journal.ppat.1002634
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002634&type=printable
A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection, J Infect Dis, vol.192, pp.1545-1556, 2005. ,
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function, 2010. ,
DOI : 10.1038/nri2707
Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology, Indian J. Exp. Biol, vol.43, pp.963-974, 2005. ,
Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission, PLoS Pathog, vol.10, p.1003982, 2014. ,
DOI : 10.1371/journal.ppat.1003982
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003982&type=printable
HIV-1-infected blood mononuclear cells form an integrin-and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer, Mol Biol Cell, vol.16, pp.4267-4279, 2005. ,
Cell-associated HIV mucosal transmission: the neglected pathway, J Infect Dis, vol.210, pp.606-614, 2014. ,
DOI : 10.1093/infdis/jiu538
URL : https://academic.oup.com/jid/article-pdf/210/suppl_3/S606/6471951/jiu538.pdf
, , 1991.
, White blood cells and HIV-1 in semen from vasectomised seropositive men, Lancet, vol.338, pp.573-574
, , 2010.
, Targeting Trojan Horse leukocytes for HIV prevention, AIDS, vol.24, pp.163-187
HIV-1 Populations in Semen Arise through Multiple Mechanisms, PLoS Pathog, vol.6, p.1001053, 2010. ,
DOI : 10.1371/journal.ppat.1001053
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001053&type=printable
, Cytokine Tuning of Intestinal Epithelial Function. Front. Immunol, vol.9, p.1270, 2018.
, , 0196.
, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy, PLoS One, vol.6, 23243.
, , 2013.
Ex vivo models of HIV sexual transmission and microbicide development, Curr HIV Res, vol.10, pp.73-78, 2012. ,
HIV Interaction With Human Host: HIV-2 As a Model of a Less Virulent Infection, AIDS Rev, vol.18, pp.44-53 ,
HIV particles detected in spermatozoa of patients with AIDS, J Submicrosc Cytol Pathol, vol.23, pp.339-345, 1991. ,
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women, N. Engl. J. Med, vol.375, pp.2121-2132, 2016. ,
Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men, AIDS, vol.8, pp.1669-1674, 1994. ,
, The Breadth of Viruses in Human Semen
Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV, J. Immunol, vol.185, pp.7596-7604, 2010. ,
HIV-1 in semen: determination of proviral and viral titres compared to blood, and quantification of semen leukocyte populations, J Med Virol, vol.59, pp.356-363, 1999. ,
Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells, J Virol, vol.85, pp.13443-13447, 2011. ,
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS), Science, vol.220, pp.868-871, 1983. ,
HIV-1 vaginal transmission: cell-free or cell-associated virus?, Am J Reprod Immunol, vol.71, pp.589-599, 2014. ,
Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages, PLoS One, vol.8, p.80908, 2013. ,
Cytofluorographic identification of activated T-cell subpopulations in the semen of men with spinal cord injuries, J. Androl, vol.23, pp.551-556 ,
, Inhibition of Human Immunodeficiency Type, 2018.
, HIV-1) Life Cycle by Different Egg White Lysozymes, Appl. Biochem. Biotechnol, vol.185, pp.786-197
, CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease, 1999.
Amyloid formation: functional friend or fearful foe?, J. Intern. Med, vol.280, pp.139-152, 2016. ,
Amount of seminal IL1beta positively correlates to HIV-1 load in the semen of infected patients, J Clin Virol, vol.36, pp.204-207, 2006. ,
Seminal plasma promotes the attraction of Langerhans cells via the secretion of CCL20 by vaginal epithelial cells: involvement in the sexual transmission of HIV, Hum Reprod, vol.21, pp.1135-1142, 2006. ,
Semen CD4(+) T Cells and Macrophages Are Productively Infected at All Stages of SIV infection in Macaques, PLoS Pathog, vol.9, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00955292
Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: the need to better understand the complexity of HIV mucosal transmission, J Infect Dis, vol.210, pp.660-666, 2014. ,
, , 1991.
, Proc Natl Acad Sci U S A, vol.88, pp.7131-7134
Cell-free human immunodeficiency virus type 1 transcytosis through primary genital epithelial cells, J Virol, vol.81, pp.395-405, 2007. ,
Role of donor genital tract HIV-1 diversity in the transmission bottleneck, Proc Natl Acad Sci U S A, vol.108, pp.1156-63, 2011. ,
Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier, Nat Med, vol.3, pp.42-47, 1997. ,
Entry of viruses through the epithelial barrier: pathogenic trickery, Nat Rev Mol Cell Biol, vol.4, pp.57-68, 2003. ,
, , 1998.
, Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM, Immunity, vol.9, pp.277-287
Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells, AIDS, vol.21, pp.13-22, 2007. ,
, , 2002.
, Opsonization of HIV-1 by semen complement enhances infection of human epithelial cells, J Immunol, vol.169, pp.3301-3306
Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner, J. Immunol, vol.178, pp.1086-1095, 2007. ,
Early events in HIV transmission through a human reconstructed vaginal mucosa, AIDS, vol.22, pp.1257-1266, 2008. ,
Vaginal pH neutralization by semen as a cofactor of HIV transmission, Clin. Microbiol. Infect, vol.3, pp.19-23, 1997. ,
Neutrophil migration across intestinal epithelium: evidence for a role of CD44 in regulating detachment of migrating cells from the luminal surface, J. Immunol, vol.185, pp.7026-7036, 2010. ,
Seminal fluid and reproduction: much more than previously thought, J. Assist. Reprod. Genet, vol.31, pp.627-636, 2014. ,
, , 2004.
Decreased semen volume and spermatozoa motility in HIV-1 infected patients under antiretroviral treatment, J Androl, vol.28, pp.444-452, 2007. ,
The origins of sexually transmitted HIV among men who have sex with men, Sci Transl Med, vol.2, pp.18-19, 2010. ,
Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection, AIDS, vol.30, pp.1197-1208, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01274885
Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men, AIDS, vol.17, pp.531-539, 2003. ,
Frequent use of lubricants for anal sex among men who have sex with men: the HIV prevention potential of a microbicidal gel, Am. J. Public Health, vol.90, pp.1117-1121, 2000. ,
Tell Juliana": Acceptability of the Candidate Microbicide VivaGel® and Two Placebo Gels Among Ethnically Diverse, 2012. ,
, AIDS Behav, vol.16, pp.1761-1774
A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group, N. Engl. J. Med, vol.337, pp.1485-1490, 1997. ,
, , p.199, 2011.
Binding of LFA-1 (CD11a) to intercellular adhesion molecule, vol.3, 2002. ,
, CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells, J Virol, vol.76, pp.32-40
Macrophage polarization and HIV-1 infection, J. Leukoc. Biol, vol.87, pp.599-608, 2010. ,
R5 HIV-1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5, EMBO Mol Med, vol.5, pp.776-794, 2013. ,
Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells, Cell Rep, vol.20, pp.984-998, 2017. ,
Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells, J Exp Med, vol.206, pp.2717-2733, 2009. ,
Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin, Nature, vol.372, pp.190-193, 1994. ,
Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer, J Immunol, vol.176, pp.5627-5636, 2006. ,
Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: A Double-Blind Randomized Trial, J. Acquir. Immune Defic. Syndr, vol.70, pp.242-249, 2015. ,
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses, J Virol, vol.81, pp.12582-12595, 2007. ,
A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function, PLoS Pathog, vol.14, p.1006806, 2018. ,
The integrin 4 7 forms a complex with cell-surface CD4 and defines a Tcell subset that is highly susceptible to infection by HIV-1, Proc. Natl. Acad. Sci, vol.106, pp.20877-20882, 2009. ,
HIV Infection of Macrophages: Implications for Pathogenesis and Cure, Pathog. Immun, vol.2, pp.179-192, 2017. ,
,
Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART, Front. Immunol, vol.9, p.1217, 2018. ,
Minidefensins: antimicrobial peptides with activity against HIV-1, Curr. Pharm. Des, vol.9, pp.1463-1473, 2003. ,
Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract, Nat Med, vol.6, pp.475-479, 2000. ,
Vaginal Microbiota and Sexually Transmitted Infections That May Influence Transmission of Cell-Associated HIV, J. Infect. Dis, vol.210, pp.616-621, 2014. ,
Intestinal Mucus Barrier in Normal and Inflamed Colon, 2009. ,
Characterization of CCL20 secretion by human epithelial vaginal cells: involvement in Langerhans cell precursor attraction, J Leukoc Biol, vol.78, pp.158-166, 2005. ,
Preclinical testing of candidate topical microbicides for antihuman immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture, Antimicrob Agents Chemother, vol.51, pp.1770-1779, 2007. ,
Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection, Gastroenterology, vol.131, pp.818-829, 2006. ,
Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization, J. Reprod. Immunol, vol.41, pp.271-290, 1998. ,
Viruses in the mammalian male genital tract and their effects on the reproductive system, Microbiol Mol Biol Rev, vol.65, pp.208-231, 2001. ,
, , 2011.
, Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo, Am J Pathol, vol.179, pp.2397-2408
Evaluation of T-lymphocyte subsets present in semen and peripheral blood of healthy donors: A report from the heterosexual transmission study, Cytometry, vol.20, pp.349-355, 1995. ,
Animal and human mucosal tissue models to study HIV biomedical interventions: can we predict success?, J Int AIDS Soc, vol.18, 2015. ,
Reformulated tenofovir gel for use as a dual compartment microbicide, J. Antimicrob. Chemother, vol.67, pp.2139-2142, 2012. ,
Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation, PLoS One, vol.9, p.201, 2014. ,
Expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in colonic epithelial cells, Gut, vol.34, pp.1593-1597, 1993. ,
Role of semen in modulating the female genital tract microenvironment--implications for HIV transmission, Am J Reprod Immunol, vol.71, pp.564-574, 2014. ,
Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct, J. Leukoc. Biol, vol.60, pp.758-765, 1996. ,
Seminal plasma proteomes and sperm fertility, Anim. Reprod. Sci, vol.194, pp.33-40, 2018. ,
DOI : 10.1016/j.anireprosci.2018.04.061
Dendritic cells in semen of infertile men: association with sperm quality and inflammatory status of the epididymis, Fertil Steril, vol.101, pp.70-77, 2014. ,
Semen alterations in HIV-1 infected men, Hum. Reprod, vol.17, pp.2112-2118, 2002. ,
DOI : 10.1093/humrep/17.8.2112
URL : https://academic.oup.com/humrep/article-pdf/17/8/2112/9818794/172112.pdf
High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy, AIDS, vol.27, pp.2201-2206, 2013. ,
DOI : 10.1097/qad.0b013e3283632ec4
URL : http://europepmc.org/articles/pmc4714465?pdf=render
The Inside Out of Lentiviral Vectors, Viruses, vol.3, pp.132-159, 2011. ,
Spermatozoa as potential carriers of HIV, Res Virol, vol.144, pp.487-495, 1993. ,
Chemokine receptor expression by human intestinal epithelial cells, Gastroenterology, vol.117, pp.359-367, 1999. ,
DOI : 10.1053/gast.1999.0029900359
Comparative Assessment of Small and Large Intestine Biopsies for Ex Vivo HIV-1 Pathogenesis Studies ,
CD4 independent binding of HIV gp120 to mannose receptor on human spermatozoa, J Acquir Immune Defic Syndr, vol.48, pp.389-397, 2008. ,
Infection of colonic epithelial cell lines by type 1 human immunodeficiency virus is associated with cell surface expression of galactosylceramide, 1993. ,
Using nonhuman primates to model HIV transmission, Curr. Opin. HIV AIDS, vol.8, pp.280-287, 2013. ,
Influence of common mucosal co-factors on HIV infection in the female genital tract, Am. J. Reprod. Immunol, vol.71, pp.543-554, 2014. ,
HIV-1 infection of human penile explant tissue and protection by candidate microbicides, AIDS, vol.23, pp.319-328, 2009. ,
Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor, Antimicrob Agents Chemother, vol.53, pp.487-495, 2009. ,
Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides, AIDS, vol.20, pp.1237-1245, 2006. ,
Continuous measurement by radio-telemetry of vaginal pH during human coitus, J. Reprod. Fertil, vol.33, pp.69-75, 1973. ,
In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level, Virology, vol.515, pp.1-10, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01663650
Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission, J. Infect. Dis, vol.195, pp.703-710, 2007. ,
Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse, J Infect Dis, vol.207, pp.1389-1396, 2013. ,
Inhibition of HIV-1 infection by human alpha-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae, PLoS One, vol.7, p.45208, 2012. ,
HIV-1 transmission in the male genital tract, Am J Reprod Immunol, vol.65, pp.284-291, 2010. ,
Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates, Mucosal Immunol, vol.3, pp.506-522, 2010. ,
, Rôles physiologiques des mucines dans la barrière colique, 2006.
Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract, Immunology, vol.129, pp.207-219, 2010. ,
Evidence of genotypic resistance diversity of archived and circulating viral strains in blood and semen of pre-treated HIV-infected men, AIDS, vol.18, pp.447-457, 2004. ,
Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIVInfected Cells, Cell Rep, vol.23, pp.942-950, 2018. ,
, The Slippery Slope: Lubricant Use and Rectal Sexually Transmitted Infections: A Newly Identified Risk, 2012.
Alternative activation of macrophages, Nat. Rev. Immunol, vol.3, pp.23-35, 2003. ,
URL : https://hal.archives-ouvertes.fr/hal-00474829
Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells, Fertil. Steril, vol.69, pp.309-317, 1998. ,
Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides, J Virol, vol.74, pp.5577-86, 2000. ,
Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue, J Virol, vol.74, pp.5347-5351, 2000. ,
, , 1997.
, Prog. Urol, vol.7, pp.496-504
Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission, Retrovirology, vol.3, p.52, 2006. ,
Intestinal barrier function: Molecular regulation and disease pathogenesis, J. Allergy Clin. Immunol, vol.124, pp.3-20, 2009. ,
Monoclonal and Single Domain Antibodies Targeting ?-Integrin Subunits Block Sexual Transmission of HIV-1 in In Vitro and In Vivo Model Systems, J. Acquir. Immune Defic. Syndr, vol.69, pp.278-285, 2015. ,
The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells, PLoS Pathog, vol.9, 2013. ,
Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa, J. Virol, vol.79, pp.5762-5773, 2005. ,
Genome organization and transactivation of the human immunodeficiency virus type 2, Nature, vol.326, pp.662-669, 1987. ,
Heterosexual Anal Intercourse: Prevalence, Cultural Factors, and HIV Infection and Other Health Risks, Part I, AIDS Patient Care STDS, vol.13, pp.717-730, 1999. ,
The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention, Antiviral Res, vol.120, pp.153-164, 2015. ,
HIV-1 transmission and acute HIV-1 infection, Br. Med. Bull, vol.58, pp.109-127, 2001. ,
The impact of eicosanoids on the crosstalk between innate and adaptive immunity: the key roles of dendritic cells, Tissue Antigens, vol.65, pp.507-514, 2005. ,
Alterations in blood leucocyte adhesion molecule profiles in HIV-1 infection, Clin. Exp. Immunol, vol.117, pp.331-334, 1999. ,
Immunophysiology and pathology of inflammation in the testis and epididymis, vol.204, 2011. ,
, J Androl, vol.32, pp.625-640
Epididymitis: revelations at the convergence of clinical and basic sciences, Asian J. Androl, 2015. ,
Reverse transcriptase inhibitors as potential colorectal microbicides, Antimicrob Agents Chemother, vol.53, pp.1797-1807, 2009. ,
Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants, AIDS, vol.25, pp.1971-1979, 2011. ,
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides, Antivir. Res, vol.74, pp.111-124, 2007. ,
Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1, Immunity, vol.26, pp.257-270, 2007. ,
Infectious Human Immunodeficiency Virus Can Rapidly Penetrate a Tight Human Epithelial Barrier by Transcytosis in a Process Impaired by Mucosal Immunoglobulins, 1999. ,
, , 2001.
, Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells, J Virol, vol.75, pp.5370-5374
, Seminal Plasma HIV-1 RNA Concentration Is Strongly Associated with Altered Levels of Seminal Plasma Interferon-gamma, Interleukin-17, and Interleukin, 2014.
, AIDS Res Hum Retroviruses
Origins of HIV-infected leukocytes and virions in semen, J, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01121761
Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs, J. Virol, vol.92, 2018. ,
Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia, Immunology, vol.85, pp.475-484, 1995. ,
Investigation of the complement receptor 3 (CD11b/CD18) in human rectal epithelium, Clin Exp Immunol, vol.102, pp.384-388, 1995. ,
, , 2018.
Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants, PLOS Pathog, vol.13, p.1006402, 2017. ,
Colonic macrophage polarization in homeostasis, p.205, 2016. ,
, Am J Physiol Gastrointest Liver Physiol, vol.311, pp.59-73
Cell-to-cell infection by HIV contributes over half of virus infection, 2015. ,
Antiviral immune responses in the genital tract: clues for vaccines, Nat Rev Immunol, vol.10, pp.699-711, 2010. ,
, Dendritic Cell Migration CD302 in Mice and Humans Reveals a Role Function of the C-Type Lectin Receptor Characterization of the Expression and, 2018.
, Antimicrobial Peptides in Gastrointestinal Inflammation. Res. Int. J. Inflamm, p.11, 2010.
, Polarization profiles of human M-CSFgenerated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin, vol.281, pp.51-61, 2013.
Requirement for an Intact T-Cell Actin and Tubulin Cytoskeleton for Efficient Assembly and Spread of Human Immunodeficiency Virus Type 1, J. Virol, vol.81, pp.5547-5560, 2007. ,
CD4 T cell subsets in the mucosa are CD28+Ki-67-HLA-DR-CD69+ but show differential infection based on alpha4beta7 receptor expression during acute SIV infection, J. Med. Primatol, vol.38, pp.24-31, 2009. ,
, , 2012.
, Endometrial epithelial cell response to semen from HIV-infected men during different stages of infection is distinct and can drive HIV-1-long terminal repeat, AIDS, vol.26, pp.27-36
Expression, function and regulation of the intercellular adhesion molecule-1 (ICAM-1) on human intestinal epithelial cell lines, Eur. J. Immunol, vol.21, pp.2415-2421, 1991. ,
Regulation of immune responses by prostaglandin E2, J Immunol, vol.188, pp.21-28 ,
Nitric oxide is an antiadhesive molecule for leukocytes, New Horiz, vol.3, pp.93-104, 1995. ,
Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin ?M290?7 (?E?7), Eur. J. Immunol, vol.25, pp.852-856, 1995. ,
Barriers to mucosal transmission of immunodeficiency viruses, Blood, vol.118, pp.839-846, 2014. ,
A cytokine switch induced by human seminal plasma: an immune modulation with implications for sexually transmitted disease, Hum Reprod, vol.12, pp.677-681, 1997. ,
Critical Review: Immunomodulation by Seminal Factors and Implications for Male-to-Female HIV-1 Transmission, J. Acquir. Immune Defic. Syndr, vol.69, pp.131-137, 2015. ,
Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI, Retrovirology, vol.7, p.55, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00663892
RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice, Mol. Ther, vol.18, pp.370-376, 2010. ,
Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway, PLoS One, vol.9, p.96760, 2014. ,
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women, Science, vol.356, pp.938-945, 2017. ,
Inactivation of human immunodeficiency virus type 1 by the amine oxidase-peroxidase system, J. Clin. Microbiol, vol.33, pp.2054-2057, 1995. ,
Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus, J. Virol, vol.87, pp.13589-13597, 2013. ,
Human Semen or Seminal Plasma Does Not Enhance HIV-1BaL Ex Vivo Infection of Human Colonic Explants, AIDS Res. Hum. Retroviruses, vol.34, pp.459-466, 2018. ,
Mass cytometry analysis of immune cells in the brain, Nat. Protoc, vol.13, pp.377-391, 2018. ,
Tracing HIV-1 strains that imprint broadly neutralizing antibody responses, Nature, vol.561, pp.406-410, 2018. ,
Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women, PLoS One, vol.10, 2015. ,
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus, J. Virol, vol.83, pp.11196-11200, 2009. ,
Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma, AIDS, vol.26, pp.785-796, 2012. ,
URL : https://hal.archives-ouvertes.fr/ujm-00749507
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages, Proc. Natl. Acad. Sci. U. S. A, vol.96, pp.5215-5220, 1999. ,
Semen of HIV-1-Infected Individuals: Local Shedding of Herpesviruses and Reprogrammed Cytokine Network, J Infect Dis, vol.205, pp.97-105, 2011. ,
,
, HIV-1 imposes rigidity on blood and semen cytokine networks, Am J Reprod Immunol, vol.68, pp.515-521
Distribution of cell-free and cell-associated HIV surrogates in the female genital tract after simulated vaginal intercourse, J. Infect. Dis, 2012. ,
Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men, J Acquir Immune Defic Syndr, vol.59, pp.10-17, 2012. ,
Semen lactoferrin promotes CCL20 production by epithelial cells: Involvement in HIV transmission, World J. Virol, vol.3, pp.11-17, 2014. ,
HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy, Trends Microbiol, vol.23, 2015. ,
, Exosomes: Implications in HIV-1 Pathogenesis. Viruses, vol.7, pp.4093-4118, 2015.
Human semen contains exosomes with potent anti-HIV-1 activity, Retrovirology, vol.11, p.102, 2014. ,
Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system, Biomaterials, vol.32, pp.8343-8355, 2011. ,
HIV binding, penetration, and primary infection in human cervicovaginal tissue, Proc Natl Acad Sci U S A, vol.102, pp.11504-11509, 2005. ,
How does the humoral response to HIV-2 infection differ from HIV-1 and can this explain the distinct natural history of infection with these two human retroviruses?, Immunol. Lett, vol.163, pp.69-75, 2015. ,
Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission, J. Exp. Med, vol.210, pp.2813-2821, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01108608
Selective transmission of CCR5-utilizing HIV-1: the "gatekeeper" problem resolved?, Nat. Rev. Microbiol, vol.4, pp.312-317, 2006. ,
Cationic polypeptides contribute to the anti-HIV-1 activity of human seminal plasma, Faseb J, vol.23, pp.3609-3618, 2009. ,
Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells, Blood, vol.120, pp.572-580, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01372479
, The Frequency of ?4?7high Memory CD4+ T Cells, p.208, 2013.
, Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection, JAIDS J. Acquir. Immune Defic. Syndr, vol.64, pp.325-331
The M1 and M2 paradigm of macrophage activation: time for reassessment, 1000. ,
Defensins in Viral Infection and Pathogenesis, Annu. Rev. Virol, vol.4, pp.69-91, 2017. ,
Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors, PLoS Pathog, vol.6, 2010. ,
Efficacy of Tenofovir 1% Vaginal Gel in Reducing the Risk of HIV-1 and HSV-2 Infection, Clin. Med. Insights. Women's Heal, vol.7, pp.1-8, 2014. ,
Interpretation of differential gene expression results of RNA-seq data: review and integration, 2018. ,
Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus, J Acquir Immune Defic Syndr, vol.63, pp.263-271, 2013. ,
The development of rectal microbicides for HIV prevention, Expert Opin Drug Deliv, vol.11, pp.69-82, 2014. ,
Rectal microbicide development, Curr Top Microbiol Immunol, vol.383, pp.117-136, 2014. ,
Exposure of rat colonic mucosa to human semen in vivo induces mucosal cytolysis, abolishes fluid absorption and raises paracellular permeability, Clin. Sci. (Lond), vol.82, pp.277-282, 1992. ,
Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells, Nat Med, vol.8, pp.150-156, 2002. ,
DOI : 10.1038/nm0202-150
, , 2011.
, Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection, Am J Reprod Immunol, vol.65, pp.268-278
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety, J Infect Dis, vol.200, pp.599-608, 2009. ,
, Humoral immune responses to the human immunodeficiency virus type-1 (HIV, 2007.
, in the genital tract compared to other mucosal sites, J. Reprod. Immunol, vol.73, pp.86-97
Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions, Am. J. Reprod. Immunol, vol.65, pp.361-367, 2011. ,
, , p.209, 2013.
, Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells, J. Infect. Dis, vol.208, pp.1756-1767
Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus, J-Virol, vol.63, pp.22-538, 1989. ,
New model for studying the migration of immune cells into intestinal epithelial cell monolayers, Cytotechnology, vol.43, pp.57-64, 2003. ,
MABGEL 1: First Phase 1 Trial of the Anti-HIV-1 Monoclonal Antibodies 2F5, 4E10 and 2G12 as a Vaginal Microbicide, PLoS One, vol.9, 2014. ,
Developmental origin and maintenance of distinct testicular macrophage populations, J. Exp. Med, vol.214, pp.2829-2841, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01764674
Semen inhibits Zika virus infection of cells and tissues from the anogenital region, Nat. Commun, vol.9, p.2207, 2018. ,
Zinc reduces epithelial barrier compromise induced by human seminal plasma, PLoS One, vol.12, 2017. ,
Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus, Retrovirology, vol.10, p.148, 2013. ,
, Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection, vol.131, pp.1059-1071, 2007.
Macrophage Polarization, Annu. Rev. Physiol, vol.79, pp.541-566, 2017. ,
Pathogenesis of HIV Infection, Infect Dis Rep, vol.5, p.6, 2013. ,
Immuno-competent cells in the murine epididymis, Int. J. Androl, vol.12, pp.85-94, 1989. ,
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation, PLoS Pathog, vol.6, p.1000852, 2010. ,
HIV-1 gp120 induces TLR2-and TLR4-mediated innate immune activation in human female genital epithelium, J Immunol, vol.191, pp.4246-4258, 2013. ,
Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes, Appl. Microbiol. Biotechnol, vol.99, pp.10399-10414, 2015. ,
Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection, Cell Mol Immunol, vol.11, pp.410-427, 2014. ,
Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention, J. Clin. Pharmacol, vol.54, pp.574-583, 2014. ,
The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing, Hum Reprod, vol.19, pp.2289-2297, 2004. ,
The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro, Int-J-STD-AIDS, vol.6, pp.267-4624, 1995. ,
CD4-Negative cells bind human immunodeficiency virus type 1 and efficiently transfer virus to T cells, J. Virol, vol.74, pp.8550-8557, 2000. ,
Distinct Cytokine Patterns in Semen Influence Local HIV Shedding and HIV Target Cell Activation, J. Infect. Dis, vol.209, pp.1174-1184, 2014. ,
Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)-and Semen-mediated Enhancement of HIV-1 Infection, J. Biol. Chem, vol.285, pp.35488-35496, 2010. ,
,
, HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4-cell lines, AIDS, vol.5, pp.275-281
Cytokine responses and epithelial function in the intestinal mucosa, Cell. Mol. Life Sci, vol.73, pp.4203-4212, 2016. ,
A review of the physical and chemical properties of human semen and the formulation of a semen simulant, J Androl, vol.26, pp.459-469, 2005. ,
Subcompartmentalization of HIV-1 Quasispecies between Seminal Cells and Seminal Plasma Indicates Their Origin in Distinct Genital Tissues, AIDS Res. Hum. Retroviruses, vol.18, pp.1271-1280, 2002. ,
Expression of adhesion molecules and CD28 on T lymphocytes during human immunodeficiency virus infection, Clin. Diagn. Lab. Immunol, vol.5, pp.583-587, 1998. ,
Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction, J. Clin. Invest, vol.88, pp.1605-1612, 1991. ,
Interferon-gamma up-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 and recruits lymphocytes into the vagina of immune mice challenged with herpes simplex virus-2, Immunology, vol.99, pp.540-545, 2000. ,
Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus, J Virol, vol.75, pp.6710-6713, 2001. ,
Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model, Sex. Transm. Dis, vol.29, pp.581-587, 2002. ,
, , 2015.
, Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study
Studies of adhesion of lymphocytic cells: implications for sexual transmission of human immunodeficiency virus, Biol-Reprod, vol.48, pp.431-3363, 1993. ,
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice, Blood, vol.95, pp.3289-3296, 2000. ,
, The third dimension: new developments in cell culture models for colorectal research
Detection of human immunodeficiency virus-1 RNA and DNA by extractive and in situ PCR in unprocessed semen and seminal fractions isolated by semen-washing procedure, Hum. Reprod, vol.21, pp.1525-1530, 2006. ,
Nonoxynol-9 enhances rectal infection by herpes simplex virus in mice, Contraception, vol.57, pp.341-348, 1998. ,
Nonoxynol-9 causes rapid exfoliation of sheets of rectal epithelium, Contraception, vol.62, pp.149-154, 2000. ,
Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs, Contraception, vol.70, pp.107-110, 2004. ,
Spermatozoon as a vehicle for HIV-1 and other viruses: a review, Mol. Reprod. Dev, vol.56, pp.238-242, 2000. ,
Macrophage Migration and Its Regulation by CSF-1, Int. J. Cell Biol, vol.2012, pp.1-12, 2012. ,
Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men, Hum Reprod, vol.22, pp.2928-2935, 2007. ,
Depletion of CD4 + T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy, 2009. ,
Characteristics and quantities of HIV host cells in human genital tract secretions, J. Infect. Dis, vol.210, pp.609-624, 2014. ,
Use of (alternative) coreceptors for HIV entry, Curr Opin HIV AIDS, vol.7, pp.440-449, 2012. ,
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery, J. Reprod. Immunol, vol.125, pp.16-24, 2018. ,
Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production, 2006. ,
Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages, AIDS Res Hum Retroviruses, vol.30, pp.241-249, 2014. ,
T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols, PLoS One, vol.10, 2015. ,
Microscopic evidence against HIV-1 infection of germ cells or attachment to sperm, J Reprod Immunol, vol.44, pp.57-77, 1999. ,
T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen, J Infect Dis, vol.176, pp.960-968, 1997. ,
Detection of HIV-1-specific CTLs in the semen of HIV-infected individuals, J Immunol, vol.161, pp.4406-4410, 1998. ,
Role of Semen in Altering the Balance Between Inflammation and Tolerance in the Female Genital Tract: Does it Contribute to HIV Risk?, Viral Immunol, vol.27, pp.200-206, 2014. ,
Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with men, South African Med. J, vol.104, p.49, 2013. ,
Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue, Mediators Inflamm, p.7650260, 2016. ,
Prostaglandins in semen compromise the immune response against sexually transmitted pathogens, Med. Hypotheses, vol.83, pp.208-210, 2014. ,
Seminal plasma protects human spermatozoa and pathogenic yeasts from capture by dendritic cells, Hum. Reprod, vol.26, pp.987-999, 2011. ,
Dendritic Cells Shuttle Microbes Across Gut Epithelial Monolayers, Immunobiology, vol.204, pp.572-581, 2001. ,
Rapid dissemination of SIV follows multisite entry after rectal inoculation, PLoS One, vol.6, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00636297
A Seminal Finding for Understanding HIV Transmission, Cell, vol.131, pp.1044-1046, 2007. ,
DOI : 10.1016/j.cell.2007.11.030
URL : https://doi.org/10.1016/j.cell.2007.11.030
The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection, J Virol, vol.83, pp.73-80, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02142246
Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection, Cell Host Microbe, vol.10, pp.541-550, 2011. ,
DOI : 10.1016/j.chom.2011.10.010
URL : https://doi.org/10.1016/j.chom.2011.10.010
Interaction of fibronectin with semen amyloids synergistically enhances HIV infection, J Infect Dis, vol.210, pp.1062-1066, 2014. ,
DOI : 10.1093/infdis/jiu220
URL : https://academic.oup.com/jid/article-pdf/210/7/1062/18070641/jiu220.pdf
Seminal fluid and fertility in women, Fertil. Steril, vol.106, pp.511-519, 2016. ,
DOI : 10.1016/j.fertnstert.2016.07.1101
Transforming growth factor beta--a mediator of immune deviation in seminal plasma, J Reprod Immunol, vol.57, pp.109-128, 2002. ,
Seminal fluid and the generation of regulatory T cells for embryo implantation, Am J Reprod Immunol, vol.69, pp.315-330, 2013. ,
Structure, function and antagonism of semen amyloids, Chem. Commun. (Camb), vol.54, pp.7557-7569, 2018. ,
Cell surface phenotype and cytokine secretion in Caco-2 cell cultures: increased RANTES production and IL-2 transcription upon stimulation with IL-1beta, Tissue Cell, vol.33, pp.570-579, 2001. ,
Seminal plasma proteins: what role do they play?, Am J Reprod Immunol, vol.66, pp.11-22, 2011. ,
Identification of genital tract markers in the human seminal plasma using an integrative genomics approach, Hum. Reprod, vol.28, pp.199-209, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00814146
A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa, PLoS One, vol.9, 2014. ,
HIV transmission biology: translation for HIV prevention, AIDS, vol.29, pp.2219-2227, 2015. ,
DOI : 10.1097/qad.0000000000000845
URL : http://europepmc.org/articles/pmc4640979?pdf=render
Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro, Am J Pathol, vol.169, pp.2094-2103, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00653727
Human seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN, J Virol, vol.81, pp.13723-13734, 2007. ,
Semen clusterin is a novel DC-SIGN ligand, J Immunol, vol.187, pp.5299-5309, 2011. ,
DOI : 10.4049/jimmunol.1101889
URL : https://hal.archives-ouvertes.fr/hal-00871196
Human seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN, J. Virol, vol.81, pp.13723-13734, 2007. ,
Etiologies of sperm oxidative stress, Int. J. Reprod. Biomed, vol.14, pp.231-240, 2016. ,
DOI : 10.29252/ijrm.14.4.231
URL : http://journals.ssu.ac.ir/ijrmnew/files/site1/user_files_b8a77b/admin-A-10-1-148-06dfeef.pdf
, , 2012.
, Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection, J. Infect. Dis, vol.205, pp.1248-1257
Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures, AIDS, vol.21, pp.377-379, 2007. ,
Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells, Mol Hum Reprod, vol.8, pp.1065-1070, 2002. ,
CCR5 expression is elevated in cervical cancer cells and is up-regulated by seminal plasma, MHR Basic Sci. Reprod. Med, vol.20, pp.1144-1157, 2014. ,
Infection of macaques after vaginal exposure to cellassociated simian immunodeficiency virus, J Infect Dis, vol.202, pp.337-344, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00657429
Heparan sulfate proteoglycans, Cold Spring Harb. Perspect. Biol, vol.3, 2011. ,
Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples, Hum. Reprod, vol.22, pp.772-777, 2007. ,
T cell differentiation antigens on lymphocytes in the human intestinal lamina propria, J. Immunol, vol.149, pp.2816-2822, 1992. ,
Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation, Mediators Inflamm, vol.2015, pp.1-23, 2015. ,
The colon: from banal to brilliant, Toxicol. Pathol, vol.42, pp.67-81, 2014. ,
Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells, Mol Hum Reprod, vol.13, pp.491-501, 2007. ,
Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus, J Immunol, vol.188, pp.2445-2454, 2012. ,
Male circumcision for the prevention of human immunodeficiency virus (HIV) acquisition: a meta-analysis, BJU Int, vol.121, pp.515-526, 2018. ,
Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection, J Virol, vol.83, pp.3258-3267, 2009. ,
Early HIV-1 target cells in human vaginal and ectocervical mucosa, Am J Reprod Immunol, vol.65, pp.261-267, 2010. ,
GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium, J Immunol, vol.184, pp.3648-3655, 2010. ,
Dendritic cells transmit HIV-1 through human small intestinal mucosa, J. Leukoc. Biol, vol.87, pp.663-670, 2010. ,
, Interactions between HIV-1 and Mucosal Cells in the Female Reproductive Tract, 2014.
HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding, J Immunol, vol.175, pp.4789-4796, 2005. ,
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy, Nature, vol.477, pp.95-98, 2011. ,
HIV preexposure prophylaxis: An essential, safe and effective prevention tool for sexual health, 2018. ,
Study on the origin of seminal leucocytes using split ejaculate technique and the effect of leucocytospermia on sperm characteristics, Urol Int, vol.61, pp.95-100, 1998. ,
The characterisation of non-sperm cells in the ejaculates of fertile men using transmission electron microscopy, Andrologia, vol.21, pp.319-333, 1989. ,
The prostate as a reservoir for HIV-1, AIDS, vol.18, pp.1600-1602, 2004. ,
, Presence of HIV-1, 2004.
, Neutralizing IgA Antibodies in Primary HIV-1 Infected Patients. Scand, J. Infect. Dis, vol.36, pp.663-669
Mass Cytometry: Single Cells, Many Features, Cell, vol.165, pp.780-791, 2016. ,
Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects, J. Acquir. Immune Defic. Syndr. Hum. Retrovirol, vol.17, pp.327-331, 1998. ,
, , p.216
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4+ T-lymphocytes, Virology, vol.391, pp.203-211, 2009. ,
, Colorectal mucus binds DC-SIGN and inhibits HIV-1 trans-infection of CD4+ T-lymphocytes, vol.10, 2015.
Singlet oxygen (1O2)-oxidazable lipids in the HIV membrane, new targets for AIDS therapy?, Med Hypotheses, vol.60, pp.575-577, 2003. ,
gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission, J Immunol, vol.179, pp.3126-3132, 2007. ,
Seminal plasma RANTES levels positively correlate with seminal plasma HIV-1 RNA levels, AIDS, vol.13, pp.2169-2171, 1999. ,
The role of secretory antibodies in infection immunity, Nat. Rev. Microbiol, vol.8, pp.656-667, 2010. ,
Early SIV Dissemination After Intrarectal SIVmac251 Challenge Was Associated With Proliferating VirusSusceptible Cells in the Colorectum, J. Acquir. Immune Defic. Syndr, vol.71, pp.353-358, 2016. ,
Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques, Mucosal Immunol, vol.11, pp.1219-1229, 2018. ,
Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection, PLoS One, vol.8, p.59777, 2013. ,
Dissimilarities in the metabolism of antiretroviral drugs used in HIV pre-exposure prophylaxis in colon and vagina tissues, Biochem. Pharmacol, vol.86, pp.979-990, 2013. ,
Infection of semen-producing organs by HIV and role in virus dissemination, Med Sci, vol.26, pp.861-868, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00669524
HIV infection of the male genital tract--consequences for sexual transmission and reproduction, Int J Androl, vol.33, pp.98-108, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00516571
Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo, Retrovirology, vol.5, p.119, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00354718
Infection of semen-producing organs by SIV during the acute and chronic stages of the disease, PLoS One, vol.3, p.1792, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00521466
Current State of Microbicide Development, Clin. Pharmacol. Ther, 2018. ,
Should probiotics be tested on ex vivo organ culture models?, Gut Microbes, vol.3, pp.442-448, 2012. ,
Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia, J Virol, vol.86, pp.2556-2570, 2011. ,
, Mucosal HIV Infection. Pathobiology, vol.66, pp.145-150, 1998.
, report on the global AIDS epidemic, UNAIDS, 2013.
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen, Nat. Commun, vol.5, p.3508, 2014. ,
Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro models, Virchows Arch, vol.443, pp.774-781, 2003. ,
Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection, AIDS, vol.30, pp.193-201, 2016. ,
Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid, J Immunol, vol.175, pp.7560-7567, 2005. ,
The biologic significance of white blood cells in semen, Fertil. Steril, vol.63, pp.1143-1157, 1995. ,
Characterization of the Micro-Environment of the Testis that Shapes the Phenotype and Function of Testicular Macrophages, J. Immunol, vol.198, pp.4327-4340, 2017. ,
Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis, 2015. ,
Semen Exosomes Promote Transcriptional Silencing of HIV-1 by Disrupting NF-?B/Sp1/Tat Circuitry, J. Virol, vol.92, 2018. ,
Durable Knockdown and Protection From HIV Transmission in Humanized Mice Treated With Gel-formulated CD4 Aptamer-siRNA Chimeras, Mol. Ther, vol.21, pp.1378-1389, 2013. ,
A major advance in ex vivo intestinal organ culture, Gut, vol.61, pp.961-962, 2012. ,
, , 2007.
Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission, Trends Mol. Med, vol.14, pp.12-19, 2008. ,
The biologic significance of white blood cells in semen, Fertil Steril, vol.63, pp.1143-1157, 1995. ,
Immunohistologic characterization and quantitation of leukocyte subpopulations in human semen, Fertil Steril, vol.49, pp.497-504, 1988. ,
Buffering capacity of human semen, Fertil Steril, vol.46, pp.114-119, 1986. ,
Dendritic-cell interactions with HIV: infection and viral dissemination, Nat Rev Immunol, vol.6, pp.859-868, 2006. ,
Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells, J Virol, vol.66, pp.4848-4854, 1992. ,
Effectiveness of semen washing to prevent human immunodeficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis, Fertil. Steril, vol.105, pp.645-655, 2016. ,
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection, Nat Med, vol.3, pp.1369-1375, 1997. ,
gp120-independent HIV infection of cells derived from the female reproductive tract, brain, and colon, J. Acquir. Immune Defic. Syndr, vol.43, pp.127-136, 2006. ,
Identification and function analysis of macrophages subsets in chronically inflamed human epididymis, 2017. ,
Clinical significance of sCD163 and its possible role in asthma (Review), Mol. Med. Rep, vol.15, pp.2931-2939, 2017. ,
The Semen pH Affects Sperm Motility and Capacitation, PLoS One, vol.10, 2015. ,
The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry, Mucosal Immunol, vol.11, pp.158-171 ,
HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells, PLoS Pathog, vol.7, 2011. ,
Le sperme « inflammatoire »: ses relations avec la fertilité, Andrologie, vol.19, pp.35-44, 2009. ,