Développement d’une méthode de déconvolution pharmacophorique pour la découverte accélérée d’antipaludiques chez les Rhodophytes

Abstract : Malaria is responsible for 445 000 deaths in 2016. The emergence and the spread of resistant P. falciparum to artemisinin-based combinations is a major health problem in South-East Asia. Research must continue to find compounds with a novel mechanism of action. The apicoplast is an interesting target. It is a Plasmodium organelle derived from a secondary endosymbiosis with a red alga. Red algae could be a special source of new antiplasmodial compounds targeting the isoprenoid biosynthesis pathway in the apicoplast. This thesis focuses on bioactive secondary metabolites identification via a new analytical strategy. A computer program called Plasmodesma was created and achieves an automatic differential analysis of 1H-1H and 1H-13C 2D NMR spectra. Bioactive compounds are isolated and identified by hyphenated HPLC-SPE-NMR. The presence of different classes of compounds including sterols could explain the antiplasmodial activity in studied the red algae species.
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Laure Margueritte. Développement d’une méthode de déconvolution pharmacophorique pour la découverte accélérée d’antipaludiques chez les Rhodophytes. Chimie analytique. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF048⟩. ⟨tel-02138926⟩

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