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, Raffaella Soleti 1 , Luisa Vergori 1 , Grégory Hilairet 1 , Morgane Le Mao 2 , Naig Gueguen 2 , Salim Khiati 2 , Ludovic Clarion 4 , Norbert Bakalara 5 , Stéphane Germain 3* , Guy Lenaers 2* , Ramaroson Andriantsitohaina 1 ?* 1. INSERM UMR1063, Stress Oxydant et Pathologies Métaboliques

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, SAS, p.34090

. Inserm-u-1051, * Co-last authors ? Corresponding author: Ramaroson Andriantsitohaina, INSERM UMR1063, Stress Oxydant et Pathologies Métaboliques, p.49933

F. Angers, Phone: +33 2 44 68 85 80. E-mail: ramaroson.andriantsitohaina@univ-angers.fr Running Title: Anti-angiogenic properties of PST 3.1a. added at 4 °C overnight to allow antibody interaction with VEGFR2 or Gal-1 protein

, Subsequently, the tubes containing the immunoprecipitates were centrifuged, and the supernatants were eliminated. Pellets were washed two times with 100 µL lysis buffer diluted to 1:5 with PBS

, Gel-loading bugger (15 µL) was then added to the pellets. The tubes were heated for 10 min at 70

, The gel was trans-blotted to perform Western analysis for VEGFR2 and Gal-1 proteins as described above. Data analysis Data are represented as mean ± SEM, °C, after which proteins were separated on 4-12% SDS-PAGE gel

, Statistical analyses were performed either using one-way ANOVA (parametric) for all in vitro angiogenesis experiments, or using Mann-Whitney U-tests (non-parametric) for other experiments, using Prism software package 5.00 (GraphPAD Software, CA)

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