P. J. Atherton and K. Smith, Muscle protein synthesis in response to nutrition and exercise, J Physiol, vol.590, issue.5, pp.1049-57, 2012.

G. Biolo, K. D. Tipton, S. Klein, and R. R. Wolfe, An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein, Am J Physiol, vol.273, issue.1, pp.122-131, 1997.

Y. Boirie, M. Dangin, P. Gachon, M. P. Vasson, J. L. Maubois et al., Slow and Fast dietary proteins differently modulate postprandial protein accretion, Proc. Natl. Acad. Sci. USA, vol.94, pp.14930-14935, 1997.
DOI : 10.1073/pnas.94.26.14930

URL : http://www.pnas.org/content/94/26/14930.full.pdf

J. D. Bosse and B. M. Dixon, Dietary protein in weight management: a review proposing protein spread and change theories, Nutr Metab (Lond), vol.12, issue.1, p.81, 2012.

D. G. Candow, N. C. Burke, T. Smith-palmer, and D. G. Burke, Effect of whey and soy protein supplementation combined with resistance training in young adults, Int J Sport Nutr Exerc Metab, vol.16, issue.3, pp.233-277, 2006.

N. M. Cermak, P. T. Res, L. Cpgm-de-groot, W. H. Saris, and L. J. Van-loon, Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis, Am J Clin Nutr, vol.96, pp.1454-64, 2012.

P. J. Cribb, A. D. Williams, M. F. Carey, and A. Hayes, The effect of whey isolate and resistance training on strength, body composition, and plasma glutamine, Int J Sport Nutr Exerc Metab, vol.16, pp.494-509, 2006.

M. Dangin, Y. Boirie, C. Garcia-rodenas, P. Gachon, J. Fauquant et al., The digestion rate of protein is an independent regulating factor of postprandial protein retention, Am J Physiol Endocrinol Metab, vol.280, issue.2, pp.340-348, 2001.

M. Dangin, Y. Boirie, C. Guillet, and B. Beaufrère, Influence of the protein digestion rate on protein turnover in young and elderly subjects, J Nutr, vol.132, issue.10, pp.3228-3261, 2002.

K. M. Dodd and A. R. Tee, Leucine and mTORC1: a complex relationship, Am J Physiol Endocrinol Metab, vol.302, issue.11, pp.1329-1371, 2012.

K. Dideriksen, S. Reitelseder, and L. Holm, Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans, Nutrients, vol.5, issue.3, pp.852-76, 2013.

B. Esmarck, J. L. Andersen, S. Olsen, E. A. Richter, M. Mizuno et al., Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans, J Physiol, vol.535, pp.301-312, 2001.

J. W. Hartman, J. E. Tang, S. B. Wilkinson, M. A. Tarnopolsky, R. L. Lawrence et al., Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters, Am J Clin Nutr, vol.86, pp.373-81, 2007.

S. R. Kimball and L. S. Jefferson, Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis, J Nutrition, vol.136, issue.1, pp.227-258, 2006.

W. J. Kraemer, K. Adams, E. Cafarelli, M. H. Stone, G. A. Dudley et al., American College of sports medicine position stand: Progression models in resistance training for healthy adults, Med Sci Sport Exercise, vol.34, issue.2, pp.364-80, 2009.

D. K. Levenhagen, J. D. Gresham, M. G. Carlson, D. J. Maron, M. J. Borel et al., Postexercise nutrient intake timing in humans is critical to recovery of leg glucose and protein homeostasis, Am J Physiol Endocrinol Metab, vol.280, pp.982-93, 2001.

C. J. Mitchell, R. A. Mcgregor, R. F. Souza, E. B. Thorstensen, J. F. Markworth et al., Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men, Nutrients, vol.7, issue.10, pp.8685-99, 2015.

F. Naclerio and E. Larumbe-zabala, Effects of Whey Protein Alone or as Part of a Multi-ingredient Formulation on Strength, Fat-Free Mass, or Lean Body Mass in Resistance-Trained Individuals: A Meta-analysis, Sports Med, vol.46, issue.1, pp.125-162, 2016.

B. Pennings, R. Koopman, M. Beelen, J. M. Senden, H. M. Saris et al., Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men, Am. J. Clin. Nutr, vol.93, pp.322-353, 2011.

S. Reitelseder, J. Agergaard, S. Doessing, I. C. Helmark, P. Lund et al., Whey and casein labeled with L-[1-13C] leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion, Am J Physiol Endocrinol Metab, vol.300, pp.231-273, 2011.

J. E. Tang, D. R. Moore, G. W. Kujbida, M. A. Tarnopolsky, and S. M. Phillips, Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men, J Appl Physiol, vol.107, pp.987-92, 2009.

K. D. Tipton, T. A. Elliott, M. G. Cree, S. E. Wolf, A. P. Sanford et al., Ingestion of Casein and Whey proteins result in muscle anabolism after resistance exercise, Med. Sci. Sports Exerc, vol.36, issue.12, pp.2073-81, 2004.

S. B. Wilkinson, M. A. Tarnopolsky, M. J. Macdonald, J. R. Macdonald, D. Armstrong et al., Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage, Am J Clin Nutr, vol.85, pp.1031-1071, 2007.

D. S. Willoughby, J. R. Stout, and C. D. Wilborn, Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength, Amino Acids, vol.32, issue.4, pp.467-77, 2007.

J. Antonio, A. Ellerbroek, C. Peacock, and T. Silver, Casein Protein Supplementation in Trained Men and Women: Morning versus Evening, Int J Exerc Sci, vol.10, issue.3, pp.479-486, 2017.

J. L. Areta, L. M. Burke, M. L. Ross, D. M. Camera, D. West et al., Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis, J Physiol, vol.591, pp.2319-2331, 2013.

N. M. Cermak, P. T. Res, L. C. De-groot, W. H. Saris, and L. J. Van-loon, Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis, Am J Clin Nutr, vol.96, pp.1454-64, 2012.

K. Häkkinen, R. U. Newton, S. E. Gordon, M. Mccormick, J. S. Volek et al., Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and older men, J Gerontol A Biol Sci Med Sci, vol.53, issue.6, pp.415-438, 1998.

M. Hopkinswg, . Sw, A. M. Batterham, and J. Hanin, Progressive statistics for studies in sports medicine and exercise science, Med Sci Sports Exerc, vol.41, pp.3-13, 2009.

R. Jager, C. M. Kerksick, B. I. Campbell, P. J. Cribb, S. D. Wells et al., International Society of Sports Nutrition Position Stand: protein and exercise, J Int Soc Sports Nutr, vol.14, p.20, 2017.

P. V. Komi, Strength and power in sport. Vol III of the encyclopaedia of sports medicine. An IOC medical commission production, p.540, 2003.

C. J. Mitchell, T. A. Churchward-venne, G. Parise, L. Bellamy, S. K. Baker et al., Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young men, PLoS One, vol.9, issue.2, p.89431, 2014.

N. Mitsiopoulos, R. N. Baumgartner, S. B. Heymsfield, W. Lyons, D. Gallagher et al., , 1998.

, Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computed tomography, J Appl Physiol, vol.85, pp.115-122

F. Naclerio and E. Larumbe-zabala, Effects of Whey Protein Alone or as Part of a Multi-ingredient Formulation on Strength, Fat-Free Mass, or Lean Body Mass in Resistance-Trained Individuals: A Meta-analysis, Sports Med, vol.46, issue.1, pp.125-162, 2016.

P. T. Res, B. Groen, B. Pennings, M. Beelen, G. A. Wallis et al., Protein ingestion before sleep improves postexercise overnight recovery, Med Sci Sports Exerc, vol.44, pp.1560-1569, 2012.

T. Snijders, P. T. Res, J. S. Smeets, S. Van-vliet, J. Van-kranenburg et al., Protein Ingestion before Sleep Increases Muscle Mass and Strength Gains during Prolonged Resistance-Type Exercise Training in Healthy Young Men, J Nutr, vol.145, issue.6, pp.1178-1184, 2015.

J. Trommelen and L. Van-loon, Pre-sleep protein ingestion to improve the skeletal muscle adaptive response to exercise training, Nutrients, vol.8, p.763, 2016.

, Nous espérons modestement que la recherche menée au cours de cette thèse influence les pratiques de supplémentation en protéines. Les suppléments protéiques sont communément utilisés chez les sportifs amateurs comme professionnels. Leur usage est souvent excessif. Nos études confirment des notions

, Dans ce cadre, l'optimisation de l'apport protéique reste primordiale. Cependant, un autre champ d'études se dégage, à savoir l'évaluation du niveau de réponse individuelle à un exercice

, De plus, afin de maximiser le gain de force anisométrique, il pourra être recommandé de consommer 30g de caséine 3h après la fin de la séance de musculation. Ces apports supplémentaires doivent s'inscrire dans la consommation protéique quotidienne, D'après nos résultats, la prise de 20g de protéines à assimilation rapide

, Durant les périodes d'entraînement sans développement hypertrophique, il conviendra de réduire les apports protéiques à 1,3-1,5g/kg/j, et en cas de non-activité physique de maintenir des apports compris entre 0,8-1g/kg/J. L'augmentation de l'apport protéique permet de majorer les réponses hypertrophiques des muscles

, Med Sci Sports Exerc, vol.41, issue.3, pp.687-708, 2009.

T. Abe, S. Fukashiro, Y. Harada, and K. Kawamoto, Relationship between sprint performance and muscle fascicle length in female sprinters, J Physiol Anthropol Appl Human Sci, vol.20, issue.2, pp.141-147, 2001.

O. A. Adegoke, A. Abdullahi, and P. Tavajohi-fini, mTORC1 and the regulation of skeletal muscle anabolism and mass, Appl Physiol Nutr Metab. 2012, vol.37, issue.3, pp.395-406

A. F. Aguiar, A. P. Grala, R. A. Da-silva, L. F. Soarescaldeira, F. L. Pacagnelli et al.,

D. K. Silva, W. B. De-andrade, and M. C. Balvedi,

, Amino Acids. 2017, vol.49, issue.7, pp.1255-1262

V. Aguilar, S. Alliouachene, A. Sotiropoulos, A. Sobering, Y. Athea et al., S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase, Cell Metab. 2007, vol.5, issue.6, pp.476-487

J. P. Ahtiainen, A. Pakarinen, M. Alen, and W. Kraemer,

J. Hakkinen and K. , Muscle hypertrophy, hormonal adaptations and strength development during strength training in strength-trained and untrained men, Eur J Appl Physiol, vol.89, issue.6, pp.555-563, 2003.

D. G. Allen, G. D. Lamb, and H. Westerblad, Skeletal muscle fatigue: cellular mechanisms, Physiol Rev, vol.88, issue.1, pp.287-332, 2008.

D. L. Allen, D. S. Hittel, and A. C. Mcpherron, Expression and function of myostatin in obesity, diabetes, and exercise adaptation, Med Sci Sports Exerc, vol.43, issue.10, pp.1828-1835, 2011.

F. H. Andrade, M. B. Reid, D. G. Allen, and H. Westerblad, Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse, J Physiol, vol.509, issue.2, pp.565-575, 1998.

J. C. Anthony, T. G. Anthony, S. R. Kimball, and L. S. Jefferson, Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine, J Nutr, vol.131, issue.3, pp.856-860, 2001.

J. Antonio, A. Ellerbroek, T. Silver, S. Orris, M. Scheiner et al., A high protein diet (3.4 g/kg/d) combined with a heavy resistance training program improves body composition in healthy trained men and women--a follow-up investigation, J Int Soc Sports Nutr. 2015, vol.12, p.39

J. Antonio, A. Ellerbroek, C. Peacock, and T. Silver, Casein Protein Supplementation in Trained Men and Women: Morning versus Evening, Int J Exerc Sci. 2017, vol.10, issue.3, pp.479-486

M. Aperghis, C. P. Velloso, M. Hameed, T. Brothwood, L. Bradley et al., Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH, Growth Horm IGF Res, vol.19, issue.1, pp.61-67, 2009.

A. A. Aragon and B. J. Schoenfeld, Nutrient timing revisited: is there a post-exercise anabolic window?, J Int Soc Sports Nutr. 2013, vol.10, issue.1, p.5

J. L. Areta, L. M. Burke, M. L. Ross, D. M. Camera, D. W. West et al., Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis, J Physiol, vol.591, issue.9, pp.2319-2331, 2013.

P. J. Atherton, T. Etheridge, P. W. Watt, D. Wilkinson, A. Selby et al., Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

, Am J Clin Nutr, vol.92, issue.5, pp.1080-1088, 2010.

P. J. Atherton and K. Smith, Muscle protein synthesis in response to nutrition and exercise, J Physiol. 2012, vol.590, issue.5, pp.1049-1057

P. J. Atherton, K. Smith, T. Etheridge, D. Rankin, and M. J. Rennie, Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells, Amino Acids, vol.38, issue.5, pp.1533-1539, 2010.

N. Babault, K. Desbrosses, M. S. Fabre, A. Michaut, and M. Pousson, Neuromuscular fatigue development during maximal concentric and isometric knee extensions, J Appl Physiol, vol.100, issue.3, pp.780-785, 1985.

P. Balagopal, J. C. Schimke, P. Ades, D. Adey, and K. S. Nair, Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise, Am J Physiol Endocrinol Metab, vol.280, issue.2, pp.203-208, 2001.

M. Barany, ATPase activity of myosin correlated with speed of muscle shortening, J Gen Physiol, vol.50, issue.6, pp.197-218, 1967.

M. Beelen, R. Koopman, A. P. Gijsen, H. Vandereyt, A. K. Kies et al.,

J. , Protein coingestion stimulates muscle protein synthesis during resistance-type exercise, Am J Physiol Endocrinol Metab, vol.295, issue.1, pp.70-77, 2008.

D. G. Behm and D. G. Sale, Velocity specificity of resistance training, Sports Med. 1993, vol.15, issue.6, pp.374-388

A. M. Bellinger, M. Mongillo, and A. R. Marks, Stressed out: the skeletal muscle ryanodine receptor as a target of stress, J Clin Invest, vol.118, issue.2, pp.445-453, 2008.

W. M. Bennet, A. A. Connacher, C. M. Scrimgeour, R. T. Jung, and M. J. Rennie, Euglycemic hyperinsulinemia augments amino acid uptake by human leg tissues during hyperaminoacidemia, Am J Physiol, vol.259, issue.2, pp.185-194, 1990.

S. Bhasin, T. W. Storer, N. Berman, K. E. Yarasheski, B. Clevenger et al.,

J. Casaburi and R. , Testosterone replacement increases fat-free mass and muscle size in hypogonadal men, J Clin Endocrinol Metab, vol.82, issue.2, pp.407-413, 1997.

S. Bhasin, L. Woodhouse, and T. W. Storer, Proof of the effect of testosterone on skeletal muscle, J Endocrinol, vol.170, issue.1, pp.27-38, 2001.

A. X. Bigard, F. Lienhard, D. Merino, and B. Serrurier,

G. Biolo, D. Fleming, R. Y. Wolfe, and R. R. , Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle, J Clin Invest, vol.95, issue.2, pp.811-819, 1995.

G. Biolo, S. P. Maggi, B. D. Williams, K. D. Tipton, and R. Wolfe, Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans, Am J Physiol, vol.268, issue.3, pp.514-520, 1995.

G. Biolo, K. D. Tipton, S. Klein, and R. R. Wolfe, An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein, Am J Physiol, vol.273, issue.1, pp.122-129, 1997.

G. Biolo, B. D. Williams, R. Y. Fleming, and R. R. Wolfe, Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise, Diabetes, vol.48, issue.5, pp.949-957, 1999.
DOI : 10.2337/diabetes.48.5.949

S. P. Bird, K. M. Tarpenning, and F. E. Marino, Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men, Eur J Appl Physiol, vol.97, issue.2, pp.225-238, 2006.

S. P. Bird, K. M. Tarpenning, and F. E. Marino, Liquid carbohydrate/essential amino acid ingestion during a short-term bout of resistance exercise suppresses myofibrillar protein degradation, Metabolism. 2006, vol.55, issue.5, pp.570-577

E. M. Blanchard and R. J. Solaro, Inhibition of the activation and troponin calcium binding of dog cardiac myofibrils by acidic pH, Circ Res, vol.55, issue.3, pp.382-391, 1984.

S. C. Bodine, T. N. Stitt, M. Gonzalez, W. O. Kline, G. L. Stover et al., Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo, Nat Cell Biol, vol.3, issue.11, pp.1014-1019, 2001.

Y. Boirie, M. Dangin, P. Gachon, M. P. Vasson, J. L. Maubois et al., Slow and fast dietary proteins differently modulate postprandial protein accretion, Proc Natl Acad Sci, vol.94, issue.26, pp.14930-14935, 1997.
DOI : 10.1073/pnas.94.26.14930

URL : http://www.pnas.org/content/94/26/14930.full.pdf

P. Bond, Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance, J Int Soc Sports Nutr, vol.13, p.8, 2016.

E. Borsheim, A. Aarsland, and R. R. Wolfe, Effect of an amino acid, protein, and carbohydrate mixture on net muscle protein balance after resistance exercise

, Int J Sport Nutr Exerc Metab. 2004, vol.14, issue.3, pp.255-271

J. D. Bosse and B. Dixon, Dietary protein in weight management: a review proposing protein spread and change theories, Nutr Metab
DOI : 10.1186/1743-7075-9-81

URL : https://nutritionandmetabolism.biomedcentral.com/track/pdf/10.1186/1743-7075-9-81

R. Bottinelli, M. Canepari, M. A. Pellegrino, and C. Reggiani, Force-velocity properties of human skeletal muscle fibres: myosin heavy chain isoform and temperature dependence, J Physiol, vol.495, issue.2, pp.573-586, 1996.
DOI : 10.1113/jphysiol.1996.sp021617

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160815/pdf

H. Brahm, K. Piehl-aulin, and B. Saltin, Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise. Calcif Tissue Int, vol.60, pp.175-180, 1997.

D. Breuille, F. Rose, M. Arnal, C. Melin, and C. Obled, Sepsis modifies the contribution of different organs to whole-body protein synthesis in rats, Clin Sci, vol.86, issue.6, pp.663-669, 1994.

M. H. Brooke and K. K. Kaiser, Muscle fiber types: how many and what kind? Arch Neurol, vol.23, pp.369-379, 1970.
DOI : 10.1001/archneur.1970.00480280083010

N. A. Burd, R. J. Andrews, D. W. West, J. P. Little, A. J. Cochran et al., Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men, J Physiol. 2012, vol.590, issue.2, pp.351-362

N. A. Burd, A. M. Holwerda, K. C. Selby, D. W. West, A. W. Staples et al., Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men, J Physiol, vol.588, pp.3119-3130, 2010.
DOI : 10.1113/jphysiol.2010.192856

URL : https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2010.192856

N. A. Burd, J. E. Tang, D. R. Moore, and S. Phillips,

M. , Exercise training and protein metabolism: influences of contraction, protein intake, and sexbased differences, J Appl Physiol, vol.106, issue.5, pp.1692-1701, 1985.

L. M. Burke, Practical Issues in Evidence-Based Use of Performance Supplements: Supplement Interactions, Repeated Use and Individual Responses, Sports Med. 2017, vol.47, issue.1, pp.79-100

L. M. Burke, J. A. Hawley, M. L. Ross, D. R. Moore, S. M. Phillips et al., Preexercise aminoacidemia and muscle protein synthesis after resistance exercise, Med Sci Sports Exerc. 2012, vol.44, issue.10, pp.1968-1977

L. M. Burke, J. A. Winter, D. Cameron-smith, M. Enslen, M. Farnfield et al., Effect of intake of different dietary protein sources on plasma amino acid profiles at rest and after exercise, Int J Sport Nutr Exerc Metab. 2012, vol.22, issue.6, pp.452-462

V. J. Caiozzo, J. J. Perrine, and V. R. Edgerton, Training-induced alterations of the in vivo forcevelocity relationship of human muscle, J Appl Physiol Respir Environ Exerc Physiol, vol.51, issue.3, pp.750-754, 1981.

D. G. Candow, N. C. Burke, T. Smith-palmer, and D. G. Burke, Effect of whey and soy protein supplementation combined with resistance training in young adults, Int J Sport Nutr Exerc Metab, vol.16, issue.3, pp.233-244, 2006.

N. M. Cermak, P. T. Res, L. C. De-groot, and W. Saris,

H. Van-loon and L. J. , Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis

, Am J Clin Nutr. 2012, vol.96, issue.6, pp.1454-1464

T. Chaillou, N. Koulmann, N. Simler, A. Meunier, B. Serrurier et al., Hypoxia transiently affects skeletal muscle hypertrophy in a functional overload model
DOI : 10.1152/ajpregu.00262.2011

, Am J Physiol Regul Integr Comp Physiol. 2012, vol.302, issue.5, pp.643-654

L. Chantranupong, R. L. Wolfson, J. M. Orozco, R. A. Saxton, S. M. Scaria et al., The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1, Cell Rep, vol.9, issue.1, pp.1-8, 2014.

T. A. Churchward-venne, L. Breen, D. Donato, D. M. Hector, A. J. Mitchell et al.,

K. Phillips and S. M. , Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial, Am J Clin Nutr, vol.99, issue.2, pp.276-286, 2014.

T. A. Churchward-venne, N. A. Burd, C. J. Mitchell, D. W. West, A. Philp et al., Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men, J Physiol. 2012, vol.590, issue.11, pp.2751-2765

T. A. Churchward-venne, N. A. Burd, and S. Phillips,

M. , Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism, Nutr Metab (Lond), vol.2012, issue.1, p.40

H. Claassen, C. Gerber, H. Hoppeler, J. M. Luthi, and P. Vock, Muscle filament spacing and short-term heavy-resistance exercise in humans, J Physiol, vol.409, pp.491-495, 1989.

P. Cormie, M. R. Mcguigan, and R. U. Newton, Developing maximal neuromuscular power: Part 1--biological basis of maximal power production, Sports Med. 2011, vol.41, issue.1, pp.17-38

P. Cormie, M. R. Mcguigan, and R. U. Newton,

A. Creer, P. Gallagher, D. Slivka, and B. Jemiolo, Fink Appl Physiol, vol.99, issue.3, pp.950-956, 1985.

P. J. Cribb and A. Hayes, Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy, Med Sci Sports Exerc, vol.38, issue.11, pp.1918-1925, 2006.

P. J. Cribb, A. D. Williams, M. F. Carey, and A. Hayes, The effect of whey isolate and resistance training on strength, body composition, and plasma glutamine, Int J Sport Nutr Exerc Metab. 2006, vol.16, issue.5, pp.494-509

J. B. Cronin and K. T. Hansen, Strength and power predictors of sports speed, J Strength Cond Res, vol.19, issue.2, pp.349-357, 2005.

M. Dangin, Y. Boirie, C. Guillet, and B. Beaufrere, Influence of the protein digestion rate on protein turnover in young and elderly subjects, J Nutr, vol.132, issue.10, pp.3228-3233, 2002.

L. Deldicque, D. Theisen, and M. Francaux, Regulation of mTOR by amino acids and resistance exercise in skeletal muscle, Eur J Appl Physiol, vol.94, issue.1-2, pp.1-10, 2005.

T. L. Delorme and A. L. Watkins, Technics of progressive resistance exercise, Arch Phys Med Rehabil. 1948, vol.29, issue.5, pp.263-273

N. E. Deutz and R. R. Wolfe, Is there a maximal anabolic response to protein intake with a meal? Clin Nutr, vol.32, pp.309-313, 2013.

M. C. Devries and S. M. Phillips, Supplemental protein in support of muscle mass and health: advantage whey, J Food Sci. 2015, vol.80, pp.8-15

J. M. Dickinson, C. S. Fry, M. J. Drummond, D. M. Gundermann, D. K. Walker et al., Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids, J Nutr. 2011, vol.141, issue.5, pp.856-862

K. M. Dodd and A. R. Tee, Leucine and mTORC1: a complex relationship, Am J Physiol Endocrinol Metab. 2012, vol.302, issue.11, pp.1329-1342

M. J. Drummond, H. C. Dreyer, C. S. Fry, and E. Glynn,

L. Rasmussen and B. B. , Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling, J Appl Physiol, vol.106, issue.4, pp.1374-1384, 1985.

K. A. Edman, The relation between sarcomere length and active tension in isolated semitendinosus fibres of the frog, J Physiol, vol.183, issue.2, pp.407-417, 1966.

B. Egan and J. R. Zierath, Exercise metabolism and the molecular regulation of skeletal muscle adaptation, Cell Metab, vol.17, issue.2, pp.162-184, 2013.

T. A. Elliot, M. G. Cree, A. P. Sanford, R. R. Wolfe, and K. D. Tipton, Milk ingestion stimulates net muscle protein synthesis following resistance exercise, Med Sci Sports Exerc, vol.38, issue.4, pp.667-674, 2006.

R. M. Enoka, Morphological features and activation patterns of motor units, J Clin Neurophysiol. 1995, vol.12, issue.6, pp.538-559

R. M. Enoka and J. Duchateau, Muscle fatigue: what, why and how it influences muscle function, J Physiol, vol.586, issue.1, pp.11-23, 2008.
DOI : 10.1113/jphysiol.2007.139477

URL : https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2007.139477

R. M. Enoka and A. J. Fuglevand, Motor unit physiology: some unresolved issues, Muscle Nerve. 2001, vol.24, issue.1, pp.4-17
DOI : 10.1002/1097-4598(200101)24:1<4::aid-mus13>3.0.co;2-f

R. M. Enoka and D. G. Stuart, Neurobiology of muscle fatigue, J Appl Physiol, issue.5, pp.1631-1648, 1985.
DOI : 10.1152/jappl.1992.72.5.1631

M. Fabre, C. Hausswirth, E. Tiollier, O. Molle, J. Louis et al., Effects of Post-Exercise Protein Intake on Muscle Mass and Strength During Resistance Training: is There an Optimal Ratio Between Fast and Slow Proteins?, Int J Sport Nutr Exerc Metab, pp.1-23, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01582515

J. A. Faulkner, D. R. Claflin, K. K. Mccully, and D. A. Jones, Contractile properties of bundles of fiber segments from skeletal muscles, Am J Physiol. 1982, vol.243, issue.1, pp.66-73

M. A. Febbraio and J. Dancey, Skeletal muscle energy metabolism during prolonged, fatiguing exercise, J Appl Physiol, vol.87, issue.6, pp.2341-2347, 1985.
DOI : 10.1152/jappl.1999.87.6.2341

URL : http://www.somasimple.com/pdf_files/skeletal_muscle.pdf

V. C. Figueiredo, L. A. Roberts, J. F. Markworth, M. P. Barnett, J. S. Coombes et al.,

M. Cameron-smith and D. , Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies, vol.4, 2016.

D. C. Fingar, S. Salama, C. Tsou, E. Harlow, and J. Blenis, Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E, Genes Dev, vol.16, issue.12, pp.1472-1487, 2002.

R. H. Fitts, K. S. Mcdonald, and J. Schluter, The determinants of skeletal muscle force and power: their adaptability with changes in activity pattern, J Biomech. 1991, vol.24, pp.111-122

M. V. Franchi, P. J. Atherton, N. D. Reeves, M. Fluck, J. Williams et al., Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle, Acta Physiol (Oxf). 2014, vol.210, issue.3, pp.642-654
DOI : 10.1111/apha.12225

URL : http://repositori.uji.es/xmlui/bitstream/10234/123723/3/66811.pdf

M. V. Franchi, N. D. Reeves, and M. Narici, Skeletal Muscle Remodeling in Response to Eccentric vs, Concentric Loading: Morphological, Molecular, and Metabolic Adaptations, vol.8, p.447, 2017.

M. V. Franchi, D. J. Wilkinson, J. I. Quinlan, W. K. Mitchell, J. N. Lund et al.,

G. Fruhbeck, Protein metabolism. Slow and fast dietary proteins, Nature, vol.391, issue.6670, p.845, 1998.

S. Fujita, T. Abe, M. J. Drummond, J. G. Cadenas, H. C. Dreyer et al.,

B. , Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis, J Appl Physiol, vol.103, issue.3, pp.903-910, 1985.

T. Fukunaga, M. Miyatani, M. Tachi, M. Kouzaki, Y. Kawakami et al., Muscle volume is a major determinant of joint torque in humans, Acta Physiol Scand. 2001, vol.172, issue.4, pp.249-255

D. A. Gabriel, G. Kamen, and G. Frost, Neural adaptations to resistive exercise: mechanisms and recommendations for training practices, Sports Med, vol.36, issue.2, pp.133-149, 2006.
DOI : 10.2165/00007256-200636020-00004

C. Gans, Fiber architecture and muscle function, Exerc Sport Sci Rev, vol.10, pp.160-207, 1982.
DOI : 10.1249/00003677-198201000-00006

D. J. Glass, Molecular mechanisms modulating muscle mass, Trends Mol Med. 2003, vol.9, issue.8, pp.344-350
DOI : 10.1016/s1471-4914(03)00138-2

E. L. Glynn, C. S. Fry, M. J. Drummond, H. C. Dreyer, S. Dhanani et al., Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise

, Am J Physiol Regul Integr Comp Physiol, vol.299, issue.2, pp.533-540, 2010.

C. A. Goodman, D. L. Mayhew, and T. Hornberger,

A. , Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass. Cell Signal, vol.23, pp.1896-1906, 2011.

B. S. Gordon, A. R. Kelleher, and S. R. Kimball, Regulation of muscle protein synthesis and the effects of catabolic states, Int J Biochem Cell Biol. 2013, vol.45, issue.10, pp.2147-2157

S. H. Gorissen, N. A. Burd, H. M. Hamer, A. P. Gijsen, B. B. Groen et al., Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion, J Clin Endocrinol Metab, vol.99, issue.6, pp.2250-2258, 2014.

E. L. Greer and A. Brunet, FOXO transcription factors at the interface between longevity and tumor suppression, Oncogene, vol.24, issue.50, pp.7410-7425, 2005.

B. B. Groen, P. T. Res, B. Pennings, E. Hertle, J. M. Senden et al., Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men, Am J Physiol Endocrinol Metab. 2012, vol.302, issue.1, pp.52-60

H. Hamarsland, G. Paulsen, M. Cotter, E. Borsheim, and T. Raastad, Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial. BMC Nutrition, 2017.

S. D. Harridge, Plasticity of human skeletal muscle: gene expression to in vivo function, Exp Physiol. 2007, vol.92, issue.5, pp.783-797

J. W. Hartman, J. E. Tang, S. B. Wilkinson, M. A. Tarnopolsky, and R. L. Lawrence,

, Am J Clin Nutr, vol.86, issue.2, pp.373-381, 2007.

B. M. Hather, C. E. Mason, and G. A. Dudley, Histochemical demonstration of skeletal muscle fibre types and capillaries on the same transverse section, Clin Physiol, vol.11, issue.2, pp.127-134, 1991.

B. M. Hather, P. A. Tesch, P. Buchanan, and G. A. Dudley, Influence of eccentric actions on skeletal muscle adaptations to resistance training, Acta Physiol Scand, vol.143, issue.2, pp.177-185, 1991.

C. Hausswirth, A. X. Bigard, R. Lepers, M. Berthelot, and C. Y. Guezennec, Sodium citrate ingestion and muscle performance in acute hypobaric hypoxia, Eur J Appl Physiol Occup Physiol, vol.71, issue.4, pp.362-368, 1995.
URL : https://hal.archives-ouvertes.fr/hal-01781417

C. J. Heckman and R. M. Enoka, Motor unit, Compr Physiol. 2012, vol.2, issue.4, pp.2629-2682

A. V. Hill, The Heat of Shortening and the Dynamic Constants of Muscle, Proceedings of the Royal Society B: Biological Sciences, vol.126, issue.843, pp.136-195, 1938.

T. A. Hillier, D. A. Fryburg, L. A. Jahn, and E. J. Barrett, Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm, Am J Physiol, vol.274, issue.6, p.1067, 1998.

J. R. Hoffman, N. A. Ratamess, C. P. Tranchina, S. L. Rashti, J. Kang et al., Effect of protein-supplement timing on strength, power, and body-composition changes in resistance-trained men, Int J Sport Nutr Exerc Metab, vol.19, issue.2, pp.172-185, 2009.

M. J. Hubal, H. Gordish-dressman, P. D. Thompson, T. B. Price, E. P. Hoffman et al., Variability in muscle size and strength gain after unilateral resistance training, Med Sci Sports Exerc, vol.37, issue.6, pp.964-972, 2005.

P. A. Huijing, Architecture of the human gastrocnemius muscle and some functional consequences, Acta Anat (Basel), vol.123, issue.2, pp.101-107, 1985.

J. J. Hulmi, V. Kovanen, H. Selanne, W. J. Kraemer, K. Hakkinen et al., Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression, Amino Acids, vol.37, issue.2, pp.297-308, 2009.

J. J. Hulmi, M. Laakso, A. A. Mero, K. Hakkinen, J. P. Ahtiainen et al., The effects of whey protein with or without carbohydrates on resistance training adaptations, J Int Soc Sports Nutr, vol.12, p.48, 2015.

P. Iannoli, J. H. Miller, H. T. Wang, B. Bode, W. W. Souba et al., Characterization of L-leucine transport system in brush border membranes from human and rabbit small intestine, Metabolism, vol.48, issue.11, pp.1432-1436, 1999.

K. Inoki, Y. Li, T. Zhu, J. Wu, and K. L. Guan, TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling, Nat Cell Biol, vol.4, issue.9, pp.648-657, 2002.

B. L. Jacobs, C. A. Goodman, and T. A. Hornberger, The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting, J Muscle Res Cell Motil. 2014, vol.35, issue.1, pp.11-21

R. Jager, C. M. Kerksick, B. I. Campbell, P. J. Cribb, S. D. Wells et al., International Society of Sports Nutrition Position Stand: protein and exercise, J Int Soc Sports Nutr, vol.14, p.20, 2017.

R. L. Jones, T. Stellingwerff, G. G. Artioli, B. Saunders, S. Cooper et al., Dose-Response of Sodium Bicarbonate Ingestion Highlights Individuality in Time Course of Blood Analyte Responses, Int J Sport Nutr Exerc Metab. 2016, vol.26, issue.5, pp.445-453

J. M. Joy, R. P. Lowery, J. M. Wilson, M. Purpura, D. Souza et al., The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance, Nutr J. 2013, vol.12, p.86

C. H. Jung, S. H. Ro, J. Cao, N. M. Otto, and D. Kim,

, H. mTOR regulation of autophagy, FEBS Lett, vol.584, issue.7, pp.1287-1295, 2010.

C. S. Katsanos, A. Aarsland, M. G. Cree, and R. R. Wolfe, Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations, J Clin Endocrinol Metab, vol.94, issue.8, pp.2984-2990, 2009.

L. Katznelson, J. S. Finkelstein, D. A. Schoenfeld, D. I. Rosenthal, E. J. Anderson et al., Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism, J Clin Endocrinol Metab, vol.81, issue.12, pp.4358-4365, 1996.

Y. Kawakami, T. Abe, H. Kanehisa, and T. Fukunaga, Human skeletal muscle size and architecture: variability and interdependence, Am J Hum Biol, vol.18, issue.6, pp.845-848, 2006.

G. Kelley, Mechanical overload and skeletal muscle fiber hyperplasia: a meta-analysis, J Appl Physiol, vol.81, issue.4, pp.1584-1588, 1985.

H. Kim, E. Barton, N. Muja, S. Yakar, P. Pennisi et al., Intact insulin and insulin-like growth vivo, Endocrinology, vol.146, issue.4, pp.1772-1779, 2005.

J. S. Kim, J. M. Cross, and M. M. Bamman, Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women

, Am J Physiol Endocrinol Metab, vol.288, issue.6, pp.1110-1119, 2005.

P. L. Kim, R. S. Staron, and S. Phillips, FastedPhysiol, vol.568, pp.283-290, 2005.

S. R. Kimball and L. S. Jefferson, Signaling pathways and molecular mechanisms through which branchedchain amino acids mediate translational control of protein synthesis, J Nutr, vol.136, issue.1, pp.227-231, 2006.

H. G. Knuttgen, P. V. Komi, T. A. Kohn, R. Burroughs, M. J. Hartman et al., Fiber type and metabolic characteristics of lion (Panthera leo), caracal (Caracal caracal) and human skeletal muscle, Comp Biochem Physiol A Mol Integr Physiol, vol.159, issue.2, pp.125-133, 1992.

P. V. Komi, Factors affecting muscular strength and principles of training

, Duodecim. 1974, vol.90, issue.7, pp.505-516

R. Koopman, M. Beelen, T. Stellingwerff, B. Pennings, W. H. Saris et al.,

R. Koopman, S. Walrand, M. Beelen, A. P. Gijsen, A. K. Kies et al.,

J. , Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men, J Nutr, vol.139, issue.9, pp.1707-1713, 2009.

W. J. Kraemer and N. A. Ratamess, Fundamentals of resistance training: progression and exercise prescription, Med Sci Sports Exerc, vol.36, issue.4, pp.674-688, 2004.

W. J. Kraemer and N. A. Ratamess, Hormonal responses and adaptations to resistance exercise and training, Sports Med. 2005, vol.35, issue.4, pp.339-361
DOI : 10.2165/00007256-200535040-00004

B. J. Krawiec, G. J. Nystrom, R. A. Frost, L. S. Jefferson, and C. H. Lang, AMP-activated protein kinase agonists increase mRNA content of the musclespecific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells, Am J Physiol Endocrinol Metab, vol.292, issue.6, pp.1555-1567, 2007.

K. Kumagai, T. Abe, W. F. Brechue, T. Ryushi, S. Takano et al., Sprint performance is related to muscle fascicle length in male 100-m sprinters, J Appl Physiol, vol.88, issue.3, pp.811-816, 1985.
DOI : 10.1152/jappl.2000.88.3.811

V. Kumar, P. Atherton, K. Smith, and M. J. Rennie, Human muscle protein synthesis and breakdown during and after exercise, J Appl Physiol, vol.106, issue.6, pp.2026-2039, 1985.
DOI : 10.1152/japplphysiol.91481.2008

T. Kvorning, M. Andersen, K. Brixen, and K. Madsen, Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study, Am J Physiol Endocrinol Metab. 2006, vol.291, issue.6, pp.1325-1332

L. Lamas, C. Ugrinowitsch, A. Rodacki, G. Pereira, E. C. Mattos et al., Effects of strength and power training on neuromuscular adaptations and jumping movement pattern and performance, J Strength Cond Res, vol.26, issue.12, pp.3335-3344, 2012.

K. H. Lange, J. L. Andersen, N. Beyer, F. Isaksson, B. Larsson et al., GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men, J Clin Endocrinol Metab, vol.87, issue.2, pp.513-523, 2002.

S. H. Lecker, A. L. Goldberg, and M. W. , Protein degradation by the ubiquitin-proteasome pathway in normal and disease states, J Am Soc Nephrol, vol.17, issue.7, pp.1807-1819, 2006.
DOI : 10.1681/asn.2006010083

URL : https://jasn.asnjournals.org/content/17/7/1807.full.pdf

P. W. Lemon, Effects of exercise on dietary protein requirements, Int J Sport Nutr, vol.8, issue.4, pp.426-447, 1998.
DOI : 10.1123/ijsn.8.4.426

D. K. Levenhagen, J. D. Gresham, M. G. Carlson, D. J. Maron, M. J. Borel et al., J Physiol Endocrinol Metab. 2001, vol.280, issue.6, pp.982-993

J. Lexell, C. C. Taylor, and M. Sjostrom, What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men, J Neurol Sci, vol.84, issue.2-3, pp.275-294, 1988.

R. L. Lieber and J. Friden, Functional and clinical significance of skeletal muscle architecture. Muscle Nerve, vol.23, pp.1647-1666, 2000.
DOI : 10.1002/1097-4598(200011)23:11<1647::aid-mus1>3.3.co;2-d

M. I. Lindinger and G. Sjogaard, Potassium regulation during exercise and recovery, Sports Med. 1991, vol.11, issue.6, pp.382-401
DOI : 10.2165/00007256-199111060-00004

C. M. Liu, Z. Yang, C. W. Liu, R. Wang, P. Tien et al., Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice. Cancer Gene Ther, vol.14, pp.945-952, 2007.

V. I. Lushchak, Free radicals, reactive oxygen species, oxidative stress and its classification, Chem Biol Interact, vol.224, pp.164-175, 2014.
DOI : 10.1016/j.cbi.2014.10.016

W. Ma and R. Quirion, The ERK/MAPK pathway, as a target for the treatment of neuropathic pain, Expert Opin Ther Targets, vol.9, issue.4, pp.699-713, 2005.

L. S. Macnaughton, S. L. Wardle, O. C. Witard, C. Mcglory, D. L. Hamilton et al., The response of

C. Mammucari, G. Milan, V. Romanello, E. Masiero, R. Rudolf et al., FoxO3 controls autophagy in skeletal muscle in vivo, Cell Metab, vol.6, issue.6, pp.458-471, 2007.

G. R. Marcotte, D. W. West, and K. Baar, The molecular basis for load-induced skeletal muscle hypertrophy. Calcif Tissue Int, vol.96, pp.196-210, 2015.

L. M. Margolis, S. J. Lessard, Y. Ezzyat, R. A. Fielding, and D. A. Rivas, Circulating MicroRNA Are Predictive of Aging and Acute Adaptive Response to Resistance Exercise in Men, J Gerontol A Biol Sci Med Sci. 2017, vol.72, issue.10, pp.1319-1326

J. F. Markworth, K. R. Maddipati, and D. Cameronsmith, Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury, Exerc Immunol Rev, vol.22, pp.110-134, 2016.

D. L. Mayhew, J. S. Kim, J. M. Cross, A. A. Ferrando, and M. Bamman, Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans, J Appl Physiol, vol.107, issue.5, pp.1655-1662, 1985.
DOI : 10.1152/japplphysiol.91234.2008

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777794/pdf

G. E. Mccall, W. C. Byrnes, S. J. Fleck, A. Dickinson, and W. J. Kraemer, Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy, Can J Appl Physiol, vol.24, issue.1, pp.96-107, 1999.
DOI : 10.1139/h99-009

J. J. Mccarthy and K. A. Esser, Anabolic and catabolic pathways regulating skeletal muscle mass. Curr Opin Clin Nutr Metab Care, vol.13, pp.230-235, 2010.

C. Mcglory, S. D. Galloway, D. L. Hamilton, C. Mcclintock, L. Breen et al., Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation, Prostaglandins Leukot Essent Fatty Acids. 2014, vol.90, issue.6, pp.199-206

C. Mcglory and S. M. Phillips, Exercise and the Regulation of Skeletal Muscle Hypertrophy, Prog Mol Biol Transl Sci, vol.135, pp.153-173, 2015.

C. Mcglory, S. L. Wardle, L. S. Macnaughton, O. C. Witard, F. Scott et al.,

D. , Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men, Physiol Rep, vol.4, issue.6, 2016.

W. E. Mitch and A. L. Goldberg, Mechanisms of muscle wasting. The role of the ubiquitinproteasome pathway, N Engl J Med, vol.335, issue.25, pp.1897-1905, 1996.

C. J. Mitchell, T. A. Churchward-venne, L. Bellamy, G. Parise, S. K. Baker et al., Muscular and systemic correlates of resistance training-induced muscle hypertrophy, PLoS One. 2013, vol.8, issue.10, p.78636

C. J. Mitchell, T. A. Churchward-venne, G. Parise, L. Bellamy, S. K. Baker et al., Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young men, PLoS One, vol.9, issue.2, p.89431, 2014.
DOI : 10.1371/journal.pone.0089431

URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089431&type=printable

C. J. Mitchell, T. A. Churchward-venne, D. W. West, N. A. Burd, L. Breen et al., Resistance exercise load does not determine training-mediated hypertrophic gains in young men
DOI : 10.1152/japplphysiol.00307.2012

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404827/pdf

, J Appl Physiol, vol.113, issue.1, pp.71-77, 1985.

C. J. Mitchell, R. A. Mcgregor, R. F. Souza, E. B. Thorstensen, J. F. Markworth et al., Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men, Nutrients, vol.7, issue.10, pp.8685-8699, 2015.

M. Miyazaki and K. A. Esser, Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals, J Appl Physiol, vol.106, issue.4, pp.1367-1373, 1985.

M. T. Moffroid and R. H. Whipple, Specificity of speed of exercise, Phys Ther, vol.50, issue.12, p.1692, 1970.

D. R. Moore, T. A. Churchward-venne, O. Witard, L. Breen, N. A. Burd et al.,

, Gerontol A Biol Sci Med Sci. 2015, vol.70, issue.1, pp.57-62

D. R. Moore, M. J. Robinson, J. L. Fry, J. E. Tang, E. I. Glover et al., Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men, Am J Clin Nutr, vol.89, issue.1, pp.161-168, 2009.

T. Moritani and H. A. Devries, Neural factors versus hypertrophy in the time course of muscle strength gain, Am J Phys Med. 1979, vol.58, issue.3, pp.115-130

R. W. Morton, C. Mcglory, and S. M. Phillips, Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy, Front Physiol, vol.6, p.245, 2015.

P. J. Moughan, Dietary protein quality in humans--an overview, J AOAC Int, vol.88, issue.3, pp.874-876, 2005.

A. Musaro, K. Mccullagh, A. Paul, L. Houghton, G. Dobrowolny et al., Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle, Nat Genet, vol.27, issue.2, pp.195-200, 2001.

F. Naclerio and E. Larumbe-zabala, Effects of Whey Protein Alone or as Part of a Multi-ingredient Formulation on Strength, Fat-Free Mass, or Lean Body Mass in Resistance-Trained Individuals: A Meta-analysis, Sports Med. 2016, vol.46, issue.1, pp.125-137

K. S. Nair, D. Halliday, and R. C. Griggs, Leucine incorporation into mixed skeletal muscle protein in humans, Am J Physiol, vol.254, issue.2, pp.208-213, 1988.

M. Narici, Human skeletal muscle architecture studied in vivo by non-invasive imaging techniques: functional significance and applications, J Electromyogr Kinesiol, vol.9, issue.2, pp.97-103, 1999.

M. V. Narici, L. Landoni, and A. E. Minetti, Assessment of human knee extensor muscles stress from in vivo physiological cross-sectional area and strength measurements, Eur J Appl Physiol Occup Physiol. 1992, vol.65, issue.5, pp.438-444

G. J. Nystrom and C. H. Lang, Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle, Int J Clin Exp Med. 2008, vol.1, issue.1, pp.50-63

R. Orchardson, The generation of nerve impulses in mammalian axons by changing the concentrations of the normal constituents of extracellular fluid, J Physiol, vol.275, pp.177-189, 1978.

M. Pahor, T. Manini, and M. Cesari, Sarcopenia: clinical evaluation, biological markers and other evaluation tools, J Nutr Health Aging, vol.13, issue.8, pp.724-728, 2009.

N. Pallet, P. Beaune, E. Thervet, C. Legendre, and D. Anglicheau,

, Med Sci (Paris), vol.22, issue.11, pp.947-952, 2006.

A. Paoli, Q. F. Pacelli, P. Cancellara, L. Toniolo, T. Moro et al., Protein Supplementation Does Not Further Increase Latissimus Dorsi Muscle Fiber Hypertrophy after Eight Weeks of Resistance Training in Novice Subjects

S. M. Phillips, Protein requirements and supplementation in strength sports, Nutrition, vol.20, issue.7-8, pp.689-695, 2004.

S. M. Phillips, Physiologic and molecular bases of muscle hypertrophy and atrophy: impact of resistance exercise on human skeletal muscle (protein and exercise dose effects), Appl Physiol Nutr Metab. 2009, vol.34, issue.3, pp.403-410

S. M. Phillips, Current Concepts and Unresolved Questions in Dietary Protein Requirements and Supplements in Adults. Front Nutr, vol.4, p.13, 2017.

S. M. Phillips, J. W. Hartman, and S. B. Wilkinson, Dietary protein to support anabolism with resistance exercise in young men, J Am Coll Nutr, vol.24, issue.2, pp.134-139, 2005.

S. M. Phillips, D. R. Moore, and J. E. Tang, A critical examination of dietary protein requirements, benefits, and excesses in athletes, Int J Sport Nutr Exerc Metab, vol.17, pp.58-76, 2007.

S. M. Phillips, K. D. Tipton, A. Aarsland, S. E. Wolf, and R. R. Wolfe, Mixed muscle protein synthesis and breakdown after resistance exercise in humans, Am J Physiol, vol.273, issue.1, pp.99-107, 1997.

S. M. Phillips, K. D. Tipton, A. A. Ferrando, and R. R. Wolfe, Resistance training reduces the acute exercise-induced increase in muscle protein turnover, Am J Physiol, vol.276, issue.1, p.118, 1999.

S. M. Phillips and L. J. Van-loon, Dietary protein for athletes: from requirements to optimum adaptation, J Sports Sci. 2011, vol.29, pp.29-38

H. J. Pritchard, D. A. Tod, M. J. Barnes, J. W. Keogh, and M. Mcguigan, Tapering Practices of New Zealand's Elite Raw Powerlifters, J Strength Cond Res, vol.30, issue.7, pp.1796-1804, 2016.

T. Raastad, M. Vagle, B. Framroze, and . Randomized, Double-Blinded Cross-Over Study Comparing Increase in Blood Leucine Levels after Ingestion of Hydrolyzed Salmon and Whey Proteins in Healthy Young Men. Nutrition and Food Technology, 2002.

D. E. Rassier, B. R. Macintosh, and W. Herzog, Length dependence of active force production in skeletal muscle, J Appl Physiol, vol.86, issue.5, pp.1445-1457, 1985.

B. Ravikumar, S. Sarkar, J. E. Davies, M. Futter, M. Garcia-arencibia et al., Regulation of mammalian autophagy in physiology and pathophysiology, Physiol Rev, vol.90, issue.4, pp.1383-1435, 2010.

P. T. Reidy and B. B. Rasmussen, Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism, J Nutr, vol.146, issue.2, pp.155-183, 2016.

S. Reitelseder, J. Agergaard, S. Doessing, I. C. Helmark, P. Lund et al., Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion, Am J Physiol Endocrinol Metab, vol.300, issue.1, pp.231-242, 2011.

R. M. , Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements

, Int J Sport Nutr Exerc Metab. 2001, vol.11, pp.170-176

M. J. Rennie, J. Bohe, K. Smith, H. Wackerhage, and P. Greenhaff, Branched-chain amino acids as fuels and anabolic signals in human muscle, J Nutr, vol.136, issue.1, pp.264-268, 2006.

P. T. Res, B. Groen, B. Pennings, M. Beelen, G. A. Wallis et al., Protein ingestion before sleep improves postexercise overnight recovery, Med Sci Sports Exerc. 2012, vol.44, issue.8, pp.1560-1569

L. A. Roberts, T. Raastad, J. F. Markworth, V. C. Figueiredo, I. M. Egner et al., Postexercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training, J Physiol, vol.593, issue.18, pp.4285-4301, 2015.

C. Rommel, S. C. Bodine, B. A. Clarke, R. Rossman, L. Nunez et al., Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI

K. Pathways, Nat Cell Biol. 2001, vol.3, issue.11, pp.1009-1013

B. R. Ronnestad, H. Nygaard, and T. Raastad, Physiological elevation of endogenous hormones results in superior strength training adaptation, Eur J Appl Physiol, vol.111, issue.9, pp.2249-2259, 2011.

B. D. Roy, Milk: the new sports drink? A Review, J Int Soc Sports Nutr, vol.5, p.15, 2008.

D. G. Sale, Neural adaptation to resistance training

, Med Sci Sports Exerc, vol.20, issue.5, pp.135-145, 1988.

M. Sandri, C. Sandri, A. Gilbert, C. Skurk, E. Calabria et al., Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy, Cell, vol.117, issue.3, pp.399-412, 2004.

R. M. Sapp, D. D. Shill, S. M. Roth, and J. Hagberg,

M. , Circulating microRNAs in acute and chronic exercise: more than mere biomarkers, J Appl Physiol, vol.122, issue.3, pp.702-717, 1985.

B. J. Schoenfeld, Postexercise hypertrophic adaptations: a reexamination of the hormone hypothesis and its applicability to resistance training program design, J Strength Cond Res, vol.27, issue.6, pp.1720-1730, 2013.

B. J. Schoenfeld, A. A. Aragon, and J. W. Krieger, The effect of protein timing on muscle strength and hypertrophy: a meta-analysis, J Int Soc Sports Nutr. 2013, vol.10, issue.1, p.53

B. J. Schoenfeld, A. A. Aragon, C. Wilborn, S. L. Urbina, S. E. Hayward et al., , p.Pre

B. J. Schoenfeld, J. M. Wilson, R. P. Lowery, and J. W. Krieger, Muscular adaptations in low-versus high-load resistance training: A meta-analysis, Eur J Sport Sci, vol.16, issue.1, pp.1-10, 2016.

W. H. Sheldon, C. W. Dupertuis, and E. Mcdermott, Atlas of Men: A guide for Somatotyping the Adult Male at All Ages. Harper & Row, pp.1-357, 1954.

T. C. Shoepe, J. E. Stelzer, D. P. Garner, and J. J. Widrick, Functional adaptability of muscle fibers to longterm resistance exercise, Med Sci Sports Exerc, vol.35, issue.6, pp.944-951, 2003.

G. Sjogaard, Muscle energy metabolism and electrolyte shifts during low-level prolonged static contraction in man, Acta Physiol Scand, vol.134, issue.2, pp.181-187, 1988.

G. Sjogaard, R. P. Adams, and B. Saltin, Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension, Am J Physiol, vol.248, issue.2, pp.190-196, 1985.

G. I. Smith, P. Atherton, D. N. Reeds, B. S. Mohammed, D. Rankin et al., J Clin Nutr, vol.93, issue.2, pp.402-412, 2011.

T. Snijders, P. T. Res, J. S. Smeets, S. Van-vliet, and . Van,

J. Kranenburg, K. Maase, A. K. Kies, L. B. Verdijk, and L. J. Van-loon, Protein Ingestion before Sleep Increases Muscle Mass and Strength Gains during Prolonged Resistance-Type Exercise Training in Healthy Young Men, J Nutr. 2015, vol.145, issue.6, pp.1178-1184

A. W. Staples, N. A. Burd, D. W. West, K. D. Currie, P. J. Atherton et al., Carbohydrate does not augment exercise-induced protein accretion versus protein alone, Med Sci Sports Exerc, vol.43, issue.7, pp.1154-1161, 2011.

M. Stark, J. Lukaszuk, A. Prawitz, and A. Salacinski, Protein timing and its effects on muscular hypertrophy and strength in individuals engaged in weight-training, J Int Soc Sports Nutr. 2012, vol.9, issue.1
DOI : 10.1186/1550-2783-9-54

URL : https://jissn.biomedcentral.com/track/pdf/10.1186/1550-2783-9-54

G. R. Steinberg and B. E. Kemp, AMPK in Health and Disease, Physiol Rev, vol.89, issue.3, pp.1025-1078, 2009.
DOI : 10.1152/physrev.00011.2008

T. J. Suchomel, S. Nimphius, and M. Stone, The Importance of Muscular Strength in Athletic Performance, Sports Med. 2016, vol.46, issue.10, pp.1419-1449

E. Svanberg, A. C. Moller-loswick, D. E. Matthews, U. Korner, M. Andersson et al., The role of glucose, long-chain triglycerides and amino acids for promotion of amino acid balance across peripheral tissues in man, Clin Physiol, vol.19, issue.4, pp.311-320, 1999.

T. B. Symons, M. Sheffield-moore, R. R. Wolfe, and D. Paddon-jones, A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects, J Am Diet Assoc, vol.109, issue.9, pp.1582-1586, 2009.

H. Takano, T. Morita, H. Iida, K. Asada, M. Kato et al., Hemodynamic and hormonal responses to a shortterm low-intensity resistance exercise with the reduction of muscle blood flow, Eur J Appl Physiol, vol.95, issue.1, pp.65-73, 2005.

J. A. Talbot and D. L. Morgan, The effects of stretch parameters on eccentric exercise-induced damage to toad skeletal muscle, J Muscle Res Cell Motil, vol.19, issue.3, pp.237-245, 1998.

J. E. Tang, D. R. Moore, G. W. Kujbida, M. A. Tarnopolsky, and S. M. Phillips, Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men, J Appl Physiol, vol.107, issue.3, pp.987-992, 1985.

J. E. Tang, J. G. Perco, D. R. Moore, and S. Wilkinson,

B. Phillips and S. M. , Resistance training alters the response of fed state mixed muscle protein synthesis in young men, Am J Physiol Regul Integr Comp Physiol, vol.294, issue.1, pp.172-178, 2008.

M. A. Tarnopolsky, S. A. Atkinson, J. D. Macdougall, A. Chesley, S. Phillips et al., Evaluation of protein requirements for trained strength athletes, J Appl Physiol, issue.5, pp.1986-1995, 1985.
DOI : 10.1152/jappl.1992.73.5.1986

G. Terzis, G. Georgiadis, G. Stratakos, I. Vogiatzis, S. Kavouras et al., Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects, Eur J Appl Physiol, vol.102, issue.2, pp.145-152, 2008.
DOI : 10.1007/s00421-007-0564-y

M. Thevis and W. Schanzer, Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis -Potential implications for sports drug testing programs, Rapid Commun Mass Spectrom. 2016, vol.30, issue.5, pp.635-651
DOI : 10.1002/rcm.7470

J. Tihanyi, P. Apor, and G. Fekete, Force-velocitypower characteristics and fiber composition in human knee extensor muscles, Eur J Appl Physiol Occup Physiol. 1982, vol.48, issue.3, pp.331-343
DOI : 10.1007/bf00430223

K. D. Tipton, Role of protein and hydrolysates before exercise, Int J Sport Nutr Exerc Metab, p.17, 2007.
DOI : 10.1123/ijsnem.17.s1.s77

URL : http://dspace.stir.ac.uk/bitstream/1893/7552/1/9899.pdf

K. D. Tipton, B. E. Gurkin, S. Matin, and R. Wolfe,

, Nutr Biochem, vol.10, issue.2, pp.89-95, 1999.

S. Trappe, N. Luden, K. Minchev, U. Raue, B. Jemiolo et al., Skeletal muscle signature of a champion sprint runner, J Appl Physiol, vol.118, issue.12, pp.1460-1466, 1985.

J. Trommelen and L. J. Van-loon, Pre-Sleep Protein Ingestion to Improve the Skeletal Muscle Adaptive Response to Exercise Training, Nutrients, 2016.
DOI : 10.3390/nu8120763

URL : https://www.mdpi.com/2072-6643/8/12/763/pdf

S. Van-vliet, N. A. Burd, and L. J. Van-loon, The Skeletal Muscle Anabolic Response to Plant-versus Animal-Based Protein Consumption, J Nutr, vol.145, issue.9, pp.1981-1991, 2015.

J. P. Van-zandwijk, M. F. Bobbert, G. C. Baan, and P. A. Huijing, From twitch to tetanus: performance of excitation dynamics optimized for a twitch in predicting tetanic muscle forces, Biol Cybern, vol.75, issue.5, pp.409-417, 1996.

C. P. Velloso, Regulation of muscle mass by growth hormone and IGF-I, Br J Pharmacol, vol.154, issue.3, pp.557-568, 2008.

S. Walrand, K. R. Short, M. L. Bigelow, A. J. Sweatt, S. M. Hutson et al., Functional impact of high protein intake on healthy elderly people, Am J Physiol Endocrinol Metab, vol.295, issue.4, pp.921-928, 2008.

J. C. Waterlow, M. H. Golden, and P. J. Garlick, Protein turnover in man measured with 15N: comparison of end products and dose regimes, Am J Physiol, vol.235, issue.2, pp.165-174, 1978.

D. W. West, N. A. Burd, V. G. Coffey, S. K. Baker, L. M. Burke et al., Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise, Am J Clin Nutr, vol.94, issue.3, pp.795-803, 2011.

D. W. West and S. M. Phillips, Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training, Eur J Appl Physiol, vol.112, issue.7, pp.2693-2702, 2012.

H. Westerblad, J. A. Lee, J. Lannergren, and D. Allen,

G. , Cellular mechanisms of fatigue in skeletal muscle, Am J Physiol, vol.261, issue.2, pp.195-209, 1991.

. White, Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease, Advances in Experimental Medicine and Biology, vol.900, p.199, 2016.

J. P. White, S. Gao, M. J. Puppa, S. Sato, S. L. Welle et al., Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle, Mol Cell Endocrinol. 2013, vol.365, issue.2, pp.174-186

J. J. Widrick, J. E. Stelzer, T. C. Shoepe, and D. P. Garner, Functional properties of human muscle fibers after short-term resistance exercise training, Am J Physiol Regul Integr Comp Physiol, vol.283, issue.2, pp.408-416, 2002.

C. D. Wilborn, L. W. Taylor, J. Outlaw, L. Williams, B. Campbell et al., The Effects of Pre-and PostExercise Whey vs. Casein Protein Consumption on Body Composition and Performance Measures in Collegiate Female Athletes, J Sports Sci Med. 2013, vol.12, issue.1, pp.74-79

D. J. Wilkinson, T. Hossain, D. S. Hill, B. E. Phillips, H. Crossland et al., Effects of leucine and its metabolite beta-hydroxy-beta-methylbutyrate on human skeletal muscle protein metabolism, J Physiol, vol.591, issue.11, pp.2911-2923, 2013.

S. B. Wilkinson, S. M. Phillips, P. J. Atherton, R. Patel, K. E. Yarasheski et al., , vol.586, pp.3701-3717, 2008.

S. B. Wilkinson, M. A. Tarnopolsky, M. J. Macdonald, J. R. Macdonald, D. Armstrong et al., J Clin Nutr, vol.85, issue.4, pp.1031-1040, 2007.

J. M. Willardson, The application of training to failure in periodized multiple-set resistance exercise programs, J Strength Cond Res, vol.21, issue.2, pp.628-631, 2007.

O. C. Witard, S. R. Jackman, L. Breen, K. Smith, A. Selby et al., Myofibrillar muscle

R. L. Wolfson, L. Chantranupong, R. A. Saxton, K. Shen, S. M. Scaria et al.,

M. , Sestrin2 is a leucine sensor for the mTORC1 pathway, Science, vol.351, issue.6268, pp.43-48, 2016.

H. Wolosker and L. De-meis, pH-dependent inhibitory effects of Ca2+, Mg2+, and K+ on Ca2+ efflux mediated by sarcoplasmic reticulum ATPase

, Am J Physiol, vol.266, issue.5, pp.1376-1381, 1994.

K. E. Yarasheski, J. A. Campbell, K. Smith, M. J. Rennie, J. O. Holloszy et al., Effect of growth hormone and resistance exercise on muscle growth in young men, Am J Physiol, vol.262, issue.3, pp.261-267, 1992.

J. Zhao, J. J. Brault, A. Schild, P. Cao, M. Sandri et al., FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells, Cell Metab, vol.6, issue.6, pp.472-483, 2007.

W. Zhao, J. Pan, Z. Zhao, Y. Wu, W. A. Bauman et al., Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation, J Steroid Biochem Mol Biol, vol.110, issue.1-2, pp.125-129, 2008.