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Dimorphismes sexuels de la neuroplasticité respiratoire associée au syndrome d'apnées obstructives du sommeil et caractérisation d'un nouveau modèle murin

Abstract : The obstructive sleep apnea syndrome (OSAS) is characterized by recurrent collapse of the upper airways during sleep, generating episodes of hypoxia/hypercapnia. Thus, OSAS leads to life-threatening cardiorespiratory comorbidities, but of which some are less severe in female patients. The prevalence in men is higher than that of pre-menopausal women and it is increased by obesity. This doctoral thesis aimed to characterize sex differences in the neuroplasticity related to cardi-orespiratory comorbidities found in OSAS. In this context, we submitted mice to a protocol of chronic intermittent hypoxia, a model that recapitulates episodic hypoxia of OSAS. On isolated brain sections, we observed differential implication of cardiorespiratory structures between male and female mice with a specific neuroplastic pattern in females that could possibly explain sex differences observed in OSAS patients. In parallel, we have characterized an obese mouse strain (New Zealand Obese) as a model of OSAS. Thus, we provide the first naturel mouse model for OSAS related to obesity. The work presented in this thesis provides better understanding of sex differences observed in OSAS and provides a new model of OSAS that should allow more complete studies of the pathology of OSAS.
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Submitted on : Monday, May 20, 2019 - 12:08:10 PM
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  • HAL Id : tel-02134089, version 1

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David Baum. Dimorphismes sexuels de la neuroplasticité respiratoire associée au syndrome d'apnées obstructives du sommeil et caractérisation d'un nouveau modèle murin. Neurobiologie. Sorbonne Université, 2018. Français. ⟨NNT : 2018SORUS044⟩. ⟨tel-02134089⟩

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