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Caractérisation et modulation de la réponse immunitaire innée au cours de l’infection par le Virus Respiratoire Syncytial en période néonatale

Abstract : Respiratory Syncytial Virus (RSV) is responsible for 70 % of bronchiolitis in children under five years old. Severe bronchiolitis in infants is a risk factor for asthma development. No vaccine against RSV is available in humans. The innate immune system is the first line of defense against infections. Moreover, in interaction with lung microbiota, innate immunity shapes adaptive immune response responsible for long-term protection against pathogens. To explain the susceptibility of young children to RSV, we characterized a novel regulatory mechanism of the innate antiviral response during neonatal RSV infection in the murine model. We also tested a new approach for modulating immune responses to RSV by the pulmonary microbiota. Thus, a better understanding of immunological and virological mechanisms responsible for severe bronchiolitis during the neonatal period will allow the development of safe and effective therapeutic strategies against RSV infection.
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https://tel.archives-ouvertes.fr/tel-02122664
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Carole Drajac. Caractérisation et modulation de la réponse immunitaire innée au cours de l’infection par le Virus Respiratoire Syncytial en période néonatale. Immunologie. Université Paris Saclay (COmUE), 2018. Français. ⟨NNT : 2018SACLA014⟩. ⟨tel-02122664⟩

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