H. T. Mcmahon and J. L. Gallop, Membrane curvature and mechanisms of dynamic cell membrane remodelling, Nature, vol.438, pp.590-596, 2005.

R. G. Parton and M. A. Del-pozo, Caveolae as plasma membrane sensors, protectors and organizers, Nat Rev Mol Cell Biol, vol.14, pp.98-112, 2013.

H. T. Mcmahon and E. Boucrot, Molecular mechanism and physiological functions of clathrin-­mediated endocytosis, Nat Rev Mol Cell Biol, vol.12, pp.517-533, 2011.

R. Levin, S. Grinstein, and J. Canton, The life cycle of phagosomes: formation, maturation, and resolution, Immunol Rev, vol.273, pp.156-179, 2016.

A. J. Ridley, Life at the leading edge, Cell, vol.145, pp.1012-1022, 2011.

H. Ham, A. Sreelatha, and K. Orth, Manipulation of host membranes by bacterial effectors

, Nat Rev Microbiol, vol.9, pp.635-646, 2011.

J. S. Rossman and R. A. Lamb, Viral membrane scission, Annu Rev Cell Dev Biol, vol.29, pp.551-569, 2013.

D. C. Sheppard and S. G. Filler, Host cell invasion by medically important fungi, Cold Spring Harb Perspect Med, vol.5, p.19687, 2014.

G. , Revisiting the extracellular lifestyle, Cell Microbiol, vol.13, pp.1114-1121, 2011.

G. Mikaty, Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stress, PLoS Pathog, vol.5, p.1000314, 2009.

D. A. Caugant and M. C. Maiden, Meningococcal carriage and disease-­-­population biology and evolution, Vaccine, vol.27, issue.2, pp.64-70, 2009.

K. Melican, P. Veloso, T. Martin, P. Bruneval, and G. Dumenil, Adhesion of

, PLoS Pathog, vol.9, p.1003139, 2013.

O. Join-­lambert, Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans, J Infect Dis, vol.208, pp.1590-1597, 2013.

K. Melican and G. Dumenil, Vascular colonization by Neisseria meningitidis, Curr Opin Microbiol, vol.15, pp.50-56, 2012.

P. Brandtzaeg and M. Van-deuren, Classification and pathogenesis of meningococcal infections, Methods Mol Biol, vol.799, pp.21-35, 2012.

X. Nassif, Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells, Mol Microbiol, vol.8, pp.719-725, 1993.

J. L. Berry and V. Pelicic, Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives, FEMS Microbiol Rev, vol.39, pp.134-154, 2015.

T. Brissac, G. Mikaty, G. Dumenil, M. Coureuil, and X. Nassif, The meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cells, Infect Immun, vol.80, pp.3297-3306, 2012.

M. , Meningococcus Hijacks a beta2-­adrenoceptor/beta-­Arrestin pathway to cross brain microvasculature endothelium, Cell, vol.143, pp.1149-1160, 2010.

X. Nassif, Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells, Proc Natl Acad Sci U S A, vol.91, pp.3769-3773, 1994.

L. Bougneres, S. E. Girardin, S. A. Weed, A. V. Karginov, J. C. Olivo-marin et al., Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells, J Cell Biol, vol.166, pp.225-260, 2004.

R. Bourdet-sicard, M. Rudiger, B. M. Jockusch, P. Gounon, P. J. Sansonetti et al., Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization, Embo J, vol.18, pp.5853-62, 1999.

D. E. Bradley, Shortening of Pseudomonas aeruginosa pili after RNA-phage adsorption, J Gen Microbiol, vol.72, pp.303-322, 1972.

P. Brandtzaeg, P. Kierulf, P. Gaustad, A. Skulberg, J. N. Bruun et al., Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease, J Infect Dis, vol.159, pp.195-204, 1989.

P. Brandtzaeg, T. E. Mollnes, and P. Kierulf, Complement activation and endotoxin levels in systemic meningococcal disease, J Infect Dis, vol.160, pp.58-65, 1989.

P. Brandtzaeg and M. Van-deuren, Classification and pathogenesis of meningococcal infections, Methods Mol Biol, vol.799, pp.21-35, 2012.

T. Brissac, G. Mikaty, G. Dumenil, M. Coureuil, and X. Nassif, The meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cells, Infect Immun, vol.80, pp.3297-306, 2012.

C. V. Broome, The carrier state: Neisseria meningitidis, J Antimicrob Chemother, vol.18, pp.25-34, 1986.

D. R. Brown, S. Helaine, E. Carbonnelle, and V. Pelicic, Systematic functional analysis reveals that a set of seven genes is involved in fine-tuning of the multiple functions mediated by type IV pili in Neisseria meningitidis, Infect Immun, vol.78, pp.3053-63, 2010.

P. J. Bruce-staskal, C. L. Weidow, J. J. Gibson, and A. H. Bouton, Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake, J Cell Sci, vol.115, pp.2689-700, 2002.

D. Bruggemann, Nanoporous Aluminium Oxide Membranes as Cell Interfaces, Journal of Nanomaterials, 2013.

E. A. Burton, R. Plattner, and A. M. Pendergast, Abl tyrosine kinases are required for infection by Shigella flexneri, Embo J, vol.22, pp.5471-5480, 2003.

Y. W. Chang, A. Kjaer, D. R. Ortega, G. Kovacikova, J. A. Sutherland et al., Architecture of the Vibrio cholerae toxin-coregulated pilus machine revealed by electron cryotomography, Nat Microbiol, vol.2, p.16269, 2017.

Y. W. Chang, L. A. Rettberg, A. Treuner-lange, J. Iwasa, L. Sogaard-andersen et al., Architecture of the type IVa pilus machine, Science, vol.351, p.2001, 2016.

B. Chang-ileto, S. G. Frere, R. B. Chan, S. V. Voronov, A. Roux et al., , 2011.

, Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission, Dev Cell, vol.20, pp.206-224

J. S. Chappie, J. A. Mears, S. Fang, M. Leonard, S. L. Schmid et al., A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke, Cell, vol.147, pp.209-231, 2011.

A. Charles-orszag, E. Lemichez, G. Tran-van-nhieu, and G. Dumenil, Microbial pathogenesis meets biomechanics, Curr Opin Cell Biol, vol.38, pp.31-38, 2016.

I. Chen and D. Dubnau, DNA uptake during bacterial transformation, Nat Rev Microbiol, vol.2, pp.241-250, 2004.

I. Chen, R. Provvedi, and D. Dubnau, A macromolecular complex formed by a pilin-like protein in competent Bacillus subtilis, J Biol Chem, vol.281, pp.21720-21727, 2006.

J. P. Cheng, C. Mendoza-topaz, G. Howard, J. Chadwick, E. Shvets et al., Caveolae protect endothelial cells from membrane rupture during increased cardiac output, J Cell Biol, vol.211, pp.53-61, 2015.

L. Chesneau, D. Dambournet, M. Machicoane, I. Kouranti, M. Fukuda et al.,

, An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis, Curr Biol, vol.22, pp.147-53

S. Chimileski, M. J. Franklin, and R. T. Papke, Biofilms formed by the archaeon Haloferax volcanii exhibit cellular differentiation and social motility, and facilitate horizontal gene transfer, BMC Biol, vol.12, p.65, 2014.

D. A. Cisneros, P. J. Bond, A. P. Pugsley, M. Campos, and O. Francetic, Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation, Embo J, vol.31, pp.1041-53, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01115170

H. Claus, M. C. Maiden, D. J. Wilson, N. D. Mccarthy, K. A. Jolley et al., Genetic analysis of meningococci carried by children and young adults, J Infect Dis, vol.191, pp.1263-71, 2005.

A. Collins, A. Warrington, K. A. Taylor, and T. Svitkina, Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis, Curr Biol, vol.21, pp.1167-75, 2011.

R. F. Collins, L. Davidsen, J. P. Derrick, R. C. Ford, and T. Tonjum, Analysis of the PilQ secretin from Neisseria meningitidis by transmission electron microscopy reveals a dodecameric quaternary structure, J Bacteriol, vol.183, pp.3825-3857, 2001.

R. F. Collins, S. A. Frye, A. Kitmitto, R. C. Ford, T. Tonjum et al., Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution, J Biol Chem, vol.279, pp.39750-39756, 2004.

S. K. Collinson, L. Emody, K. H. Muller, T. J. Trust, and W. W. Kay, Purification and characterization of thin, aggregative fimbriae from Salmonella enteritidis, J Bacteriol, vol.173, pp.4773-81, 1991.

M. Comanducci, S. Bambini, D. A. Caugant, M. Mora, B. Brunelli et al., NadA diversity and carriage in Neisseria meningitidis, Infect Immun, vol.72, pp.4217-4240, 2004.

I. R. Cooke and M. Deserno, Coupling between lipid shape and membrane curvature, Biophys J, vol.91, pp.487-95, 2006.

M. Coureuil, H. Lecuyer, S. Bourdoulous, and X. Nassif, A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers, Nat Rev Microbiol, vol.15, pp.149-159, 2017.

M. Coureuil, H. Lecuyer, M. G. Scott, C. Boularan, H. Enslen et al., Meningococcus Hijacks a beta2-adrenoceptor/betaArrestin pathway to cross brain microvasculature endothelium, Cell, vol.143, pp.1149-60, 2010.

M. Coureuil, G. Mikaty, F. Miller, H. Lecuyer, C. Bernard et al., Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium, Science, vol.325, pp.83-90, 2009.

L. Craig, M. E. Pique, and J. A. Tainer, Type IV pilus structure and bacterial pathogenicity, Nat Rev Microbiol, vol.2, pp.363-78, 2004.

A. Curtis and C. Wilkinson, New depths in cell behaviour: reactions of cells to nanotopography, Biochem Soc Symp, vol.65, pp.15-26, 1999.

M. J. Dalby, N. Gadegaard, M. O. Riehle, C. D. Wilkinson, and A. S. Curtis, Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size, Int J Biochem Cell Biol, vol.36, pp.2005-2020, 2004.

M. J. Dalby, M. O. Riehle, H. Johnstone, S. Affrossman, and A. S. Curtis, In vitro reaction of endothelial cells to polymer demixed nanotopography, Biomaterials, vol.23, pp.2945-54, 2002.

T. Davidsen and T. Tonjum, Meningococcal genome dynamics, Nat Rev Microbiol, vol.4, pp.11-22, 2006.

S. C. De-greeff, H. E. De-melker, L. M. Schouls, L. Spanjaard, and M. Van-deuren, Preadmission clinical course of meningococcal disease and opportunities for the earlier start of appropriate intervention: a prospective epidemiological study on 752 patients in the Netherlands, Eur J Clin Microbiol Infect Dis, vol.27, pp.985-92, 2003.

M. I. De-jonge, H. J. Hamstra, L. Van-alphen, J. Dankert, and P. Van-der-ley, Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors, Mol Microbiol, vol.50, pp.1005-1020, 2003.

F. P. De-vries, R. Cole, J. Dankert, M. Frosch, and J. P. Van-putten, Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors, Mol Microbiol, vol.27, pp.1203-1215, 1998.

F. P. De-vries, A. Van-der-ende, J. P. Van-putten, and J. Dankert, Invasion of primary nasopharyngeal epithelial cells by Neisseria meningitidis is controlled by phase variation of multiple surface antigens, Infect Immun, vol.64, pp.2998-3006, 1996.

A. E. Deghmane, D. Giorgini, M. Larribe, J. M. Alonso, and M. K. Taha, Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory protein, Mol Microbiol, vol.43, pp.1555-64, 2002.

C. Dehio, M. Meyer, J. Berger, H. Schwarz, and C. Lanz, Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome, J Cell Sci, vol.110, pp.2141-54, 1997.

K. W. Deitsch, S. A. Lukehart, and J. R. Stringer, Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens, Nat Rev Microbiol, vol.7, pp.493-503, 2009.

I. W. Devoe and J. E. Gilchrist, Pili on meningococci from primary cultures of nasopharyngeal carriers and cerebrospinal fluid of patients with acute disease, J Exp Med, vol.141, pp.297-305, 1975.

A. Disanza, S. Bisi, M. Winterhoff, F. Milanesi, D. S. Ushakov et al., CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP, Embo J, vol.32, pp.2735-50, 2013.

G. J. Doherty and H. T. Mcmahon, Mechanisms of endocytosis, Annu Rev Biochem, vol.78, pp.857-902, 2009.

J. M. Dolan-livengood, Y. K. Miller, L. E. Martin, R. Urwin, and D. S. Stephens, Genetic basis for nongroupable Neisseria meningitidis, J Infect Dis, vol.187, pp.1616-1644, 2003.

Y. A. Domanov, S. Aimon, G. E. Toombes, M. Renner, F. Quemeneur et al., Mobility in geometrically confined membranes, Proc Natl Acad Sci U S A, vol.108, pp.12605-12615, 2011.

M. Drogari-apiranthitou, E. J. Kuijper, N. Dekker, and J. Dankert, Complement activation and formation of the membrane attack complex on serogroup B Neisseria meningitidis in the presence or absence of serum bactericidal activity, Infect Immun, vol.70, pp.3752-3760, 2002.

G. Dumenil, Revisiting the extracellular lifestyle, Cell Microbiol, vol.13, pp.1114-1135, 2011.

G. Dunger, C. R. Guzzo, M. O. Andrade, J. B. Jones, and C. S. Farah, Xanthomonas citri subsp. citri type IV Pilus is required for twitching motility, biofilm development, and adherence, Mol Plant Microbe Interact, vol.27, pp.1132-1179, 2014.

N. Dupin, H. Lecuyer, A. Carlotti, C. Poyart, M. Coureuil et al., Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers, Clin Infect Dis, vol.54, pp.1162-1167, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-02085535

H. Echenique-rivera, A. Muzzi, E. Del-tordello, K. L. Seib, P. Francois et al., Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival, PLoS Pathog, vol.7, 2011.

S. C. Eicher and C. Dehio, Bartonella entry mechanisms into mammalian host cells, Cell Microbiol, vol.14, pp.1166-73, 2012.

S. El-abed, S. K. Ibnsouda, H. Latrache, H. Meftah, N. J. Tahri et al., , 2012.

, Environmental Scanning Electron Microscopy characterization of the adhesion of conidia from Penicillium expansum to cedar wood substrata at different pH values, World Journal of Microbiology & Biotechnology, vol.28, pp.1707-1713

N. Elkhatib, E. Bresteau, F. Baschieri, A. L. Rioja, G. Van-niel et al., Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration, Science, vol.356, 2017.

C. Elkins, C. E. Thomas, H. S. Seifert, and P. F. Sparling, Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence, J Bacteriol, vol.173, pp.3911-3914, 1991.

E. Eugene, I. Hoffmann, C. Pujol, P. O. Couraud, S. Bourdoulous et al., Microvillilike structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells, J Cell Sci, vol.115, pp.1231-1272, 2002.

R. W. Evans, J. B. Crawley, C. L. Joannou, and N. D. Sharma, Iron proteins, Iron and infection: molecular, physiological, and clinical aspects, vol.1, pp.27-86, 1999.
URL : https://hal.archives-ouvertes.fr/jpa-00215816

H. Ewers, W. Romer, A. E. Smith, K. Bacia, S. Dmitrieff et al., GM1 structure determines SV40-induced membrane invagination and infection, Nat Cell Biol, vol.12, pp.11-19, 2010.

O. T. Fackler and R. Grosse, Cell motility through plasma membrane blebbing, J Cell Biol, vol.181, pp.879-84, 2008.

M. Faulstich, J. P. Bottcher, T. F. Meyer, M. Fraunholz, and T. Rudel, Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling, PLoS Pathog, vol.9, 2013.

J. Gault, C. Malosse, G. Dumenil, and J. Chamot-rooke, A combined mass spectrometry strategy for complete posttranslational modification mapping of Neisseria meningitidis major pilin, J Mass Spectrom, vol.48, pp.1199-206, 2013.

T. W. Gedde-dahl, E. A. Hoiby, A. Schillinger, A. Lystad, and K. Bovre, An epidemiological, clinical and microbiological follow-up study of incident meningococcal disease cases in Norway, winter 1981-1982. Material and epidemiology in the MenOPP project, NIPH Ann, vol.6, pp.155-68, 1983.

M. Georgiadou, M. Castagnini, G. Karimova, D. Ladant, and V. Pelicic, Large-scale study of the interactions between proteins involved in type IV pilus biology in Neisseria meningitidis: characterization of a subcomplex involved in pilus assembly, Mol Microbiol, vol.84, pp.857-73, 2012.

H. Gil, J. L. Benach, and D. G. Thanassi, Presence of pili on the surface of Francisella tularensis, Infect Immun, vol.72, pp.3042-3049, 2004.

C. L. Giltner, Y. Nguyen, and L. L. Burrows, Type IV pilin proteins: versatile molecular modules, Microbiol Mol Biol Rev, vol.76, pp.740-72, 2012.

J. A. Giron, O. G. Gomez-duarte, K. G. Jarvis, and J. B. Kaper, Longus pilus of enterotoxigenic Escherichia coli and its relatedness to other type-4 pili--a minireview, Gene, vol.192, pp.39-43, 1997.

J. G. Goetz, B. Joshi, P. Lajoie, S. S. Strugnell, T. Scudamore et al., Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1, J Cell Biol, vol.180, pp.1261-75, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00285445

I. Goldschneider, E. C. Gotschlich, and M. S. Artenstein, Human immunity to the meningococcus. I. The role of humoral antibodies, J Exp Med, vol.129, pp.1307-1333, 1969.
DOI : 10.1084/jem.129.6.1307

URL : http://jem.rupress.org/content/129/6/1307.full.pdf

I. Goldschneider, E. C. Gotschlich, and M. S. Artenstein, Human immunity to the meningococcus. II. Development of natural immunity, J Exp Med, vol.129, pp.1327-1375, 1969.
DOI : 10.1084/jem.129.6.1307

URL : http://jem.rupress.org/content/129/6/1307.full.pdf

V. J. Goosens, A. Busch, M. Georgiadou, M. Castagnini, K. T. Forest et al., Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili, Proc Natl Acad Sci U S A, vol.114, pp.4978-4986, 2017.

J. F. Graves, G. D. Biswas, and P. F. Sparling, Sequence-specific DNA uptake in transformation of Neisseria gonorrhoeae, J Bacteriol, vol.152, pp.1071-1078, 1982.

E. Griffiths, Iron in biological systems, Iron and infection: molecular, physiological and clinical aspects, vol.1, pp.1-26, 1999.

E. Griffiths and P. Williams, The iron-uptake systems of pathogenic bacteria, fungi and protozoa, Iron and infection: molecular, physiological and clinical aspects, vol.1, pp.87-212, 1999.

N. J. Griffiths, C. J. Bradley, R. S. Heyderman, and M. Virji, IFN-gamma amplifies NFkappaBdependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1, Cell Microbiol, vol.9, pp.2968-83, 2007.

N. J. Griffiths, D. J. Hill, E. Borodina, R. B. Sessions, N. I. Devos et al., Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance, Mol Microbiol, vol.82, pp.1129-1178, 2011.
DOI : 10.1111/j.1365-2958.2011.07876.x

A. J. Groffen, S. Martens, R. Diez-arazola, L. N. Cornelisse, N. Lozovaya et al., Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release, Science, vol.327, pp.1614-1622, 2010.
DOI : 10.1126/science.1183765

URL : http://europepmc.org/articles/pmc2846320?pdf=render

H. Gu, R. J. Botelho, M. Yu, S. Grinstein, and B. G. Neel, Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis, J Cell Biol, vol.161, pp.1151-61, 2003.
DOI : 10.1083/jcb.200212158

URL : http://jcb.rupress.org/content/161/6/1151.full.pdf

J. Guarner, P. W. Greer, A. Whitney, W. J. Shieh, M. Fischer et al., Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays, Am J Clin Pathol, vol.122, pp.754-64, 2004.
DOI : 10.1309/3489075u03lmk9ae

J. Guizetti, L. Schermelleh, J. Mantler, S. Maar, I. Poser et al., Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments, Science, vol.331, pp.1616-1636, 2011.
DOI : 10.1126/science.1201847

J. Hacker and J. B. Kaper, Pathogenicity islands and the evolution of microbes, Annu Rev Microbiol, vol.54, pp.641-79, 2000.

H. A. Hadi, K. G. Wooldridge, K. Robinson, and D. A. Ala'aldeen, Identification and characterization of App: an immunogenic autotransporter protein of Neisseria meningitidis, Mol Microbiol, vol.41, pp.611-634, 2001.

M. B. Hallett and S. Dewitt, Ironing out the wrinkles of neutrophil phagocytosis, Trends Cell Biol, vol.17, pp.209-223, 2007.
DOI : 10.1016/j.tcb.2007.03.002

A. Halstensen, S. H. Pedersen, B. Haneberg, B. Bjorvatn, and C. O. Solberg, Case fatality of meningococcal disease in western Norway, Scand J Infect Dis, vol.19, pp.35-42, 1987.
DOI : 10.3109/00365548709032375

S. Hammarstrom, The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues, Semin Cancer Biol, vol.9, pp.67-81, 1999.

S. Hammerschmidt, A. Muller, H. Sillmann, M. Muhlenhoff, R. Borrow et al., Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease, Mol Microbiol, vol.20, pp.1211-1231, 1996.

C. G. Hansen, N. A. Bright, G. Howard, and B. J. Nichols, SDPR induces membrane curvature and functions in the formation of caveolae, Nat Cell Biol, vol.11, pp.807-821, 2009.

C. G. Hansen, G. Howard, and B. J. Nichols, Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis, J Cell Sci, vol.124, pp.2777-85, 2011.
DOI : 10.1242/jcs.084319

URL : http://jcs.biologists.org/content/124/16/2777.full.pdf

C. G. Hansen, E. Shvets, G. Howard, K. Riento, and B. J. Nichols, Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae, Nat Commun, vol.4, p.1831, 2013.

S. D. Hansen and R. D. Mullins, Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments, 2015.
DOI : 10.7554/elife.06585

URL : https://doi.org/10.7554/elife.06585

W. D. Hardt, L. M. Chen, K. E. Schuebel, X. R. Bustelo, and J. E. Galan, S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells, Cell, vol.93, pp.815-841, 1998.
URL : https://hal.archives-ouvertes.fr/inserm-00926613

O. B. Harrison, H. Claus, Y. Jiang, J. S. Bennett, H. B. Bratcher et al., Description and nomenclature of Neisseria meningitidis capsule locus, Emerg Infect Dis, vol.19, pp.566-73, 2013.

O. B. Harrison, C. Schoen, A. C. Retchless, X. Wang, K. A. Jolley et al., Neisseria genomics: current status and future perspectives, 2017.
DOI : 10.1093/femspd/ftx060

URL : https://academic.oup.com/femspd/article-pdf/75/6/ftx060/24690709/ftx060.pdf

A. Hartsock and W. J. Nelson, Adherens and tight junctions: structure, function and connections to the actin cytoskeleton, Biochim Biophys Acta, vol.1778, pp.660-669, 2008.

S. Hartung, A. S. Arvai, T. Wood, S. Kolappan, D. S. Shin et al., , 2011.

, Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential, J Biol Chem, vol.286, pp.44254-65

D. L. Higashi, G. H. Zhang, N. Biais, L. R. Myers, N. J. Weyand et al., Influence of type IV pilus retraction on the architecture of the Neisseria gonorrhoeae-infected cell cortex, Microbiology, vol.155, pp.4084-92, 2009.

M. M. Hill, M. Bastiani, R. Luetterforst, M. Kirkham, A. Kirkham et al., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function, Cell, vol.132, pp.113-137, 2008.
DOI : 10.1016/j.cell.2007.11.042

URL : https://doi.org/10.1016/j.cell.2007.11.042

W. R. Hill and T. D. Kinney, The cutaneous lesions in acute meningococcemia; a clinical and pathologic study, J Am Med Assoc, vol.134, pp.513-521, 1947.

L. M. Hoang, E. Thomas, S. Tyler, A. J. Pollard, G. Stephens et al., Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus, Clin Infect Dis, vol.40, pp.38-42, 2005.

M. M. Hobbs, B. Malorny, P. Prasad, G. Morelli, B. Kusecek et al., Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical origins, Microbiology, vol.144, pp.157-66, 1998.

A. Hoess, A. Thormann, A. Friedmann, and A. Heilmann, Self-supporting nanoporous alumina membranes as substrates for hepatic cell cultures, Journal of Biomedical Materials Research Part A, vol.100, pp.2230-2238, 2012.

C. Hoffmann, A. Berking, F. Agerer, A. Buntru, F. Neske et al., Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectinbinding pathogens, J Cell Sci, vol.123, pp.4280-91, 2010.
DOI : 10.1242/jcs.064006

URL : http://jcs.biologists.org/content/123/24/4280.full.pdf

I. Hoffmann, E. Eugene, X. Nassif, P. O. Couraud, and S. Bourdoulous, Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis, J Cell Biol, vol.155, pp.133-176, 2001.

H. L. Howie, M. Glogauer, and M. So, The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism, PLoS Biol, vol.3, p.100, 2005.

K. Hubert, M. C. Pawlik, H. Claus, H. Jarva, S. Meri et al., Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci, PLoS One, vol.7, p.45132, 2012.
DOI : 10.1371/journal.pone.0045132

URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045132&type=printable

E. Hui, C. P. Johnson, J. Yao, F. M. Dunning, and E. R. Chapman, Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion, Cell, vol.138, pp.709-730, 2009.

I. Hurbain and M. Sachse, The future is cold: cryo-preparation methods for transmission electron microscopy of cells, Biol Cell, vol.103, pp.405-425, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-01131341

R. M. Hyland, J. Sun, T. P. Griener, G. L. Mulvey, J. S. Klassen et al., The bundlin pilin protein of enteropathogenic Escherichia coli is an Nacetyllactosamine-specific lectin, Cell Microbiol, vol.10, pp.177-87, 2008.

A. F. Imhaus and G. Dumenil, The number of Neisseria meningitidis type IV pili determines host cell interaction, Embo J, 2014.

R. H. Insall and L. M. Machesky, Actin dynamics at the leading edge: from simple machinery to complex networks, Dev Cell, vol.17, pp.310-332, 2009.

J. M. Isas, M. R. Ambroso, P. B. Hegde, J. Langen, and R. Langen, Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding, Structure, vol.23, pp.873-81, 2015.

R. R. Isberg and J. M. Leong, Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells, Cell, vol.60, pp.861-71, 1990.

R. R. Isberg, D. L. Voorhis, and S. Falkow, Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells, Cell, vol.50, pp.769-78, 1987.

T. S. Istivan and P. J. Coloe, Phospholipase A in Gram-negative bacteria and its role in pathogenesis, Microbiology, vol.152, pp.1263-74, 2006.

J. H. Jacobs, C. Viboud, E. T. Tchetgen, J. Schwartz, C. Steiner et al., The association of meningococcal disease with influenza in the United States, PLoS One, vol.9, 1989.

G. Jacquemet, H. Hamidi, and J. Ivaska, Filopodia in cell adhesion, 3D migration and cancer cell invasion, Curr Opin Cell Biol, vol.36, pp.23-31, 2015.

R. Z. Jafri, A. Ali, N. E. Messonnier, C. Tevi-benissan, D. Durrheim et al., Global epidemiology of invasive meningococcal disease, Popul Health Metr, vol.11, p.17, 2013.

S. Jain, K. B. Moscicka, M. P. Bos, E. Pachulec, M. C. Stuart et al., Structural characterization of outer membrane components of the type IV pili system in pathogenic Neisseria, PLoS One, vol.6, 2011.

C. A. Janeway, J. Medzhitov, and R. , Innate immune recognition, Annu Rev Immunol, vol.20, pp.197-216, 2002.

K. F. Jarrell, Y. Ding, D. B. Nair, and S. Siu, Surface appendages of archaea: structure, function, genetics and assembly, Life (Basel), vol.3, pp.86-117, 2013.

I. K. Jarsch, F. Daste, and J. L. Gallop, Membrane curvature in cell biology: An integration of molecular mechanisms, J Cell Biol, vol.214, pp.375-87, 2016.

H. Jarva, S. Ram, U. Vogel, A. M. Blom, and S. Meri, Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis, J Immunol, vol.174, pp.6299-307, 2005.

M. P. Jennings, Y. N. Srikhanta, E. R. Moxon, M. Kramer, J. T. Poolman et al., The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis, Microbiology, vol.145, pp.3013-3034, 1999.

H. P. Jennissen, Hyperhydrophilic rough surfaces and imaginary contact angles, Materialwissenschaft Und Werkstofftechnik, vol.43, pp.743-750, 2012.

H. Jiang and F. Grinnell, Cell-matrix entanglement and mechanical anchorage of fibroblasts in threedimensional collagen matrices, Mol Biol Cell, vol.16, pp.5070-5076, 2005.

A. J. Jimenez, P. Maiuri, J. Lafaurie-janvore, S. Divoux, M. Piel et al., ESCRT machinery is required for plasma membrane repair, Science, vol.343, p.1247136, 2014.

G. Joberty, C. Petersen, L. Gao, and I. G. Macara, The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42, Nat Cell Biol, vol.2, pp.531-540, 2000.

L. Johansson, A. Rytkonen, P. Bergman, B. Albiger, H. Kallstrom et al., CD46 in meningococcal disease, Science, vol.301, pp.373-378, 2003.

M. D. Johnson, C. K. Garrett, J. E. Bond, K. A. Coggan, M. C. Wolfgang et al., , 2011.

O. Join-lambert, H. Lecuyer, F. Miller, L. Lelievre, A. Jamet et al., Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans, Pseudomonas aeruginosa PilY1 binds integrin in an RGD-and calcium-dependent manner, vol.6, pp.1590-1597, 2013.

D. M. Jones, R. Borrow, A. J. Fox, S. Gray, K. A. Cartwright et al., The lipooligosaccharide immunotype as a virulence determinant in Neisseria meningitidis, Microb Pathog, vol.13, pp.219-243, 1992.

A. B. Jonsson, G. Nyberg, and S. Normark, Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly, Embo J, vol.10, pp.477-88, 1991.

B. Joshi, M. Bastiani, S. S. Strugnell, C. Boscher, R. G. Parton et al., , 2012.

, Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation, J Cell Biol, vol.199, pp.425-460

B. A. Jude and R. K. Taylor, The physical basis of type 4 pilus-mediated microcolony formation by Vibrio cholerae O1, J Struct Biol, vol.175, pp.1-9, 2011.

A. S. Juncker, H. Willenbrock, G. Von-heijne, S. Brunak, H. Nielsen et al., Prediction of lipoprotein signal peptides in Gram-negative bacteria, Protein Sci, vol.12, pp.1652-62, 2003.

K. Jyssum and S. Lie, Genetic Factors Determining Competence in Transformation of Neisseria Meningitidis. 1. A Permanent Loss of Competence, Acta Pathol Microbiol Scand, vol.63, pp.306-322, 1965.

H. Kallstrom, M. K. Liszewski, J. P. Atkinson, and A. B. Jonsson, Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria, Mol Microbiol, vol.25, pp.639-686, 1997.

F. Kanai, H. Liu, S. J. Field, H. Akbary, T. Matsuo et al.,

, The PX domains of p47phox and p40phox bind to lipid products of PI(3)K, Nat Cell Biol, vol.3, pp.675-683

M. Karlsson, E. Palsgard, P. R. Wilshaw, D. Silvio, and L. , Initial in vitro interaction of osteoblasts with nano-porous alumina, Biomaterials, vol.24, pp.3039-3085, 2003.

T. Karlsson, A. Bolshakova, M. A. Magalhaes, V. M. Loitto, and K. E. Magnusson, Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusions, PLoS One, vol.8, p.59901, 2013.

B. Kenny, R. Devinney, M. Stein, D. J. Reinscheid, E. A. Frey et al., , 1997.

E. Enteropathogenic and . Coli, EPEC) transfers its receptor for intimate adherence into mammalian cells, Cell, vol.91, pp.511-531

B. Kenny, S. Ellis, A. D. Leard, J. Warawa, H. Mellor et al., Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules, Mol Microbiol, vol.44, pp.1095-1107, 2002.

T. Kirchhausen, Bending membranes, Nat Cell Biol, vol.14, pp.906-914, 2012.

M. Kirchner, D. Heuer, and T. F. Meyer, CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells, Infect Immun, vol.73, pp.3072-82, 2005.

T. J. Kirn, M. J. Lafferty, C. M. Sandoe, and R. K. Taylor, Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization by Vibrio cholerae, Mol Microbiol, vol.35, pp.896-910, 2000.

S. Knutton, I. Rosenshine, M. J. Pallen, I. Nisan, B. C. Neves et al., A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells, Embo J, vol.17, pp.2166-76, 1998.

W. Koh, R. D. Mahan, and G. E. Davis, Cdc42-and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling, J Cell Sci, vol.121, pp.989-1001, 2008.
DOI : 10.1242/jcs.020693

URL : http://jcs.biologists.org/content/121/7/989.full.pdf

R. Kohler, K. Schafer, S. Muller, G. Vignon, K. Diederichs et al., Structure and assembly of the pseudopilin PulG, Mol Microbiol, vol.54, pp.647-64, 2004.

S. Kolappan, M. Coureuil, X. Yu, X. Nassif, E. H. Egelman et al., Structure of the Neisseria meningitidis Type IV pilus, Nat Commun, vol.7, p.13015, 2016.

J. M. Koomey and S. Falkow, Cloning of the recA gene of Neisseria gonorrhoeae and construction of gonococcal recA mutants, J Bacteriol, vol.169, pp.790-795, 1987.

A. J. Kosmalska, L. Casares, A. Elosegui-artola, J. J. Thottacherry, R. Moreno-vicente et al., Physical principles of membrane remodelling during cell mechanoadaptation, Nat Commun, vol.6, p.7292, 2015.

O. Kovtun, V. A. Tillu, W. Jung, N. Leneva, N. Ariotti et al., Structural insights into the organization of the cavin membrane coat complex, Dev Cell, vol.31, pp.405-424, 2014.

S. J. Krebs and R. K. Taylor, Protection and attachment of Vibrio cholerae mediated by the toxincoregulated pilus in the infant mouse model, J Bacteriol, vol.193, pp.5260-70, 2011.

C. J. Kristich, V. T. Nguyen, T. Le, A. M. Barnes, S. Grindle et al., Development and use of an efficient system for random mariner transposon mutagenesis to identify novel genetic determinants of biofilm formation in the core Enterococcus faecalis genome, Appl Environ Microbiol, vol.74, pp.3377-86, 2008.

J. S. Kroll, K. E. Wilks, J. L. Farrant, and P. R. Langford, Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens, Proc Natl Acad Sci U S A, vol.95, pp.12381-12386, 1998.

C. Kronlage, M. Schafer-herte, D. Boning, H. Oberleithner, and J. Fels, Feeling for Filaments: Quantification of the Cortical Actin Web in Live Vascular Endothelium, Biophys J, vol.109, pp.687-98, 2015.

L. A. Kueltzo, J. Osiecki, J. Barker, W. L. Picking, B. Ersoy et al., Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri, J Biol Chem, vol.278, pp.2792-2800, 2003.
DOI : 10.1074/jbc.m208383200

URL : http://www.jbc.org/content/278/5/2792.full.pdf

S. Kuhn, C. Erdmann, F. Kage, J. Block, L. Schwenkmezger et al., The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation, Nat Commun, vol.6, p.7088, 2015.

R. Kurre, A. Hone, M. Clausen, C. Meel, and B. Maier, PilT2 enhances the speed of gonococcal type IV pilus retraction and of twitching motility, Mol Microbiol, 2012.

P. Kuzemenska, V. Burian, and M. Hausenblasova, Circulation of N. meningitidis in a child community, J Hyg Epidemiol Microbiol Immunol, vol.22, pp.90-107, 1978.

R. Lakshminarayan, C. Wunder, U. Becken, M. T. Howes, C. Benzing et al., Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers, Nat Cell Biol, vol.16, pp.595-606, 2014.
DOI : 10.1038/ncb2970

T. T. Lam, H. Claus, M. Frosch, and U. Vogel, Sequence analysis of serotype-specific synthesis regions II of Haemophilus influenzae serotypes c and d: evidence for common ancestry of capsule synthesis in Pasteurellaceae and Neisseria meningitidis, Res Microbiol, vol.162, pp.483-490, 2011.

M. Lambotin, I. Hoffmann, M. P. Laran-chich, X. Nassif, P. O. Couraud et al., Invasion of endothelial cells by Neisseria meningitidis requires cortactin recruitment by a phosphoinositide-3-kinase/Rac1 signalling pathway triggered by the lipo-oligosaccharide, J Cell Sci, vol.118, pp.3805-3821, 2005.

R. Laurenceau, G. Pehau-arnaudet, S. Baconnais, J. Gault, C. Malosse et al., A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae, PLoS Pathog, vol.9, 2013.
DOI : 10.1371/journal.ppat.1003473

URL : https://hal.archives-ouvertes.fr/hal-00947054

M. Lecuit, S. Dramsi, C. Gottardi, M. Fedor-chaiken, B. Gumbiner et al., A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes, Embo J, vol.18, pp.3956-63, 1999.

M. Lecuit, R. Hurme, J. Pizarro-cerda, H. Ohayon, B. Geiger et al., A role for alpha-and beta-catenins in bacterial uptake, Proc Natl Acad Sci U S A, vol.97, pp.10008-10021, 2000.

M. Lecuit, D. M. Nelson, S. D. Smith, H. Khun, M. Huerre et al., Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin, Proc Natl Acad Sci U S A, vol.101, pp.6152-6159, 2004.

M. Lecuit, S. Vandormael-pournin, J. Lefort, M. Huerre, P. Gounon et al., A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier, Science, vol.292, pp.1722-1727, 2001.

H. Lecuyer, X. Nassif, and M. Coureuil, Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells, Infect Immun, vol.80, pp.175-86, 2012.

S. W. Lee, D. L. Higashi, A. Snyder, A. J. Merz, L. Potter et al., PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells, Cell Microbiol, vol.7, pp.1271-84, 2005.

R. Levin, S. Grinstein, and J. Canton, The life cycle of phagosomes: formation, maturation, and resolution, Immunol Rev, vol.273, pp.156-79, 2016.

L. A. Lewis and D. W. Dyer, Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin, J Bacteriol, vol.177, pp.1299-306, 1995.

L. A. Lewis, M. Gipson, K. Hartman, T. Ownbey, J. Vaughn et al., Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2, Mol Microbiol, vol.32, pp.977-89, 1999.

L. A. Lewis, J. Ngampasutadol, R. Wallace, J. E. Reid, U. Vogel et al., The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement, PLoS Pathog, vol.6, 2010.

L. A. Lewis and S. Ram, Meningococcal disease and the complement system, Virulence, vol.5, pp.98-126, 2014.

L. A. Lewis, D. M. Vu, S. Vasudhev, J. Shaughnessy, D. M. Granoff et al., Factor Hdependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis, MBio, vol.4, pp.339-352, 2013.

H. Li and D. H. Walker, rOmpA is a critical protein for the adhesion of Rickettsia rickettsii to host cells, Microb Pathog, vol.24, pp.289-98, 1998.

J. Li, E. H. Egelman, and L. Craig, Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus, J Mol Biol, vol.418, pp.47-64, 2012.

N. Li, G. S. Xiang, H. Dokainish, K. Ireton, and L. A. Elferink, The Listeria protein internalin B mimics hepatocyte growth factor-induced receptor trafficking, Traffic, vol.6, pp.459-73, 2005.

J. A. Lieberman, C. D. Petro, S. Thomas, A. Yang, and M. S. Donnenberg, Type IV pilus secretins have extracellular C termini, MBio, vol.6, 2015.

G. Y. Liu, C. M. Tang, and R. M. Exley, Non-pathogenic Neisseria: members of an abundant, multihabitat, diverse genus, Microbiology-Sgm, vol.161, pp.1297-1312, 2015.

E. Loh, E. Kugelberg, A. Tracy, Q. Zhang, B. Gollan et al., Temperature triggers immune evasion by Neisseria meningitidis, Nature, vol.502, pp.237-277, 2013.

M. Long, S. H. Huang, C. H. Wu, G. M. Shackleford, and A. Jong, Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells, J Biomed Sci, vol.19, 2012.

J. Loscalzo and A. Schafer, Thrombosis and Hemorrhage: Lippincott Williams and Wilkins, 2002.

M. B. Lowry, A. M. Duchemin, J. M. Robinson, and C. L. Anderson, Functional separation of pseudopod extension and particle internalization during Fc gamma receptor-mediated phagocytosis, J Exp Med, vol.187, pp.161-76, 1998.

S. Lu, M. Giuliani, H. Harvey, L. L. Burrows, R. A. Wickham et al., Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili, Biophys J, vol.108, pp.2865-75, 2015.

R. Lundmark, G. J. Doherty, M. T. Howes, K. Cortese, Y. Vallis et al., The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway, Curr Biol, vol.18, pp.1802-1810, 2008.

L. P. Macfadyen, D. Chen, H. C. Vo, D. Liao, R. Sinotte et al., Competence development by Haemophilus influenzae is regulated by the availability of nucleic acid precursors, Mol Microbiol, vol.40, pp.700-707, 2001.

L. Machesky, P. Jurdic, and B. Hinz, Grab, stick, pull and digest: the functional diversity of actinassociated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion, EMBO Rep, vol.9, pp.139-182, 2008.

F. G. Mackinnon, R. Borrow, A. R. Gorringe, A. J. Fox, D. M. Jones et al., , 1993.

, Demonstration of lipooligosaccharide immunotype and capsule as virulence factors for Neisseria meningitidis using an infant mouse intranasal infection model, Microb Pathog, vol.15, pp.359-66

G. Madico, J. A. Welsch, L. A. Lewis, A. Mcnaughton, D. H. Perlman et al., The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance, J Immunol, vol.177, pp.501-511, 2006.

M. C. Maiden, J. A. Bygraves, E. Feil, G. Morelli, J. E. Russell et al., Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms, Proc Natl Acad Sci U S A, vol.95, pp.3140-3145, 1998.

B. Maier, L. Potter, M. So, C. D. Long, H. S. Seifert et al., Single pilus motor forces exceed 100 pN, Proc Natl Acad Sci U S A, vol.99, pp.16012-16019, 2002.
DOI : 10.1073/pnas.242523299

URL : http://www.pnas.org/content/99/25/16012.full.pdf

E. Mairey, A. Genovesio, E. Donnadieu, C. Bernard, F. Jaubert et al., Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier, J Exp Med, vol.203, pp.1939-50, 2006.
DOI : 10.1083/jcb1744oia7

N. Maissa, V. Covarelli, S. Janel, B. Durel, N. Simpson et al., Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/beta2-adrenoceptor clusters assembled by alpha-actinin-4, 2017.

, Nat Commun, vol.8, 15764.

R. Marathe, C. Meel, N. C. Schmidt, L. Dewenter, R. Kurre et al., Bacterial twitching motility is coordinated by a two-dimensional tug-of-war with directional memory, Nat Commun, vol.5, p.3759, 2014.

D. Martin, N. Cadieux, J. Hamel, and B. R. Brodeur, Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection, J Exp Med, vol.185, pp.1173-83, 1997.
DOI : 10.1084/jem.185.7.1173

URL : http://jem.rupress.org/content/185/7/1173.full.pdf

P. Martin, T. Van-de-ven, N. Mouchel, A. C. Jeffries, D. W. Hood et al., , 2003.

, Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variation, Mol Microbiol, vol.50, pp.245-57

J. J. Martinez and P. Cossart, Early signaling events involved in the entry of Rickettsia conorii into mammalian cells, J Cell Sci, vol.117, pp.5097-106, 2004.

J. J. Martinez, S. Seveau, E. Veiga, S. Matsuyama, and P. Cossart, Ku70, a component of DNAdependent protein kinase, is a mammalian receptor for Rickettsia conorii, Cell, vol.123, pp.1013-1036, 2005.

N. Matthey and M. Blokesch, The DNA-Uptake Process of Naturally Competent Vibrio cholerae, Trends Microbiol, vol.24, pp.98-110, 2016.

P. K. Mattila and P. Lappalainen, Filopodia: molecular architecture and cellular functions, Nat Rev Mol Cell Biol, vol.9, pp.446-54, 2008.

P. K. Mattila, A. Pykalainen, J. Saarikangas, V. O. Paavilainen, H. Vihinen et al., Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism, J Cell Biol, vol.176, pp.953-64, 2007.

M. Mccallum, S. Tammam, A. Khan, L. L. Burrows, and P. L. Howell, The molecular mechanism of the type IVa pilus motors, Nat Commun, vol.8, p.15091, 2017.

E. J. Mcghie, R. D. Hayward, and V. Koronakis, Control of actin turnover by a salmonella invasion protein, Mol Cell, vol.13, pp.497-510, 2004.

H. T. Mcmahon and E. Boucrot, Molecular mechanism and physiological functions of clathrinmediated endocytosis, Nat Rev Mol Cell Biol, vol.12, pp.517-550, 2011.

H. T. Mcmahon and E. Boucrot, Membrane curvature at a glance, J Cell Sci, vol.128, pp.1065-70, 2015.

L. K. Mcneil, R. J. Zagursky, S. L. Lin, E. Murphy, G. W. Zlotnick et al., Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease, Microbiol Mol Biol Rev, vol.77, pp.234-52, 2013.

K. Melican, P. Michea-veloso, T. Martin, P. Bruneval, and G. Dumenil, Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model, PLoS Pathog, vol.9, p.1003139, 2013.

A. J. Merz, C. A. Enns, and M. So, Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells, Mol Microbiol, vol.32, pp.1316-1348, 1999.

A. J. Merz and M. So, Attachment of piliated, Opa-and Opc-gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins, Infect Immun, vol.65, pp.4341-4350, 1997.

A. J. Merz, M. So, and M. P. Sheetz, Pilus retraction powers bacterial twitching motility, Nature, vol.407, pp.98-102, 2000.

J. Meyer, T. Brissac, E. Frapy, H. Omer, D. Euphrasie et al., Characterization of MDAPhi, a temperate filamentous bacteriophage of Neisseria meningitidis, Microbiology, vol.162, pp.268-82, 2016.

P. A. Mickelsen, E. Blackman, and P. F. Sparling, Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from lactoferrin, Infect Immun, vol.35, pp.915-935, 1982.

P. A. Mickelsen and P. F. Sparling, Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds, Infect Immun, vol.33, pp.555-64, 1981.

G. Mikaty, M. Soyer, E. Mairey, N. Henry, D. Dyer et al., Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stress, PLoS Pathog, vol.5, 2009.

F. Miller, G. Phan, T. Brissac, C. Bouchiat, G. Lioux et al., The hypervariable region of meningococcal major pilin PilE controls the host cell response via antigenic variation, MBio, vol.5, pp.1024-1037, 2014.

C. Mim and V. M. Unger, Membrane curvature and its generation by BAR proteins, Trends Biochem Sci, vol.37, pp.526-559, 2012.

J. Moore, S. E. Bailey, Z. Benmechernene, C. Tzitzilonis, N. J. Griffiths et al., Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidis, J Biol Chem, vol.280, pp.31489-97, 2005.

P. C. Morand, E. Bille, S. Morelle, E. Eugene, J. L. Beretti et al., Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins, Embo J, vol.23, pp.2009-2026, 2004.

P. C. Morand, P. Tattevin, E. Eugene, J. L. Beretti, and X. Nassif, The adhesive property of the type IV pilus-associated component PilC1 of pathogenic Neisseria is supported by the conformational structure of the N-terminal part of the molecule, Mol Microbiol, vol.40, pp.846-56, 2001.

B. Moren, C. Shah, M. T. Howes, N. L. Schieber, H. T. Mcmahon et al., EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization, Mol Biol Cell, vol.23, pp.1316-1345, 2012.

S. Morlot, V. Galli, M. Klein, N. Chiaruttini, J. Manzi et al., Membrane shape at the edge of the dynamin helix sets location and duration of the fission reaction, Cell, vol.151, pp.619-648, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01138988

I. C. Morrow and R. G. Parton, Flotillins and the PHB domain protein family: rafts, worms and anaesthetics, Traffic, vol.6, pp.725-765, 2005.

E. R. Moxon, P. B. Rainey, M. A. Nowak, and R. E. Lenski, Adaptive evolution of highly mutable loci in pathogenic bacteria, Curr Biol, vol.4, pp.24-33, 1994.

K. E. Mueller and K. Wolf, C. pneumoniae disrupts eNOS trafficking and impairs NO production in human aortic endothelial cells, Cell Microbiol, 2014.
URL : https://hal.archives-ouvertes.fr/in2p3-00011438

P. Muenzner, C. Dehio, T. Fujiwara, M. Achtman, T. F. Meyer et al., , 2000.

, Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells, Infect Immun, vol.68, pp.3601-3608

J. F. Nabhan, R. Hu, R. S. Oh, S. N. Cohen, and Q. Lu, Formation and release of arrestin domaincontaining protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein, Proc Natl Acad Sci U S A, vol.109, pp.4146-51, 2012.

D. Nakane and T. Nishizaka, Asymmetric distribution of type IV pili triggered by directional light in unicellular cyanobacteria, Proc Natl Acad Sci U S A, vol.114, pp.6593-6598, 2017.

E. Namork and P. Brandtzaeg, Fatal meningococcal septicaemia with "blebbing" meningococcus, Lancet, vol.360, p.1741, 2002.
DOI : 10.1016/s0140-6736(02)11721-1

X. Nassif, J. L. Beretti, J. Lowy, P. Stenberg, P. O'gaora et al., Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells, Proc Natl Acad Sci U S A, vol.91, pp.3769-73, 1994.

X. Nassif, J. Lowy, P. Stenberg, P. O'gaora, A. Ganji et al., Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells, Mol Microbiol, vol.8, pp.719-744, 1993.

A. Neisser, Ueber eine der Gonorrhoe eigentümliche Micrococcusform, Centralbatt für die medicinischen Wissenschaften, 1879.

Y. Nguyen, S. Sugiman-marangos, H. Harvey, S. D. Bell, C. L. Charlton et al., Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin, J Biol Chem, vol.290, pp.601-612, 2015.

K. Niebuhr, S. Giuriato, T. Pedron, D. J. Philpott, F. Gaits et al., Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology, Embo J, vol.21, pp.5069-78, 2002.

M. Nivaskumar, G. Bouvier, M. Campos, N. Nadeau, X. Yu et al., Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers, Structure, vol.22, pp.685-96, 2014.

M. Nivaskumar and O. Francetic, Type II secretion system: a magic beanstalk or a protein escalator, Biochim Biophys Acta, vol.1843, pp.1568-77, 2014.

K. P. Obergfell and H. S. Seifert, The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation, PLoS Genet, vol.12, p.1006069, 2016.

P. Olcen, J. Kjellander, D. Danielsson, and B. L. Lindquist, Epidemiology of Neisseria meningitidis; prevalence and symptoms from the upper respiratory tract in family members to patients with meningococcal disease, Scand J Infect Dis, vol.13, pp.105-114, 1981.

D. Opitz and B. Maier, Rapid cytoskeletal response of epithelial cells to force generation by type IV pili, PLoS One, vol.6, 2011.

J. C. Ottow, Ecology, physiology, and genetics of fimbriae and pili, Annu Rev Microbiol, vol.29, pp.79-108, 1975.

R. Ovstebo, P. Brandtzaeg, B. Brusletto, K. B. Haug, K. Lande et al., Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease, J Clin Microbiol, vol.42, pp.2980-2987, 2004.

H. Ozdemir, T. Kendirli, E. Ciftci, and E. Ince, Purpura fulminans in a child due to Neisseria meningitidis, Infection, vol.40, pp.717-725, 2012.

M. S. Paget, Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution, Biomolecules, vol.5, pp.1245-65, 2015.
DOI : 10.3390/biom5031245

URL : https://www.mdpi.com/2218-273X/5/3/1245/pdf

S. Paladino, D. Sarnataro, R. Pillich, S. Tivodar, L. Nitsch et al., Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins, J Cell Biol, vol.167, pp.699-709, 2004.
URL : https://hal.archives-ouvertes.fr/pasteur-00167021

O. Palander, M. El-zeiry, and W. S. Trimble, Uncovering the Roles of Septins in Cilia, Front Cell Dev Biol, vol.5, p.36, 2017.

M. O. Parat, R. Z. Stachowicz, and P. L. Fox, Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells, Biochem J, vol.361, pp.681-689, 2002.

S. K. Parida, E. Domann, M. Rohde, S. Muller, A. Darji et al., Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells, Mol Microbiol, vol.28, pp.81-93, 1998.

J. Parkhill, M. Achtman, K. D. James, S. D. Bentley, C. Churcher et al., Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491, Nature, vol.404, pp.502-508, 2000.

R. G. Parton and M. A. Del-pozo, Caveolae as plasma membrane sensors, protectors and organizers, Nat Rev Mol Cell Biol, vol.14, pp.98-112, 2013.
DOI : 10.1038/nrm3512

R. G. Parton, M. Hanzal-bayer, and J. F. Hancock, Biogenesis of caveolae: a structural model for caveolin-induced domain formation, J Cell Sci, vol.119, pp.787-96, 2006.

I. R. Peak, Y. Srikhanta, M. Dieckelmann, E. R. Moxon, and M. P. Jennings, Identification and characterisation of a novel conserved outer membrane protein from Neisseria meningitidis, FEMS Immunol Med Microbiol, vol.28, pp.329-363, 2000.

A. K. Perras, G. Wanner, A. Klingl, M. Mora, A. K. Auerbach et al., Grappling archaea: ultrastructural analyses of an uncultivated, coldloving archaeon, and its biofilm, Front Microbiol, vol.5, p.397, 2014.

B. J. Peter, H. M. Kent, I. G. Mills, Y. Vallis, P. J. Butler et al., BAR domains as sensors of membrane curvature: the amphiphysin BAR structure, Science, vol.303, pp.495-504, 2004.

N. Phillips, R. D. Hayward, and V. Koronakis, Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation, Nat Cell Biol, vol.6, pp.618-643, 2004.

J. Pizarro-cerda and P. Cossart, Bacterial adhesion and entry into host cells, Cell, vol.124, pp.715-742, 2006.

M. Pizza, V. Scarlato, V. Masignani, M. M. Giuliani, B. Arico et al., Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing, Science, vol.287, pp.1816-1836, 2000.
DOI : 10.1126/science.287.5459.1816

L. Plancon, L. Du-merle, S. Le-friec, P. Gounon, M. Jouve et al., Recognition of the cellular beta1-chain integrin by the bacterial AfaD invasin is implicated in the internalization of afa-expressing pathogenic Escherichia coli strains, Cell Microbiol, vol.5, pp.681-93, 2003.

A. E. Platonov, I. V. Vershinina, E. J. Kuijper, R. Borrow, and H. Kayhty, Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine, Vaccine, vol.21, pp.4437-4484, 2003.

M. Pohlschroder and R. N. Esquivel, Archaeal type IV pili and their involvement in biofilm formation, Front Microbiol, vol.6, 0190.

J. T. Poolman, C. T. Hopman, and H. C. Zanen, Immunogenicity of meningococcal antigens as detected in patient sera, Infect Immun, vol.40, pp.398-406, 1983.

K. Postle and R. J. Kadner, Touch and go: tying TonB to transport, Mol Microbiol, vol.49, pp.869-82, 2003.

N. Poweleit, P. Ge, H. H. Nguyen, R. R. Loo, R. P. Gunsalus et al., CryoEM structure of the Methanospirillum hungatei archaellum reveals structural features distinct from the bacterial flagellum and type IV pili, vol.2, p.16222, 2016.

C. Prevost, H. Zhao, J. Manzi, E. Lemichez, P. Lappalainen et al.,

, IRSp53 senses negative membrane curvature and phase separates along membrane tubules, Nat Commun, vol.6, p.8529

A. R. Pries, T. W. Secomb, T. Gessner, M. B. Sperandio, J. F. Gross et al., Resistance to blood flow in microvessels in vivo, Circ Res, vol.75, pp.904-919, 1994.

S. M. Prince, M. Achtman, and J. P. Derrick, Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis, Proc Natl Acad Sci U S A, vol.99, pp.3417-3438, 2002.

C. Pujol, E. Eugene, L. De-saint-martin, and X. Nassif, Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells, Infect Immun, vol.65, pp.4836-4878, 1997.

C. Pujol, E. Eugene, M. Marceau, and X. Nassif, The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion, Proc Natl Acad Sci U S A, vol.96, pp.4017-4039, 1999.

C. Putonti, B. Nowicki, M. Shaffer, Y. Fofanov, and S. Nowicki, Where does Neisseria acquire foreign DNA from: an examination of the source of genomic and pathogenic islands and the evolution of the Neisseria genus, BMC Evol Biol, vol.13, p.184, 2013.

F. Quemeneur, J. K. Sigurdsson, M. Renner, P. J. Atzberger, P. Bassereau et al., Shape matters in protein mobility within membranes, Proc Natl Acad Sci U S A, vol.111, pp.5083-5090, 2014.

D. Quere, Wetting and roughness, Annual Review of Materials Research, vol.38, pp.71-99, 2008.

C. Radel and V. Rizzo, Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization, Am J Physiol Heart Circ Physiol, vol.288, pp.936-981, 2005.

Y. Rao and V. Haucke, Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily, Cell Mol Life Sci, vol.68, pp.3983-93, 2011.

P. N. Reardon and K. T. Mueller, Structure of the type IVa major pilin from the electrically conductive bacterial nanowires of Geobacter sulfurreducens, J Biol Chem, vol.288, pp.29260-29266, 2013.

T. A. Rhomberg, M. C. Truttmann, P. Guye, Y. Ellner, and C. Dehio, A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome, Cell Microbiol, vol.11, pp.927-972, 2009.

A. J. Ridley, Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking, Trends Cell Biol, vol.16, pp.522-531, 2006.

A. J. Ridley, Life at the leading edge, Cell, vol.145, pp.1012-1034, 2011.

W. Romer, L. Berland, V. Chambon, K. Gaus, B. Windschiegl et al., Shiga toxin induces tubular membrane invaginations for its uptake into cells, Nature, vol.450, pp.670-675, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00323875

A. Roy, A. Kucukural, and Y. Zhang, I-TASSER: a unified platform for automated protein structure and function prediction, Nat Protoc, vol.5, pp.725-763, 2010.

T. Rudel, I. Scheurerpflug, and T. F. Meyer, Neisseria PilC protein identified as type-4 pilus tiplocated adhesin, Nature, vol.373, pp.357-366, 1995.

V. Ruprecht, P. Monzo, A. Ravasio, Z. Yue, E. Makhija et al., How cells respond to environmental cues -insights from bio-functionalized substrates, Journal of Cell Science, vol.130, pp.51-61, 2017.

U. S. Sajjan, L. Sun, R. Goldstein, and J. F. Forstner, Cable (cbl) type II pili of cystic fibrosisassociated Burkholderia (Pseudomonas) cepacia: nucleotide sequence of the cblA major subunit pilin gene and novel morphology of the assembled appendage fibers, J Bacteriol, vol.177, pp.1030-1038, 1995.

J. Sarkari, N. Pandit, E. R. Moxon, and M. Achtman, Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly-cytidine, 1994.

, Mol Microbiol, vol.13, pp.207-224

N. Sauvonnet, G. Vignon, A. P. Pugsley, and P. Gounon, Pilus formation and protein secretion by the same machinery in Escherichia coli, Embo J, vol.19, pp.2221-2229, 2000.

M. Scarselli, D. Serruto, P. Montanari, B. Capecchi, J. Adu-bobie et al., Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin, Mol Microbiol, vol.61, pp.631-675, 2006.

A. Schlegel and M. P. Lisanti, A molecular dissection of caveolin-1 membrane attachment and oligomerization. Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivo, J Biol Chem, vol.275, pp.21605-21622, 2000.

C. Schmitt, D. Turner, M. Boesl, M. Abele, M. Frosch et al., A functional twopartner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cells, J Bacteriol, vol.189, pp.7968-76, 2007.

C. Schoen, J. Blom, H. Claus, A. Schramm-gluck, P. Brandt et al., Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis, Proc Natl Acad Sci U S A, vol.105, pp.3473-3481, 2008.

R. J. Scholten, B. Kuipers, H. A. Valkenburg, J. Dankert, W. D. Zollinger et al.,

, Lipo-oligosaccharide immunotyping of Neisseria meningitidis by a whole-cell ELISA with monoclonal antibodies, J Med Microbiol, vol.41, pp.236-279

A. B. Schryvers and G. C. Gonzalez, Receptors for transferrin in pathogenic bacteria are specific for the host's protein, Can J Microbiol, vol.36, pp.145-152, 1990.

A. B. Schryvers and B. C. Lee, Comparative analysis of the transferrin and lactoferrin binding proteins in the family Neisseriaceae, Can J Microbiol, vol.35, pp.409-424, 1989.

A. B. Schryvers and L. J. Morris, Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis, Infect Immun, vol.56, pp.1144-1153, 1988.

A. B. Schryvers and L. J. Morris, Identification and characterization of the transferrin receptor from Neisseria meningitidis, Mol Microbiol, vol.2, pp.281-289, 1988.

A. B. Schryvers and I. Stojiljkovic, Iron acquisition systems in the pathogenic Neisseria, Mol Microbiol, vol.32, pp.1117-1140, 1999.

A. Schubert-unkmeir, C. Konrad, H. Slanina, F. Czapek, S. Hebling et al., , 2010.

, Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8, PLoS Pathog, vol.6, 1000874.

E. Segal, P. Hagblom, H. S. Seifert, and M. So, Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments, Proc Natl Acad Sci U S A, vol.83, pp.2177-81, 1986.

L. M. Senff, W. S. Wegener, G. F. Brooks, W. R. Finnerty, and R. A. Makula, Phospholipid composition and phospholipase A activity of Neisseria gonorrhoeae, J Bacteriol, vol.127, pp.874-80, 1976.

Y. Senju, Y. Itoh, K. Takano, S. Hamada, and S. Suetsugu, Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting, J Cell Sci, vol.124, pp.2032-2072, 2011.

D. Serruto, J. Adu-bobie, M. Scarselli, D. Veggi, M. Pizza et al., , 2003.

, Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity, Mol Microbiol, vol.48, pp.323-357

D. Serruto, M. J. Bottomley, S. Ram, M. M. Giuliani, and R. Rappuoli, The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens, Vaccine, vol.30, issue.2, pp.87-97, 2012.

S. Seveau, H. Bierne, S. Giroux, M. C. Prevost, and P. Cossart, Role of lipid rafts in E-cadherin--and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells, J Cell Biol, vol.166, pp.743-53, 2004.

R. Shahapure, R. P. Driessen, M. F. Haurat, S. V. Albers, and R. T. Dame, The archaellum: a rotating type IV pilus, Mol Microbiol, vol.91, pp.716-739, 2014.

Y. Shen, M. Naujokas, M. Park, and K. Ireton, InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase, Cell, vol.103, pp.501-511, 2000.

J. Shin, H. Jo, and H. Park, Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu, Biochem Biophys Res Commun, vol.339, pp.737-778, 2006.

F. Sidikou, M. Zaneidou, I. Alkassoum, S. Schwartz, B. Issaka et al., Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data, Lancet Infect Dis, vol.16, pp.1288-1294, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01357718

M. Simunovic, G. A. Voth, A. Callan-jones, and P. Bassereau, When Physics Takes Over: BAR Proteins and Membrane Curvature, Trends Cell Biol, vol.25, pp.780-92, 2015.

R. N. Singh and M. P. Pitale, Competence and deoxyribonucleic acid uptake in Bacillus subtilis, J Bacteriol, vol.95, pp.864-870, 1968.

B. Sinha, D. Koster, R. Ruez, P. Gonnord, M. Bastiani et al., Cells respond to mechanical stress by rapid disassembly of caveolae, Cell, vol.144, pp.402-415, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00821331

A. Siryaporn, S. L. Kuchma, G. A. O'toole, and Z. Gitai, Surface attachment induces Pseudomonas aeruginosa virulence, Proc Natl Acad Sci U S A, vol.111, pp.16860-16865, 2014.

S. T. Sit and E. Manser, Rho GTPases and their role in organizing the actin cytoskeleton, J Cell Sci, vol.124, pp.679-83, 2011.

J. M. Skerker and L. Shapiro, Identification and cell cycle control of a novel pilus system in Caulobacter crescentus, Embo J, vol.19, pp.3223-3257, 2000.

R. Sorkin, A. Greenbaum, M. David-pur, S. Anava, A. Ayali et al., Process entanglement as a neuronal anchorage mechanism to rough surfaces, Nanotechnology, vol.20, p.15101, 2009.

M. Soyer, A. Charles-orszag, T. Lagache, S. Machata, A. F. Imhaus et al., Early sequence of events triggered by the interaction of Neisseria meningitidis with endothelial cells, Cell Microbiol, vol.16, pp.878-95, 2014.

P. F. Sparling, Genetic transformation of Neisseria gonorrhoeae to streptomycin resistance, J Bacteriol, vol.92, pp.1364-71, 1966.

B. G. Spratt, L. D. Bowler, Q. Y. Zhang, J. Zhou, and J. M. Smith, Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species, J Mol Evol, vol.34, pp.115-140, 1992.

T. Sprong, A. S. Moller, A. Bjerre, E. Wedege, P. Kierulf et al., Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide, Infect Immun, vol.72, pp.3344-3353, 2004.

J. C. Stachowiak, C. C. Hayden, and D. Y. Sasaki, Steric confinement of proteins on lipid membranes can drive curvature and tubulation, Proc Natl Acad Sci U S A, vol.107, pp.7781-7787, 2010.

J. C. Stachowiak, E. M. Schmid, C. J. Ryan, H. S. Ann, D. Y. Sasaki et al., Membrane bending by protein-protein crowding, Nat Cell Biol, vol.14, pp.944-953, 2012.

T. P. Stauffer, S. Ahn, and T. Meyer, Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells, Curr Biol, vol.8, pp.343-349, 1998.

P. S. Steeg, K. A. Camphausen, and Q. R. Smith, Brain metastases as preventive and therapeutic targets, Nat Rev Cancer, vol.11, pp.352-63, 2011.

L. Steeghs, R. Den-hartog, A. Den-boer, B. Zomer, P. Roholl et al., Meningitis bacterium is viable without endotoxin, Nature, vol.392, pp.449-50, 1998.

D. S. Stephens, B. Greenwood, and P. Brandtzaeg, Epidemic meningitis, meningococcaemia, and Neisseria meningitidis, Lancet, vol.369, pp.2196-2210, 2007.

D. S. Stephens, L. H. Hoffman, and Z. A. Mcgee, Interaction of Neisseria meningitidis with human nasopharyngeal mucosa: attachment and entry into columnar epithelial cells, J Infect Dis, vol.148, pp.369-76, 1983.

D. S. Stephens and Z. A. Mcgee, Attachment of Neisseria meningitidis to human mucosal surfaces: influence of pili and type of receptor cell, J Infect Dis, vol.143, pp.525-557, 1981.

A. Stern and T. F. Meyer, Common mechanism controlling phase and antigenic variation in pathogenic neisseriae, Mol Microbiol, vol.1, pp.5-12, 1987.

M. Stoeber, I. K. Stoeck, C. Hanni, C. K. Bleck, G. Balistreri et al., Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin, Embo J, vol.31, pp.2350-64, 2012.

I. Stojiljkovic, V. Hwa, L. De-saint-martin, P. O'gaora, X. Nassif et al., , 1995.

, The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence, Mol Microbiol, vol.15, pp.531-572

I. Stojiljkovic, J. Larson, V. Hwa, S. Anic, and M. So, HmbR outer membrane receptors of pathogenic Neisseria spp.: iron-regulated, hemoglobin-binding proteins with a high level of primary structure conservation, J Bacteriol, vol.178, pp.4670-4678, 1996.

I. Stojiljkovic and N. Srinivasan, Neisseria meningitidis tonB, exbB, and exbD genes: Ton-dependent utilization of protein-bound iron in Neisseriae, J Bacteriol, vol.179, pp.805-817, 1997.

S. Suetsugu and A. Gautreau, Synergistic BAR-NPF interactions in actin-driven membrane remodeling, Trends Cell Biol, vol.22, pp.141-50, 2012.

M. Sun, N. Northup, F. Marga, T. Huber, F. J. Byfield et al., The effect of cellular cholesterol on membrane-cytoskeleton adhesion, J Cell Sci, vol.120, pp.2223-2254, 2007.

Y. Suzuki, H. Yamamura, S. Ohya, and Y. Imaizumi, Caveolin-1 facilitates the direct coupling between large conductance Ca2+-activated K+ (BKCa) and Cav1.2 Ca2+ channels and their clustering to regulate membrane excitability in vascular myocytes, J Biol Chem, vol.288, pp.36750-61, 2013.

T. M. Svitkina, E. A. Bulanova, O. Y. Chaga, D. M. Vignjevic, S. Kojima et al., Mechanism of filopodia initiation by reorganization of a dendritic network, J Cell Biol, vol.160, pp.409-430, 2003.

J. Swanson, Studies on gonococcus infection. XIV. Cell wall protein differences among color/opacity colony variants of Neisseria gonorrhoeae, Infect Immun, vol.21, pp.292-302, 1978.

A. Swimm, B. Bommarius, Y. Li, D. Cheng, P. Reeves et al., Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals, Mol Biol Cell, vol.15, pp.3520-3529, 2004.
DOI : 10.1091/mbc.e04-02-0093

URL : http://europepmc.org/articles/pmc491815?pdf=render

Z. Szabo, A. O. Stahl, S. V. Albers, J. C. Kissinger, A. J. Driessen et al., Identification of diverse archaeal proteins with class III signal peptides cleaved by distinct archaeal prepilin peptidases, J Bacteriol, vol.189, pp.772-780, 2007.

A. Tala, C. Progida, M. De-stefano, L. Cogli, M. R. Spinosa et al., The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidis, Cell Microbiol, vol.10, pp.2461-82, 2008.

Y. Tan, R. Y. Adhikari, N. S. Malvankar, J. E. Ward, T. L. Woodard et al., Expressing the Geobacter metallireducens PilA in Geobacter sulfurreducens Yields Pili with Exceptional Conductivity, MBio, vol.8, 2017.

M. J. Taylor, D. Perrais, and C. J. Merrifield, A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis, PLoS Biol, vol.9, 2011.

H. Tettelin, N. J. Saunders, J. Heidelberg, A. C. Jeffries, K. E. Nelson et al., Complete genome sequence of Neisseria meningitidis serogroup B strain MC58, Science, vol.287, pp.1809-1824, 2000.

W. J. Todd, G. P. Wray, and P. J. Hitchcock, Arrangement of pili in colonies of Neisseria gonorrhoeae, J Bacteriol, vol.159, pp.312-332, 1984.

S. Tollis, A. E. Dart, G. Tzircotis, and R. G. Endres, The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape, BMC Syst Biol, vol.4, p.149, 2010.

J. Tonnesen, G. Katona, B. Rozsa, and U. V. Nagerl, Spine neck plasticity regulates compartmentalization of synapses, Nat Neurosci, vol.17, pp.678-85, 2014.

T. Tosi, L. F. Estrozi, V. Job, I. Guilvout, A. P. Pugsley et al., , 2014.

, Structural Similarity of Secretins from Type II and Type III Secretion Systems, Structure, vol.22, pp.1348-55

C. L. Trotter and B. M. Greenwood, Meningococcal carriage in the African meningitis belt, Lancet Infect Dis, vol.7, pp.797-803, 2007.

M. C. Truttmann, T. A. Rhomberg, and C. Dehio, Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells, Cell Microbiol, vol.13, pp.284-99, 2011.

D. P. Turner, A. G. Marietou, L. Johnston, K. K. Ho, A. J. Rogers et al., Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis, Infect Immun, vol.74, pp.2957-64, 2006.

Y. L. Tzeng, J. A. Bazan, A. N. Turner, X. Wang, A. C. Retchless et al., Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen, Proc Natl Acad Sci, 2017.

Y. L. Tzeng, L. E. Martin, and D. S. Stephens, Environmental survival of Neisseria meningitidis, Epidemiol Infect, vol.142, pp.187-90, 2014.

T. Uchiyama, Adherence to and invasion of Vero cells by recombinant Escherichia coli expressing the outer membrane protein rOmpB of Rickettsia japonica, Ann N Y Acad Sci, vol.990, pp.585-90, 2003.

A. Unkmeir, K. Latsch, G. Dietrich, E. Wintermeyer, B. Schinke et al., Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells, Mol Microbiol, vol.46, pp.933-979, 2002.

N. Unwin, Refined structure of the nicotinic acetylcholine receptor at 4A resolution, J Mol Biol, vol.346, pp.967-89, 2005.

M. J. Uria, Q. Zhang, Y. Li, A. Chan, R. M. Exley et al., A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies, J Exp Med, vol.205, pp.1423-1457, 2008.

T. Uruno, J. Liu, P. Zhang, Y. Fan, C. Egile et al., Activation of Arp2/3 complex-mediated actin polymerization by cortactin, Nat Cell Biol, vol.3, pp.259-66, 2001.

A. Van-der-ende, C. T. Hopman, S. Zaat, B. B. Essink, B. Berkhout et al., Variable expression of class 1 outer membrane protein in Neisseria meningitidis is caused by variation in the spacing between the -10 and -35 regions of the promoter, J Bacteriol, vol.177, pp.2475-80, 1995.

M. Van-deuren, P. Brandtzaeg, and J. W. Van-der-meer, Update on meningococcal disease with emphasis on pathogenesis and clinical management, Clin Microbiol Rev, vol.13, pp.144-66, 2000.

E. J. Van-schaik, C. L. Giltner, G. F. Audette, D. W. Keizer, D. L. Bautista et al., DNA binding: a novel function of Pseudomonas aeruginosa type IV pili, J Bacteriol, vol.187, pp.1455-64, 2005.

P. Van-ulsen, L. Rutten, M. Feller, J. Tommassen, and A. Van-der-ende, Two-partner secretion systems of Neisseria meningitidis associated with invasive clonal complexes, Infect Immun, vol.76, pp.4649-58, 2008.

L. Vandeputte-rutten, M. P. Bos, J. Tommassen, and P. Gros, Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential, J Biol Chem, vol.278, pp.24825-24855, 2003.

D. J. Vandyke, J. Wu, S. Y. Ng, M. Kanbe, B. Chaban et al., Identification of a putative acetyltransferase gene, MMP0350, which affects proper assembly of both flagella and pili in the archaeon Methanococcus maripaludis, J Bacteriol, vol.190, pp.5300-5307, 2008.

M. Vargas, N. S. Malvankar, P. L. Tremblay, C. Leang, J. A. Smith et al., Aromatic amino acids required for pili conductivity and long-range extracellular electron transport in Geobacter sulfurreducens, MBio, vol.4, pp.105-118, 2013.

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, Directed actin polymerization is the driving force for epithelial cell-cell adhesion, Cell, vol.100, pp.209-228, 2000.

E. Veiga and P. Cossart, Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells, Nat Cell Biol, vol.7, pp.894-900, 2005.

G. Vidarsson, N. Overbeeke, A. M. Stemerding, G. Van-den-dobbelsteen, P. Van-ulsen et al., Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease, Infect Immun, vol.73, pp.6721-6727, 2005.

G. Vignon, R. Kohler, E. Larquet, S. Giroux, M. C. Prevost et al., , 2003.

, Type IV-like pili formed by the type II secreton: specificity, composition, bundling, polar localization, and surface presentation of peptides, J Bacteriol, vol.185, pp.3416-3444

M. Virji, D. Evans, A. Hadfield, F. Grunert, A. M. Teixeira et al., Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae: identification of Opa adhesiotopes on the N-domain of CD66 molecules, Mol Microbiol, vol.34, pp.538-51, 1999.

M. Virji, K. Makepeace, D. J. Ferguson, M. Achtman, J. Sarkari et al., Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis, Mol Microbiol, vol.6, pp.2785-95, 1992.

M. Virji, K. Makepeace, and E. R. Moxon, Distinct mechanisms of interactions of Opc-expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactions, Mol Microbiol, vol.14, pp.173-84, 1994.

M. Virji, K. Makepeace, I. R. Peak, D. J. Ferguson, M. P. Jennings et al., Opcand pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides, Mol Microbiol, vol.18, pp.741-54, 1995.

U. Vogel, H. Claus, L. Muller, D. Bunjes, J. Elias et al., Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl), J Clin Microbiol, vol.42, pp.2898-901, 2004.

T. Wakatsuki, B. Schwab, N. C. Thompson, and E. L. Elson, Effects of cytochalasin D and latrunculin B on mechanical properties of cells, J Cell Sci, vol.114, pp.1025-1061, 2001.

S. Wang, M. R. Parsek, D. J. Wozniak, and L. Z. Ma, A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms, Environ Microbiol, vol.15, pp.2238-53, 2013.

S. Watanabe and E. Boucrot, Fast and ultrafast endocytosis, Curr Opin Cell Biol, vol.47, pp.64-71, 2017.
DOI : 10.1016/j.ceb.2017.02.013

URL : http://discovery.ucl.ac.uk/1552799/1/Boucrot_Watanabe%20and%20Boucrot%20accepted%20manuscript.pdf

A. M. Weaver, J. E. Heuser, A. V. Karginov, W. L. Lee, J. T. Parsons et al., Interaction of cortactin and N-WASp with Arp2/3 complex, Curr Biol, vol.12, pp.1270-1278, 2002.

A. M. Weaver, A. V. Karginov, A. W. Kinley, S. A. Weed, Y. Li et al., Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation, Curr Biol, vol.11, pp.370-374, 2001.
DOI : 10.1016/s0960-9822(01)00098-7

URL : https://doi.org/10.1016/s0960-9822(01)00098-7

J. H. Werner, G. A. Montano, A. L. Garcia, N. A. Zurek, E. A. Akhadov et al., Formation and Dynamics of Supported Phospholipid Membranes on a Periodic Nanotextured Substrate, Langmuir, vol.25, pp.2986-2993, 2009.

M. Wolfgang, P. Lauer, H. S. Park, L. Brossay, J. Hebert et al., PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae, Mol Microbiol, vol.29, pp.321-351, 1998.

M. Wolfgang, J. P. Van-putten, S. F. Hayes, and M. Koomey, The comP locus of Neisseria gonorrhoeae encodes a type IV prepilin that is dispensable for pilus biogenesis but essential for natural transformation, Mol Microbiol, vol.31, pp.1345-57, 1999.

K. W. Wong and R. R. Isberg, Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake, J Exp Med, vol.198, pp.603-617, 2003.

M. E. Wormann, C. L. Horien, J. S. Bennett, K. A. Jolley, M. C. Maiden et al., Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences, BMC Genomics, vol.15, p.253, 2014.

L. Wu, J. Huang, X. Yu, X. Zhou, C. Gan et al., AFM of the ultrastructural and mechanical properties of lipid-raft-disrupted and/or cold-treated endothelial cells, J Membr Biol, vol.247, pp.189-200, 2014.

K. Yamamoto, K. Furuya, M. Nakamura, E. Kobatake, M. Sokabe et al., Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells, J Cell Sci, vol.124, pp.3477-83, 2011.

T. Yamanaka, Y. Horikoshi, A. Suzuki, Y. Sugiyama, K. Kitamura et al., PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex, Genes Cells, vol.6, pp.721-752, 2001.

J. Yang, R. Yan, A. Roy, D. Xu, J. Poisson et al., The I-TASSER Suite: protein structure and function prediction, Nat Methods, vol.12, pp.7-8, 2015.

S. Yonemura, S. Tsukita, and S. Tsukita, Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins, J Cell Biol, vol.145, pp.1497-509, 1999.

S. Yoshida, E. Katayama, A. Kuwae, H. Mimuro, T. Suzuki et al., Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization, Embo J, vol.21, pp.2923-2958, 2002.

T. Yoshida, S. R. Kim, and T. Komano, Twelve pil genes are required for biogenesis of the R64 thin pilus, J Bacteriol, vol.181, pp.2038-2081, 1999.

S. Yurist-doutsch, B. Chaban, D. J. Vandyke, K. F. Jarrell, and J. Eichler, Sweet to the extreme: protein glycosylation in Archaea, Mol Microbiol, vol.68, pp.1079-84, 2008.

M. L. Zarantonelli, M. Szatanik, D. Giorgini, E. Hong, M. Huerre et al., Transgenic mice expressing human transferrin as a model for meningococcal infection, Infect Immun, vol.75, pp.5609-5623, 2007.

B. Zhang, F. Peng, D. Wu, A. J. Ingram, B. Gao et al., Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells, Cell Signal, vol.19, pp.1690-700, 2007.

Y. Zhang, I-TASSER server for protein 3D structure prediction, BMC Bioinformatics, vol.9, p.40, 2008.

H. Zhao, A. Michelot, E. V. Koskela, V. Tkach, D. Stamou et al., Membrane-sculpting BAR domains generate stable lipid microdomains, Cell Rep, vol.4, pp.1213-1236, 2013.
DOI : 10.1016/j.celrep.2013.08.024

URL : https://doi.org/10.1016/j.celrep.2013.08.024

Y. Zhao, J. Liu, C. Yang, B. R. Capraro, T. Baumgart et al., Exo70 generates membrane curvature for morphogenesis and cell migration, Dev Cell, vol.26, pp.266-78, 2013.

C. P. Zschiedrich, V. Keidel, and H. Szurmant, Molecular Mechanisms of Two-Component Signal Transduction, J Mol Biol, vol.428, pp.3752-75, 2016.

N. Zurek, L. Sparks, and G. Voeltz, Reticulon short hairpin transmembrane domains are used to shape ER tubules, Traffic, vol.12, pp.28-41, 2011.