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Modification du pigment maculaire lors du vieillissement oculaire : analyse à partir de l'étude de population Montrachet

Abstract : Given the limits of the literature on the environmental nutritional impact in ocular aging witch is partially due to the lack of data in general population notably in French elderly, first, we were interested in the relationships of diet, plasma xanthophylls and macular pigment optical density as well as its spatial distribution and second of plasma fatty acids and dry eye disease signs in the 1153 Montrachet study participants.Firstly, we reported the high consumption of squash, the high plasma lutein and zeaxanthin levels and also the high plasma lutein level, the high macular pigment optical density level in nonsmokers subjects. In addition, the macular pigment values we provided in the study could be used as reference in population based study. Our results are very consistent with those found in other epidemiological studies even though our population is on average older. Secondly, we have shown that dry eye disease signs are more frequent in elderly subjects with low plasma polyunsaturated and saturated fatty acids level. Thus, our results provide new elements in the involvement of fatty acids in the process of dry eye disease.Finally, this work enriches the literature on macular pigment, its density, as well as its spatial distribution and its determinants as well as the determinants of dry eye disease. However, given the transversal nature of our studies, these results make only possible to formulate hypotheses that will be confirmed with longitudinal studies and could reinforce the interest of interventions based xanthophylls carotenoids supplementation in elderly.
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Submitted on : Friday, May 3, 2019 - 5:12:49 PM
Last modification on : Tuesday, March 17, 2020 - 1:55:28 AM


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Seydou Alassane. Modification du pigment maculaire lors du vieillissement oculaire : analyse à partir de l'étude de population Montrachet. Médecine humaine et pathologie. Université Bourgogne Franche-Comté, 2018. Français. ⟨NNT : 2018UBFCI007⟩. ⟨tel-02119386⟩



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