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Autisme et cervelet : le gradient des ions chlorures en question

Abstract : The aims of my PhD were to characterize the development of the chloride gradient in Purkinje cells in a model of autism: mice prenatally exposed to sodium valproate. To this end, I measured GABAergic currents along the post-natal development of these mice and made histological observations of the Purkinje cells linear density. Secondly, I took part of a behavioral study to test the influence of a compound acting on the chloride gradient in two genetic models of autism: Oprm1-/- and Fmr1-/- mice. During my thesis I showed a delay in the development of the chloride gradient. I also observed that a prenatal exposition of sodium valproate induced a post-natal Purkinje cells loss. Finally, the compound I worked with improves the autistic phenotype and opens the perspective for translational potential.
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Sébastien Roux. Autisme et cervelet : le gradient des ions chlorures en question. Neurosciences. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAJ030⟩. ⟨tel-02116164⟩

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