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Dosimétrie neutron en radiothérapie : étude expérimentale et développement d'un outil personnalisé de calcul de dose Monte Carlo

Abstract : Treatment optimization in radiotherapy aims at increasing the accuracy of cancer cell irradiation while saving the surrounding healthy organs. However, the peripheral dose deposited in healthy tissues far away from the tumour are currently not calculated by the treatment planning systems even if it can be responsible for radiation induced secondary cancers. Among the different components, neutrons produced through photo-nuclear processes are suffering from an important lack of dosimetric data. An experimental and Monte Carlo simulation study of the secondary neutron production in radiotherapy led us to develop an algorithm using the Monte Carlo calculation precision to estimate the 3D neutron dose delivered to the patient. Such a tool will allow the generation of dosimetric data bases ready to be used for the improvement of “dose-risk” mathematical models specific to the low dose irradiation to peripheral organs occurring in radiotherapy.
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Halima Elazhar. Dosimétrie neutron en radiothérapie : étude expérimentale et développement d'un outil personnalisé de calcul de dose Monte Carlo. Physique [physics]. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAE013⟩. ⟨tel-02088062⟩

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