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, Polarisation et migration d'une cellule individuelle

, Différents exemples de migration individuelle

, Rôle des cellules directrices durant la migration collective 10

, Rôle et dynamique des jonctions adhérentes durant la migration collective

L. .. , , p.14

, Le modèle de migration astrocytaire in vitro, p.16

L. .. , , vol.18

, La dynamique d'assemblage des filaments intermédiaires 19

, Quelques exemples de polarité cellulaire in vivo, p.21

, L'orientation de l'axe noyau-centrosome dans les cellules

, Les fonctions associées à l'orientation de l'axe noyaucentrosome

, Les voies de signalisation contribuant à la polarisation du réseau de microtubules et à la réorientation du centrosome dans les astrocytes

. .. Les-jonction-intercellulaires, , p.28

. .. Les, , p.29

, Modèle d'intéraction entre les différents composants des jonctions adhérentes

. .. Les-jonction-intercellulaires, , p.33

, Dynamique de l'adhésion à la matrice extra-cellulaire, vol.34

, Composition moléculaires des plaques d'adhérence durant leur maturation

. .. La-famille-des-intégrines, , p.36

, L'association des intégrines entre elles et le cytosquelette d'actine et les signaux induits

, L'intégration des intégrines à l'avant induit l'activation de Cdc42

. .. Structure, , vol.46

. .. Structure-d'un-microtubule, , p.48

, Les différents organisations du réseau de microtubules, p.49

L. .. , , p.51

, Les différents composants modulant l'instabilité dynamique des microtubules

E. .. Structure-d'un-dimère-de-protéine, , p.55

L. Différents-domaines and . .. Fonctions-d'apc, , vol.56

L. .. , 57 2.10 Les différents isotypes de tubuline ?-et ? humaine et les modifications post-traductionnelles associées à leur queue C-terminale

, Représentation schématique du dimère d'?-et ?-tubuline et les modifications post-traductionnelles qui lui sont associées

. .. Mécanisme-de-polyglutamylation, 61 2.13 Les enzymes catalysant la polyglutamylation et la dé-glutamylation

, 64 2.15 Diversité des queues carboxy-terminale de la tubuline . 66 2.16 Les enzymes impliquées dans tyrosination/detyrosination 67 2.17 Les autres modifications post-traductionnelles de la tubuline, 14 localisation cellulaire et subcellulaire de la polyglutamy

, Localisation de l'acétylation de la lysine 40 de la tubuline ? sur la surface luminale des microtubules, p.72

, Les enzymes impliquées dans l'acetylation des microtubules 73

.. .. Structure-d'?tat1,

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, Régulation de la dynamique des plaques d'adhérence par les microtubules durant la migration, p.96

, Les intéractions entre les +TIP des microtubules et les plaques d'adhérence

, Le trafic vésiculaire via les microtubules est impliqué dans la dynamique des plaques d'adhérence, p.102

, Anticorps reconnaissant spécifiquement la polyglutamylation

, Profil d'expression de la glutamylation dans les astrocytes à 8h de migration

, Méthode d'étude de la polarité dans les astrocytes, p.121

, La déplétion de TTLL1 n'affecte pas la polarité du centrosome

, Profil de glutamylation du cil primaire dans les astrocytes124

, Polarité du cil primaire dans les astrocytes en migration 125

, La déplétion de TTLL1 n'affecte pas l'orientation du cil primaire

, La sur-expression de CCP5 n'a pas d'effet sur la polarité du centrosome

, La sur-expression de CCP5 n'a pas d'effet sur la polarité du cil primaire

, 132 2.2 Diminution du niveau d'acétylation des microtubules en ciblant ?TAT1, L'acétylation et la détyrosination des microtubules

, Diminution du niveau de détyrosination des microtubules

D. Le-niveau, acétylation des microtubules régule la vitesse de migration des astrocytes

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, L'inhibition d'HDAC6 hyper-acétyle la totalité du réseau de microtubules

, Linhibition d'HDAC6 affecte la vitesse de migration des astrocytes

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, L'acétyl-transférase ?TAT1 est localisée au niveau des microtubules et des plaques d'adhérence, p.150

. .. , La déplétion d'?TAT1 induit une augmentation du nombre de plaques d'adhérence, p.152

, La diminution du niveau de détyrosination des microtubules n'affecte ni le nombre ni la taille des plaques d'adhérence

, La déplétion d'?TAT1 induit une perturbation de la distribution des plaques d'adhérence durant la migration des astrocytes

, La diminution du niveau de detyrosination des microtubules n'affecte pas la distribution des plaques d'adhé-rence durant la migration des astrocytes

, L'hypo-acétylation des microtubules par sur-expression d'HDAC6 n'affecte pas la dynamique des plaques d'adhé-rence

, L'hyper-acétylation des microtubules par inhibtion d'H-DAC6 affecte la dynamique des plaques d'adhérence mais pas leur distribution

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, Sauvetage phénotypique par surexpression d'?TAT1, p.168

, Lien entre APC et l'acétylation des microtubules, p.170

. .. , La déplétion d'APC induit une perturbation de la dynamique des plaques d'adhérence, p.172

, 176 4.2 ?TAT1 est nécessaire au recrutement de MICAL3 mais pas de ELK, MICAL3 et ELK sont recrutés à proximité des plaques d'adhérence

, la déplétion d'?TAT1 induit une perturbation de la fusion des vésicules Rab6A positives, p.180

, Le trafic vésiculaire dépendant de Rab6A est nécessaire à la dynamique des plaques d'adhérence, p.182

, Polyglutamylation des microtubules dans les neurones, p.187

, Augmentation du niveau de polyglutamylation des microtubules dans les astrocytes qui surexpriment TTLL5 189

, Différences de localisation de l'acétylation et de la déty-rosination des microtubules

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, La déplétion de MICAL3 induit une diminution du niveau d'acétylation des microtubules, p.197

, Modèle de régulation de la dynamique des plaques d'adhérence par l'acétylation des microtubules, p.201