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Repenser la désinhibition alimentaire dans l’obésité, sous l’angle de l’hypothèse de l’addiction à l’alimentation

Abstract : Food addiction (FA) is an old concept, but still subject to controversy. It affects 18 to 24% of obese people. In this thesis, we are interested in overlaps between food behavior regulation, addiction and FA, in order to better understand the mechanisms linked to food intake disinhibition. Our work leads to several results: 1) A review of the literature has shown the existence of close interaction between eating behavior regulation levels and how FA could be an example of their disturbance. 2) A cohort study demonstrated the existence of common clinical features between addiction and FA and a probable addiction transfer from nicotine to food. 3) From an experimental point of view, we have shown that there are disturbances of P300 and N200 ERP, in obesity and food disinhibition, close to those observed in addictions. 4) Finally, our results suggest the potential role of ghrelin as a marker for eating disorders increased risk. This work opens experimental perspectives, with the suggestion of more relevant control groups; clinical perspectives, with the creation of a screening tool; therapeutics perspectives, with the establishment of a therapeutic trial by tDCS
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Sylvain Iceta. Repenser la désinhibition alimentaire dans l’obésité, sous l’angle de l’hypothèse de l’addiction à l’alimentation. Neurosciences. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1003⟩. ⟨tel-02086573⟩

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