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Nouvelles voies de synthèse énantiosélective pour l'accès à des composés difluorométhylés

Abstract : Despite being largely absent from natural products and biological processes, fluorine plays an increasingly important role in numerous areas of our daily life. The presence of fluorine atoms or fluoroalkyl groups in bioactive molecules can indeed deeply modify their physical, chemical and biological properties. In addition to these outstanding properties common to many emerging fluorinated groups, the -CHF2 group has been shown to be an interesting bioisostere of hydroxyl, thiol and amine groups and a strong hydrogen bond donor. However, in contrast to enantioselective trifluoromethylation, the enantioselective introduction of a difluoromethyl group is still in its infancy. For instance only few examples in the literature describe the synthesis of enantioenriched α,α-difluoromethyl alcohols. As part of our study to overcome this scarcity, we envisaged two different strategies to synthesise these compounds. The first method aimed to access highly enantioenriched α,α-difluoromethyl alcohols by using an enantiopure aryl α,α-difluoromethyl sulfoxide as chiral and traceless auxiliary. Phase transfer catalysis was chosen as a second strategy for the enantioselective difluoromethylation of carbonyl derivatives in presence of chiral cyclopeptoïds. Those two methods and the results obtained are discussed in this manuscript.
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Chloé Batisse. Nouvelles voies de synthèse énantiosélective pour l'accès à des composés difluorométhylés. Chimie organique. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF041⟩. ⟨tel-02082914⟩

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