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Theses

Synthèse de structures complexes par réactions en cascade et catalyse au rhodium

Abstract : Through the course of two projects, this thesis work was concerned with the synthesis of complex scaffolds by means of cascade reactions and rhodium catalysis.In a first part, a new methodology was developed for the synthesis of non-symmetrical and fully substituted 2,4,6-cycloheptatrienones by rhodium-catalysed [2+2+2+1] carbonylative cycloaddition. Mechanisms for the formations of the observed compounds were proposed.In a second part, the application of rhodium-catalysed desymmetrising hydroformylation to the total synthesis of Aspidosperma indole alkaloids was studied. A key intermediate in the synthesis of eburnan-type alkaloids was thus obtained, and its transformation into th desired compounds using various strategies was explored. The total synthesis of aspidosperma-type alkaloids was studied, and the explored syntheses will be applied to aldehydes obtained by desymmetrising hydroformylation.
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Laura Salacz. Synthèse de structures complexes par réactions en cascade et catalyse au rhodium. Autre. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF034⟩. ⟨tel-02082830⟩

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