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Effets des troubles métaboliques et du surpoids liés à l’obésité sur le système musculo-squelettique murin arthrosique ou non : traitement potentiel par vibration corps entier.

Abstract : Obesity is associated with a risk of musculoskeletal fragility, especially osteoarthritis (OA). Our goal is to explore their contributions of metabolic and overweight conditions. MM obesity (mechanical and metabolic) is obtained through a diet. Obesity M (mechanical) is mimed by hypergravity at 2g. OA is induced by surgery. We explored the effects of MM and M obesity on the non-OA mouse musculoskeletal system. MMs have preserved trabecular bone, deteriorated cortical bone and weakened muscles. In M, bone is preserved and muscles are strengthened. Metabolic disorders are responsible for the weakening of cortical bone and muscle. In a second part, the consequences of OA are evaluated in non-obese mice, MM or M. OA in non-obese only weakens the trabecular bone. OA in MM accentuates the decrease in cortical thickness. OA in M mice further weakens cortical bone and muscle than in MM mice. However, if we consider only the OA mice, the MM component is always more deleterious than the M component. Finally, we tested entire body vibrations during the last 4 weeks as a potential treatment for musculoskeletal deterioration of MM, whether or not coupled to OA. Vibrations do not affect obesity and OA. A muscular effect is observed at the molecular level, these decreases being greater in OA. No change in muscle mass is observed. The bone tissue is not influenced. In conclusion, in non-OA mice, only metabolic disorders decrease cortical thickness. In OA, however, the mechanical impact is added to the metabolic impact to increase the fragility of the cortical bone. MM obesity is deleterious to muscles with or without OA. Metabolic disorders are accompanied by a lack of vascularization and an increase in adiposity in bone and muscle. Hypergravity corrects fat, muscle invasion, and bone marrow in non-OA only
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Benoît Dechaumet. Effets des troubles métaboliques et du surpoids liés à l’obésité sur le système musculo-squelettique murin arthrosique ou non : traitement potentiel par vibration corps entier.. Médecine humaine et pathologie. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSES045⟩. ⟨tel-02080233v1⟩

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