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Développement de nouvelles réactions domino initiées par une cyclisation d'iso-Nazarov pour la synthèse de composés polycycliques

Abstract : Polycyclic molecules represent a challenge in organic synthesis due to the complexity of their backbone. Their presence in many bioactive natural products makes them valuable in drug discovery. The objective of the PhD work deals with the synthesis of polycyclic architectures from easily available substrates via different iso-Nazarov-initiated domino sequences. This one-step method leads to complex and diverse structures with the creation of several cycles, several bonds and several stereocenters.
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Anne-Sophie Marques. Développement de nouvelles réactions domino initiées par une cyclisation d'iso-Nazarov pour la synthèse de composés polycycliques. Chimie organique. Université Paris-Saclay, 2018. Français. ⟨NNT : 2018SACLV075⟩. ⟨tel-02077444⟩

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