K. L. Mansfield, A. C. Banyard, L. Mcelhinney, N. Johnson, D. L. Horton et al., Rift Valley fever virus: A review of diagnosis and vaccination, and implications for emergence in Europe, Vaccine, vol.33, pp.5520-5531, 2015.

B. Faburay, A. Labeaud, D. Mcvey, W. Wilson, and J. Richt, Current Status of Rift Valley Fever Vaccine Development, vol.5, p.29, 2017.
DOI : 10.3390/vaccines5030029
URL : https://www.mdpi.com/2076-393X/5/3/29/pdf

B. Faburay, W. C. Wilson, N. N. Gaudreault, A. S. Davis, V. Shivanna et al., A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep, Sci Rep, vol.6, pp.1-12, 2016.

T. G. Besselaar and N. K. Blackburn, The synergistic neutralization of Rift Valley fever virus by monoclonal antibodies to the envelope glycoproteins, Arch Virol, vol.125, pp.239-250, 1992.

J. Kortekaas, A. Antonis, J. Kant, R. Vloet, A. Vogel et al., Efficacy of three candidate Rift Valley fever vaccines in sheep, Vaccine, vol.30, pp.3423-3429, 2012.

N. Bhardwaj, M. T. Heise, and T. M. Ross, Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing Gn protects mice against rift valley fever virus, PLoS Negl Trop Dis, vol.4, p.725, 2010.
DOI : 10.1371/journal.pntd.0000725
URL : https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000725&type=printable

S. Jorritsma, E. J. Gowans, B. Grubor-bauk, and D. K. Wijesundara, Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines, Vaccine, vol.34, pp.5488-5494, 2016.

C. Lehmann, L. Heger, G. Heidkamp, A. Baranska, J. Lühr et al.,

, Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies. Vaccines, vol.4, 2016.

C. Dutertre, L. Wang, and F. Ginhoux, Aligning bona fide dendritic cell populations across species, Cell Immunol, vol.291, pp.3-10, 2014.
DOI : 10.1016/j.cellimm.2014.08.006

V. Contreras, C. Urien, R. Guiton, Y. Alexandre, T. Vu-manh et al., Existence of CD8?-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species, J Immunol, vol.185, pp.3313-3325, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00611156

G. Nchinda, J. Kuroiwa, M. Oks, C. Trumpfheller, C. G. Park et al., The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells, Conflict, vol.118, 2008.

J. Cao, Y. Jin, W. Li, B. Zhang, Y. He et al., DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice, BMC Immunol, vol.14, p.39, 2013.
DOI : 10.1186/1471-2172-14-39
URL : https://bmcimmunol.biomedcentral.com/track/pdf/10.1186/1471-2172-14-39

Y. Hua, Y. Jiao, Y. Ma, X. Peng, Y. Fu et al., Enhanced humoral and CD8 + T cell immunity in mice vaccinated by DNA vaccine against human respiratory syncytial virus through targeting the encoded F protein to dendritic cells, Int Immunopharmacol, vol.46, pp.62-69, 2017.

L. M. Njongmeta, J. Bray, C. J. Davies, W. C. Davis, C. J. Howard et al., CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody and CD4 + T cell responses following DNA vaccination of outbred animals, Vaccine, vol.30, pp.1624-1635, 2012.
DOI : 10.1016/j.vaccine.2011.12.110

F. Saade and N. Petrovsky, Technologies for enhanced efficacy of DNA vaccines, Expert Rev Vaccines, vol.11, pp.189-209, 2012.
DOI : 10.1586/erv.11.188
URL : http://europepmc.org/articles/pmc3293989?pdf=render

A. Gothelf and J. Gehl, What you always needed to know about electroporation based DNA vaccines, vol.8, pp.1694-1702, 2012.
DOI : 10.4161/hv.22062
URL : http://europepmc.org/articles/pmc3601144?pdf=render

B. H. Bird, M. L. Khristova, P. E. Rollin, T. G. Ksiazek, and N. St, Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry, J Virol, vol.81, pp.2805-2816, 2007.

J. M. Meegan, The Rift Valley fever epizootic in Egypt 1977-1978 1. Description of the epizootic and virological studies, Trans R Soc Trop Med Hyg, vol.73, pp.618-623, 1979.

H. Caplen, C. J. Peters, and D. Bishop, Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development, J Gen Virol, vol.66, pp.2271-2277, 1985.

N. Coconi-linares, E. Ortega-dávila, M. López-gonzález, J. García-machorro, J. García-cordero et al., Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice, Vaccine, vol.31, pp.2366-2371, 2013.

C. Drosten, S. Göttig, S. Schilling, M. Panning, H. Schmitz et al., Rapid Detection and Quantification of RNA of Ebola and Marburg Viruses , Lassa Virus , Crimean-Congo Hemorrhagic Fever Virus , Rift Valley Fever Virus , Dengue Virus , and Yellow Fever Virus by Real-Time Reverse Rapid Detection and Quantification of RNA o, J Clin Microbiol, vol.40, pp.2323-2330, 2002.

M. G. Prabagar, H. Choi, . Jwa, J. Y. Park, S. Loh et al., Intravenous immunoglobulinmediated immunosuppression and the development of an IVIG substitute, Clin Exp Med, vol.14, pp.361-373, 2014.

C. Gommet, A. Billecocq, G. Jouvion, M. Hasan, T. Z. Do-valle et al., Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice, PLoS Negl Trop Dis, vol.5, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-01325748

S. M. De-boer, J. Kortekaas, A. F. Antonis, J. Kant, J. L. Van-oploo et al., Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge, Vaccine, vol.28, pp.2330-2339, 2010.

C. Macri, C. Dumont, A. P. Johnston, and J. D. Mintern, Targeting dendritic cells: a promising strategy to improve vaccine effectiveness, Clin Transl Immunol, vol.5, p.66, 2016.
DOI : 10.1038/cti.2016.6
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1038/cti.2016.6

T. Niezold, M. Storcksdieck-genannt-bonsmann, A. Maaske, V. Temchura, V. Heinecke et al., DNA vaccines encoding DEC205-targeted antigens: Immunity or Tolerance?, Immunology, 2015.
DOI : 10.1111/imm.12467
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/imm.12467

K. Mahnke, S. Ring, and A. H. Enk, Antibody targeting of "steady-state" dendritic cells induces tolerance mediated by regulatory T cells, Front Immunol, vol.7, 2016.
DOI : 10.3389/fimmu.2016.00063
URL : https://doi.org/10.3389/fimmu.2016.00063

B. Todorova, L. Adam, S. Culina, R. Boisgard, F. Martinon et al., Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques, vol.7, pp.1-11, 2017.

K. Matthews, S. M. Rhind, A. G. Gossner, R. G. Dalziel, and J. Hopkins, The effect of gene gundelivered pGM-CSF on the immunopathology of the vaccinated skin, Scand J Immunol, vol.65, pp.298-307, 2007.

C. Cheong, J. Choi, L. Vitale, L. He, C. Trumpfheller et al., Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti -human DEC205 monoclonal antibody, Blood, vol.116, pp.3828-3838, 2010.

K. Amorim, E. V. Rampazo, R. Antonialli, M. M. Yamamoto, M. M. Rodrigues et al., The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells, Sci Rep, vol.6, pp.1-15, 2016.

H. Park, P. S. Tan, R. Kavishna, A. Ker, J. Lu et al., Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells, vol.2, p.31, 2017.

M. H. Lahoud, A. F. Kitsoulis, S. Wan, S. S. Vremec, D. Lee et al., Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype, J Immunol, vol.187, 2011.

A. Agarwal, Impact of transmission cycles and vector competence on global expansion and emergence of arboviruses 1-12, 2017.

A. Kamal, S. Kamal, and S. A. , Observations on rift valley fever virus and vaccines in Egypt, Virol. J, vol.8, 2011.

C. P. Åkesson, C. Mcl-press, A. Espenes, and M. Aleksandersen, Phenotypic characterisation of intestinal dendritic cells in sheep, Dev. Comp. Immunol, vol.32, pp.837-849, 2008.

B. Alvarez, T. Poderoso, F. Alonso, A. Ezquerra, J. Domínguez et al., Antigen targeting to APC: From mice to veterinary species, Dev. Comp. Immunol, vol.41, pp.153-163, 2013.

A. F. Antonis, J. Kortekaas, J. Kant, R. P. Vloet, . Vogel-brink et al., Vertical Transmission of Rift Valley Fever Virus Without Detectable Maternal Viremia. Vector Borne Zoonotic Dis, vol.13, pp.1-6, 2013.

L. Ardouin, H. Luche, R. Chelbi, S. Carpentier, A. Shawket et al., Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery, Immunity, vol.45, pp.305-318, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01374574

E. Ayari-fakhfakh, A. Ghram, A. Bouattour, I. Larbi, L. Gribâa-dridi et al., First serological investigation of peste-des-petits-ruminants and Rift Valley fever in Tunisia, Vet. J, vol.187, pp.402-404, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00606752

A. Bachem, S. Güttler, E. Hartung, F. Ebstein, M. Schaefer et al., , 2010.

, CD11c + CD141 + cells as homologues of mouse CD8 + dendritic cells, J. Exp. Med, vol.207, pp.1273-1281

M. Baranowska, A. G. Hauge, C. Hoornaert, B. Bogen, and G. Gr??deland, Targeting of nucleoprotein to chemokine receptors by DNA vaccination results in increased CD8+-mediated cross protection against influenza, Vaccine, vol.33, pp.6988-6996, 2015.

B. J. Barnard and M. J. Botha, An inactivated rift valley fever vaccine, J. S. Afr. Vet. Assoc, vol.48, pp.45-48, 1977.

A. Baskerville, K. A. Hubbard, and J. R. Stephenson, Comparison of the pathogenicity for pregnant sheep of Rift Valley fever virus and a live attenuated vaccine, Res Vet Sci, vol.52, pp.307-311, 1992.

M. Baudin, A. M. Jumaa, H. J. Jomma, M. S. Karsany, G. Bucht et al., Association of Rift Valley fever virus infection with miscarriage in Sudanese women: a cross-sectional study, Lancet Glob. Heal, vol.4, pp.864-871, 2016.

C. G. Beckett, J. Tjaden, T. Burgess, J. R. Danko, C. Tamminga et al., Evaluation of a prototype dengue-1 DNA vaccine in a Phase 1 clinical trial, Vaccine, vol.29, pp.960-968, 2011.

C. Bernelin-cottet, C. Deloizy, O. S. Barc3, C. , E. Bouguyon1 et al., A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01569908

T. G. Besselaar and N. K. Blackburn, The synergistic neutralization of Rift Valley fever virus by monoclonal antibodies to the envelope glycoproteins, Arch. Virol, vol.125, pp.239-250, 1992.

T. G. Besselaar and N. K. Blackburn, Topological mapping of antigenic sites on the Rift Valley fever virus envelope glycoprotein using monoclonal antibodies, Arch Virol, vol.121, pp.111-124, 1991.

T. G. Besselaar, N. K. Blackburn, and G. M. Meenehan, Antigenic analysis of Pdft Valley fever virus isolates : monoclona | antibodies distinguish between wild-type and neurotropic virus strains 2131, pp.469-474, 1991.

B. H. Bird, M. L. Khristova, P. E. Rollin, T. G. Ksiazek, and S. T. Nichol, Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry, J. Virol, vol.81, pp.2805-2816, 2007.

B. H. Bird and T. G. Ksiazek, Zoonosis Update Rift Valley fever virus, J. Am. Vet. Med. Assoc, vol.234, pp.883-893, 2009.

B. H. Bird, L. H. Maartens, S. Campbell, B. J. Erasmus, B. R. Erickson et al.,

C. G. Albariño, S. T. Nichol, B. E. Al, and J. Irol, Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep, J. Virol, vol.85, pp.12901-12910, 2011.

S. M. Boer, . De, J. Kortekaas, C. A. Haan, . De et al., Heparan Sulfate Facilitates Rift Valley Fever Virus Entry into the Cell, vol.86, pp.13767-13771, 2012.

L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. C. Nussenzweig et al., Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8 + T Cell Tolerance, J. Exp. Med, vol.196, pp.1627-1638, 2002.

L. C. Bonifaz, D. P. Bonnyay, A. Charalambous, D. I. Darguste, S. Fujii et al., Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination 199, 2004.

M. Bonneau, M. Epardaud, F. Payot, V. Niborski, M. Thoulouze et al., Migratory monocytes and 154 granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node, J. Leukoc. Biol, vol.79, pp.268-76, 2006.

B. Botros, A. Omar, K. Elian, G. Mohamed, A. Soliman et al., Adverse Response of Non-Indigenous Cattle of European Breeds to Live Attenuated Smithburn Rift Valley Fever Vaccine, J. Med. Virol. J. Med. Virol, vol.78, 2006.

L. E. Bouloy, C. Janzen, P. Vialat, H. Khun, J. Pavlovic et al., Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs, J. Virol, vol.75, pp.1371-1377, 2001.

G. Breton, J. Lee, Y. J. Zhou, J. J. Schreiber, T. Keler et al., Circulating precursors of human CD1c + and CD141 + dendritic cells, J. Exp. Med, vol.212, pp.401-413, 2015.

S. W. Brubaker, K. S. Bonham, I. Zanoni, and J. C. Kagan, Innate Immune Pattern Recognition: A Cell Biological Perspective, Annual Review of Immunology, 2015.

R. Bujdoso, J. Hopkins, B. Dutia, P. Young, I. et al., Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage, J. Exp. Med, vol.170, pp.1285-301, 1989.

N. Busquets, G. Lorenzo, E. López-gil, R. Rivas, D. Solanes et al., Efficacy assessment of an MVA vectored Rift Valley Fever vaccine in lambs, 2014.

, Antiviral Res, vol.108, pp.165-172

N. Busquets, F. Xavier, G. Lorenzo, R. Rivas, J. Iglesias et al., , p.10, 2010.

I. Caminschi, A. I. Proietto, F. Ahmet, S. Kitsoulis, J. S. Teh et al., The dendritic cell subtype-restricted Ctype lectin, vol.112, pp.3264-3274, 2008.

J. Cao, Y. Jin, W. Li, B. Zhang, Y. He et al., DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice, BMC Immunol, vol.14, p.39, 2013.

M. Caridade, L. Graca, and R. M. Ribeiro, Mechanisms underlying CD4+ Treg immune regulation in the adult: From experiments to models, Front. Immunol, vol.4, pp.1-9, 2013.

F. V. Castro, A. L. Tutt, A. L. White, J. L. Teeling, S. James et al., CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses, Eur. J. Immunol, vol.38, pp.2263-2273, 2008.

V. Chevalier, M. Pépin, L. Plée, and R. Lancelot, Rift Valley fever--a threat for Europe?, Euro Surveill, vol.15, 2010.

C. Chu, N. Ali, P. Karagiannis, P. Di-meglio, A. Skowera et al., Resident CD141 (BDCA3) + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation, J. Exp. Med, vol.209, pp.935-945, 2012.

J. A. Coetzer, THE PATHOLOGY OF RIFT VALLEY FEVER . II . LESIONS OCCURRING IN FIELD CASES IN ADULT CATTLE, CALVES AND ABORTED FOETUSES, vol.17, pp.11-17, 1982.

L. Cohn, B. Chatterjee, F. Esselborn, A. Smed-sörensen, N. Nakamura et al., Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation, J. Exp. Med, vol.210, pp.1049-63, 2013.

M. Collin and P. Milne, Europe PMC Funders Group Langerhans cell origin and regulation, vol.23, pp.28-35, 2016.

V. Contreras, C. Urien, R. Guiton, Y. Alexandre, T. Vu-manh et al., Existence of CD8?-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species, J. Immunol, vol.185, pp.3313-3325, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00611156

K. Crozat, R. Guiton, V. Contreras, V. Feuillet, C. Dutertre et al., The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells, J. Exp. Med, vol.207, pp.1283-92, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00493468

K. Crozat, R. Guiton, M. Guilliams, S. Henri, T. Baranek et al., Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets, Immunol. Rev, vol.234, pp.177-198, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00502980

L. J. Cruz, R. A. Rosalia, J. Willem, F. Rueda, C. W. Löwik et al., Targeting nanoparticles to CD40 , DEC-205 or CD11c molecules on dendritic cells for ef fi cient CD8 + T cell response : A comparative study, J. Control. Release, vol.192, pp.209-218, 2014.

L. J. Cruz, P. J. Tacken, J. M. Pots, R. Torensma, S. I. Buschow et al., Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN, Biomaterials, vol.33, pp.4229-4239, 2012.

S. Daouam, F. Ghzal, Y. Naouli, K. O. Tadlaoui, M. M. Ennaji et al., Safety and immunogenecity of a live attenuated Rift Valley fever vaccine ( CL13T ) in camels, BMC Vet. Res. 8-12, 2016.

D. Tang, M. Devit, and S. A. Johnston, Genetic immunization is a simple method for eliciting an immune response 359, pp.150-152, 1992.

S. M. De-boer, J. Kortekaas, A. F. Antonis, J. Kant, J. L. Van-oploo et al., , p.157

R. J. Moormann and B. J. Bosch, Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge, Vaccine, vol.28, pp.2330-2339, 2010.

S. M. De-boer, J. Kortekaas, L. Spel, P. J. Rottier, R. J. Moormann et al., Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion protein, 2012.

, J. Virol, vol.86, pp.13642-52

D. Silva, N. S. Klein, and U. , Dynamics of B cells in germinal centres, Nat. Rev. Immunol, vol.15, pp.137-148, 2015.

L. Delamarre, H. Holcombe, and I. Mellman, Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation, J. Exp. Med, vol.198, pp.111-122, 2003.

C. Demangel, J. Zhou, A. B. Choo, G. Shoebridge, G. M. Halliday et al., Single chain antibody fragments for the selective targeting of antigens to dendritic cells, 2005.

, Mol. Immunol, vol.42, pp.979-985

J. M. Den-haan, S. M. Lehar, and M. J. Bevan, CD8(+) but not CD8(-) dendritic cells crossprime cytotoxic T cells in vivo, J. Exp. Med, vol.192, pp.1685-96, 2000.

M. V. Dhodapkar, M. Sznol, B. Zhao, D. Wang, R. D. Carvajal et al., Induction of AntigenSpecific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205, vol.6, pp.1-10, 2014.

R. E. Dickinson, P. Milne, L. Jardine, S. Zandi, S. I. Swierczek et al., The evolution of cellular de fi ciency in GATA2 mutation, vol.123, pp.863-874, 2014.

J. Dimier, A. Ferrier-rembert, K. Pradeau-aubreton, M. Hebben, D. Spehner et al., , p.158, 2011.

, J. Virol, vol.85, pp.5016-5026

T. Z. Valle, A. Billecocq, L. Guillemot, R. Alberts, C. Gommet et al., A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever, J. Immunol, vol.185, pp.6146-6156, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-01325858

K. A. Dodd, B. H. Bird, M. G. Metcalfe, S. T. Nichol, and C. G. Albariño, Single-Dose Immunization with Virus Replicon Particles Confers Rapid Robust Protection against Rift Valley Fever Virus Challenge 4204-4212, 2012.

K. A. Dodd, A. K. Mcelroy, M. E. Jones, S. T. Nichol, and C. F. Spiropoulou, Rift Valley fever virus clearance and protection from neurologic disease are dependent on CD4+ T cell and virus-specific antibody responses, J. Virol, vol.87, pp.6161-71, 2013.

K. A. Dodd, A. K. Mcelroy, T. L. Jones, S. R. Zaki, S. T. Nichol et al., Rift Valley Fever Virus Encephalitis Is Associated with an Ineffective Systemic Immune Response and Activated T Cell Infiltration into the CNS in an Immunocompetent Mouse Model 8, 2014.

B. G. Dorner, M. B. Dorner, X. Zhou, C. Opitz, A. Mora et al., Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells, Immunity, vol.31, pp.823-833, 2009.

T. W. Dubensky, B. A. Campbell, and L. P. Villarreal, Direct transfection of viral and plasmid DNA into the liver or spleen of mice, Proc. Natl. Acad. Sci, vol.81, pp.7529-7533, 1984.

D. Dudziak, A. Kampfhorst, G. Heidkamp, V. Buhcholz, C. Trumpfheller et al., Dendritic Cell Subsets in Vivo. Science (80-. ), vol.315, pp.107-112, 2007.

D. Dudziak, A. O. Kamphorst, G. F. Heidkamp, V. R. Buchholz, C. Trumpfheller et al., , p.159

M. C. Nussenzweig, Differential Antigen Processing by Dendritic Cell Subsets in, 2007.

. Vivo, , vol.315, pp.107-111

B. Dungu, I. Louw, A. Lubisi, P. Hunter, B. F. Teichman et al., Evaluation of the efficacy and safety of the Rift Valley Fever Clone 13 vaccine in sheep, Vaccine, vol.28, pp.4581-4587, 2010.

M. Dupage and J. A. Bluestone, Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease, Nat. Rev. Immunol, vol.16, pp.149-163, 2016.

M. Durand and E. Segura, The known unknowns of the human dendritic cell network, Front. Immunol, vol.6, issue.2-8, 2015.

C. Dutertre, L. Wang, and F. Ginhoux, Aligning bona fide dendritic cell populations across species, Cell. Immunol, vol.291, pp.3-10, 2014.

B. T. Edelson, W. Kc, R. Juang, M. Kohyama, L. A. Benoit et al., Peripheral CD103 + dendritic cells form a unified subset developmentally related to CD8? + conventional dendritic cells, J. Exp. Med, vol.207, pp.823-836, 2010.

E. Segura, Dendritic Cell Protocols, Elodie Segura, vol.595, 2010.

M. Epardaud, M. Bonneau, F. Payot, C. Cordier, C. Howard et al., Enrichment for a CD26 hi SIRP -subset in lymph dendritic cells from the upper aerodigestive tract 76, 2004.

B. Faburay, A. Labeaud, D. Mcvey, W. Wilson, and J. Richt, Current Status of Rift Valley Fever Vaccine Development, vol.5, 2017.

F. Facchetti, C. De-wolf-peeters, D. Y. Mason, K. Pulford, J. J. Van-den-oord et al., Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin, Am. J. Pathol, vol.133, pp.15-21, 1988.

S. J. Fach, S. L. Brockmeier, L. A. Hobbs, H. D. Lehmkuhl, and R. E. Sacco, Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue, Vet. Immunol, 2006.

, Immunopathol, vol.112, pp.171-182

C. G. Figdor, Y. Van-kooyk, and G. J. Adema, Lectin receptors on DC cells and related sugars_Useful, Nat. Rev. Immunol, vol.2, pp.77-84, 2002.

C. M. Filone, M. Heise, R. W. Doms, and A. Bertolotti-ciarlet, Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors, Virology, vol.356, pp.155-164, 2006.

E. Fossum, G. Grødeland, D. Terhorst, A. A. Tveita, E. Vikse et al., Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8+ T-cell responses against influenza virus, Eur. J. Immunol, vol.45, pp.624-635, 2015.

A. B. Fredriksen, I. Sandlie, and B. Bogen, DNA Vaccines Increase Immunogenicity of Idiotypic Tumor Antigen by Targeting Novel Fusion Proteins to, vol.13, pp.776-785, 2006.

A. N. Freiberg, M. B. Sherman, M. C. Morais, M. R. Holbrook, and S. J. Watowich, Threedimensional organization of Rift Valley fever virus revealed by cryoelectron tomography, J. Virol, vol.82, pp.10341-10348, 2008.

H. Fujita, K. E. Nograles, T. Kikuchi, J. Gonzalez, J. A. Carucci et al., Human Langerhans cells induce distinct IL-22-producing CD4 ? T cells lacking IL-17 production, vol.106, pp.21795-21800, 2009.

D. H. Fuller, P. Loudon, and C. Schmaljohn, Preclinical and clinical progress of particlemediated DNA vaccines for infectious diseases, Methods, vol.40, pp.86-97, 2006.

E. F. Fynan, R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro et al., DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun 161 inoculations, Proc. Natl. Acad. Sci, vol.90, pp.11478-11482, 1993.

S. Gaudreau, C. Guindi, M. Ménard, G. Besin, G. Dupuis et al., Granulocytemacrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells, J. Immunol, vol.179, pp.3638-3647, 2007.

S. A. Geherin, S. R. Fintushel, M. H. Lee, R. P. Wilson, R. T. Patel et al., The Skin, a Novel Niche for Recirculating B Cells, 2012.

. Immunol, , vol.188, pp.6027-6035

S. R. Gerrard and S. T. Nichol, Synthesis, proteolytic processing and complex formation of N-terminally nested precursor proteins of the Rift Valley fever virus glycoproteins, 2007.

, Virology, vol.357, pp.124-133

S. R. Gerrard and S. T. Nichol, Characterization of the Golgi Retention Motif of Rift Valley Fever Virus G N Glycoprotein, J. Virol, vol.76, pp.12200-12210, 2002.

F. Ginhoux, K. Liu, J. Helft, M. Bogunovic, M. Greter et al., The origin and development of nonlymphoid tissue CD103 + DCs, vol.206, pp.3115-3130, 2009.

D. R. Gliddon, J. C. Hope, G. P. Brooke, and C. J. Howard, DEC-205 expression on migrating dendritic cells in afferent lymph, Immunology, vol.111, pp.262-272, 2004.

C. Gommet, A. Billecocq, G. Jouvion, M. Hasan, T. Z. Valle et al., Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice, PLoS Negl. Trop. Dis, vol.5, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-01325748

A. Goubier, B. Dubois, H. Gheit, G. Joubert, C. Asselin-paturel et al., , vol.29, pp.464-475, 2013.

A. A. Grobbelaar, J. Weyer, P. A. Leman, A. Kemp, J. T. Paweska et al., Molecular Epidemiology of Rift Valley Fever Virus, Emerg. Infect. Dis. J, vol.17, pp.2270-2276, 2011.

G. Grodeland, A. B. Fredriksen, G. Å. Løset, E. Vikse, L. Fugger et al., Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination, 2016.

. Immunol, , vol.197, pp.3575-3585

J. E. Grotzke, P. Kozik, J. Morel, F. Impens, N. Pietrosemoli et al., Sec61 blockade by mycolactone inhibits antigen crosspresentation independently of endosome-to-cytosol export, Proc. Natl. Acad. Sci, vol.114, pp.5910-5919, 2017.

T. Grunwald, M. Tenbusch, R. Schulte, K. Raue, H. Wolf et al., Novel vaccine regimen elicits strong airway immune responses and control of respiratory syncytial virus in nonhuman primates, J. Virol, vol.88, pp.3997-4007, 2014.

A. Gudjonsson, A. Lysén, S. Balan, V. Sundvold-gjerstad, C. Arnold-schrauf et al., Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses, J. Immunol, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01996173

M. Guilliams, F. Ginhoux, C. Jakubzick, S. H. Naik, N. Onai et al., Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny, Nat. Rev. Immunol, vol.14, pp.571-578, 2014.

E. Gutiérrez-martínez, R. Planès, G. Anselmi, M. Reynolds, S. Menezes et al., Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets, Front. Immunol, vol.6, 2015.

M. Haniffa, A. Shin, V. Bigley, N. Mcgovern, P. Teo et al., Human Tissues Contain CD141 hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103 + Nonlymphoid Dendritic Cells, vol.37, pp.60-73, 2012.

H. Will, R. Cattaneo, H. Koch, G. Darai, and H. S. , Cloned HBV DNA causes hepatitis in chimpanzees, 1982.

D. Hawiger, K. Inaba, Y. Dorsett, M. Guo, K. Mahnke et al., Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo, J. Exp. Med, vol.194, pp.769-779, 2001.

W. He, G. S. Tan, C. E. Mullarkey, A. J. Lee, M. M. Lam et al., Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.11931-11936, 2016.

B. A. Heesters, C. E. Van-der-poel, A. Das, and M. C. Carroll, Antigen Presentation to B Cells, Trends Immunol, vol.37, pp.844-854, 2016.

C. Hesse, W. Ginter, T. Förg, C. T. Mayer, A. M. Baru et al., In vivo targeting of human DC-SIGN drastically enhances CD8+ T-cell-mediated protective immunity, Eur. J, 2013.

. Immunol, , vol.43, pp.2543-2553

K. Hildner, B. T. Edelson, W. E. Purtha, M. Diamond, H. Matsushita et al., Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity, Science, vol.322, pp.1097-100, 2008.

P. Hunter, B. J. Erasmus, and J. H. Vorster, Teratogenicity of a mutagenised Rift Valley fever virus (MVP 12) in sheep, Onderstepoort J. Vet. Res, vol.69, pp.95-103, 2002.

J. Idoyaga, C. Fiorese, L. Zbytnuik, A. Lubkin, J. Miller et al., Specialized role of migratory dendritic cells in peripheral tolerance induction, J. Clin. Invest, vol.4, pp.1-11, 2014.

J. Idoyaga, A. Lubkin, C. Fiorese, M. H. Lahoud, I. Caminschi et al., Comparable T helper 1 ( Th1 ) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within 1, 1-6, 2010.

B. Z. Igyártá, K. Haley, D. Ortner, A. Bobr, and M. Gerami-nejad, , vol.35, pp.260-272, 2012.

T. Ikegami, Rift Valley Fever vaccines: An overview of the safety and efficacy of the live-attenuated MP-12 vaccine candidate 16, pp.601-611, 2017.

T. Ikegami, Molecular biology and genetic diversity of Rift Valley fever virus, 2012.

, Antiviral Res, vol.95, pp.293-310

T. Ikegami, T. E. Hill, J. K. Smith, L. Zhang, T. L. Juelich et al., Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of, 2015.

, J. Virol, vol.89, pp.7262-7276

T. Ikegami and S. Makino, The pathogenesis of rift valley fever, Viruses, vol.3, pp.493-519, 2011.

T. Ikegami and S. Makino, Rift Valley Fever Vaccines, Vaccine, vol.27, pp.69-72, 2010.

K. Inaba, W. J. Swiggard, M. Inaba, J. Meltzer, A. Miryza et al., Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145: I. Expression on Dendritic Cells and Other Subsets of Mouse Leukocytes, Cell. Immunol, vol.163, pp.148-156, 1995.

V. Irani, A. J. Guy, D. Andrew, J. G. Beeson, P. A. Ramsland et al., Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases, Mol. Immunol, vol.67, pp.171-182, 2015.

K. J. Ishii, T. Kawagoe, S. Koyama, K. Matsui, H. Kumar et al., TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines, Nature, vol.451, pp.725-729, 2008.

H. M. Ishikawa, HHS Public Access, vol.347, pp.882-886, 2015.

T. Iyoda, S. Shimoyama, K. Liu, Y. Omatsu, Y. Akiyama et al., The CD8 + Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo, J. Exp. Med, vol.195, pp.1289-1302, 2002.

D. Jáuregui-zúñiga, M. Pedraza-escalona, G. P. Espino-solís, V. Quintero-hernández, A. Olvera-rodríguez et al., Research in Veterinary Science Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens : Hemagglutinin of avian in fl uenza virus example, YRVSC, vol.111, pp.55-62, 2017.

A. Joachim, P. J. Munseri, C. Nilsson, M. Bakari, S. Aboud et al., Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers, AIDS Res. Hum. Retroviruses, vol.33, pp.1-9, 2017.

O. P. Joffre, D. Sancho, S. Zelenay, A. M. Keller, and C. Reis-e-sousa, Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A, Eur. J. Immunol, vol.40, pp.1255-1265, 2010.

T. S. Johnson, K. Mahnke, V. Storn, K. Schönfeld, S. Ring et al., Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable molecule, Clin. Cancer Res, vol.14, pp.8169-8177, 2008.

S. L. Jongbloed, A. J. Kassianos, K. J. Mcdonald, G. J. Clark, X. Ju et al., Human CD141 + (BDCA-3) + dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens, J. Exp. Med, vol.207, pp.1247-1260, 2010.

S. Jung, D. Unutmaz, P. Wong, G. I. Sano, K. De-los-santos et al., In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens, Immunity, vol.17, issue.02, pp.365-370, 2002.

S. Kannanganat, L. S. Wyatt, S. Gangadhara, V. Chamcha, L. S. Chea et al., High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5?-Restrictive Macaques, J. Immunol, vol.197, pp.3586-3596, 2016.

W. Kastenmüller, K. Kastenmüller, C. Kurts, and R. A. Seder, Dendritic cell-targeted vaccines -hope or hype?, Nat. Rev. Immunol, vol.14, pp.705-711, 2014.

M. Kato, K. J. Mcdonald, S. Khan, I. L. Ross, S. Vuckovic et al., Expression of human DEC-205 (CD205) multilectin receptor on leukocytes, Int. Immunol, vol.18, pp.857-869, 2006.

Y. Kato, A. Zaid, G. M. Davey, S. N. Mueller, S. L. Nutt et al., , 2015.

H. L. Kaufman, C. E. Ruby, T. Hughes, and C. L. Jr, Current status of granulocytemacrophage colony-stimulating factor in the immunotherapy of melanoma, 2014.

K. Kautz-neu, M. Noordegraaf, S. Dinges, C. L. Bennett, D. John et al., Langerhans cells are negative regulators of the anti-Leishmania response 208, 2011.

E. Klechevsky, R. Morita, M. Liu, Y. Cao, L. Thompson-snipes et al., , vol.29, pp.497-510, 2008.

G. A. Koretzky, Multiple Roles of CD4 and CD8 in T Cell Activation, 2010.

J. Kortekaas, A. F. Antonis, J. Kant, R. P. Vloet, A. Vogel et al., Efficacy of three candidate Rift Valley fever vaccines in sheep, Vaccine, vol.30, pp.3423-3429, 2012.

J. Kortekaas, N. Oreshkova, L. Van-keulen, J. Kant, B. J. Bosch et al., Comparative efficacy of two next-generation Rift Valley fever vaccines, Vaccine, vol.32, pp.4901-4908, 2014.

K. Felix, L. Guillemot, M. Ermonval, C. Tamietti, M. Flamand et al., The Rift Valley fever accessory proteins NSm and P78 / NSm-G N are distinct determinants of virus propagation in vertebrate and invertebrate hosts, 2014.

C. Kurts, CD11c: Not merely a murine DC marker, but also a useful vaccination target, 2008.

, Eur. J. Immunol, vol.38, pp.2072-2075

N. Lagerqvist, B. Moiane, G. Bucht, J. Fafetine, J. T. Paweska et al., Stability of a formalin-inactivated Rift Valley fever vaccine: Evaluation of a vaccination campaign for cattle in Mozambique, Vaccine, vol.30, pp.6534-6540, 2012.

N. Lagerqvist, J. Näslund, A. A. Lundkvist, M. Bouloy, C. Ahlm et al., Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs, Virol. J, vol.6, pp.1-10, 2009.

M. H. Lahoud, F. Ahmet, S. Kitsoulis, S. S. Wan, D. Vremec et al., Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype, J. Immunol, vol.187, pp.842-850, 2011.

M. H. Lahoud, F. Ahmet, J. Zhang, S. Meuter, A. N. Policheni et al., DEC-205 is a cell surface receptor for CpG oligonucleotides, Proc. Natl. Acad. Sci, vol.109, pp.16270-16275, 2012.

B. J. Laidlaw, J. E. Craft, and S. M. Kaech, The multifaceted role of CD4+ T cells in CD8+ T cell memory, Nat. Publ. Gr, 2016.

R. Lathan, D. Simon-chazottes, G. Jouvion, and O. Godon, Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models 1-11, 2017.

H. Lauterbach, B. Bathke, S. Gilles, C. Traidl-hoffmann, C. A. Luber et al., Mouse CD8? + DCs and human BDCA3 + DCs are major producers of IFN-? in response to poly IC, J. Exp. Med, vol.207, pp.2703-2717, 2010.

P. Léger, M. Tetard, B. Youness, N. Cordes, R. N. Rouxel et al., Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis, Traffic, vol.17, pp.639-656, 2016.

C. Lehmann, L. Heger, G. Heidkamp, A. Baranska, J. Lühr et al., Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01438144

B. León, M. López-bravo, and C. Ardavín, Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the Induction of Protective T Helper 1 Responses against Leishmania, Immunity, vol.26, pp.519-531, 2007.

J. Li, F. Ahmet, L. C. Sullivan, A. G. Brooks, S. J. Kent et al., , p.169

C. , Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates, pp.854-864, 2015.

L. Liu, C. C. Celma, and P. Roy, Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins, Virol. J, vol.5, 2008.

M. A. Liu, DNA vaccines: An historical perspective and view to the future, Immunol. Rev, vol.239, pp.62-84, 2011.

E. López-gil, G. Lorenzo, E. Hevia, B. Borrego, M. Eiden et al., A Single Immunization with MVA Expressing GnGc Glycoproteins Promotes Epitope-specific CD8+-T Cell Activation and Protects Immune-competent Mice against a Lethal RVFV Infection, PLoS Negl. Trop. Dis, 2013.

G. Lorenzo, R. Martín-folgar, F. Rodríguez, and A. Brun, Priming with DNA plasmids encoding the nucleocapsid protein and glycoprotein precursors from Rift Valley fever virus accelerates the immune responses induced by an attenuated vaccine in sheep, Vaccine, vol.26, pp.5255-5262, 2008.

P. Y. Lozach, A. Kühbacher, R. Meier, R. Mancini, D. Bitto et al., DC-SIGN as a receptor for phleboviruses, Cell Host Microbe, vol.10, pp.75-88, 2011.

S. Lumley, D. L. Horton, L. L. Hernandez-triana, N. Johnson, and A. R. Fooks, Rift Valley fever virus : strategies for maintenance , survival and vertical transmission in mosquitoes 875-887, 2017.

H. J. Ly and T. Ikegami, Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins, Virol. J, vol.13, 2016.

K. Mahnke, Y. Qian, J. Jurgen-knop, and A. H. , Induction of CD4 ? / CD25 ? regulatory T cells by targeting of antigens to immature dendritic cells, vol.101, pp.4862-4869, 2003.

K. Mahnke, S. Ring, and A. H. Enk, Antibody targeting of "steady-state" dendritic cells induces tolerance mediated by regulatory T cells, Front. Immunol, 2016.

B. Makoschey, E. Van-kilsdonk, W. R. Hubers, M. P. Vrijenhoek, M. Smit et al., Rift Valley Fever Vaccine Virus Clone 13, 2016.

, Is Able to Cross the Ovine Placental Barrier Associated with Foetal Infections, Malformations, and Stillbirths, PLoS Negl. Trop. Dis, vol.10, pp.1-15

B. Malissen, S. Tamoutounour, and S. Henri, The origins and functions of dendritic cells and macrophages in the skin, Nat. Rev. Immunol, vol.14, pp.417-445, 2014.

R. B. Mandell, R. Koukuntla, L. J. Mogler, A. K. Carzoli, A. N. Freiberg et al., A replicationincompetent Rift Valley fever vaccine: Chimeric virus-like particles protect mice and rats against lethal challenge, Virology, vol.397, pp.187-198, 2010.

T. P. Manh, J. Elhmouzi-younes, C. Urien, S. Ruscanu, L. Jouneau et al., Defining mononuclear phagocyte subset homology across several distant warm, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01179563

, Front. Immunol, vol.6, pp.1-26

J. F. Mann, P. F. Mckay, A. Fiserova, K. Klein, A. Cope et al., , 2014.

, DNA Vaccine Delivered with Electroporation via Combined Intramuscular and Intradermal Routes, J. Virol, vol.88, pp.6959-69

M. Martínez-lópez, S. Iborra, R. Conde-garrosa, and D. Sancho, Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice, Eur. J. Immunol, vol.45, pp.119-129, 2015.

F. Martinon, K. Kaldma, R. Sikut, S. ?ulina, G. Romain et al., Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates, Hum. Gene Ther, vol.20, pp.1291-1307, 2009.

M. Mashayekhi, M. Sandau, I. Dunay, E. Frickel, A. Khan et al., CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites, Immunity, vol.35, pp.249-259, 2011.

K. Matthews, S. M. Rhind, A. G. Gossner, R. G. Dalziel, and J. Hopkins, The effect of gene gun-delivered pGM-CSF on the immunopathology of the vaccinated skin, 2007.

. Immunol, , vol.65, pp.298-307

L. Mcallister, J. Anderson, K. Werth, I. Cho, K. Copeland et al., Needle-free jet injection for administration of influenza vaccine: A randomised non-inferiority trial, Lancet, vol.384, pp.674-681, 2014.

, , pp.60524-60533

A. Mildner and S. Jung, Development and function of dendritic cell subsets, Immunity, vol.40, pp.642-656, 2014.

J. Miller, B. Brown, T. Shay, E. Gautier, and V. Jojic, Deciphering the transcriptional network of the dendritic cell lineage, Nature, vol.13, pp.888-899, 2012.

M. Mir and T. Panganiban, The Hantavirus Nucleocapsid Protein Recognizes Specific Features of the Viral RNA Panhandle and Is Altered in Conformation upon RNA Binding The Hantavirus Nucleocapsid Protein Recognizes Specific Features of the Viral RNA Panhandle and Is Altered in Confo, vol.79, pp.1824-1835, 2005.

J. C. Morrill, L. Carpenter, D. Taylor, H. H. Ramsburg, J. Quance et al., Further evaluation of a mutagen-attenuated Rift Valley fever vaccine in sheep, Vaccine, vol.9, pp.35-41, 1991.

J. C. Morrill, R. C. Laughlin, N. Lokugamage, R. Pugh, E. Sbrana et al., Safety and immunogenicity of recombinant Rift Valley fever MP-12 vaccine candidates in sheep, Vaccine, vol.31, pp.559-565, 2013.

J. C. Morrill, C. A. Mebus, and C. J. Peters, Safety and efficacy of a mutagen-attenuated Rift Valley fever virus vaccine in cattle, Am. J. Vet. Res, vol.58, pp.1104-1113, 1997.

J. C. Morrill and C. J. Peters, Mucosal Immunization of Rhesus Macaques With Rift Valley Fever MP-12 Vaccine, J. Infect. Dis, vol.204, pp.617-625, 2011.

J. C. Morrill and C. J. Peters, Protection of MP-12-vaccinated rhesus macaques against parenteral and aerosol challenge with virulent Rift Valley fever virus, J. Infect. Dis, vol.204, pp.229-236, 2011.

S. Moutailler, G. Krida, F. Schaffner, M. Vazeille, and A. Failloux, Potential vectors of Rift Valley fever virus in the Mediterranean region. Vector Borne Zoonotic Dis, vol.8, pp.749-753, 2008.
URL : https://hal.archives-ouvertes.fr/pasteur-01696142

S. Moutailler, B. Roche, J. M. Thiberge, V. Caro, F. Rougeon et al., Host alternation is necessary to maintain the genome stability of Rift Valley fever virus, PLoS Negl. Trop. Dis, vol.5, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00597944

S. Mukherjee, K. A. Dowd, C. J. Manhart, J. E. Ledgerwood, A. P. Durbin et al., Mechanism and Significance of Cell Type-Dependent Neutralization of Flaviviruses, J. Virol, vol.88, pp.7210-7220, 2014.

R. Muller, J. F. Saluzzo, N. Lopez, T. Dreier, M. Turell et al., Characterization of clone 13, a naturally attenuated avirulent isolate of Rift Valley fever virus, which is altered in the small segment, Am. J. Trop. Med. Hyg, vol.53, pp.405-411, 1995.

R. M. Murithi, P. Munyua, P. M. Ithondeka, J. M. Macharia, . Hightower et al., Rift Valley fever in Kenya: history of epizootics and identification of vulnerable districts, Epidemiol. Infect, vol.139, pp.372-80, 2011.

T. L. Murphy, G. E. Grajales-reyes, X. Wu, R. Tussiwand, C. G. Briseño et al., Transcriptional Control of Dendritic Cell Development, Annu. Rev. Immunol, vol.34, pp.93-119, 2016.

H. Nakano, M. Yanagita, and M. D. Gunn, CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells, J. Exp, 2001.

. Med, , vol.194, pp.1171-1178

M. O. Nanyingi, P. Munyua, S. G. Kiama, G. M. Muchemi, S. M. Thumbi et al., A systematic review of Rift Valley Fever epidemiology, pp.1-12, 1931.

G. Nchinda, J. Kuroiwa, M. Oks, C. Trumpfheller, C. G. Park et al., The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells, 2008.

C. K. Nfon, P. Marszal, S. Zhang, and H. M. Weingartl, Innate immune response to rift valley fever virus in goats, PLoS Negl. Trop. Dis, vol.6, 2012.

L. N. Ngu, N. N. Nji, G. E. Ambada, B. Sagnia, C. N. Sake et al., vivo targeting of protein antigens to dendritic cells using anti-DEC-205 single chain antibody improves HIV Gag specific CD4 þ T cell responses protecting from airway challenge with recombinant vaccinia-gag virus, pp.1-13, 2017.

P. M. Nguku, S. K. Sharif, D. Mutonga, S. Amwayi, J. Omolo et al., An investigation of a major outbreak of rift valley fever in Kenya: 2006-2007, Am. J. Trop. Med. Hyg, vol.83, pp.5-13, 2010.

V. Niborski, Y. Li, F. Brennan, M. Lane, .. M. Torché et al., Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV, Vaccine, vol.24, pp.7204-7213, 2006.

T. Niezold, M. Storcksdieck-genannt-bonsmann, A. Maaske, V. Temchura, V. Heinecke et al., DNA vaccines encoding DEC205-targeted antigens: Immunity or Tolerance? Immunology n, 2015.

B. Niklasson, Rift Valley Fever Virus Vaccine Trial: Study of Side-Effects in Humans, Scand. J. Infect. Dis, vol.14, pp.105-109, 1982.

B. Niklasson, C. J. Peters, E. Bengtsson, and E. Norrby, Rift Valley fever virus vaccine trial: study of neutralizing antibody response in humans, Vaccine, vol.3, pp.123-127, 1985.

, , pp.90061-90062

F. Nimmerjahn and J. V. Ravetch, Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding 1663, 2005.

G. Nizzoli, J. Krietsch, A. Weick, S. Steinfelder, F. Facciotti et al., Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses, Blood, vol.122, pp.932-942, 2013.

M. K. Njenga, L. Njagi, S. M. Thumbi, and S. Kahariri, Randomized Controlled Field Trial to Assess the Immunogenicity and Safety of Rift Valley Fever Clone 13 Vaccine in Livestock, vol.6, pp.1-13, 2015.

M. C. Nussenzweig, R. M. Steinman, B. Gutchinov, and Z. A. Cohn, Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes, J. Exp. Med, vol.152, pp.1070-84, 1980.

M. M. Olive, S. M. Goodman, and J. M. Reynes, The role of wild mammals in the maintenance of Rift Valley fever virus, J. Wildl. Dis, vol.48, pp.241-266, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00836148

J. C. Osborne and R. M. Elliott, RNA binding properties of bunyamwera virus nucleocapsid protein and selective binding to an element in the 5' terminus of the negative-sense S segment, J. Virol, vol.74, pp.9946-52, 2000.

T. Ouchi, A. Kubo, M. Yokouchi, T. Adachi, T. Kobayashi et al., Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome, vol.208, pp.2607-2613, 2011.
DOI : 10.1084/jem.20111718
URL : http://jem.rupress.org/content/jem/208/13/2607.full.pdf

O. El-mamy, A. B. Baba, M. O. Barry, Y. Isselmou, K. Dia et al., Unexpected rift valley fever outbreak, Northern Mauritania. Emerg. Infect. Dis, vol.17, pp.1894-1896, 2011.

H. Park, P. S. Tan, R. Kavishna, A. Ker, J. Lu et al., Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells, 2017.
DOI : 10.1038/s41541-017-0033-5
URL : https://www.nature.com/articles/s41541-017-0033-5.pdf

H. Park, A. Light, M. H. Lahoud, D. M. Tarlinton, and K. Shortman, Evolution of B Cell Responses to Clec9A-Targeted Antigen, 2013.

M. Pepin, M. Bouloy, B. H. Bird, A. Kemp, and J. Paweska, Rift Valley fever virus (Bunyaviridae: Phlebovirus): An update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention, Vet. Res, vol.41, 2010.
DOI : 10.1051/vetres/2010033
URL : https://hal.archives-ouvertes.fr/hal-00903196

M. Perales, J. Yuan, S. Powel, H. F. Gallardo, S. Teresa et al., , vol.16, pp.2022-2029, 2014.

A. Pernthaner, S. A. Cole, T. Gatehouse, and W. R. Hein, Phenotypic diversity of antigenpresenting cells in ovine-afferent intestinal lymph, Arch. Med. Res, vol.33, pp.405-412, 2002.

, , pp.375-377

E. Persson, H. Uronen-hansson, M. Semmrich, A. Rivollier, K. Hägerbrand et al., , p.4, 2013.

, Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation, Immunity, vol.38, pp.958-969

I. Phoenix, N. Lokugamage, S. Nishiyama, and T. Ikegami, Mutational analysis of the rift valley fever virus glycoprotein precursor proteins for Gn protein expression, Viruses, vol.8, pp.1-14, 2016.

I. Phoenix, S. Nishiyama, N. Lokugamage, T. E. Hill, M. B. Huante et al., N-glycans on the rift valley fever virus envelope glycoproteins Gn and Gc redundantly support viral infection via DC-SIGN, 2016.
DOI : 10.3390/v8050149
URL : https://www.mdpi.com/1999-4915/8/5/149/pdf

P. R. Pittman, S. L. Norris, E. S. Brown, M. V. Ranadive, B. A. Schibly et al., , 2016.

, vaccine Phase 2 clinical trial : Safety , immunogenicity , and genetic characterization of virus isolates, Vaccine, vol.34, pp.523-530

M. Plantinga, M. Guilliams, M. Vanheerswynghels, K. Deswarte, F. Branco-madeira et al., Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen, Immunity, vol.38, pp.322-335, 2013.

D. Pokorna, I. Rubio, and M. Müller, DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants, Genet. Vaccines Ther, vol.6, 2008.

J. L. Pooley, W. R. Heath, and K. Shortman, Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8-Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells, J. Immunol, vol.166, pp.5327-5330, 2001.

R. Daubney and J. R. Hudson, Enzootic Hepatitis of Rift valley fever, 1930.

M. Ramamoorth and A. Narvekar, Non viral vectors in gene therapy -An overview, J. Clin. Diagnostic Res, vol.9, pp.1-06, 2015.

B. Reizis, A. Bunin, H. S. Ghosh, K. L. Lewis, and V. Sisirak, Plasmacytoid Dendritic Cells: Recent Progress and Open Questions, Ann. Rev. Immunol, vol.29, pp.163-183, 2011.

A. Reuter, S. E. Panozza, C. Macri, C. Dumont, J. Li et al., Criteria for Dendritic Cell Receptor Selection for Efficient Antibody-Targeted Vaccination, J. Immunol, 2015.

S. Ring, M. Maas, D. M. Nettelbeck, H. Enk, and K. Mahnke, Targeting of Autoantigens to DEC205 + Dendritic Cells In Vivo Suppresses Experimental Allergic Encephalomyelitis in Mice, 2017.

P. A. Roche and K. Furuta, The ins and outs of MHC class II-mediated antigen processing and presentation, Nat. Rev. Immunol, vol.15, pp.203-216, 2015.

M. Rols, M. Golzio, and J. Teissie, Direct visualization at the single-cell level of electrically mediated gene delivery 99, 2002.

N. Romani, B. E. Clausen, and P. Stoitzner, UKPMC Funders Group subsets in the skin, Immunol. Rev, vol.234, pp.120-141, 2010.

A. K. Roos, F. Eriksson, J. Timmons, J. Gerhardt, U. Nyman et al., Skin electroporation: Effects on transgene expression, DNA persistence and local tissue environment, PLoS One, vol.4, 2009.

M. K. Rostal, J. E. Liang, D. Zimmermann, R. Bengis, J. Paweska et al., Rift Valley Fever : Does Wildlife Play a Role ? 1-12, 2017.

J. M. Rusnak, P. Gibbs, E. Boudreau, D. P. Clizbe, and P. Pittman, Immunogenicity and safety of an inactivated Rift Valley fever vaccine in a 19-year study, Vaccine, vol.29, pp.3222-3229, 2011.

M. Rusu, R. Bonneau, M. R. Holbrook, S. J. Watowich, S. Birmanns et al., An assembly model of Rift Valley fever virus, Front. Microbiol, vol.3, pp.1-15, 2012.

F. Saade and N. Petrovsky, Technologies for enhanced efficacy of DNA vaccines, Expert Rev. Vaccines, vol.11, pp.189-209, 2012.

C. Sadhu, H. J. Ting, B. Lipsky, K. Hensley, L. F. Garcia-martinez et al., CD11c / CD18 : novel ligands and a role in delayed-type hypersensitivity, vol.81, pp.1395-1403, 2007.

A. Said, M. Elmanzalawy, G. Ma, A. M. Damiani, and N. Osterrieder, An equine herpesvirus type 1 (EHV-1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep, Virol. J, vol.14, pp.16-23, 2017.

A. A. Sall, Y. Thiongane, and M. Bouloy, Genetic Reassortment of Rift Valley Fever Virus in, Nature, vol.73, pp.8196-8200, 1999.

D. Sancho, O. P. Joffre, A. M. Keller, N. C. Rogers, and D. Martinez, Identification of a dendritic cell receptor that couples sensing of necrosis to immunity, vol.458, pp.899-903, 2009.

R. Sanjua, Mechanisms of viral mutation´4433mutation´mutation´4433-4448, 2016.

A. T. Satpathy, W. Kc, J. C. Albring, B. T. Edelson, N. M. Kretzer et al., Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages, J. Exp. Med, vol.209, pp.1135-1152, 2012.

A. Savina and S. Amigorena, Phagocytosis and antigen presentation in dendritic cells, Immunol. Rev, vol.219, pp.143-156, 2007.

A. Schlitzer, N. Mcgovern, P. Teo, T. Zelante, K. Atarashi et al.,

H. A. Purvis, C. M. Hilkens, J. Tam, M. Poidinger, E. R. Stanley et al., IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses, Immunity, vol.38, pp.970-983, 2013.

E. Schlosser, M. Mueller, S. Fischer, S. Basta, D. H. Busch et al., TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses, pp.1626-1637, 2008.

P. J. Schreur, L. Keulen, . Van, J. Kant, and J. Kortekaas, Four-segmented Rift Valley fever virus-based vaccines can be applied safely in ewes during pregnancy, 2017.

I. Schwartz-cornil, M. Epardaud, and M. Bonneau, Cervical duct cannulation in sheep for collection of afferent lymph dendritic cells from head tissues, Nat. Protoc, vol.1, pp.874-879, 2006.

E. Segura, M. Durand, and S. Amigorena, Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells, J. Exp. Med, vol.210, pp.1035-1047, 2013.

E. Segura, M. Touzot, A. Bohineust, A. Cappuccio, G. Chiocchia et al., Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation, Immunity, vol.38, pp.336-348, 2013.

E. Segura, J. Valladeau-guilemond, M. Donnadieu, X. Sastre-garau, V. Soumelis et al., Characterization of resident and migratory dendritic cells in human lymph nodes, J. Exp. Med, vol.209, pp.653-660, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00723792

C. Seillet, J. T. Jackson, K. A. Markey, H. J. Brady, G. R. Hill et al., CD8?+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3, Blood, vol.121, pp.1574-1583, 2013.

J. Seneschal, R. A. Clark, A. Gehad, C. M. Baecher-allan, and T. S. Kupper, Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells, Immunity, vol.36, pp.873-884, 2012.

M. Shari, F. Pasmans, C. Adriaensen, S. Devisscher, T. Adriaens et al., Rift Valley and West Nile Virus Antibodies in Camels, North Africa, vol.17, pp.2372-2374, 2011.

R. E. Shrimpton, M. Butler, A. Morel, E. Eren, S. S. Hue et al., CD205 ( DEC-205 ): A recognition receptor for apoptotic and necrotic self, vol.46, pp.1229-1239, 2009.

F. P. Siegal, The Nature of the Principal Type 1 Interferon-Producing Cells 180, 1999.

, Human Blood. Science, vol.284, pp.1835-1837

D. Sissoko, C. Giry, P. Gabrie, A. Tarantola, F. Pettinelli et al., Rift valley fever, mayotte, Emerg. Infect. Dis, vol.15, pp.568-570, 2007.

D. R. Smith, K. E. Steele, J. Shamblin, A. Honko, J. Johnson et al., The pathogenesis of Rift Valley fever virus in the mouse model, Virology, vol.407, pp.256-267, 2010.

K. C. Smithburn, A. J. Haddow, and J. D. Gillett, RIFT VALLEY FEVER . ISOLATION OF THE VIRUS FROM WILD MOSQUITOES, 1948.

R. Spiering, B. Margry, C. Keijzer, A. Hoek, J. Wagenaar-hilbers et al., DEC205 + Dendritic Cell ? Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis, 2017.

K. Spik, A. Shurtleff, A. K. Mcelroy, M. C. Guttieri, J. W. Hooper et al., Immunogenicity of combination DNA vaccines for Rift Valley fever virus, tick-borne encephalitis virus, Hantaan virus, and Crimean Congo hemorrhagic fever virus, Vaccine, vol.24, pp.4657-4666, 2006.

R. M. Steinman, Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice, J Exp Med, pp.1142-1162, 1973.

R. M. Steinman, G. Kaplan, M. D. Witmer, and Z. A. Cohn, Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro, J. Exp. Med, vol.149, pp.1-16, 1979.

R. M. Steinman and M. D. Witmer, Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice Immunology, vol.75, pp.5132-5136, 1978.

J. J. Suschak, S. Wang, K. A. Fitzgerald, and S. Lu, A cGAS-Independent STING/IRF7, 2016.

, Pathway Mediates the Immunogenicity of DNA Vaccines, J. Immunol, vol.196, pp.310-316

J. J. Suschak, S. Wang, K. A. Fitzgerald, and S. Lu, Identification of Aim2 as a Sensor for DNA Vaccines, J. Immunol, vol.194, pp.630-636, 2015.

M. Swiecki and M. Colonna, The multifaceted biology of plasmacytoid dendritic cells, Nat. Rev. Immunol, vol.15, pp.471-485, 2015.

J. Tel, S. P. Sittig, R. A. Blom, L. J. Cruz, G. Schreibelt et al., Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion, J. Immunol, vol.191, pp.5005-5012, 2013.

M. Tenbusch, R. Ignatius, G. Nchinda, C. Trumpfheller, A. M. Salazar et al., Immunogenicity of DNA vaccines encoding Simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques, PLoS One, vol.7, pp.1-9, 2012.

D. Terhorst, E. Fossum, A. Baranska, S. Tamoutounour, C. Malosse et al., Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses, J. Immunol, vol.194, pp.5895-5902, 2015.

C. A. Thaiss, V. Semmling, L. Franken, H. Wagner, and C. Kurts, Chemokines: A new dendritic cell signal fort cell activation, Front. Immunol, vol.2, pp.1-9, 2011.

S. Tokuda, T. Z. Valle, . Do, L. Batista, L. Guillemot et al., The genetic basis for susceptibility to Rift Valley fever disease in MBT / Pas mice, p.1325818, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01325818

O. D. Tomori and J. L. Schmitz, Experimental infection of three Nigerian breeds of sheep with the Zinga strain of the Rift Valley Fever virus, 1996.

J. S. Tregoning and E. Kinnear, Using Plasmids as DNA Vaccines for Infectious Diseases, Plasmids Biol. Impact Biotechnol. Discov, vol.2, pp.651-668, 2014.

J. Ulmer, J. Donnelly, S. Parker, G. Rhodes, P. Felgner et al., Heterologous protection against influenza by injection of DNA encoding a viral protein, vol.259, pp.1745-1749, 1993.

C. L. Van-broekhoven, C. R. Parish, C. Demangel, W. J. Britton, and J. G. Altin, Targeting dendritic cells with antigen-containing liposomes: A highly effective procedure for induction of antitumor immunity and for tumor immunotherapy, Cancer Res, vol.64, pp.4357-4365, 2004.

J. H. Van-den-berg, B. Nuijen, J. H. Beijnen, A. Vincent, H. Van-tinteren et al., Optimization of Intradermal Vaccination by DNA Tattooing in Human Skin, 2009.

, Gene Ther, vol.20, pp.181-189

S. Vasan, A. Hurley, S. J. Schlesinger, D. Hannaman, D. F. Gardiner et al., In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers, PLoS One, vol.6, pp.1-10, 2011.

B. E. Verstrepen, A. D. Bins, C. S. Rollier, P. Mooij, G. Koopman et al., Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates, Vaccine, vol.26, pp.3346-3351, 2008.

T. Vicente, A. Roldão, C. Peixoto, M. J. Carrondo, and P. M. Alves, Large-scale production and purification of VLP-based vaccines, J. Invertebr. Pathol, vol.107, pp.42-48, 2011.

V. Teichman, B. Engelbrecht, A. Zulu, G. Dungu, B. Pardini et al., Safety and efficacy of Rift Valley fever Smithburn and Clone 13 vaccines in calves, 2011.

, Vaccine, vol.29, pp.5771-5777

T. P. Vu-manh, N. Bertho, A. Hosmalin, I. Schwartz-cornil, and M. Dalod, Investigating evolutionary conservation of dendritic cell subset identity and functions, Front. Immunol, vol.6, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01170364

D. B. Wallace, C. E. Ellis, . Espach, S. J. Smith, R. R. Greyling et al., Protective immune responses induced by different recombinant vaccine regimes to Rift Valley fever, Vaccine, vol.24, pp.7181-7189, 2006.

Q. Wang, W. Cao, Z. G. Yang, and G. F. Zhao, Dc targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice, Int. J. Clin. Exp. Med, vol.8, pp.17565-17577, 2015.

Q. Wang, W. Jiang, Y. Chen, P. Liu, C. Sheng et al., In Vivo Electroporation of Minicircle DNA as a Novel Method of Vaccine Delivery To Enhance HIV-1-Specific Immune Responses, J. Virol, vol.88, pp.1924-1934, 2014.

G. M. Warimwe, J. Gesharisha, B. V. Carr, S. Otieno, K. Otingah et al., Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever, Sci. Rep, vol.6, pp.1-7, 2016.

H. Wei, S. Wang, D. Zhang, S. Hou, W. Qian et al., Cancer Therapy : Preclinical argeted Delivery of T umor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice, vol.15, pp.4612-4622, 2009.

H. M. Weingartl, C. K. Nfon, S. Zhang, P. Marszal, W. C. Wilson et al., Efficacy of a recombinant rift valley fever virus MP-12 with NSm deletion as a vaccine candidate in sheep, Vaccine, vol.32, pp.2345-2349, 2014.

A. L. White, A. L. Tutt, S. James, K. A. Wilkinson, F. V. Castro et al., Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant, Immunology, vol.131, pp.141-151, 2010.

W. Schreur, P. J. Kortekaas, and J. , Single-Molecule FISH Reveals Non-selective Packaging of Rift Valley Fever Virus Genome Segments, PLoS Pathog, vol.12, pp.1-21, 2016.

G. Widera, M. Austin, D. Rabussay, C. Goldbeck, S. W. Barnett et al., Increased DNA Vaccine Delivery and Immunogenicity by Electroporation In Vivo, J. Immunol, vol.164, pp.4635-4640, 2000.

M. D. Witmer-pack, W. J. Swiggard, A. Mirza, K. Inaba, and R. M. Steinman, Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145, Cell. Immunol, vol.163, pp.157-162, 1995.

J. A. Wolff, R. W. Malone, P. Williams, C. Wang, G. Acsadi et al., Direct gene transfer into mouse muscle in vivo, vol.247, pp.1465-1468, 1990.

S. Won, T. Ikegami, C. J. Peters, and S. Makino, NSm Protein of Rift Valley Fever Virus Suppresses Virus-Induced Apoptosis ? 81, pp.13335-13345, 2007.

Y. Wu, Y. Zhu, F. Gao, Y. Jiao, B. O. Oladejo et al., Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope, Proc. Natl. Acad. Sci, vol.114, pp.7564-7573, 2017.

W. Xu, D. M. Watts, M. C. Costanzo, X. Tang, L. A. Venegas et al., The Nucleocapsid Protein of Rift Valley Fever Virus Is a, 2013.

T. Yoshida, T. Imai, M. Kakizaki, M. Nishimura, S. Takagi et al., Identification of Single C Motif-1 / Lymphotactin Receptor XCR1 * 273, pp.16551-16554, 1998.

L. J. Young, N. S. Wilson, P. Schnorrer, A. Proietto, T. Ten-broeke et al., Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells, Nat. Immunol, vol.9, pp.1244-1252, 2008.

C. I. Yu, C. Becker, Y. Wang, F. Marches, J. Helft et al., Human cd1c+ dendritic cells drive the differentiation of cd103+ cd8+ mucosal effector t cells via the cytokine tgf-?, Immunity, vol.38, pp.818-830, 2013.

S. Zelenay, A. M. Keller, P. G. Whitney, B. U. Schraml, S. Deddouche et al., The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virusinfected mice 122, pp.1615-1627, 2012.

H. Zhang, H. Kong, X. Zeng, L. Guo, X. Sun et al., Subsets of regulatory T cells and their roles in allergy, J. Transl. Med, vol.12, pp.1-11, 2014.

, Annexes A. Annexe 1 -Liste des congrès nationaux et internationaux Communications orales -20 au 21/03/17 : 10 ème colloque du Club Vaccinologie Société Française d'ImmunologieLyon