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Microbulles de gaz comme vecteur de médicament

Abstract : This work deals with the stabilization of gaz microbubbles dispersed in aqueous solutions by using LipidNanoCapsules (LNC). The main objective is the development of a Drug Delivery System where the release is triggered by ultrasonation. Firstly, we investigated the ability of LNC to behave as real air/water interfacial stabilization agents. It is shown that LNC can decrease the surface tension at the air/water interface more than the Solutol®, main pegylated surfactant of the LNC. Usual stirring method seems the more efficient to produce stabilized air microbubbles. Microbubbles are characterized by a mean size below 2μm and are concentrated at 2.72x1012 /mL. The size distribution ishomogeneous with a convenient polydispersity index.The gas holdup inherent to the microbubbles was estimated to 0.17. Microbubbles are surrounded by a film constituted by Solutol® and Lipoïd®. Their stability at room temperature was kept up to 7 days. Sodium Fusidate was chosen as a drug model with an encapsulation rate in a 27-35% range. The drug release upon ultrasound was between 50-55 % in comparison with 40-50 % without ultrasounds focusing.
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  • HAL Id : tel-02073613, version 1

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Celia Rosemonde Mouzouvi. Microbulles de gaz comme vecteur de médicament. Médecine humaine et pathologie. Université d'Angers; Université d'Abomey-Calavi (Bénin), 2017. Français. ⟨NNT : 2017ANGE0066⟩. ⟨tel-02073613⟩

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