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Développement de nanoparticules de poly(hydroxy)uréthane pH- et thermo-stimulable par nanoprécipitation

Abstract : The use of polymer nanoparticles for substance encapsulation generates a growing interest in medicine, cosmetics or agro-chemistry. Among the polymers used as nano-encapsulation agents, polyurethane has the advantage to be biocompatible, biodegradable and versatile. However, the use of noxious diisocyanates for polyurethane synthesis is a major drawback. This thesis project consists in synthesizing a non-isocyanate polyurethane, poly(hydroxyl)urethane (PHU), and then preparing nanoparticles by PHU nanoprecipitation. An additional objective is the development of thermos and pH-responsive PHU nanoparticles. In a first section, a model PHU was synthesized and characterized. The polymer was then nanoprecipitated in the absence of surfactant in order to ensure the feasibility of the process. The second section focused on the in-depth study and optimization of the model PHU nanoprecipitation in the presence of a surfactant. To characterize the polymer-solvent-water-surfactant system, surfactant micellization and polymer-solvent interactions were studied. A full-factorial design was performed to optimize the nanoprecipitation process using DMSO as an organic solvent. Main and interaction effects of the polymer concentration, water volume and surfactant concentration on nanoparticle size and size distribution were determined. With the aim of eliminating the organic solvent by evaporation, PHU nanoprecipitation was also carried out using THF as the organic solvent. In the third section, three pH- and thermos-responsive PHUs were synthesized and characterized. Small and monodisperse nanoparticles were then prepared by nanoprecipitation. Once the solvent eliminated, responsive PHU nanoparticles were submitted to pH and temperature changes and size variations were studied.
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Submitted on : Thursday, March 14, 2019 - 3:17:07 PM
Last modification on : Wednesday, October 14, 2020 - 3:57:41 AM
Long-term archiving on: : Saturday, June 15, 2019 - 7:54:05 PM


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  • HAL Id : tel-02068015, version 1


Thomas Querette. Développement de nanoparticules de poly(hydroxy)uréthane pH- et thermo-stimulable par nanoprécipitation. Matériaux. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSEI075⟩. ⟨tel-02068015⟩



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