, Reading Frames Located in the Leader of Protein Kinase Mzeta mRNA Regulate Its Translation, Front Mol, vol.9, p.103

M. G. Barouki, Le stress du re?ticulumre?ticulum endoplasmique : adaptation et toxicite?.toxicite?, Medecine, vol.18, pp.585-594, 2002.

C. Basilico and D. Moscatelli, The FGF family of growth factors and oncogenes, Adv Cancer, vol.59, pp.115-165, 1992.

A. Bastide, Z. Karaa, S. Bornes, C. Hieblot, E. Lacazette et al., An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform, Nucleic Acids, vol.36, issue.7, pp.2434-2445, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01543718

I. Baumgartner, A. Pieczek, O. Manor, R. Blair, M. Kearney et al., Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia, Circulation97, issue.12, pp.1114-1123, 1998.

G. J. Belsham and N. Sonenberg, RNA-protein interactions in regulation of picornavirus RNA translation, Microbiol, vol.60, issue.3, pp.499-511, 1996.

L. Beretta, A. C. Gingras, Y. V. Svitkin, M. N. Hall, and N. Sonenberg, Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits capdependent initiation of translation, EMBO, vol.15, issue.3, pp.658-664, 1996.

J. Bernstein, O. Sella, S. Y. Le, and O. Elroy-stein, PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES), J Biol, vol.272, issue.14, pp.9356-9362, 1997.

S. Bonnal, F. Pileur, C. Orsini, F. Parker, F. Pujol et al., Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA, J Biol, vol.280, issue.6, pp.4144-4153, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00307810

S. Bonnal, C. Schaeffer, L. Creancier, S. Clamens, H. Moine et al., A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons, J Biol, vol.278, issue.41, pp.39330-39336, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00307489

F. Bonnet-magnaval, C. Philippe, L. Van-den, H. Berghe, C. Prats et al., Hypoxia and ER stress promote Staufen1 paraspeckle formation through HIF-2alpha dependent transcriptional activation of NEAT1 leading to cancer cell survival, Oncogene34, issue.34, pp.4482-4490, 2016.

J. L. Christmann and M. E. Dahmus, Monoclonal antibody specific for calf thymus RNA polymerases IIO and IIA, J Biol, vol.256, issue.22, pp.11798-11803, 1981.

L. C. Cobbold, K. A. Spriggs, S. J. Haines, H. C. Dobbyn, C. Hayes et al., Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs, Mol Cell, vol.28, issue.1, pp.40-49, 2008.

W. C. Claycomb, N. A. Lanson, B. S. Stallworth, D. B. Egeland, J. B. Delcarpio et al., HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte, Proc Natl Acad Sci, vol.95, issue.6, pp.2979-2984, 1998.

B. Cohen, Y. Addadi, S. Sapoznik, G. Meir, V. Kalchenko et al., Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75, vol.11, pp.921-933, 2009.

M. J. Coldwell, M. L. Deschoolmeester, G. A. Fraser, B. M. Pickering, G. Packham et al., The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock, Oncogene20, issue.30, pp.4095-4100, 2001.

M. J. Coldwell, S. A. Mitchell, M. Stoneley, M. Macfarlane, and A. E. Willis, Initiation of Apaf-1 translation by internal ribosome entry, Oncogene19, issue.7, pp.899-905, 2000.

C. Conte, N. Ainaoui, A. Delluc-clavieres, M. P. Khoury, R. Azar et al., Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism, Nucleic Acids, vol.37, issue.16, pp.5267-5278, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00410389

C. Conte, E. Riant, C. Toutain, F. Pujol, J. F. Arnal et al., FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha, PLoS, vol.3, issue.8, p.3078, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00317714

L. Cobbold, K. A. Lc, S. J. Spriggs, H. C. Haines, C. Dobbyn et al., Identification of, 2008.

E. Dejean, M. H. Renalier, M. Foisseau, X. Agirre, N. Joseph et al., Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas, pp.1882-1890, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00611903

M. T. Dellinger and R. A. Brekken, Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium, PLoS One6, issue.12, p.28947, 2011.

M. T. Dellinger, S. M. Meadows, K. Wynne, O. Cleaver, and R. A. Brekken, Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature, PLoS, vol.8, issue.9, p.74686, 2013.

J. Deng, J. Cui, N. Jiang, R. Zhang, L. Zhang et al., STAT3 regulation the expression of VEGF-D in HGC-27 gastric cancer cell, Am J Transl, vol.6, issue.6, pp.756-767, 2014.

J. N. Dholakia and A. J. Wahba, Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein, J Biol, vol.264, issue.1, pp.546-550, 1989.

Q. Du, L. Jiang, X. Wang, M. Wang, F. She et al., Tumor necrosis factor-alpha promotes the lymphangiogenesis of gallbladder carcinoma through nuclear factor-kappaB-mediated upregulation of vascular endothelial growth factor-C, Cancer, vol.105, issue.10, pp.1261-1271, 2014.

H. Eguchi, T. Ikuta, T. Tachibana, Y. Yoneda, and K. Kawajiri, A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex, J Biol, vol.272, issue.28, pp.17640-17647, 1997.

D. Durie, M. Hatzoglou, P. Chakraborty, and M. Holcik, HuR controls mitochondrial morphology through the regulation of BclxL translation, Translation1, issue.1, p.23980, 2013.

D. Durie, S. M. Lewis, U. Liwak, M. Kisilewicz, M. Gorospe et al., RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation, Oncogene30, issue.12, pp.1460-1469, 2011.

B. M. Emerson, Specificity of gene regulation, vol.109, pp.267-270, 2002.

J. R. Evans, S. A. Mitchell, K. A. Spriggs, J. Ostrowski, K. Bomsztyk et al., Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo, Oncogene22, issue.39, pp.8012-8020, 2003.

D. Fan, A. Takawale, M. Shen, W. Wang, X. Wang et al., ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis, Cardiomyocyte A Disintegrin And Metalloproteinase, vol.17, issue.5, pp.970-979, 2015.
DOI : 10.1161/circheartfailure.114.002029
URL : https://www.ahajournals.org/doi/pdf/10.1161/CIRCHEARTFAILURE.114.002029

J. Fernandez, C. I.-yaman, H. Huang, A. B. Liu, A. A. Lopez et al., Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation, Mol, vol.17, issue.3, pp.405-416, 2005.
DOI : 10.1016/j.molcel.2004.12.024
URL : https://doi.org/10.1016/j.molcel.2004.12.024

N. Ferrara, The role of VEGF in the regulation of physiological and pathological angiogenesis, EXS, issue.94, pp.209-231, 2005.

N. Ferrara and T. Davis-smyth, The biology of vascular endothelial growth factor, Endocr, vol.18, issue.1, pp.4-25, 1997.

N. Ferrara and R. S. Kerbel, Angiogenesis as a therapeutic target, Nature438, issue.7070, pp.967-974, 2005.
DOI : 10.1038/nature04483

A. Flynn and G. Proud, Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway, FEBS, vol.389, issue.2, pp.162-166, 1996.

D. R. Forsdyke, The heat-shock response and the molecular basis of genetic dominance, J Theor, vol.167, issue.1, pp.1-5, 1994.

J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung et al., Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1, Mol Cell, vol.16, issue.9, pp.4604-4613, 1996.

H. Fox, Y. W. Lam, A. K. Leung, C. E. Lyon, J. Andersen et al., Paraspeckles: a novel nuclear domain, Curr. Biol, vol.12, issue.1, pp.13-25, 2002.

L. Furic, L. Rong, O. Larsson, I. H. Koumakpayi, K. Yoshida et al., eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression, Proc Natl Acad Sci, vol.107, issue.32, pp.14134-14139, 2010.

Y. Furuichi, A. Lafiandra, and A. J. Shatkin, 5'-Terminal structure and mRNA stability, Nature266, issue.5599, pp.235-239, 1977.

F. Gaccioli, C. C. Huang, C. Wang, E. Bevilacqua, R. Franchi-gazzola et al., Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation, J Biol, vol.281, issue.26, pp.17929-17940, 2006.

S. Galbán, Y. Kuwano, R. Pullmann, J. L. Martindale, H. H. Kim et al., RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha, Mol. Cell. Biol, issue.1, pp.93-107, 2008.

N. L. Garneau, J. Wilusz, and C. J. Wilusz, The highways and byways of mRNA decay, Nat Rev Mol Cell, vol.8, issue.2, pp.113-126, 2007.

A. C. Gavin and S. Schorderet-slatkine, Ribosomal S6 kinase p90rsk and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes, Mol Reprod, vol.46, issue.3, pp.383-391, 1997.

D. Gerald, E. Berra, Y. M. Frapart, D. A. Chan, A. J. Giaccia et al., JunD reduces tumor angiogenesis by protecting cells from oxidative stress, Cell118, issue.6, pp.781-794, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00322373

H. Gerhardt and C. Betsholtz, How do endothelial cells orientate?, EXS, issue.94, pp.3-15, 2005.

S. Germain, C. Monnot, L. Muller, and A. Eichmann, Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding, Curr Opin, vol.17, issue.3, pp.245-251, 2010.
URL : https://hal.archives-ouvertes.fr/hal-02125738

G. Gill, Regulation of the initiation of eukaryotic transcription, Essays, vol.37, pp.33-43, 2001.

A. C. Gingras, Y. Svitkin, G. J. Belsham, A. Pause, and N. Sonenberg, Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus, Proc Natl Acad Sci, vol.93, issue.11, pp.5578-5583, 1996.

J. M. Isner, A. Pieczek, R. Schainfeld, R. Blair, L. Haley et al., Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb, pp.370-374, 1996.

K. Immamura, N. Imamachi, G. Akizuki, M. Kumakura, A. Kawaguchi et al., Long non-coding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli, Mol, vol.53, issue.3, pp.393-406, 2014.

A. Jackson, S. Friedman, X. Zhan, K. A. Engleka, R. Forough et al., Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells, Proc Natl Acad Sci, vol.89, issue.22, pp.10691-10695, 1992.

R. J. Jackson, RNA translation. Picornaviruses break the rules, Nature334, issue.6180, pp.292-293, 1988.

S. K. Jang, H. G. Krausslich, M. J. Nicklin, G. M. Duke, A. C. Palmenberg et al., A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation, J, vol.62, issue.8, pp.2636-2643, 1988.

A. Jazwa, M. Tomczyk, H. M. Taha, E. Hytonen, M. Stoszko et al., Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia, Vasc Cell5, p.13, 2013.

G. Jego, A. Hazoume, R. Seigneuric, and C. Garrido, Targeting heat shock proteins in cancer, Cancer, vol.332, issue.2, pp.275-285, 2013.

U. R. Jewell, I. Kvietikova, A. Scheid, C. Bauer, R. H. Wenger et al., Induction of HIF-1alpha in response to hypoxia is instantaneous, FASEB, vol.15, issue.7, pp.1312-1314, 2001.

Y. Jiang, A. Dai, Q. Li, and R. Hu, Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha, Acta Biochim Biophys Sin (Shanghai), vol.39, issue.1, pp.73-80, 2007.

G. Johannes, M. S. Carter, M. B. Eisen, P. O. Brown, and P. Sarnow, Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray, Proc Natl Acad Sci, vol.96, issue.23, pp.13118-13123, 1999.

C. L. Jopling, K. A. Spriggs, S. A. Mitchell, M. Stoneley, and A. E. Willis, L-Myc protein synthesis is initiated by internal ribosome entry, vol.10, pp.287-298, 2004.

B. Joshi, A. Cameron, and R. Jagus, Characterization of mammalian eIF4E-family members, Eur J, vol.271, issue.11, pp.2189-2203, 2004.

S. Joshi-barve, W. Rychlik, and R. E. Rhoads, Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex, J Biol, vol.265, issue.5, pp.2979-2983, 1990.

A. Kahvejian, G. Roy, and N. Sonenberg, The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation, Cold Spring Harb Symp Quant, vol.66, pp.293-300, 2001.

Z. S. Karaa, J. S. Iacovoni, A. Bastide, E. Lacazette, C. Touriol et al., The VEGF IRESes are differentially susceptible to translation inhibition by miR-16, vol.15, pp.249-254, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00410605

M. J. Karkkainen, P. Haiko, K. Sainio, J. Partanen, J. Taipale et al.,

A. , Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins, Nat, vol.5, issue.1, pp.74-80, 2004.

T. Karpanen and K. Alitalo, Lymphatic vessels as targets of tumor therapy?, J Exp, vol.194, issue.6, pp.37-42, 2001.

J. S. Kieft, Viral IRES RNA structures and ribosome interactions, Trends Biochem, vol.33, issue.6, pp.274-283, 2008.

J. S. Kieft, Comparing the three-dimensional structures of Dicistroviridae IGR IRES RNAs with other viral RNA structures, Virus, vol.139, issue.2, pp.148-156, 2009.

Y. K. Kim and S. K. Jang, Continuous heat shock enhances translational initiation directed by internal ribosomal entry site, Biochem Biophys Res, vol.297, issue.2, pp.224-231, 2002.

S. R. Kimball, J. R. Fabian, G. D. Pavitt, A. G. Hinnebusch, and L. S. Jefferson, Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alphaand delta-subunits of eiF2b, J Biol, vol.273, issue.21, pp.12841-12845, 1998.

H. A. King, L. C. Cobbold, and A. E. Willis, The role of IRES transacting factors in regulating translation initiation, Biochem Soc Trans38, issue.6, pp.1581-1586, 2010.

A. E. Koromilas, A. Lazaris-karatzas, and N. Sonenberg, mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E, EMBO, vol.11, issue.11, pp.4153-4158, 1992.

M. Kozak, Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes, Mol Cell, vol.7, issue.10, pp.3438-3445, 1987.

M. E. Kroon, P. Koolwijk, B. Van-der-vecht, and V. W. Van-hinsbergh, Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix, vol.96, pp.2775-2783, 2000.

C. Kupatt, R. Hinkel, A. Pfosser, C. El-aouni, A. Wuchrer et al., Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adenoassociated virus resolves chronic ischemic malperfusion role of vessel maturation, J Am Coll, vol.56, issue.5, pp.414-422, 2010.

K. Y. Kwek, S. Murphy, A. Furger, B. Thomas, W. O'gorman et al., U1 snRNA associates with TFIIH and regulates transcriptional initiation, Nat Struct, vol.9, issue.11, pp.800-805, 2002.

T. E. Lagrandeur and R. Parker, mRNA decapping activities and their biological roles, vol.78, pp.1049-1055, 1996.

T. Lagrange, A. N. Kapanidis, H. Tang, D. Reinberg, and R. H. Ebright, New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB, Genes, vol.12, issue.1, pp.34-44, 1998.

K. J. Lang, A. Kappel, and G. J. Goodall, Hypoxia-inducible factor1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia, Mol Biol, vol.13, issue.5, pp.1792-1801, 2002.

D. Lanneau, M. Brunet, E. Frisan, E. Solary, M. Fontenay et al., Heat shock proteins: essential proteins for apoptosis regulation, J Cell Mol, vol.12, issue.3, pp.743-761, 2008.

H. Layman, M. Sacasa, A. E. Murphy, A. M. Murphy, S. M. Pham et al., Co-delivery of FGF-2 and G-CSF from gelatinbased hydrogels as angiogenic therapy in a murine critical limb ischemic model, Acta, vol.5, issue.1, pp.230-239, 2009.

J. P. Le-quesne, M. Stoneley, G. A. Fraser, and A. E. Willis, Derivation of a structural model for the c-myc IRES, J Mol, vol.310, issue.1, pp.111-126, 2001.

A. H. Lee, N. N. Iwakoshi, and L. H. Glimcher, XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response, Mol Cell, vol.23, issue.21, pp.7448-7459, 2003.

J. S. Lee, J. M. Kim, K. L. Kim, H. S. Jang, I. S. Shin et al., Combined administration of naked DNA vectors encoding VEGF and bFGF enhances tissue perfusion and arteriogenesis in ischemic hindlimb, Biochem Biophys Res, vol.360, issue.4, pp.752-758, 2007.

N. S. Levy, S. Chung, H. Furneaux, and A. P. Levy, Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNAbinding protein HuR, J Biol, vol.273, issue.11, pp.6417-6423, 1998.

Y. Liu, S. R. Cox, T. Morita, and S. Kourembanas, Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer, Circ, vol.77, issue.3, pp.638-643, 1995.

J. C. Long and J. F. Caceres, The SR protein family of splicing factors: master regulators of gene expression, Biochem, vol.417, issue.1, pp.15-27, 2009.

P. D. Lu, C. Jousse, S. J. Marciniak, Y. Zhang, I. Novoa et al., Cytoprotection by preemptive conditional phosphorylation of translation initiation factor 2, EMBO, vol.23, issue.1, pp.169-179, 2004.

Z. Luo, M. Diaco, T. Murohara, N. Ferrara, J. M. Isner et al., Vascular endothelial growth factor attenuates myocardial ischemiareperfusion injury, Ann Thorac, vol.64, issue.4, pp.993-998, 1997.

M. J. Clemens, Protein kinases that phosphorylate eIF2 and eIF2B, and their role in eukaryotic cell translational control, Translational Control, pp.139-172, 1996.

D. G. Macejak and P. Sarnow, Internal initiation of translation mediated by the 5' leader of a cellular mRNA, Nature353, issue.6339, pp.90-94, 1991.

T. Makinen, T. Veikkola, S. Mustjoki, T. Karpanen, B. Catimel et al., Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3, EMBO, vol.20, issue.17, pp.4762-4773, 2001.

V. Marcel, S. E. Ghayad, S. Belin, G. Therizols, A. More et al.,

F. Saurin, A. Catez, A. Prats, J. Puisieux, and . Diaz, p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer, Cancer Cell, vol.24, issue.3, pp.318-330, 2013.

M. Marko, M. Leichter, M. Patrinou-georgoula, and A. Guilis, hnRNP M interacts with PSF and p54 nrb and co-localizes within defined nuclear structures, Exp Cell, vol.316, issue.3, pp.390-400, 2009.

Y. Martineau, C. L. Bec, L. Monbrun, V. Allo, I. M. Chiu et al., Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs, Mol Cell, vol.24, issue.17, pp.7622-7635, 2004.

G. Martinez-sanchez and A. Giuliani, Cellular redox status regulates hypoxia inducible factor-1 activity. Role in tumour development, J Exp Clin Cancer, vol.26, issue.1, pp.39-50, 2007.

N. Masson and P. J. Ratcliffe, Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways, Cancer, vol.2, issue.1, p.3, 2014.

D. J. Mathis and P. Chambon, The SV40 early region TATA box is required for accurate in vitro initiation of transcription, Nature290, issue.5804, pp.310-315, 1981.

M. Mathison, V. P. Singh, R. P. Gersch, M. O. Ramirez, A. Cooney et al., Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors, J Thorac Cardiovasc, vol.148, issue.4, pp.1656-1664, 2014.

H. Matsunaga and H. Ueda, Evidence for serum-deprivation-induced co-release of FGF-1 and S100A13 from astrocytes, Neurochem, vol.49, issue.3, pp.294-303, 2006.

J. W. Mcavoy, C. G. Chamberlain, R. U. De-iongh, N. A. Richardson, and F. J. Lovicu, The role of fibroblast growth factor in eye lens development, Ann N Y Acad, vol.638, pp.256-274, 1991.

S. Mccracken, N. Fong, K. Yankulov, S. Ballantyne, G. Pan et al., The C-terminal domain of RNA polymerase II couples mRNA processing to transcription, Nature385, issue.6614, pp.357-361, 1997.

K. N. Meadows, P. Bryant, and K. Pumiglia, Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation, J Biol, vol.276, issue.52, pp.49289-49298, 2001.

Z. Meng, P. H. King, L. B. Nabors, N. L. Jackson, C. Y. Chen et al., The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation, Nucleic Acids Res, vol.33, issue.9, pp.2962-79, 2005.

W. C. Merrick, Mechanism and regulation of eukaryotic protein synthesis, Microbiol, vol.56, issue.2, pp.291-315, 1992.

R. Mihailescu, Gene expression regulation: lessons from noncoding RNAs, vol.21, pp.695-696, 2015.

J. Milanini, F. Vinals, J. Pouyssegur, and G. Pages, p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts, J Biol, vol.273, issue.29, pp.18165-18172, 1998.

M. A. Miller and W. M. Olivas, Roles of Puf proteins in mRNA degradation and translation, Wiley Interdiscip Rev, vol.2, issue.4, pp.471-492, 2011.

Y. Min, S. Ghose, K. Boelte, J. Li, L. Yang et al., C/EBPdelta regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1alpha, Oncogene30, issue.49, pp.4901-4909, 2011.

E. Minet, G. Michel, D. Mottet, J. P. Piret, A. Barbieux et al., c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells, Exp Cell, vol.265, issue.1, pp.114-124, 2001.

J. Ming, Q. Zhang, X. Qiu, and E. Wang, Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancer, Eur J, vol.45, issue.5, pp.866-873, 2009.

S. A. Mitchell, E. C. Brown, M. J. Coldwell, R. J. Jackson, and A. E. Willis, Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of Nras, Mol Cell, vol.21, issue.10, pp.3364-3374, 2001.

S. A. Mitchell, K. A. Spriggs, M. J. Coldwell, R. J. Jackson, and A. E. Willis, The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr, Mol, vol.11, issue.3, pp.757-771, 2003.

Y. Miyagi, A. Sugiyama, A. Asai, T. Okazaki, Y. Kuchino et al., Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines, Cancer, vol.91, issue.2, pp.247-252, 1995.

H. Miyashita, T. Watanabe, H. Hayashi, Y. Suzuki, T. Nakamura et al., Angiogenesis inhibitor casohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1, PloS One, vol.7, issue.10, p.46459, 2012.

D. F. Moore, H. Li, N. Jeffries, V. Wright, R. A. Cooper et al.,

. Baird, Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation, Circulation111, issue.2, pp.212-221, 2005.

F. Morfoisse, A. Kuchnio, C. Frainay, A. Gomez-brouchet, M. B. Delisle et al., Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1alpha-independent translation-mediated mechanism, Cell, vol.6, issue.1, pp.155-167, 2014.

M. Morita, L. W. Ler, M. R. Fabian, N. Siddiqui, M. Mullin et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development, Mol Cell, vol.32, issue.17, pp.3585-3593, 2012.

S. J. Morley, Intracellular signalling pathways regulating initiation factor eIF4E phosphorylation during the activation of cell growth, Biochem Soc, vol.25, issue.2, pp.503-509, 1997.

S. J. Morley and V. M. Pain, Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation, J Cell, vol.108, pp.1751-1760, 1995.

C. Mouta-carreira, M. Landriscina, S. Bellum, I. Prudovsky, and T. Maciag, The comparative release of FGF1 by hypoxia and temperature stress, Growth, vol.18, issue.4, pp.277-285, 2001.

C. Mouta-carreira, T. M. Lavallee, F. Tarantini, A. Jackson, J. T. Lathrop et al., S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro, J Biol, vol.273, issue.35, pp.22224-22231, 1998.

G. Mudo, A. Bonomo, V. D. Liberto, M. Frinchi, K. Fuxe et al., The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain, J Neural Transm, vol.116, issue.8, pp.995-1005, 2009.

R. L. Myers, M. Chedid, S. R. Tronick, and I. M. Chiu, Different fibroblast growth factor 1 (FGF-1) transcripts in neural tissues, glioblastomas and kidney carcinoma cell lines, vol.11, pp.785-789, 1995.

R. L. Myers, R. A. Payson, M. A. Chotani, L. L. Deaven, and I. M. Chiu, Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts, vol.8, pp.341-349, 1993.

J. A. Nagy, E. Vasile, D. Feng, C. Sundberg, L. F. Brown et al., VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations, Cold Spring Harb Symp Quant, vol.67, pp.227-237, 2002.

T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta, Nature403, issue.6765, pp.98-103, 2000.
DOI : 10.1038/47513

C. Nanbru, I. Lafon, S. Audigier, M. C. Gensac, S. Vagner et al., Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site, J Biol, vol.272, issue.51, pp.32061-32066, 1997.

S. Nikol, I. Baumgartner, E. Van-belle, C. Diehm, A. Visona et al., Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia, Mol, vol.16, issue.5, pp.972-978, 2008.

S. K. Oh and P. Sarnow, Gene regulation: translational initiation by internal ribosome binding, Curr Opin Genet, vol.3, issue.2, pp.295-300, 1993.
DOI : 10.1016/0959-437x(93)90037-p

T. Okada, H. Yoshida, R. Akazawa, M. Negishi, and K. Mori, Distinct roles of activating transcription factor 6 (ATF6) and doublestranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response, Biochem, vol.366, pp.585-594, 2002.

T. Okamoto, S. Yamamoto, Y. Watanabe, T. Ohta, F. Hanaoka et al., Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit, J Biol, vol.273, issue.31, pp.19866-19876, 1998.

G. Orphanides and D. Reinberg, A unified theory of gene expression, vol.108, pp.439-451, 2002.

G. Pages and J. Pouyssegur, Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors, Cardiovasc, vol.65, issue.3, pp.564-573, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00321947

M. Palmen, M. J. Daemen, L. J. De-windt, J. Willems, W. R. Dassen et al., Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism, J Am Coll, vol.44, issue.5, pp.1113-1123, 2004.
DOI : 10.1016/j.jacc.2004.05.067
URL : https://doi.org/10.1016/j.jacc.2004.05.067

S. Pandit, D. Wang, and X. D. Fu, Functional integration of transcriptional and RNA processing machineries, Curr Opin Cell Biol, issue.3, pp.260-265, 2008.

Y. S. Park, G. Kim, Y. M. Jin, J. Y. Lee, J. W. Shin et al., Expression of angiopoietin-1 in hypoxic pericytes: Regulation by hypoxiainducible factor-2alpha and participation in endothelial cell migration and tube formation, Biochem Biophys Res, vol.469, issue.2, pp.263-269, 2016.

L. A. Passmore, T. M. Schmeing, D. Maag, D. J. Applefield, M. G. Acker et al., The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome, Mol, vol.26, issue.1, pp.41-50, 2007.

R. A. Payson, M. A. Chotani, and I. M. Chiu, Regulation of a promoter of the fibroblast growth factor 1 gene in prostate and breast cancer cells, J Steroid Biochem Mol, vol.66, issue.3, pp.93-103, 1998.

J. Pelletier and N. Sonenberg, The involvement of mRNA secondary structure in protein synthesis, Biochem Cell, vol.65, issue.6, pp.576-581, 1987.

J. Pelletier and N. Sonenberg, Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA, Nature334, issue.6180, pp.320-325, 1988.

T. V. Pestova, C. U. Hellen, and I. N. Shatsky, Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry, Mol Cell, vol.16, issue.12, pp.6859-6869, 1996.

C. Philippe, A. Dubrac, C. Quelen, A. Desquesnes, L. Van-den et al., PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress, Sci, vol.9, issue.426, p.44, 2016.

B. M. Pickering, S. A. Mitchell, K. A. Spriggs, M. Stoneley, and A. E. Willis, Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly (rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1, Mol Cell, vol.24, issue.12, pp.5595-5605, 2004.

P. Gourdy, F. O. Jean-franc?-ois, and A. , Oestrogènes et risque cardiovasculaire, Sang Thrombose Vaisseaux, issue.3, pp.155-161, 2005.

R. S. Pollenz, C. A. Sattler, and A. Poland, The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy, Mol, vol.45, issue.3, pp.428-438, 1994.

F. Poulin, A. C. Gingras, H. Olsen, S. Chevalier, and N. Sonenberg, 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family, J Biol, vol.273, issue.22, pp.14002-14007, 1998.

A. C. Prats, S. Vagner, H. Prats, and F. Amalric, cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor mRNA, Mol Cell, vol.12, issue.10, pp.4796-4805, 1992.

H. Prats, M. Kaghad, A. C. Prats, M. Klagsbrun, J. M. Lelias et al., High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons, Proc Natl Acad Sci, vol.86, issue.6, pp.1836-1840, 1989.

N. J. Proudfoot, A. Furger, and M. J. Dye, Integrating mRNA processing with transcription, Cell108, issue.4, pp.501-512, 2002.

S. Pyronnet, H. Imataka, A. C. Gingras, R. Fukunaga, T. Hunter et al., Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E, EMBO, vol.18, issue.1, pp.270-279, 1999.

N. Quarto, F. P. Finger, and D. B. Rifkin, The NH2-terminal extension of high molecular weight bFGF is a nuclear targeting signal, J Cell, vol.147, issue.2, pp.311-318, 1991.

N. Quarto, D. Talarico, R. Florkiewicz, and D. B. Rifkin, Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells, Cell, vol.2, issue.9, pp.699-708, 1991.

P. S. Ray, R. Grover, and S. Das, Two internal ribosome entry sites mediate the translation of p53 isoforms, EMBO, vol.7, issue.4, pp.404-410, 2006.

A. Rayssac, C. Neveu, M. Pucelle, L. Van-den-berghe, L. Prado-lourenco et al., IRES-based vector coexpressing FGF2 and Cyr61 provides synergistic and safe therapeutics of lower limb ischemia, Mol Ther17, issue.12, pp.2010-2019, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00419435

E. Renaud-gabardos, , 2016.

E. Renaud-gabardos, F. Hantelys, F. Morfoisse, X. Chaufour, B. Garmysusini et al., Internal ribosome entry site-based vectors for combined gene therapy, World J Exp, vol.5, issue.1, pp.11-20, 2015.
DOI : 10.5493/wjem.v5.i1.11
URL : https://doi.org/10.5493/wjem.v5.i1.11

M. Renko, N. Quarto, T. Morimoto, and D. B. Rifkin, Nuclear and cytoplasmic localization of different basic fibroblast growth factor species, J Cell, vol.144, issue.1, pp.108-114, 1990.

G. W. Rogers, N. J. Jr, W. F. Richter, W. C. Lima, and . Merrick, Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F, J Biol, vol.276, issue.33, pp.30914-30922, 2001.

L. Romero-ramirez, H. Cao, D. Nelson, E. Hammond, A. H. Lee et al., XBP1 is essential for survival under hypoxic conditions and is required for tumor growth, Cancer, vol.64, issue.17, pp.5943-5947, 2004.

E. Rosonina, J. Y. Ip, J. A. Calarco, M. A. Bakowski, A. Emili et al., Role for PSF in mediating transcriptional activator-dependent stimulation of premRNA processing in vivo, Mol Cell, vol.25, issue.15, pp.6734-6746, 2005.

T. Rouault and R. Klausner, Regulation of iron metabolism in eukaryotes, Curr Top Cell, vol.35, pp.1-19, 1997.

A. G. Rowlands, K. S. Montine, E. C. Henshaw, and R. Panniers, Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells, Eur J, vol.175, issue.1, pp.93-99, 1988.

G. M. Rubanyi, Mechanistic, technical, and clinical perspectives in therapeutic stimulation of coronary collateral development by angiogenic growth factors, Mol, vol.21, issue.4, pp.725-738, 2013.

G. M. Saed, K. L. Collins, and M. P. Diamond, Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia, Am J Reprod, vol.48, issue.6, pp.387-393, 2002.

S. Salceda and J. Caro, Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes, J Biol, vol.272, issue.36, pp.22642-22647, 1997.

P. Sarnow, Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis, J, vol.77, issue.5, pp.2801-2806, 2003.

G. Schafer, C. Wissmann, J. Hertel, V. Lunyak, and M. Hocker, Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2, Cancer, vol.68, issue.2, pp.457-466, 2008.

B. Schwanhausser, D. Busse, N. Li, G. Dittmar, J. Schuchhardt et al., Global quantification of mammalian gene expression control, Nature473, issue.7347, pp.337-342, 2011.

S. M. Schwartz and L. Liaw, Growth control and morphogenesis in the development and pathology of arteries, J Cardiovasc Pharmacol21 Suppl, vol.1, pp.31-49, 1993.

G. Seghezzi, S. Patel, C. J. Ren, A. Gualandris, G. Pintucci et al., Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis, J Cell, vol.141, issue.7, pp.1659-1673, 1998.

O. Sella, G. Gerlitz, S. Y. Le, and O. Elroy-stein, Differentiationinduced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein, Mol Cell, vol.19, issue.8, pp.5429-5440, 1999.

G. L. Semenza, S. T. Koury, M. K. Nejfelt, J. D. Gearhart, and S. E. Antonarakis, Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice, Proc Natl Acad Sci, vol.88, pp.8725-8729, 1991.

M. Sevin, F. Girodon, C. Garrido, and A. De-thonel, HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms, Mediators Inflamm2015, p.970242, 2015.

Y. Shi, D. C. Di-giammartino, D. Taylor, A. Sarkeshik, W. J. Rice et al., Molecular architecture of the human pre-mRNA 3' processing complex, Mol, vol.33, issue.3, pp.365-376, 2009.

Y. Shi, Y. Yang, B. Hoang, C. Bardeleben, B. Holmes et al., Therapeutic potential of targeting IRES-dependent cmyc translation in multiple myeloma cells during ER stress, Oncogene35, issue.8, pp.1015-1024, 2016.

L. A. Shimoda, M. Fallon, S. Pisarcik, J. Wang, and G. L. Semenza, HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes, Am J Physiol Lung Cell Mol, vol.291, issue.5, pp.941-949, 2006.

J. T. Shin, S. R. Opalenik, J. N. Wehby, V. K. Mahesh, A. Jackson et al., Serum-starvation induces the extracellular appearance of FGF-1, Biochim Biophys Acta1312, issue.1, pp.27-38, 1996.

M. Skobe, T. Hawighorst, D. G. Jackson, R. Prevo, L. Janes et al., Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis, Nat, vol.7, issue.2, pp.192-198, 2001.

F. Smih, F. Desmoulin, M. Berry, A. Turkieh, R. Harmancey et al., Blood signature of pre-heart failure: a microarrays study, PLoS, vol.6, issue.6, p.20414, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00615568

N. Sonenberg, Translational control, pp.245-269, 1996.
URL : https://hal.archives-ouvertes.fr/pasteur-01002317

N. Sonenberg and A. C. Gingras, The mRNA 5' cap-binding protein eIF4E and control of cell growth, Curr Opin Cell, vol.10, issue.2, pp.268-275, 1998.

N. Sonenberg, M. A. Morgan, W. C. Merrick, and A. J. Shatkin, A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA, Proc Natl Acad Sci, vol.75, issue.10, pp.4843-4847, 1978.

N. Sonenberg, K. M. Rupprecht, S. M. Hecht, and A. J. Shatkin, Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP, Proc Natl Acad Sci, vol.76, issue.9, pp.4345-4349, 1979.

H. Sonoda, H. Ohta, K. Watanabe, H. Yamashita, H. Kimura et al., Multiple processing forms and their biological activities of a novel angiogenesis inhibitor, Biochem Biophys Res, vol.342, issue.2, pp.640-646, 2006.

R. Sood, A. C. Porter, D. A. Olsen, D. R. Cavener, and R. C. Wek, A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha, vol.154, pp.787-801, 2000.

I. Stein, A. Itin, P. Einat, R. Skaliter, Z. Grossman et al., Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia, Mol Cell, vol.18, issue.6, pp.3112-3119, 1998.

M. D. Sternfeld, J. E. Hendrickson, W. W. Keeble, J. T. Rosenbaum, J. E. Robertson et al., Differential expression of mRNA coding for heparin-binding growth factor type 2 in human cells, J Cell, vol.136, issue.2, pp.297-304, 1988.

M. Stoneley, F. E. Paulin, J. P. Le-quesne, S. A. Chappell, and A. E. Willis, C-Myc 5' untranslated region contains an internal ribosome entry segment, vol.16, pp.423-428, 1998.

M. Stoneley, T. Subkhankulova, J. P. Le-quesne, M. J. Coldwell, C. L. Jopling et al., Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment, Nucleic Acids, vol.28, issue.3, pp.687-694, 2000.

M. Stoneley and A. E. Willis, Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression, Oncogene23, issue.18, pp.3200-3207, 2004.

J. L. Su, C. J. Yen, P. S. Chen, S. E. Chuang, C. C. Hong et al., The role of the VEGF-C/VEGFR-3 axis in cancer progression, Br J, vol.96, issue.4, pp.541-545, 2007.

R. Sullivan and C. H. Graham, Hypoxia-driven selection of the metastatic phenotype, Cancer Metastasis, vol.26, issue.2, pp.319-331, 2007.

Y. Tang, E. Pacary, T. Freret, D. Divoux, E. Petit et al., Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: identification of potential neuroprotective candidates for stroke, Neurobiol, vol.21, issue.1, pp.18-28, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00018635

R. M. Tanguay, Y. Wu, and E. W. Khandjian, Tissue-specific expression of heat shock proteins of the mouse in the absence of stress, Dev, vol.14, issue.2, pp.112-118, 1993.

S. Teshima-kondo, K. Kondo, L. Prado-lourenco, I. G. Gonzalez-herrera, K. Rokutan et al., Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site, FASEB, vol.18, issue.13, pp.1583-1585, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00162046

M. C. Thomas and C. M. Chiang, The general transcription machinery and general cofactors, Crit Rev Biochem Mol, vol.41, issue.3, pp.105-178, 2006.

A. Tissieres, H. K. Mitchell, and U. M. Tracy, Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs, J Mol, vol.84, issue.3, pp.389-398, 1974.

C. Touriol, A. Morillon, M. C. Gensac, H. Prats, and A. C. Prats, Expression of human fibroblast growth factor 2 mRNA is posttranscriptionally controlled by a unique destabilizing element present in the 3'-untranslated region between alternative polyadenylation sites, J Biol, vol.274, issue.30, pp.21402-21408, 1999.

C. Touriol, M. Roussigne, M. C. Gensac, H. Prats, and A. C. Prats, Alternative translation initiation of human fibroblast growth factor 2 mRNA controlled by its 3'-untranslated region involves a Poly (A) switch and a translational enhancer, J Biol, vol.275, issue.25, pp.19361-19367, 2000.

T. Trcek, D. R. Larson, A. Moldon, C. C. Query, and R. H. Singer, Single-molecule mRNA decay measurements reveal promoter-regulated mRNA stability in yeast, Cell147, issue.7, pp.1484-1497, 2011.

K. Tsukiyama-kohara, F. Poulin, M. Kohara, C. T. Demaria, A. Cheng et al., Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1, Nat, vol.7, issue.10, pp.1128-1132, 2001.

K. Tsukiyama-kohara, S. M. Vidal, A. C. Gingras, T. W. Glover, S. M. Hanash et al., Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2, Genomics38, issue.3, pp.353-363, 1996.

J. Uniacke, C. E. Holterman, G. Lachance, A. Franovic, M. D. Jacob et al., An oxygenregulated switch in the protein synthesis machinery, Nature486, issue.7401, pp.126-129, 2012.

S. Uriel, E. M. Brey, and H. P. Greisler, Sustained low levels of fibroblast growth factor-1 promote persistent microvascular network formation, Am J, vol.192, issue.5, pp.604-609, 2006.

S. Vagner, M. C. Gensac, A. Maret, F. Bayard, F. Amalric et al., Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes, Mol Cell, vol.15, issue.1, pp.35-44, 1995.

S. Vagner, C. Touriol, B. Galy, S. Audigier, M. C. Gensac et al., Translation of CUG-but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells, J Cell, vol.135, issue.5, pp.1391-1402, 1996.

R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions, Arterioscler Thromb Vasc, vol.20, issue.5, pp.1262-1275, 2000.

X. Wang, M. Chen, J. Zhou, and X. Zhang, HSP27, 70 and 90, antiapoptotic proteins, in clinical cancer therapy (Review), Int J, vol.45, issue.1, pp.18-30, 2014.

X. Wang and A. Schneider, HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia, Carcinogenesis31, issue.7, pp.1202-1210, 2010.

K. Watanabe, Y. Hasegawa, H. Yamashita, K. Shimizu, Y. Ding et al., Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis, J. Clin. Invest, vol.114, issue.7, pp.898-907, 2004.

T. E. Webb, A. Hughes, D. S. Smalley, and K. A. Spriggs, An internal ribosome entry site in the 5' untranslated region of epidermal growth factor receptor allows hypoxic expression, p.134, 2015.

E. D. Werner, J. L. Brodsky, and A. A. Mccracken, Proteasomedependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate, Proc Natl Acad Sci, vol.93, issue.24, pp.13797-13801, 1996.

S. Wickner, M. R. Maurizi, and S. Gottesman, Posttranslational quality control: folding, refolding, and degrading proteins, Science286, issue.5446, pp.1888-1893, 1999.

C. Wu, Heat shock transcription factors: structure and regulation, Annu Rev Cell Dev, vol.11, pp.441-469, 1995.

T. R. Wuest and D. J. Carr, VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis, J Exp, vol.207, issue.1, pp.101-115, 2010.

Z. Xu, J. N. Dholakia, and M. B. Hille, Maturation hormone induced an increase in the translational activity of starfish oocytes coincident with the phosphorylation of the mRNA cap binding protein, eIF-4E, and the activation of several kinases, Dev, vol.14, issue.6, pp.424-439, 1993.

S. Xue, S. Tian, K. Fujii, W. Kladwang, R. Das et al., RNA regulons in Hox 5? UTRs confer ribosome specificity to gene regulation, Nature, vol.517, issue.7532, pp.33-38, 2015.

X. Ye, P. Fong, N. Iizuka, D. Choate, and D. R. Cavener, Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation, Mol Cell, vol.17, issue.3, pp.1714-1721, 1997.

C. H. Yeh, L. Y. Hung, C. Hsu, S. Y. Le, P. T. Lee et al., RNA-binding Protein HuR Interacts with Thrombomodulin 5?Untranslated Region and Represses Internal Ribosome Entry Site-mediated Translation under IL-1? Treatment, Mol Biol, vol.19, issue.9, pp.3812-3822, 2008.

Z. Yin, J. Haynie, X. Yang, B. Han, S. Kiatchoosakun et al., The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation, Proc Natl Acad Sci, vol.99, issue.16, pp.10488-10493, 2002.

H. J. Yost and S. Lindquist, RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis, vol.45, pp.185-193, 1986.

I. Zachary and G. Gliki, Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family, Cardiovasc, vol.49, issue.3, pp.568-581, 2001.

C. Zeng and S. M. Berget, Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicing, Mol Cell, vol.20, issue.21, pp.8290-8301, 2000.

C. Zhang, K. Z. Wang, H. Qiang, Y. L. Tang, Q. Li et al., Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo, Acta Pharmacol, vol.31, issue.7, pp.821-830, 2010.

K. Zhang and R. J. Kaufman, Signaling the unfolded protein response from the endoplasmic reticulum, J Biol, vol.279, issue.25, pp.25935-25938, 2004.

X. Zhang, O. A. Ibrahimi, S. K. Olsen, H. Umemori, M. Mohammadi et al., Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family, J Biol, vol.281, issue.23, pp.15694-15700, 2006.