, Nous rechercheronségalementrechercheronségalement un lien entre l'´ evolution clinique du niveau de conscience et l'´ evolution de la connectivité fonctionnelle au cours du temps. Pour cela nous recruterons 15 patients cérébrolésés traumatiques conscients et autant enétatenétat de conscience altéré lors de leur hospitalisation en réanimation au CHU de Grenoble. La période de recrutement devrait durer deux ans pour cetté etude mono-centrique. Les sujets bénéficieront d'uné evaluation clinique de la conscience et d'une IRMf, réalisées avant leur sortie de réanimation. Un suivi longitudinal sera effectué après 60 jours. Notre but serait d'identifier un marqueur neuro-physiologique issu des réseaux de connectivité cérébrale observés, décrire ces régions dans le cadre d'uné etude pilote. Nous allons comparer la connectivité fonctionnelle du traumatisé crânien un mois après l'accident et ensuite environ trois mois après

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A. Annexe, Summary Small-world properties have been demonstrated for many complex networks. Here, we applied the discrete wavelet transform to functional magnetic resonance imaging (fMRI) time series, acquired from healthy volunteers in the resting state, to estimate frequencydependent correlation matrices characterizing functional connectivity between 90 cortical and subcortical regions. After thresholding the wavelet correlation matrices to create undirected graphs of brain functional networks, texte complet des publications mentionnées dans le manuscrit A.1 (Achard et al. 2006) Pour télécharger l'article