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, Importantly, the CB 1 receptor labeling is absent in CB 1 -KO (b). In GFAP-CB 1 -RS, CB 1 receptor gold particles are only detected on astrocytes and astrocytic mitochondria but not on neuronal synaptic compartments (c). Conversely, CB 1 receptor immunolabeling is only present on synaptic boutons and not on astrocytes of GFAP-CB 1 -KO (d). The CB 1 receptor labeling is not observed in the STOP-CB 1 mouse (e), GFAPhrGFP-CB 1 -WT, CB 1 receptor immunoparticles are localized on membranes of presynaptic terminals, astrocytic processes and astrocytic mitochondria

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