, mutant mouse hippocampus.??????..??????????, p.135
, Synapse-specific astrocyte gating of amygdala-related behavior, p.150
, Astroglial Type-1 cannabinoid receptor (CB 1 ): a new player at the tripartite synapse, p.162
Astrocyte-endothelial interactions at the blood-brain barrier, Nat. Rev. Neurosci, vol.7, pp.41-53, 2006. ,
Properties and mechanisms of LTP maintenance, Neuroscientist, vol.9, pp.463-474, 2003. ,
The emerging role of in vitro electrophysiological methods in CNS safety pharmacology, Journal of Pharmacological and Toxicological Methods, vol.81, pp.47-59, 2016. ,
Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. I, Journal of the American Chemical Society, vol.62, pp.196-200, 1940. ,
Astrocytes in Memory Function: Pioneering Findings and Future Directions, Neuroscience, vol.370, pp.14-26, 2018. ,
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement, Cell, vol.174, pp.59-71, 2018. ,
Electrophysiological properties and gap junction coupling of striatal astrocytes, Neurochem. Int, vol.52, pp.1365-1372, 2008. ,
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes, Neuron, vol.93, pp.587-605, 2017. ,
Hippocampal short-and longterm plasticity are not modulated by astrocyte Ca2+ signaling, Science, vol.327, pp.1250-1254, 2010. ,
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system, Chem. Rev, vol.108, pp.1687-1707, 2008. ,
Retrograde signalling in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells, J. Physiol, vol.496, pp.197-209, 1996. ,
Signaling between glia and neurons: focus on synaptic plasticity, Curr. Opin. Neurobiol, vol.15, pp.542-548, 2005. ,
The three-dimensional organization of the hippocampal formation: a review of anatomical data, Neuroscience, vol.31, pp.571-591, 1989. ,
,
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin, J. Neurochem, vol.72, pp.2113-2119, 1999. ,
A synaptic model of memory: long-term potentiation in the hippocampus, Nature, vol.361, pp.31-39, 1993. ,
Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path, J. Physiol, vol.232, pp.357-374, 1973. ,
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol, vol.232, pp.331-356, 1973. ,
Endothelins regulate astrocyte gap junctions in rat hippocampal slices, Eur. J. Neurosci, vol.19, pp.1005-1015, 2004. ,
Astrocytic GABA transporter activity modulates excitatory neurotransmission, Nat Commun, vol.7, p.13572, 2016. ,
The postsynaptic density, Cell Tissue Res, vol.326, pp.409-422, 2006. ,
Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo, J. Neurosci, vol.34, pp.13139-13150, 2014. ,
The pharmacologic and clinical effects of medical cannabis, Pharmacotherapy, vol.33, pp.195-209, 2013. ,
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells, J. Biol. Chem, vol.270, pp.13973-13980, 1995. ,
GFAP promoter directs astrocyte-specific expression in transgenic mice, J. Neurosci, vol.14, pp.1030-1037, 1994. ,
Junctions between intimately apposed cell membranes in the vertebrate brain, J. Cell Biol, vol.40, pp.648-677, 1969. ,
Light microscopic autoradiographic localisation of [3H]glycine and [3H]strychnine binding sites in rat brain, Eur. J. Pharmacol, vol.126, pp.303-307, 1986. ,
Novel cannabinoid receptors, Br. J. Pharmacol, vol.152, pp.567-575, 2007. ,
Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate, J. Neurosci, vol.20, pp.7880-7887, 2000. ,
Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic Review, Biol. Psychiatry, vol.79, pp.557-567, 2016. ,
Acute behavioral effects of MK-801 in rhesus monkeys: assessment using an operant test battery, Pharmacol. Biochem. Behav, vol.48, pp.935-940, 1994. ,
Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains, J. Neurosci, vol.22, pp.183-192, 2002. ,
Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development, Int. J. Dev. Neurosci, vol.22, pp.73-86, 2004. ,
Dissecting the cannabinergic control of behavior: The where matters, Bioessays, vol.37, pp.1215-1225, 2015. ,
Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation, A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function, vol.113, pp.264-278, 2008. ,
Sobre un sencillo proceder de impregnación de las fibrillas interiores del protoplasma nervioso, Arch. latinos Med. Biol, vol.1, pp.1-8, 1903. ,
Neuroglie et neurofibrilles du lumbricus, Trab. Lab. Inv. Bio, vol.3, pp.301-310, 1904. ,
Histologie de systeme nerveux de l'homme et des vertebras, 1911. ,
Control of pain initiation by endogenous cannabinoids, Nature, vol.394, pp.277-281, 1998. ,
Cannabinoid receptors CB1 and CB2 form functional heteromers in brain, J. Biol. Chem, vol.287, pp.20851-20865, 2012. ,
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke, Nature Neuroscience, vol.12, pp.259-267, 2009. ,
Effects of Cannabis sativa (marihuana) on maze performance of the rat, Psychopharmacologia, vol.7, pp.175-181, 1965. ,
Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities, J. Cell Biol, vol.86, pp.831-845, 1980. ,
Effects of marihuana in laboratory animals and in man, Br. J. Pharmacol, vol.50, pp.299-309, 1974. ,
Endocannabinoids facilitate the induction of LTP in the hippocampus, Nat. Neurosci, vol.5, pp.723-724, 2002. ,
Presynaptic LTP and LTD of excitatory and inhibitory synapses, Cold Spring Harb Perspect Biol, vol.4, 2012. ,
Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein, DNA Seq, vol.5, pp.385-388, 1995. ,
Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmium, Neurosci. Lett, vol.249, pp.57-60, 1998. ,
Cellular and subcellular localization of the 2B-subunit of the NMDA receptor in the adult rat telencephalon, Brain Res, vol.816, pp.609-617, 1999. ,
Spatial buffering of potassium ions in brain extracellular space, Biophys. J, vol.78, pp.2776-2797, 2000. ,
Connexons and pannexons: newcomers in neurophysiology, Front Cell Neurosci, vol.8, p.348, 2014. ,
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability, Neuron, vol.38, pp.461-472, 2003. ,
Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission, J. Neurosci, vol.34, pp.11228-11232, 2014. ,
Astroglial connexin 43 sustains glutamatergic synaptic efficacy, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.369, pp.20130596-20130596, 2014. ,
Synaptic plasticity: multiple forms, functions, and mechanisms, Neuropsychopharmacology, vol.33, pp.18-41, 2008. ,
Gene transfer into the CNS using recombinant adeno-associated virus: analysis of vector DNA forms resulting in sustained expression, J Drug Target, vol.7, pp.269-283, 1999. ,
The time course of glutamate in the synaptic cleft, Science, vol.258, pp.1498-1501, 1992. ,
Storage and release of ATP from astrocytes in culture, J. Biol. Chem, vol.278, pp.1354-1362, 2003. ,
Assessing rodent hippocampal involvement in the novel object recognition task. A review, Behav. Brain Res, vol.285, pp.105-117, 2015. ,
Memories of NMDA receptors and LTP, Trends Neurosci, vol.18, pp.54-56, 1995. ,
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus, J. Physiol, vol.334, pp.33-46, 1983. ,
Receptor trafficking and synaptic plasticity, Nat. Rev. Neurosci, vol.5, pp.952-962, 2004. ,
The cocktail party phenomenon revisited: the importance of working memory capacity, Psychon Bull Rev, vol.8, pp.331-335, 2001. ,
The excitatory neurotransmitter glutamate causes filopodia formation in cultured hippocampal astrocytes, Glia, vol.3, pp.322-334, 1990. ,
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides, Nature, vol.384, pp.83-87, 1996. ,
Synaptobrevin2-expressing vesicles in rat astrocytes: insights into molecular characterization, dynamics and exocytosis, J. Physiol, vol.570, pp.567-582, 2006. ,
Cell adhesion molecules: signalling functions at the synapse, Nat. Rev. Neurosci, vol.8, pp.206-220, 2007. ,
Functional specialization and topographic segregation of hippocampal astrocytes, J. Neurosci, vol.18, pp.4425-4438, 1998. ,
Differential role of KIR channel and Na(+)/K(+)-pump in the regulation of extracellular K(+) in rat hippocampus, J. Neurophysiol, vol.87, pp.87-102, 2002. ,
Glutamate uptake, Prog. Neurobiol, vol.65, pp.1-105, 2001. ,
ATP mediates rapid microglial response to local brain injury in vivo, Nat. Neurosci, vol.8, pp.752-758, 2005. ,
A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells, J. Biol. Chem, vol.278, pp.48973-48980, 2003. ,
Human serine racemase: moleular cloning, genomic organization and functional analysis, Gene, vol.256, pp.183-188, 2000. ,
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-Daspartate (NMDA) receptor coagonist D-serine, Proc. Natl. Acad. Sci. U.S.A, vol.99, pp.14542-14547, 2002. ,
Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms, Neurobiol Learn Mem, vol.90, pp.1-9, 2008. ,
, , 2009.
, Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes, J Biol Phys, vol.35, pp.383-411
Are the glia with very few processes homologous with Schwann cells? by Pío del Río-Hortega, Clin. Neuropathol, vol.31, pp.460-462, 1922. ,
Episodic-like memory in mice: simultaneous assessment of object, place and temporal order memory, Brain Res. Brain Res. Protoc, vol.16, pp.10-19, 2005. ,
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents, Neurosci Biobehav Rev, vol.31, pp.673-704, 2007. ,
, , 1988.
Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, vol.258, pp.1946-1949, 1992. ,
Local Ca2+ detection and modulation of synaptic release by astrocytes, Nat. Neurosci, vol.14, pp.1276-1284, 2011. ,
Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Nature, vol.372, pp.686-691, 1994. ,
The biosynthesis, fate and pharmacological properties of endocannabinoids, Handb Exp Pharmacol, pp.147-185, 2005. ,
The glutamate receptor ion channels, Pharmacol. Rev, vol.51, pp.7-61, 1999. ,
The glutamate receptor ion channels, Pharmacol. Rev, vol.51, pp.7-61, 1999. ,
A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation, Chem. Phys. Lipids, vol.121, pp.149-158, 2002. ,
Brain monoglyceride lipase participating in endocannabinoid inactivation, Proc. Natl. Acad. Sci. U.S.A, vol.99, pp.10819-10824, 2002. ,
DOI : 10.1073/pnas.152334899
URL : http://www.pnas.org/content/99/16/10819.full.pdf
P2X7 receptor-mediated release of excitatory amino acids from astrocytes, J. Neurosci, vol.23, pp.1320-1328, 2003. ,
Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis, Cereb. Cortex, vol.17, pp.175-191, 2007. ,
Cautionary insights on knockout mouse studies: the gene or not the gene?, Brain Behav. Immun, vol.23, pp.318-324, 2009. ,
One-trial object recognition in rats and mice: methodological and theoretical issues, Behav. Brain Res, vol.215, pp.244-254, 2010. ,
DOI : 10.1016/j.bbr.2009.12.036
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data, Behav. Brain Res, vol.31, pp.47-59, 1988. ,
, , 2011.
Subunit arrangement and function in NMDA receptors, Nature, vol.438, pp.185-192, 2005. ,
Glial transporters for glutamate, glycine, and GABA: II. GABA transporters, J. Neurosci. Res, vol.63, pp.461-468, 2001. ,
DOI : 10.1002/jnr.1040
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.1040
, , 2006.
, Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development, Curr. Pharm. Des, vol.12, pp.2319-2325
, , 2004.
, GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain, Nat. Neurosci, vol.7, pp.1233-1241
, , 2010.
, Object familiarization and novel-object preference in rats, Behav. Processes, vol.83, pp.61-71
, , 2004.
, Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test, Pharmacol. Biochem. Behav, vol.77, pp.567-573
, , 2006.
, , 1991.
The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia, Cannabinoids and the Brain, pp.423-483, 2008. ,
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nat. Neurosci, vol.5, pp.446-451, 2002. ,
Perisynaptic astroglial processes: dynamic processors of neuronal information, Brain Struct Funct, vol.221, pp.2427-2442, 2016. ,
From a glial syncytium to a more restricted and specific glial networking, J. Physiol. Paris, vol.106, pp.34-39, 2012. ,
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system, Brain Res Rev, vol.63, pp.160-176, 2010. ,
Astrocytic energy metabolism consolidates memory in young chicks, Neuroscience, vol.141, pp.9-13, 2006. ,
Wilder Penfield, Pío Del Río-hortega, and the Discovery of Oligodendroglia, Neurosurgery, vol.60, pp.940-948, 2007. ,
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor, J. Neurosci, vol.17, pp.5327-5333, 1997. ,
The Ancient Cultivation of Hemp, Antiquity, vol.41, pp.42-49, 1966. ,
Unloading and refilling of two classes of spatially resolved endoplasmic reticulum Ca(2+) stores in astrocytes, Glia, vol.31, pp.15-28, 2000. ,
Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels, Neuroscience, vol.167, pp.969-973, 2010. ,
Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study, J. Anat, vol.93, pp.420-433, 1959. ,
Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells, Nat. Neurosci, vol.2, pp.139-143, 1999. ,
The therapeutic potential of cannabis and cannabinoids, Dtsch Arztebl Int, vol.109, pp.495-501, 2012. ,
Segregation of two endocannabinoid-hydrolyzing enzymes into pre-and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala, Eur. J. Neurosci, vol.20, pp.441-458, 2004. ,
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons, Mol. Pharmacol, vol.65, pp.665-674, 2004. ,
,
Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses, J. Neurosci, vol.26, pp.8881-8891, 2006. ,
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss, Neuron, vol.61, pp.213-219, 2009. ,
The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety, Eur. J. Neurosci, vol.16, pp.1395-1398, 2002. ,
Regional distribution and postnatal changes of D-amino acids in rat brain, Biochim. Biophys. Acta, vol.1334, pp.214-222, 1997. ,
Do astrocytes really exocytose neurotransmitters?, Nat. Rev. Neurosci, vol.11, pp.227-238, 2010. ,
, , pp.1039-1050, 2012148.
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor, Proc. Natl. Acad. Sci. U.S.A, vol.98, pp.3662-3665, 2001. ,
Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration, PLoS ONE, vol.6, 2011. ,
Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices, J. Physiol, vol.584, pp.509-519, 2007. ,
Free D-aspartate and D-serine in the mammalian brain and periphery, Prog. Neurobiol, vol.52, pp.325-353, 1997. ,
Anatomical distribution and postnatal changes in endogenous free D-aspartate and D-serine in rat brain and periphery, Eur. J. Neurosci, vol.7, pp.1657-1663, 1995. ,
Endocannabinoids and synaptic function in the CNS, Neuroscientist, vol.13, pp.127-137, 2007. ,
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway, Neuron, vol.82, pp.413-429, 2014. ,
GLIA: listening and talking to the synapse, Nat. Rev. Neurosci, vol.2, pp.185-193, 2001. ,
The cannabinoid receptors, Prostaglandins Other Lipid Mediat, pp.619-631, 2002. ,
Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes, Mol. Pharmacol, vol.26, pp.532-538, 1984. ,
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs, Mol. Pharmacol, vol.29, pp.307-313, 1986. ,
Deciphering Resting Microglial Morphology and Process Motility from a Synaptic Prospect, Front Integr Neurosci, vol.9, p.73, 2015. ,
Distribution of the Endocannabinoid System in the Central Nervous System, Handb Exp Pharmacol, vol.231, pp.59-93, 2015. ,
Enhancement of spontaneous and heatevoked activity in spinal nociceptive neurons by the endovanilloid/endocannabinoid N-arachidonoyldopamine (NADA), J. Neurophysiol, vol.95, pp.1207-1212, 2006. ,
New role of taurine as an osmomediator between glial cells and neurons in the rat supraoptic nucleus, Adv. Exp. Med. Biol, vol.483, pp.227-237, 2000. ,
Changing the tune: plasticity and adaptation of retrograde signals, Trends Neurosci, vol.36, pp.471-479, 2013. ,
New tools for investigating astrocyte-to-neuron communication, Front Cell Neurosci, vol.7, 0193. ,
Physiological characteristics of NG2-expressing glial cells, J. Neurocytol, vol.31, pp.537-549, 2002. ,
The molecular basis of CaMKII function in synaptic and behavioural memory, Nat. Rev. Neurosci, vol.3, pp.175-190, 2002. ,
A biosynthetic pathway for anandamide, Proc. Natl. Acad. Sci. U.S.A, vol.103, pp.13345-13350, 2006. ,
Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents, Neuron, vol.6, pp.565-574, 1991. ,
New insights into the not-so-new NR3 subunits of N-methyl-D-aspartate receptor: localization, structure, and function, Mol. Pharmacol, vol.78, pp.1-11, 2010. ,
An Introduction to the Endogenous Cannabinoid System, Biol. Psychiatry, vol.79, pp.516-525, 2016. ,
Restless AMPA receptors: implications for synaptic transmission and plasticity, Trends Neurosci, vol.24, pp.665-670, 2001. ,
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD), Cold Spring Harb Perspect Biol, vol.4, 2012. ,
Role of AMPA receptor cycling in synaptic transmission and plasticity, Neuron, vol.24, pp.649-658, 1999. ,
Long-term potentiation and memory, Physiol. Rev, vol.84, pp.87-136, 2004. ,
, , 1983.
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons, Cell Metab, vol.23, pp.94-102, 2016. ,
Cannabinoid receptor homo-and heterodimerization, Life Sci, vol.77, pp.1667-1673, 2005. ,
Cannabinoid receptors as therapeutic targets, Annu. Rev. Pharmacol. Toxicol, vol.46, pp.101-122, 2006. ,
Cannabinoid receptors: where they are and what they do, J. Neuroendocrinol, vol.20, pp.10-14, 2008. ,
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor, J. Neurosci, vol.15, pp.6552-6561, 1995. ,
Norepinephrine and cyclic adenosine 3':5'-cyclic monophosphate enhance a nifedipine-sensitive calcium current in cultured rat astrocytes, Glia, vol.1, pp.359-365, 1988. ,
A cellular perspective on brain energy metabolism and functional imaging, Neuron, vol.86, pp.883-901, 2015. ,
Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences, Nat. Neurosci, vol.16, pp.790-797, 2013. ,
Neuronal or glial progeny: regional differences in radial glia fate, Neuron, vol.37, pp.751-764, 2003. ,
Synaptic plasticity in the hippocampus: LTP and LTD, Cell, vol.78, pp.535-538, 1994. ,
The long-term potential of LTP, Nat. Rev. Neurosci, vol.4, pp.923-926, 2003. ,
LTP and LTD: an embarrassment of riches, Neuron, vol.44, pp.5-21, 2004. ,
Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission, Science, vol.242, pp.81-84, 1988. ,
AMPA receptor trafficking and synaptic plasticity, Annu. Rev. Neurosci, vol.25, pp.103-126, 2002. ,
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP, Science, vol.245, pp.862-866, 1989. ,
Selfmodulation of neocortical pyramidal neurons by endocannabinoids, Nat. Neurosci, vol.12, pp.1488-1490, 2009. ,
Cannabinoid Control of Learning and Memory through HCN Channels, Neuron, vol.89, pp.1059-1073, 2016. ,
Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses, Nature, vol.339, pp.378-380, 1989. ,
Axomyelinic neurotransmission: a novel mode of cell signalling in the central nervous system, Nat. Rev. Neurosci, vol.19, pp.49-58, 2018. ,
Marijuana in medicine: past, present and future, Calif Med, vol.110, pp.34-40, 1969. ,
Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct, J. Neurosci, vol.4, pp.585-592, 1984. ,
Cellular and molecular mechanisms of memory: the LTP connection, Curr. Opin. Genet. Dev, vol.9, pp.333-337, 1999. ,
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses, Nat. Neurosci, vol.15, pp.746-753, 2012. ,
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine, Pain, vol.152, pp.1340-1348, 2011. ,
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures, J. Neurosci. Res, vol.67, pp.829-836, 2002. ,
The endocannabinoid system controls key epileptogenic circuits in the hippocampus, Neuron, vol.51, pp.455-466, 2006. ,
Heteromeric NMDA receptors: molecular and functional distinction of subtypes, Science, vol.256, pp.1217-1221, 1992. ,
Cannabinoids and anxiety, Curr Top Behav Neurosci, vol.2, pp.429-450, 2010. ,
Immunocytochemical localization of D-amino acid oxidase in rat brain, J. Neurocytol, vol.28, pp.169-185, 1999. ,
,
, Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons, Neuroscience, vol.141, pp.157-165
Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro, J. Physiol, vol.539, pp.191-200, 2002. ,
Molecular cloning and characterization of the rat NMDA receptor, Nature, vol.354, pp.31-37, 1991. ,
Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5, J. Neurosci, vol.9, pp.3040-3057, 1989. ,
Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.329, pp.187-204, 1990. ,
, , 2006.
, The cognitive neuroscience of remote episodic, semantic and spatial memory, Curr. Opin. Neurobiol, vol.16, pp.179-190
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor, Proc. Natl. Acad. Sci. U.S.A, vol.97, pp.4926-4931, 2000. ,
,
, Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine, Proc. Natl. Acad. Sci
, , vol.102, pp.5606-5611
Molecular characterization of a peripheral receptor for cannabinoids, Nature, vol.365, pp.61-65, 1993. ,
Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission, Biochim. Biophys. Acta, vol.18, pp.208-211, 1992. ,
DOI : 10.1038/nn.3901
URL : https://hal.archives-ouvertes.fr/hal-01154386
Endocannabinoids mediate neuron-astrocyte communication, Neuron, vol.57, pp.883-893, 2008. ,
DOI : 10.1016/j.neuron.2008.01.029
URL : https://doi.org/10.1016/j.neuron.2008.01.029
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes, Neuron, vol.68, pp.113-126, 2010. ,
DOI : 10.1016/j.neuron.2010.08.043
URL : https://doi.org/10.1016/j.neuron.2010.08.043
Myelination and the trophic support of long axons, Nat. Rev. Neurosci, vol.11, pp.275-283, 2010. ,
Direct signaling from astrocytes to neurons in cultures of mammalian brain cells, Science, vol.263, pp.1768-1771, 1994. ,
Glial cell inhibition of neurons by release of ATP, J. Neurosci, vol.23, pp.1659-1666, 2003. ,
Lactate produced by glycogenolysis in astrocytes regulates memory processing, PLoS ONE, vol.6, 2011. ,
DOI : 10.1371/journal.pone.0028427
URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028427&type=printable
The soothing touch: microglial contact influences neuronal excitability, Dev. Cell, vol.23, pp.1125-1126, 2012. ,
DOI : 10.1016/j.devcel.2012.11.015
URL : https://doi.org/10.1016/j.devcel.2012.11.015
Astrocytic mGluR5 and the tripartite synapse, Neuroscience, vol.323, pp.29-34, 2016. ,
DOI : 10.1016/j.neuroscience.2015.03.063
Glia-derived D-serine controls NMDA receptor activity and synaptic memory, Cell, vol.125, pp.775-784, 2006. ,
DOI : 10.1016/j.cell.2006.02.051
URL : https://hal.archives-ouvertes.fr/inserm-00078312
,
Dissecting tripartite synapses with STED microscopy, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.369, 2014. ,
DOI : 10.1098/rstb.2013.0597
URL : http://europepmc.org/articles/pmc4173283?pdf=render
Molecular basis of NMDA receptor functional diversity, Eur. J. Neurosci, vol.33, pp.1351-1365, 2011. ,
DOI : 10.1111/j.1460-9568.2011.07628.x
NMDA receptor subunits: function and pharmacology, Curr Opin Pharmacol, vol.7, pp.39-47, 2007. ,
DOI : 10.1016/j.acpain.2007.04.009
URL : https://hal.archives-ouvertes.fr/hal-00115220
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease, Nat. Rev. Neurosci, vol.14, pp.383-400, 2013. ,
DOI : 10.1038/nrn3504
Organization, control and function of extrasynaptic NMDA receptors, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.369, 2014. ,
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists, Cell, vol.150, pp.633-646, 2012. ,
Astroglial versus Neuronal D-Serine: Fact Checking, Trends Neurosci, vol.40, pp.517-520, 2017. ,
, , 2017.
, Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness, Neuron, vol.94, pp.840-854
Octanol, a gap junction uncoupling agent, changes intracellular [H+] in rat astrocytes, Glia, vol.16, pp.7-15, 1996. ,
Potential role for astroglial D-amino acid oxidase in extracellular D-serine metabolism and cytotoxicity, J. Biochem, vol.139, pp.295-304, 2006. ,
Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes, J. Neurosci, vol.33, pp.7206-7219, 2013. ,
Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons, Proc. Natl. Acad. Sci, 2000. ,
, , pp.8629-8634
Neuroglia at the Crossroads of Homoeostasis, Metabolism and Signalling: Evolution of the Concept, ASN Neuro, vol.4, p.20120019, 2012. ,
,
, Glutamate-mediated astrocyte-neuron signalling, Nature, vol.369, pp.744-747
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation, Nat. Neurosci, vol.4, pp.803-812, 2001. ,
Synaptic inhibition mediated by glia, Neuron, vol.40, pp.873-875, 2003. ,
Astrocytic purinergic signaling coordinates synaptic networks, Science, vol.310, pp.113-116, 2005. ,
Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ, J. Neurosci, vol.17, pp.7817-7830, 1997. ,
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. U.S.A, vol.91, pp.10625-10629, 1994. ,
Neuroenergetics: calling upon astrocytes to satisfy hungry neurons, Neuroscientist, vol.10, pp.53-62, 2004. ,
Sweet sixteen for ANLS, J. Cereb. Blood Flow Metab, vol.32, pp.1152-1166, 2012. ,
Activity-dependent regulation of energy metabolism by astrocytes: an update, Glia, vol.55, pp.1251-1262, 2007. ,
Glial calcium signaling and neuron-glia communication, Cell Calcium, vol.38, pp.375-382, 2005. ,
Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes, J. Neurosci, vol.25, pp.2192-2203, 2005. ,
Pharmacology of cannabinoid CB1 and CB2 receptors, Pharmacol. Ther, vol.74, pp.129-180, 1997. ,
Cannabinoid receptors and their ligands, Prostaglandins Leukot. Essent. Fatty Acids, vol.66, pp.101-121, 2002. ,
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB? and CB?, Pharmacol. Rev, vol.62, pp.588-631, 2010. ,
Organization of NMDA receptors at extrasynaptic locations, Neuroscience, vol.167, pp.68-87, 2010. ,
Loss of IP3 receptordependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity, J. Neurosci, vol.28, pp.4967-4973, 2008. ,
Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex, Neuropharmacology, vol.41, pp.762-770, 2001. ,
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk, Proc. Natl. Acad. Sci. U.S.A, vol.101, pp.2151-2155, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-00000063
The molecular logic of endocannabinoid signalling, Nat. Rev. Neurosci, vol.4, pp.873-884, 2003. ,
More surprises lying ahead. The endocannabinoids keep us guessing, Neuropharmacology, vol.76, pp.228-234, 2014. ,
Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells, J. Neurosci, vol.12, pp.4122-4132, 1992. ,
A genetic switch for long-term memory, C. R. Acad. Sci. III, Sci. Vie, vol.321, pp.91-96, 1998. ,
Physiological functions of D-amino acid oxidases: from yeast to humans, Cell. Mol. Life Sci, vol.64, pp.1373-1394, 2007. ,
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor, J. Pharmacol. Exp. Ther, vol.301, pp.1020-1024, 2002. ,
Developmental and evolutionary adaptations of cortical radial glia, Cereb. Cortex, vol.13, pp.541-549, 2003. ,
The myeloid cells of the central nervous system parenchyma, Nature, vol.468, pp.253-262, 2010. ,
Cannabinoid receptors contribute to astroglial Ca 2+ -signalling and control of synaptic plasticity in the neocortex, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.369, 2014. ,
Structure-activity relationships in cannabinoids, Pharmacol. Rev, vol.38, pp.75-149, 1986. ,
Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons, Nature, vol.416, pp.736-740, 2002. ,
Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory, Nature, vol.431, pp.699-703, 2004. ,
Choroid plexus and ependymal cells in CSF cytology, Clin Neurol Neurosurg, vol.88, pp.177-179, 1986. ,
Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission, Neuropsychopharmacology, vol.37, pp.2624-2634, 2012. ,
Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes, J. Neurosci, vol.28, pp.9682-9691, 2008. ,
Glial transport of the neuromodulator D-serine, Brain Res, vol.929, pp.202-209, 2002. ,
Glutamate receptor function in learning and memory, Behav. Brain Res, vol.140, pp.1-47, 2003. ,
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor, Nature, vol.389, pp.725-730, 1997. ,
Long-term potentiation and N-methyl-Daspartate receptors: foundations of memory and neurologic disease?, Neurosci Biobehav Rev, vol.19, pp.533-552, 1995. ,
, , 2002.
, Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens, Proc. Natl. Acad. Sci. U.S.A, vol.99, pp.8384-8388
, Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory, vol.98, pp.935-944, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01930790
Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels, Biophys. J, vol.68, pp.501-506, 1995. ,
, , 1996.
, Sustained somatic gene inactivation by viral transfer of Cre recombinase, Nat. Biotechnol, vol.14, pp.1562-1565
Cannabinoidinduced actomyosin contractility shapes neuronal morphology and growth, vol.3, p.3159, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01356874
Localization of neuronal and glial glutamate transporters, Neuron, vol.13, pp.713-725, 1994. ,
, , 2008.
, Astroglial metabolic networks sustain hippocampal synaptic transmission, Science, vol.322, pp.1551-1555
Calcium signaling in Schwann cells at synaptic and extra-synaptic sites: active glial modulation of neuronal activity, Glia, vol.54, pp.691-699, 2006. ,
Ca2+ transients in astrocyte fine processes occur via Ca2+ influx in the adult mouse hippocampus, Glia, vol.64, pp.2093-2103, 2016. ,
History of cannabis and its preparations in saga, science, and sobriquet, Chem. Biodivers, vol.4, pp.1614-1648, 2007. ,
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy, Curr. Pharm. Des, vol.19, pp.2499-2511, 2013. ,
,
, Anandamide and WIN 55212-2 inhibit cyclic AMP formation through Gprotein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes, Eur. J. Neurosci, vol.11, pp.691-699
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons, Science, vol.246, pp.815-818, 1989. ,
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit, Nature, vol.373, pp.151-155, 1995. ,
Clustering sodium channels at the node of Ranvier: close encounters of the axon-glia kind, Neuron, vol.18, pp.843-846, 1997. ,
Cre-stimulated recombination at loxPcontaining DNA sequences placed into the mammalian genome, Nucleic Acids Res, vol.17, pp.147-161, 1989. ,
Components of astrocytic intercellular calcium signaling, Mol. Neurobiol, vol.22, pp.167-179, 2000. ,
Astrocyte calcium waves: what they are and what they do, Glia, vol.54, pp.716-725, 2006. ,
Implicit and explicit memory for novel visual objects: structure and function, J Exp Psychol Learn Mem Cogn, vol.19, pp.995-1009, 1993. ,
The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspective, Philos. Trans. R. Soc. Lond., B, Biol. Sci, vol.359, pp.943-964, 2004. ,
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release, Proc. Natl. Acad. Sci. U.S.A, vol.92, pp.3948-3952, 1995. ,
D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors, J. Neurosci, vol.17, pp.1604-1615, 1997. ,
Multidisciplinary approaches for investigating the mechanisms of hippocampus-dependent memory: a focus on inbred mouse strains, Neurosci Biobehav Rev, vol.28, pp.463-483, 2004. ,
Modulation of transmitter release via presynaptic cannabinoid receptors, Trends Pharmacol. Sci, vol.22, pp.565-572, 2001. ,
,
Selectively Initiates Glial Glutamate Release and Inhibits Cueinduced Cocaine Seeking, Biol. Psychiatry, vol.78, pp.441-451 ,
,
, The NMDA receptor channel: molecular design of a coincidence detector, Recent Prog. Horm. Res, vol.50, pp.19-34
Ionotropic glutamate receptors in astrocytes, Prog. Brain Res, vol.132, pp.287-299, 2001. ,
, , 2001.
, Astrocytes give rise to new neurons in the adult mammalian hippocampus, J. Neurosci, vol.21, pp.7153-7160
Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain, J. Comp. Neurol, vol.406, pp.207-220, 1999. ,
Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures, J. Neurosci, vol.16, pp.4322-4334, 1996. ,
The postsynaptic architecture of excitatory synapses: a more quantitative view, Annu. Rev. Biochem, vol.76, pp.823-847, 2007. ,
Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes, Glia, vol.49, pp.211-219, 2005. ,
Comparison of type 2 inositol 1,4,5-trisphosphate receptor distribution and subcellular Ca2+ release sites that support Ca2+ waves in cultured astrocytes, J. Neurochem, vol.68, pp.2317-2327, 1997. ,
Astrocytic IP3 Rs: Contribution to Ca2+ signalling and hippocampal LTP, Glia, vol.65, pp.502-513, 2017. ,
Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses, J. Gen. Physiol, vol.141, pp.633-647, 2013. ,
Probing the Complexities of Astrocyte Calcium Signaling, Trends Cell Biol, vol.26, pp.300-312, 2016. ,
Understanding functional residues of the cannabinoid CB1, Curr Top Med Chem, vol.10, pp.779-798, 2010. ,
NMDA receptordependent synaptic reinforcement as a crucial process for memory consolidation, Science, vol.290, pp.1170-1174, 2000. ,
Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor, Biochim. Biophys. Acta, vol.1307, pp.132-136, 1996. ,
, The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. PLoS Comput, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01236312
, Biol, vol.11, 1004137.
Performance of different mouse strains in an object recognition task, Behav. Brain Res, vol.147, pp.49-54, 2003. ,
Supply and demand in cerebral energy metabolism: the role of nutrient transporters, J. Cereb. Blood Flow Metab, vol.27, pp.1766-1791, 2007. ,
Voltage-dependent ion channels in glial cells, Glia, vol.11, pp.156-172, 1994. ,
, Habenular CB1 Receptors Control the Expression of Aversive Memories, vol.88, pp.306-313, 2015.
,
, tasks. Pharmacol. Biochem. Behav, vol.40, pp.949-958
Mechanisms of memory, Science, vol.232, pp.1612-1619, 1986. ,
Declarative and nondeclarative memory: multiple brain systems supporting learning and memory, J Cogn Neurosci, vol.4, pp.232-243, 1992. ,
Structure and function of declarative and nondeclarative memory systems, Proc. Natl. Acad. Sci. U.S.A, vol.93, pp.13515-13522, 1996. ,
Recognition memory and the medial temporal lobe: a new perspective, Nat. Rev. Neurosci, vol.8, pp.872-883, 2007. ,
Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo, Nat. Neurosci, vol.18, pp.708-717, 2015. ,
Biochemistry and pharmacology of endovanilloids, Pharmacol. Ther, vol.114, pp.13-33, 2007. ,
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala, FASEB J, vol.26, pp.3649-3657, 2012. ,
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas, Glia, vol.58, pp.1017-1030, 2010. ,
Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat, J. Comp. Neurol, vol.169, pp.347-370, 1976. ,
Visualization of endosome dynamics in living nerve terminals with four-dimensional fluorescence imaging, J Vis Exp, 2014. ,
Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels, J. Biol. Chem, vol.277, pp.10482-10488, 2002. ,
, , 1999.
, Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system, Proc. Natl. Acad. Sci. U.S.A, vol.96, pp.14565-14570
, , 2014.
Exploratory rearing: a contextand stress-sensitive behavior recorded in the open-field test, 2018. ,
Neuron-glia interactions: the roles of Schwann cells in neuromuscular synapse formation and function, Biosci. Rep, vol.31, pp.295-302, 2011. ,
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain, Biochem. Biophys. Res. Commun, vol.215, pp.89-97, 1995. ,
AMPA receptor mediated D-serine release from retinal glial cells, J. Neurochem, vol.115, pp.1681-1689, 2010. ,
Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes, Neuron, vol.88, pp.957-972, 2015. ,
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory, Cell, vol.127, pp.49-58, 2006. ,
Astrocyte-neuron lactate transport is required for long-term memory formation, Cell, vol.144, pp.810-823, 2011. ,
Effects of cannabinoids on neurotransmission, 2005. ,
, Handb Exp Pharmacol, pp.327-365
Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum, Neuroscience, vol.85, pp.395-403, 1998. ,
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, Nature, vol.410, pp.588-592, 2001. ,
, , 2004.
, Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe, J. Neurosci, vol.24, pp.5901-5908
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol, Neuropsychopharmacology, vol.34, pp.2072-2080, 2009. ,
Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus, Glia, vol.55, pp.13-23, 2007. ,
Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex, J. Comp. Neurol, vol.307, pp.437-459, 1991. ,
Serine racemase and the serine shuttle between neurons and astrocytes, Biochim. Biophys. Acta, vol.1814, pp.1558-1566, 2011. ,
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission, Proc. Natl. Acad. Sci. U.S.A, vol.96, pp.13409-13414, 1999. ,
Purification of serine racemase: biosynthesis of the neuromodulator D-serine, Proc. Natl. Acad. Sci. U.S.A, vol.96, pp.721-725, 1999. ,
, Astroglial Versus Neuronal D-Serine: Check Your Controls! Trends Neurosci, vol.40, pp.520-522, 2017.
, , 2010.
Immunohistochemical study of inositol 1,4,5-trisphosphate receptor type 3 in rat central nervous system, Neuroreport, vol.6, pp.273-276, 1995. ,
57% 6 4.81% in GFAP-CB 1 -RS and 57.37% 6 6.26% in GFAPhrGFP-CB 1 -WT. 23.15% 6 .93% of them were located between 800 and 1,200 nm in CB 1 -WT, 43.79% 6 3.13% in GFAP-CB 1 -RS and 35, CB 1 -WT, vol.23, pp.3588-3596, 2003. ,
No CB 1 receptor immunoparticles are observed in STOP-CB 1 (e). In GFAPhrGFP-CB 1 -WT (f and g), presynaptic terminals and astrocytic processes are CB 1 receptor positive. Mitochondrial CB 1 receptor labeling is also visualized in identified astrocytes (g). No CB 1 receptor immunolabeling is detected in GFAPhrGFP-CB 1 -KO (h). Black arrowheads: excitatory synapses; white arrowheads: inhibitory synapses; black thin arrows: neuronal CB 1 receptor immunoparticles; black thick arrows: astrocytic CB 1 receptor immunoparticles; white thick arrows: mitochondrial CB 1 receptor labeling in astrocytes, FIG URE 3 CB 1 receptor localization in identified astrocytes and astrocytic mitochondria in the CA1 stratum radiatum of mutant mice. Preembedding immunogold and immunoperoxidase method for electron microscopy, 2012. ,
, , 2014.
, , 2012.
, , 2016.
, , 1999.
In order to address this, we used conditional CB 1 receptor rescue mice re-expressing the CB 1 receptor exclusively in astrocytic GFAP expressing cells (GFAP-CB 1 -RS), as well as CB 1 -WT and CB 1 -KO mice expressing hrGFP, 2005. ,
, Importantly, the CB 1 receptor labeling is absent in CB 1 -KO (b). In GFAP-CB 1 -RS, CB 1 receptor gold particles are only detected on astrocytes and astrocytic mitochondria but not on neuronal synaptic compartments (c). Conversely, CB 1 receptor immunolabeling is only present on synaptic boutons and not on astrocytes of GFAP-CB 1 -KO (d). The CB 1 receptor labeling is not observed in the STOP-CB 1 mouse (e), GFAPhrGFP-CB 1 -WT, CB 1 receptor immunoparticles are localized on membranes of presynaptic terminals, astrocytic processes and astrocytic mitochondria
white arrowheads: inhibitory synapses; black thin arrows: neuronal CB 1 receptor immunoparticles; black thick arrows: astrocytic CB 1 receptor immunoparticles; white arrows: mitochondrial CB 1 receptor labeling in astrocytes; as: astrocytic processes; ter: terminal; den: dendrite; sp: dendritic spine; m: CB 1 receptor-positive astrocytic mitochondria. Scale bars: 0.5 mm REFERENCES Aguado ,
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells, The Journal of Neuroscience, vol.26, issue.5, pp.1551-1561, 2006. ,
Gliotransmitters travel in time and space, Neuron, vol.81, issue.4, pp.728-739, 2014. ,
Synaptic functions of endocannabinoid signaling in health and disease, Neuropharmacology, vol.124, pp.13-24, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01826136
Pharmacological blockade of cannabinoid CB1 receptors in diet-induced obesity regulates mitochondrial dihydrolipoamide dehydrogenase in muscle, PLoS One, vol.10, issue.12, 2015. ,
Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes, Journal of Neurochemistry, vol.133, issue.1, pp.26-37, 2015. ,
Mitochondrial CB1 receptors regulate neuronal energy metabolism, Nature Neuroscience, vol.15, issue.4, pp.558-564, 2012. ,
Astrocytes: powering memory, Cell, vol.144, issue.5, pp.644-645, 2011. ,
,
Adolescent ethanol intake alters cannabinoid type-1 receptor localization in astrocytes of the adult mouse hippocampus, Addiction Biology, 2017. ,
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes, Molecular Metabolism, vol.2, issue.4, pp.393-404, 2013. ,
CB 1 receptor signaling in the brain: extracting specificity from ubiquity, Neuropsychopharmacology, vol.43, issue.1, pp.4-20, 2018. ,
,
A restricted population of CB1 cannabinoid receptors with neuroprotective activity, Proceedings of the National Academy of Sciences of the United States of America, vol.111, pp.8257-8262, 2014. ,
Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus, PLoS One, vol.7, issue.5, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00700517
Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model, Neuroscience, vol.289, pp.153-165, 2015. ,
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons, Proceedings of the National Academy of Sciences, vol.112, issue.44, pp.13693-13698, 2015. ,
Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-Hydroxyphenyl)-2-phenyl]-1-butenyl]phenoxyacetic acid, The Journal of Organic Chemistry, vol.67, pp.9489-9491, 2002. ,
Martín-Fern andez ,
Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission, Cerebral Cortex, vol.25, issue.10, pp.3699-3712, 2015. ,
,
Anatomical characterization of the cannabinoid CB1 receptor in cell-type-specific mutant mouse rescue models, Journal of Comparative Neurology, vol.525, issue.2, pp.302-318, 2017. ,
Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response, Human Gene Therapy, vol.20, issue.3, pp.225-237, 2009. ,
Synaptic islands defined by the territory of a single astrocyte, The Journal of Neuroscience, vol.27, issue.24, pp.6473-6477, 2007. ,
,
Acute cannabinoids impair working memory through astroglial CB 1 receptor modulation of hippocampal LTD, Cell, vol.148, issue.5, pp.1039-1050, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01160047
A cannabinoid link between mitochondria and memory, Nature, vol.539, issue.7630, pp.555-559, 2016. ,
Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor, Molecular Metabolism, vol.3, issue.4, pp.495-504, 2014. ,
Studying mitochondrial CB1 receptors: Yes we can, Molecular Metabolism, vol.3, issue.4, 2014. ,
Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2, Glia, vol.54, issue.1, pp.11-20, 2006. ,
Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system, Current Opinion in Cell Biology, vol.32, pp.121-130, 2015. ,
Multiple functions of endocannabinoid signaling in the brain, Annual Review of Neuroscience, vol.35, issue.1, pp.529-558, 2012. ,
The generation of knock-in mice expressing fluorescently tagged galanin receptors 1 and 2, Molecular and Cellular Neuroscience, vol.68, pp.258-271, 2015. ,
Hypothalamic POMC neurons promote cannabinoid-induced feeding, Nature, vol.519, issue.7541, pp.45-50, 2015. ,
Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice, Brain Structure and Function, vol.222, issue.1, pp.247-266, 2017. ,
,
Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat, Molecular Psychiatry, vol.22, issue.10, pp.1422-1430, 2017. ,
An introduction to the endogenous cannabinoid system, Biological Psychiatry, vol.79, issue.7, pp.516-525, 2016. ,
The endocannabinoid system in guarding against fear, anxiety and stress, Nature Reviews. Neuroscience, vol.16, issue.12, pp.705-718, 2015. ,
A cellular perspective on brain energy metabolism and functional imaging, Neuron, vol.86, issue.4, pp.883-901, 2015. ,
CB1 cannabinoid receptors and ondemand defense against excitotoxicity, Science, vol.302, issue.5642, pp.84-88, 2003. ,
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain, European Journal of Neuroscience, vol.11, pp.4213-4225, 1999. ,
The endogenous cannabinoid system controls extinction of aversive memories, Nature, vol.418, issue.6897, pp.530-534, 2002. ,
,
Synapse-specific astrocyte gating of amygdala-related behavior, Nature Neuroscience, vol.20, issue.11, pp.1540-1548, 2017. ,
Differential control of cocaine self-administration by GABAergic and glutamatergic CB1 cannabinoid receptors, Neuropsychopharmacology, vol.41, issue.9, pp.2192-2205, 2016. ,
,
Cannabinoid CB1 receptors are localized in striated muscle mitochondria and regulate mitochondrial respiration, Frontiers in Physiology, vol.7, 2016. ,
,
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi, International Journal of Clinical and Experimental Pathology, vol.7, pp.2825-2837, 2014. ,
Rising stars: Modulation of brain functions by astroglial type-1 cannabinoid receptors, Glia, vol.63, issue.3, pp.353-364, 2015. ,
The endocannabinoid system controls key epileptogenic circuits in the hippocampus, Neuron, vol.51, issue.4, pp.455-466, 2006. ,
Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus, The Journal of Neuroscience, vol.35, issue.9, pp.3842-3850, 2015. ,
Endocannabinoids mediate neuronastrocyte communication, Neuron, vol.57, issue.6, pp.883-893, 2008. ,
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes, Neuron, vol.68, issue.1, pp.113-126, 2010. ,
Astrocytes in endocannabinoid signalling, Philosophical Transactions of the Royal Society of London.Series B, vol.369, 1654. ,
Astrocyte calcium signal and gliotransmission in human brain tissue, Cerebral Cortex, vol.23, issue.5, pp.1240-1246, 2013. ,
Gene marking of human neural stem/ precursor cells using green fluorescent proteins, The Journal of Gene Medicine, vol.7, issue.1, pp.18-29, 2005. ,
GFAP promoter-controlled EGFP-expressing transgenic mice: A tool to visualize astrocytes and astrogliosis in living brain tissue, Glia, vol.33, issue.1, pp.72-86, 2001. ,
Astroglial type-1 cannabinoid receptor (CB1): a new player in the tripartite synapse, Neuroscience, vol.323, pp.35-42, 2016. ,
Structural and functional plasticity of astrocyte processes and dendritic spine interactions, The Journal of Neuroscience, vol.34, issue.38, pp.12738-12744, 2014. ,
Endocannabinoids and their pharmacological actions, Handbook of Experimental Pharmacology, vol.231, pp.1-37, 2015. ,
The CB1 receptor as the cornerstone of exostasis, Neuron, vol.93, issue.6, pp.1252-1274, 2017. ,
The molecular logic of endocannabinoid signalling, Nature Reviews Neuroscience, vol.4, issue.11, pp.873-884, 2003. ,
Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons, Brain Structure and Function, vol.222, issue.8, pp.3431-3452, 2017. ,
Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat caudate putamen nucleus, The Journal of Neuroscience, vol.21, pp.823-833, 2001. ,
Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: Distinctive sufficiency for hippocampusdependent and amygdala-dependent synaptic and behavioral functions, The Journal of Neuroscience, vol.33, issue.25, pp.10264-10277, 2013. ,
Cannabinoids inhibit sodium-dependent, highaffinity excitatory amino acid transport in cultured rat cortical astrocytes, Biochemical Pharmacology, vol.73, issue.12, 2004. ,
The endocannabinoid system controls food intake via olfactory processes, Nature Neuroscience, vol.17, issue.3, pp.407-415, 2014. ,
Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus, Journal of Neurochemistry, vol.124, issue.6, pp.795-807, 2013. ,
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas, Glia, vol.58, issue.9, 2010. ,
Endocannabinoid system in the adult rat circumventricular areas: An immunohistochemical study, The Journal of Comparative Neurology, vol.518, issue.15, pp.3065-3085, 2010. ,
Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus, The Journal of Neuroscience, vol.31, issue.21, pp.7700-7714, 2011. ,
Astrocytes, from brain glue to communication elements: The revolution continues, Nature Reviews Neuroscience, vol.6, issue.8, pp.626-640, 2005. ,
Glial promoter selectivity following AAV-delivery to the immature brain, PloS One, vol.8, issue.6, 2013. ,
An energy transfer protein in coelenterate bioluminescence. Characterization of the Renilla greenfluorescent protein, The Journal of Biological Chemistry, vol.254, pp.781-788, 1979. ,
Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator, The Journal of Organic Chemistry, vol.68, issue.24, pp.9489-9491, 2003. ,
Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus, Glia, vol.66, pp.1417-1431, 2018. ,
Emotion circuits in the brain, Annu. Rev. Neurosci, vol.23, pp.155-184, 2000. ,
Amygdala microcircuits controlling learned fear, Neuron, vol.82, pp.966-980, 2014. ,
Amygdala inhibitory circuits and the control of fear memory, Neuron, vol.62, pp.757-771, 2009. ,
Neurons of the lateral and basolateral amygdaloid nuclei: a Golgi study in the rat, J. Comp. Neurol, vol.212, pp.293-312, 1982. ,
Topographic organization of neurons in the acoustic thalamus that project to the amygdala, J. Neurosci, vol.10, pp.1043-1054, 1990. ,
Cortical pathways to the mammalian amygdala, Prog. Neurobiol, vol.55, pp.257-332, 1998. ,
Cytoarchitecture of the central amygdaloid nucleus of the rat, J. Comp. Neurol, vol.208, pp.401-418, 1982. ,
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear, J. Neurosci, vol.8, pp.2517-2529, 1988. ,
Midbrain circuits for defensive behaviour, Nature, vol.534, pp.206-212, 2016. ,
Experience-dependent modification of a central amygdala fear circuit, Nat. Neurosci, vol.16, pp.332-339, 2013. ,
The paraventricular thalamus controls a central amygdala fear circuit, Nature, vol.519, pp.455-459, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02068203
Genetic dissection of an amygdala microcircuit that gates conditioned fear, Nature, vol.468, pp.270-276, 2010. ,
Encoding of conditioned fear in central amygdala inhibitory circuits, Nature, vol.468, pp.277-282, 2010. ,
Synaptic correlates of fear extinction in the amygdala, Nat. Neurosci, vol.13, pp.489-494, 2010. ,
Amygdala circuitry mediating reversible and bidirectional control of anxiety, Nature, vol.471, pp.358-362, 2011. ,
Oxytocin selectively gates fear responses through distinct outputs from the central amygdala, Science, vol.333, pp.104-107, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02166043
Gliotransmitters travel in time and space, Neuron, vol.81, pp.728-739, 2014. ,
Tripartite synapses: glia, the unacknowledged partner, Trends Neurosci, vol.22, pp.208-215, 1999. ,
Glial biology in learning and cognition, Neuroscientist, vol.20, pp.426-431, 2014. ,
Tripartite synapses: astrocytes process and control synaptic information, Trends Neurosci, vol.32, pp.421-431, 2009. ,
Synaptically released acetylcholine evokes Ca 2+ elevations in astrocytes in hippocampal slices, J. Neurosci, vol.22, pp.2443-2450, 2002. ,
Local Ca 2+ detection and modulation of synaptic release by astrocytes, Nat. Neurosci, vol.14, pp.1276-1284, 2011. ,
Astrocyte Ca 2+ signalling: an unexpected complexity, Nat. Rev. Neurosci, vol.15, pp.327-335, 2014. ,
Spontaneous astrocytic Ca 2+ oscillations in situ drive NMDAR-mediated neuronal excitation, Nat. Neurosci, vol.4, pp.803-812, 2001. ,
Long-term potentiation depends on release of D-serine from astrocytes, Nature, vol.463, pp.232-236, 2010. ,
Astrocytes potentiate transmitter release at single hippocampal synapses, Science, vol.317, pp.1083-1086, 2007. ,
Astrocytes are endogenous regulators of basal transmission at central synapses, Cell, vol.146, pp.785-798, 2011. ,
Do stars govern our actions? Astrocyte involvement in rodent behavior, Trends Neurosci, vol.38, pp.535-549, 2015. ,
Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking, Biol. Psychiatry, vol.78, pp.441-451, 2015. ,
Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD, Cell, vol.148, pp.1039-1050, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01160047
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss, Neuron, vol.61, pp.213-219, 2009. ,
Endocannabinoids mediate neuron-astrocyte communication, Neuron, vol.57, pp.883-893, 2008. ,
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways, Science, vol.349, pp.730-734, 2015. ,
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses, Nat. Neurosci, vol.15, pp.746-753, 2012. ,
Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala, Neuropsychopharmacology, vol.36, pp.652-663, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00589420
Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses, Neuron, vol.81, pp.1111-1125, 2014. ,
Hippocampal short-and long-term plasticity are not modulated by astrocyte Ca 2+ signaling, Science, vol.327, pp.1250-1254, 2010. ,
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes, Neuron, vol.68, pp.113-126, 2010. ,
Putative single quantum and single fibre excitatory postsynaptic currents show similar amplitude range and variability in rat hippocampal slices, Eur. J. Neurosci, vol.4, pp.113-117, 1992. ,
Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses, J. Pharmacol. Exp. Ther, vol.268, pp.537-545, 1994. ,
Astrocytic purinergic signaling coordinates synaptic networks, Science, vol.310, pp.113-116, 2005. ,
Glia-derived D-serine controls NMDA receptor activity and synaptic memory, Cell, vol.125, pp.775-784, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00078312
Astrocytic IP3 Rs: contribution to Ca 2+ signalling and hippocampal LTP, Glia, vol.65, pp.502-513, 2017. ,
Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks, vol.5, p.20362, 2016. ,
GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression, J. Neurosci, vol.26, pp.5370-5382, 2006. ,
Astrocytes regulate cortical state switching in vivo, Proc. Natl. Acad. Sci. USA, vol.113, pp.2675-2684, 2016. ,
Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission, Cereb. Cortex, vol.25, pp.3699-3712, 2015. ,
Endocannabinoid signaling and synaptic function, Neuron, vol.76, pp.70-81, 2012. ,
Endocannabinoid-mediated control of synaptic transmission, Physiol. Rev, vol.89, pp.309-380, 2009. ,
Lateral regulation of synaptic transmission by astrocytes, Neuroscience, vol.323, pp.62-66, 2016. ,
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice, Proc. Natl. Acad. Sci. USA, vol.96, pp.5780-5785, 1999. ,
Endothelin-1-induced arrhythmogenic Ca 2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate (IP3)-receptor type 2-deficient mice, Circ. Res, vol.96, pp.1274-1281, 2005. ,
Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifeninducible DNA recombinase variant CreERT2, Glia, vol.54, pp.11-20, 2006. ,
Physiological properties of central amygdala neurons: species differences, Eur. J. Neurosci, vol.15, pp.545-552, 2002. ,
Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala, J. Neurosci, vol.23, pp.442-452, 2003. ,
Structural and functional plasticity of astrocyte processes and dendritic spine interactions, J. Neurosci, vol.34, pp.12738-12744, 2014. ,
Confocal microscopy for astrocyte in vivo imaging: recycle and reuse in microscopy, Front. Cell. Neurosci, vol.7, p.51, 2013. ,
Specific in vivo staining of astrocytes in the whole brain after intravenous injection of sulforhodamine dyes, PLoS One, vol.7, p.35169, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00738160
Unspecific labelling of oligodendrocytes by sulforhodamine 101 depends on astrocytic uptake via the thyroid hormone transporter OATP1C1 (SLCO1C1), Neurosci. Lett, vol.631, pp.13-18, 2016. ,
Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors, J. Biol. Chem, vol.284, pp.31052-31061, 2009. ,
Toll-like receptors modulate adult hippocampal neurogenesis, Nat. Cell Biol, vol.9, pp.1081-1088, 2007. ,
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage, Biochem. Biophys. Res. Commun, vol.224, pp.855-862, 1996. ,
Expression of the APC tumor suppressor protein in oligodendroglia, Glia, vol.17, pp.169-174, 1996. ,
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, Nature, vol.410, pp.588-592, 2001. ,
, Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit is suitable for immunofluorescence using brain section from mice. The product reacts specifically with GFAP and labels astrocytes in immunohistochemical staining, rabbit GFAP-specific antibody: Sigma, cat # G9269, Anti-Glial Fibrillary Acidic Protein, lot # 083M4830
, Anti-NeuN antibody has a species reactivity to mouse and "specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS neuronal cell types of all vertebrates tested, mouse NeuN-specific antibody: Millipore, cat # MAB377, Neuronal Nuclei, lot # 2562102
, Anti-NeuN antibody has a species cross-reactivity to mouse and "is found exclusively in the nuclei of neuronal cells, rabbit NeuN-specific antibody: Millipore, cat # MABN140, clone 27-4, lot # 2858898, vol.284, pp.31052-31061, 2009.
Anti-NG2 Chondroitin Sulfate Proteoglycan antibody has a species cross-reactivity to mouse and "is found on the surfaces of glial cells within the developing and mature central nervous system that have the properties of oligodendrocyte precursor cells (i.e., O-2A progenitor cells), mouse NG2-specific antibody: Millipore, cat # AB5320, Anti-NG2 Chondroitin Sulfate Proteoglycan, lot # 2834672, vol.9, pp.1081-1089, 2007. ,
Anti-Iba1 is "specific to microglia and macrophage, but not cross-reactive with neuron and astrocyte. Reactive with mouse Iba1, rabbit Iba1 antibody: Wako, cat # 019-19741, Anti-Iba1, lot # LKR1186, vol.224, p.855, 1996. ,
Eukaryotic cell lines a. State the source of each eukaryotic cell line used. No eukaryotic cell lines were used. misidentified cell lines maintained by ICLAC, provide a scientific rationale for their use, Glia, vol.17, 1996. ,
, Animals and human research participants Policy information about studies involving animals; when reporting animal research, follow the ARRIVE guidelines 11. Description of research animals Provide details on animals and/or animal-derived materials used in the study
, Male C57BL/6J mice (14-21 days old) were used for slice electrophysiology. For specific experiments, slices were obtained from male GFAP-CB1R-/-and GFAP-CB1RWT (12-20 week old) and from male IP3R2-/-(14-21 days old) generously donated by Dr. G. Marsicano and Dr. J Chen respectively1,2. Regarding DREADDs (AAV8-GFAP-hM3D-mCherry) activation experiments: 9-20 week old male C57BL/6J were used for slice electrophysiology as well as for in vivo electrophysiology and 9
Adult neurogenesis: from precursors to network and physiology, Physiol Rev, vol.85, pp.523-569, 2005. ,
Gliotransmitters travel in time and space, Neuron, vol.81, pp.728-739, 2014. ,
Tripartite synapses: glia, the unacknowledged partner, Trends Neurosci, vol.22, pp.208-215, 1999. ,
Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids, Nature, vol.431, pp.312-316, 2004. ,
The role of astroglia in neuroprotection, Dialogues Clin Neurosci, vol.11, pp.281-295, 2009. ,
Bimodal control of stimulated food intake by the endocannabinoid system, Nat Neurosci, vol.13, pp.281-283, 2010. ,
Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes, J Neurochem, vol.133, pp.26-37, 2015. ,
Mitochondrial CB(1) receptors regulate neuronal energy metabolism, Nat Neurosci, vol.15, pp.558-564, 2012. ,
Adult neurogenesis: basic concepts of signaling, Cell Cycle, vol.5, pp.722-728, 2006. ,
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes, Mol Metab, vol.2, pp.393-404, 2013. ,
Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains, J Neurosci, vol.22, pp.183-192, 2002. ,
The good and the bad effects of (-) trans-delta-9-tetrahydrocannabinol (delta 9-THC) on humans, Toxicon, vol.44, pp.461-467, 2004. ,
Endocannabinoid signaling and synaptic function, Neuron, vol.76, pp.70-81, 2012. ,
Endocannabinoidmediated synaptic plasticity in the CNS, Annu Rev Neurosci, vol.29, pp.37-76, 2006. ,
Local Ca 2+ detection and modulation of synaptic release by astrocytes, Nat Neurosci, vol.14, pp.1276-1284, 2011. ,
The endocannabinoid system and its therapeutic exploitation, Nat Rev Drug Discov, vol.3, pp.771-784, 2004. ,
Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice, Neuropsychopharmacology, vol.37, pp.1885-1900, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00683606
The spike-timing dependence of plasticity, Neuron, vol.75, pp.556-571, 2012. ,
Mechanisms of control of neuron survival by the endocannabinoid system, Curr Pharm Des, vol.14, pp.2279-2288, 2008. ,
Astroglial networks: a step further in neuroglial and gliovascular interactions, Nat Rev Neurosci, vol.11, pp.87-99, 2010. ,
Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission, Cereb Cortex, 2014. ,
Exocytosis in astrocytes: transmitter release and membrane signal regulation, Neurochem Res, vol.37, pp.2351-2363, 2012. ,
Do astrocytes really exocytose neurotransmitters?, Nat Rev Neurosci, vol.11, pp.227-238, 2010. ,
Cannabinoids, hippocampal function and memory, Life Sci, vol.65, pp.715-723, 1999. ,
Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD, Cell, vol.148, pp.1039-1050, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01160047
Morphological plasticity of astroglia: understanding synaptic microenvironment, Glia, 2015. ,
Cannabinoid receptor localization in brain, Proc Natl Acad Sci U S A, vol.87, pp.1932-1936, 1990. ,
The cannabinoid receptors, Prostaglandins Other Lipid Mediat, vol.68, pp.619-631, 2002. ,
CB(1) cannabinoid receptors and their associated proteins, Curr Med Chem, vol.17, pp.1382-1393, 2010. ,
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice, Mol Pharmacol, vol.66, pp.204-208, 2004. ,
Endocannabinoid-mediated control of synaptic transmission, Physiol Rev, vol.89, pp.309-380, 2009. ,
A new chapter in the field of memory: adult hippocampal neurogenesis, Eur J Neurosci, vol.33, pp.1101-1114, 2011. ,
Potassium buffering in the central nervous system, Neuroscience, vol.129, pp.1045-1056, 2004. ,
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats, Psychopharmacology, vol.119, pp.282-290, 1995. ,
Neuron-glia metabolic coupling and plasticity, J Exp Biol, vol.209, pp.2304-2311, 2006. ,
Selfmodulation of neocortical pyramidal neurons by endocannabinoids, Nat Neurosci, vol.12, pp.1488-1490, 2009. ,
Anatomical distribution of receptors, ligands and enzymes in the brain and the spinal cord: circuitries and neurochemistry, pp.161-202, 2008. ,
Roles of the endocannabinoid system in learning and memory, Curr Top Behav Neurosci, vol.1, pp.201-230, 2009. ,
Rising stars: modulation of brain functions by astroglial type-1 cannabinoid receptors, Glia, vol.63, pp.353-364, 2015. ,
Bimodal control of fear-coping strategies by CB(1) cannabinoid receptors, J Neurosci, vol.32, pp.7109-7118, 2012. ,
Astrocyte signaling controls spike timingdependent depression at neocortical synapses, Nat Neurosci, vol.15, pp.746-753, 2012. ,
Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study, Peptides, vol.21, pp.1735-1742, 2000. ,
Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission, Nat Neurosci, vol.18, pp.219-226, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01154386
Endocannabinoids mediate neuronastrocyte communication, Neuron, vol.57, pp.883-893, 2008. ,
, Neuroscience, vol.323, p.41, 2016.
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes, Neuron, vol.68, pp.113-126, 2010. ,
DOI : 10.1016/j.neuron.2010.08.043
URL : https://doi.org/10.1016/j.neuron.2010.08.043
Astrocytes in endocannabinoid signalling, Philos Trans R Soc Lond B Biol Sci, vol.369, 2014. ,
The endocannabinoid system as an emerging target of pharmacotherapy, Pharmacol Rev, vol.58, pp.389-462, 2006. ,
Astrocytes are endogenous regulators of basal transmission at central synapses, Cell, vol.146, pp.785-798, 2011. ,
Gliotransmission: exocytotic release from astrocytes, Brain Res Rev, vol.63, pp.83-92, 2010. ,
DOI : 10.1016/j.brainresrev.2009.11.008
URL : http://europepmc.org/articles/pmc2862866?pdf=render
Neuron-glia networks: integral gear of brain function, Front Cell Neurosci, vol.8, p.378, 2014. ,
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling, Nat Rev Neurosci, vol.4, pp.1152-1158, 2003. ,
The acute effects of cannabinoids on memory in humans: a review, Psychopharmacology, vol.188, pp.425-444, 2006. ,
Endocannabinoids and stress, Stress, vol.14, pp.384-397, 2011. ,
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors, Neuron, vol.39, pp.641-654, 2003. ,
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala, FASEB J, vol.26, pp.3649-3657, 2012. ,
Endocannabinoid signaling in microglial cells, Neuropharmacology, vol.56, issue.1, pp.244-253, 2009. ,
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas, Glia, vol.58, pp.1017-1030, 2010. ,
Glutamate-dependent neuroglial calcium signaling differs between young and adult brain, Science, vol.339, pp.197-200, 2013. ,
DOI : 10.1126/science.1226740
URL : http://europepmc.org/articles/pmc3569008?pdf=render
Astrocyte-neuron lactate transport is required for long-term memory formation, Cell, vol.144, pp.810-823, 2011. ,
Calcium signalling in astroglia, Mol Cell Endocrinol, vol.353, pp.45-56, 2012. ,
Cannabinoids and neuroinflammation, Br J Pharmacol, vol.141, pp.775-785, 2004. ,
DOI : 10.1038/sj.bjp.0705667
URL : https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1038/sj.bjp.0705667