Y. Agrawal, E. A. Platz, and J. K. Niparko, Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, Archives of internal medicine, vol.168, pp.1522-1530, 1999.

J. Ahn, X. Li, H. L. Davis, and C. E. Canman, Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain, The Journal of biological chemistry, vol.277, 2002.

J. Ahn, J. K. Schwarz, H. Piwnica-worms, and C. E. Canman, Threonine 68 Phosphorylation by Ataxia Telangiectasia Mutated Is Required for Efficient Activation of Chk2 in Response to Ionizing Radiation, Cancer Research, vol.60, p.5934, 2000.

S. A. Alam, K. Ikeda, T. Oshima, M. Suzuki, T. Kawase et al., Cisplatininduced apoptotic cell death in Mongolian gerbil cochlea, Hearing research, vol.141, pp.28-38, 2000.

R. K. Allemann and M. Egli, DNA recognition and bending, Chemistry & biology, vol.4, p.643, 1997.

W. H. Ang, M. Myint, and S. J. Lippard, Transcription inhibition by platinum-DNA cross-links in live mammalian cells, J Am Chem Soc, vol.132, pp.7429-7435, 2010.

M. Anniko and A. Sobin, Cisplatin: evaluation of its ototoxic potential, Am J Otolaryngol, vol.7, pp.276-293, 1986.

K. Aoshiba, T. Tsuji, S. Kameyama, M. Itoh, S. Semba et al., , 2013.

, Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury, Toxikologische Pathologie, vol.65, pp.1053-1062

E. Appella, A. , and C. W. , Post-translational modifications and activation of p53 by genotoxic stresses, Eur J Biochem, vol.268, pp.2764-2772, 2001.

I. K. Arenberg, R. E. Mischke, and W. P. Gibson, Negative observation of intravenously administered fluorescein in perilymph at stapes surgery, The American journal of otology, vol.14, pp.95-96, 1993.

K. L. Arienti, A. Brunmark, U. Frank, K. M. Axe, A. Lee et al., Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles, Journal of medicinal chemistry, vol.48, p.1873, 2005.

D. Arsenijevic, H. Onuma, C. Pecqueur, S. Raimbault, B. S. Manning et al., Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production, Nature genetics, vol.26, pp.435-439, 2000.

S. M. Baek, S. Y. Yu, Y. Son, and H. S. Hong, Substance P promotes the recovery of oxidative stressdamaged retinal pigmented epithelial cells by modulating Akt/GSK-3beta signaling, Mol Vis, vol.22, pp.1015-1023, 2016.

U. Bai, M. D. Seidman, R. Hinojosa, and W. S. Quirk, Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study, The American journal of otology, vol.18, pp.449-453, 1997.

W. M. Baird, L. A. Hooven, and B. Mahadevan, Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action, Environmental and molecular mutagenesis, vol.45, pp.106-114, 2005.

D. J. Baker, K. B. Jeganathan, J. D. Cameron, M. Thompson, S. Juneja et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice, Nature genetics, vol.36, pp.744-749, 2004.

C. J. Bakkenist and M. B. Kastan, DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation, Nature, vol.421, pp.499-506, 2003.

J. Bar, N. Moskovits, O. , and M. , Involvement of stromal p53 in tumor-stroma interactions, Semin Cell Dev Biol, vol.21, pp.47-54, 2010.

J. Bartek, L. , and J. , Mammalian G1-and S-phase checkpoints in response to DNA damage, Current opinion in cell biology, vol.13, pp.738-747, 2001.

C. A. Bauer, T. J. Brozoski, and K. S. Myers, Acoustic injury and TRPV1 expression in the cochlear spiral ganglion, The international tinnitus journal, vol.13, pp.21-28, 2007.

M. E. Bauer, C. M. Jeckel, L. , and C. , The role of stress factors during aging of the immune system, Annals of the New York Academy of Sciences 1153, p.139, 2009.

J. Baure, A. Izadi, V. Suarez, E. Giedzinski, J. E. Cleaver et al., Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity, Mutagenesis, vol.24, pp.161-167, 2009.

R. F. Beers, . Jr, and I. W. Sizer, A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase, The Journal of biological chemistry, vol.195, pp.133-140, 1952.

S. Bekker-jensen, C. Lukas, F. Melander, J. Bartek, L. et al., Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1, J Cell Biol, vol.170, pp.201-211, 2005.

S. Bellon, J. Ravanat, D. Gasparutto, J. ;. Cadet, K. Johnson et al., Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced, Chemical research in toxicology 15, 598. Benamira, vol.16, p.99, 1995.

N. Benkafadar, J. Menardo, J. Bourien, R. Nouvian, F. Francois et al., Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy, EMBO molecular medicine, vol.9, pp.7-26, 2017.
DOI : 10.15252/emmm.201606230
URL : https://hal.archives-ouvertes.fr/hal-01427877

M. Bennett, K. Macdonald, S. W. Chan, J. P. Luzio, R. Simari et al., Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis, Science, vol.282, pp.290-293, 1998.

P. Bertheau, E. Turpin, D. S. Rickman, M. Espie, A. De-reynies et al., Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen, PLoS Med, vol.4, p.90, 2007.
DOI : 10.1371/journal.pmed.0040090
URL : https://hal.archives-ouvertes.fr/inserm-00700961

C. Bertram and R. Hass, Cellular responses to reactive oxygen species-induced DNA damage and aging, Biological chemistry, vol.389, p.211, 2008.
DOI : 10.1515/bc.2008.031

S. Betlejewski, , 2008.

, Otolaryngologia polska = The Polish otolaryngology, vol.62, pp.344-347

L. Bignold, Mechanisms of clastogen-induced chromosomal aberrations A critical review and description of a model based on failures of tethering of DNA strand ends to strand-breaking enzymes, Mutation research, vol.681, p.271, 2009.

S. Biton, M. Gropp, P. Itsykson, Y. Pereg, L. Mittelman et al., , 2007.

, ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells, DNA repair, vol.6, pp.128-134

C. Blanchet, C. Erostegui, M. Sugasawa, and D. Dulon, Acetylcholine-induced potassium current of guinea pig outer hair cells: its dependence on a calcium influx through nicotinic-like receptors, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.16, pp.2574-2584, 1996.

R. P. Bobbin and T. Konishi, Acetylcholine mimics crossed olivocochlear bundle stimulation, Nature: New biology, vol.231, pp.222-223, 1971.

A. G. Bodnar, M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu et al., Extension of life-span by introduction of telomerase into normal human cells, Science, vol.279, pp.349-352, 1998.

C. Bokemeyer, C. C. Berger, J. T. Hartmann, C. Kollmannsberger, H. J. Schmoll et al., Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer, British journal of cancer, vol.77, pp.1355-1362, 1998.

W. M. Bonner, C. E. Redon, J. S. Dickey, A. J. Nakamura, O. A. Sedelnikova et al., GammaH2AX and cancer, Nat Rev Cancer, vol.8, pp.957-967, 2008.

F. Bouquet, C. Muller, and B. Salles, The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage, Cell Cycle, vol.5, pp.1116-1122, 2006.

J. C. Bourdon, J. Renzing, P. L. Robertson, K. N. Fernandes, and D. P. Lane, Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane, J Cell Biol, vol.158, pp.235-246, 2002.

J. Bourien, Y. Tang, C. Batrel, A. Huet, M. Lenoir et al., Contribution of auditory nerve fibers to compound action potential of the auditory nerve, Journal of neurophysiology, vol.112, pp.1025-1039, 2014.

A. C. Bowling and M. F. Beal, Bioenergetic and oxidative stress in neurodegenerative diseases, Life sciences, vol.56, pp.1151-1171, 1995.

A. Bozzato, V. Bozzato, B. Al-kadah, and B. Schick, A novel multipurpose modular mini-endoscope for otology, European archives of oto-rhino-laryngology : official journal of the European Federation of OtoRhino-Laryngological Societies, vol.271, pp.3341-3348, 2014.

A. Brandt, J. Striessnig, and T. Moser, CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, pp.10832-10840, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00757396

A. P. Breen and J. A. Murphy, Reactions of oxyl radicals with DNA, Free Radic Biol Med, vol.18, pp.1033-1077, 1995.

T. Browder, C. E. Butterfield, B. M. Kraling, B. Shi, B. Marshall et al., , 2000.

, Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer, Cancer research, vol.60, pp.1878-1886

E. J. Brown and D. Baltimore, ATR disruption leads to chromosomal fragmentation and early embryonic lethality, Genes & development, vol.14, pp.397-402, 2000.

W. E. Brownell, C. R. Bader, D. Bertrand, and Y. D. Ribaupierre, Evoked mechanical responses of isolated cochlear outer hair cells, Science, vol.227, p.194, 1985.

F. Bunz, P. M. Hwang, C. Torrance, T. Waldman, Y. Zhang et al., Disruption of p53 in human cancer cells alters the responses to therapeutic agents, The Journal of clinical investigation, vol.104, pp.263-269, 1999.

L. G. Burdelya, E. A. Komarova, J. E. Hill, T. Browder, N. D. Tararova et al., Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice, Cancer research, vol.66, pp.9356-9361, 2006.

M. V. Burga, J. J. Dongena, and D. C. Gent, DNA-PKcs deficiency in human: long predicted, finally found. Current opinion in allergy and clinical immunology 9, p.503, 2009.

B. M. Burgering and R. H. Medema, Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty, Journal of leukocyte biology, vol.73, pp.689-701, 2003.

S. Burma, B. P. Chen, M. Murphy, A. Kurimasa, C. et al., ATM phosphorylates histone H2AX in response to DNA double-strand breaks, The Journal of biological chemistry, vol.276, pp.42462-42467, 2001.

D. A. Butterfield and H. F. Poon, The senescence-accelerated prone mouse (SAMP8): a model of agerelated cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease, Experimental gerontology, vol.40, pp.774-783, 2005.

K. W. Caldecott, Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors, Nature Reviews Genetics, vol.9, pp.513-522, 2005.

C. E. Canman, D. Lim, K. A. Cimprich, Y. Taya, K. Tamai et al., Activation of the ATM kinase by ionizing radiation and phosphorylation of p53, Science, vol.281, p.1677, 1998.

Y. Cao and D. J. Klionsky, Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein, Cell Res, vol.17, pp.839-849, 2007.

F. Cardozo-pelaeza, M. Sanchez-contrerasa, N. , and A. B. , Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP, Neurochemistry International, vol.61, p.721, 2012.

F. Casas, L. Pessemesse, S. Grandemange, P. Seyer, N. Gueguen et al., Overexpression of the mitochondrial T3 receptor p43 induces a shift in skeletal muscle fiber types, PloS one, vol.3, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01189356

A. Celeste, O. Fernandez-capetillo, M. J. Kruhlak, D. R. Pilch, D. W. Staudt et al., Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks, Nat Cell Biol, vol.5, pp.675-679, 2003.

A. Celeste, S. Petersen, P. J. Romanienko, O. Fernandez-capetillo, H. T. Chen et al.,

B. Martin, V. Coppola, E. Meffre, and M. J. Difilippantonio, Genomic Instability in Mice Lacking Histone H2AX, Science, vol.296, p.922, 2002.

A. Celeste, S. Petersen, P. J. Romanienko, O. Fernandez-capetillo, H. T. Chen et al.,

B. Martin, V. Coppola, E. Meffre, and M. J. Difilippantonio, Genomic instability in mice lacking histone H2AX, Science, vol.296, pp.922-927, 2002.

H. Chaachouay, P. Ohneseit, M. Toulany, R. Kehlbach, G. Multhoff et al., Autophagy contributes to resistance of tumor cells to ionizing radiation, Radiother Oncol, vol.99, pp.287-292, 2011.

C. Chatgilialogu and P. Neill, Free radicals associated with DNA damage, Experimental Gerontology, vol.36, p.1459, 2001.

P. Chaturvedi, W. K. Eng, Y. Zhu, M. R. Mattern, R. Mishra et al., Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway, Oncogene, vol.18, pp.4047-4054, 1999.

M. A. Cheatham, K. H. Huynh, J. Gao, J. Zuo, and P. Dallos, Cochlear function in Prestin knockout mice, The Journal of Physiology, vol.560, p.821, 2004.

Y. Chen and R. Y. Poon, The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability, Frontiers in bioscience : a journal and virtual library, vol.13, pp.5016-5029, 2008.

P. Chene, Targeting p53 in cancer, Curr Med Chem Anticancer Agents, vol.1, pp.151-161, 2001.

A. G. Cheng, L. L. Cunningham, and E. W. Rubel, Mechanisms of hair cell death and protection. Current opinion in otolaryngology & head and neck surgery, vol.13, pp.343-348, 2005.

Q. Cheng, B. Cross, B. Li, L. Chen, Z. Li et al., Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage, Molecular and Cellular Biology, vol.31, p.4951, 2011.

J. E. Chipuk, T. Kuwana, L. Bouchier-hayes, N. M. Droin, D. D. Newmeyer et al.,

, Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis, Science, vol.303, p.1010

M. J. Chong, M. R. Murray, E. C. Gosink, H. R. Russell, A. Srinivasan et al., Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system, Proceedings of the National Academy of Sciences of the United States of America, vol.97, pp.889-894, 2000.

K. Christensen, H. Frederiksen, and H. J. Hoffman, Genetic and environmental influences on selfreported reduced hearing in the old and oldest old, Journal of the American Geriatrics Society, vol.49, pp.1512-1517, 2001.

A. Clausen, S. Doctrow, and M. Baudry, Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice, Neurobiology of aging, vol.31, pp.425-433, 2010.

J. E. Cleaver, gammaH2Ax: biomarker of damage or functional participant in DNA repair "all that glitters is not gold, Photochem Photobiol, vol.87, pp.1230-1239, 2011.

W. J. Clerici, Effects of superoxide dismutase and U74389G on acute trimethyltin-induced cochlear dysfunction, Toxicol Appl Pharmacol, vol.136, pp.236-242, 1996.

M. Collado, M. A. Blasco, and M. Serrano, Cellular senescence in cancer and aging, Cell, vol.130, pp.223-233, 2007.

K. J. Contrera, J. Betz, J. A. Deal, J. S. Choi, H. N. Ayonayon et al., Association of Hearing Impairment and Emotional Vitality in Older Adults, The journals of gerontology Series B, Psychological sciences and social sciences, vol.71, pp.400-404, 2016.

E. Convery, E. K. Shin, Q. Ding, W. Wang, P. Douglas et al., Inhibition of homologous recombination by variants of the catalytic subunit of the DNAdependent protein kinase (DNA-PKcs), Proceedings of the National Academy of Sciences of the United States of America, vol.102, p.1345, 2005.

P. J. Cook, B. G. Ju, F. Telese, X. Wang, C. K. Glass et al., Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions, Nature, vol.458, pp.591-596, 2009.

J. C. Cooper and . Jr, Health and Nutrition Examination Survey of 1971-75: Part I. Ear and race effects in hearing, Journal of the American Academy of Audiology, vol.5, pp.30-36, 1994.

F. Cortés-ledesma and A. Aguilera, Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange, EMBO reports, vol.7, p.919, 2006.

D. Cortez, S. Guntuku, J. Qin, and S. J. Elledge, ATR and ATRIP: partners in checkpoint signaling, Science, vol.294, pp.1713-1716, 2001.

J. A. Costalupes, E. D. Young, and D. J. Gibson, Effects of continuous noise backgrounds on rate response of auditory nerve fibers in cat, Journal of neurophysiology, vol.51, pp.1326-1344, 1984.

X. Cui, Y. Yu, S. Gupta, Y. Cho, S. P. Lees-miller et al., Autophosphorylation of DNADependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice, Molecular and Cellular Biology, vol.25, p.10842, 2005.

D. D'amours, J. , and S. P. , The Mre11 complex: at the crossroads of dna repair and checkpoint signalling, Nat Rev Mol Cell Biol, vol.3, pp.317-327, 2002.

D. F. Dai, T. Chen, S. C. Johnson, H. Szeto, and P. S. Rabinovitch, Cardiac aging: from molecular mechanisms to significance in human health and disease, Antioxidants & redox signaling, vol.16, pp.1492-1526, 2012.

P. Dallos, The active cochlea, The Journal of Neuroscience, vol.12, p.4575, 1992.

K. N. Darrow, S. F. Maison, and M. C. Liberman, Cochlear efferent feedback balances interaural sensitivity, Nature neuroscience, vol.9, pp.1474-1476, 2006.

K. N. Darrow, S. F. Maison, and M. C. Liberman, Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury, Journal of neurophysiology, vol.97, pp.1775-1785, 2007.

P. C. Dedon, J. Plastaras, C. A. Rouzer, and L. J. Marnett, Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal, Proceedings of the National Academy of Sciences of the United States of America 95, p.11113, 1998.

N. Dehne, J. Lautermann, F. Petrat, U. Rauen, and H. De-groot, Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals, Toxicol Appl Pharmacol, vol.174, pp.27-34, 2001.

S. Delacroix, J. M. Wagner, M. Kobayashi, K. Yamamoto, and L. M. Karnitz, The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1, Genes & development, vol.21, pp.1472-1477, 2007.

R. Di-micco, A. Cicalese, M. Fumagalli, M. Dobreva, A. Verrecchia et al., , 2008.

, DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization, Cell Cycle, vol.7, pp.3601-3606

G. P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott et al., A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proceedings of the National Academy of Sciences of the United States of America, vol.92, pp.9363-9367, 1995.

R. A. Ditullio, . Jr, T. A. Mochan, M. Venere, J. Bartkova et al., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer, Nat Cell Biol, vol.4, pp.998-1002, 2002.

M. Donzelli and G. F. Draetta, Regulating mammalian checkpoints through Cdc25 inactivation, EMBO reports, vol.4, p.671, 2003.

P. Douglas, X. Cui, W. D. Block, Y. Yu, S. Gupta et al., The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain, Molecular and Cellular Biology, vol.27, p.1581, 2007.

P. Douglas, G. P. Sapkota, N. Morrice, Y. Yu, A. A. Goodarzi et al., Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase, The Biochemical journal, vol.368, p.243, 2002.

R. M. Douglas and G. G. Haddad, Can O2 dysregulation induce premature aging?, Physiology, vol.23, p.333, 2008.

M. L. Dronkert, R. Kanaar, J. R. Dubno, D. D. Dirks, and D. E. Morgan, Effects of age and mild hearing loss on speech recognition in noise, The Journal of the Acoustical Society of America, vol.76, pp.87-96, 1984.

E. Dufour and N. G. Larsson, Understanding aging: revealing order out of chaos, Biochim Biophys Acta, vol.1658, pp.122-132, 2004.

W. S. El-deiry, S. E. Kern, J. A. Pietenpol, K. W. Kinzler, and B. Vogelstein, Definition of a consensus binding site for p53, Nature genetics, vol.1, pp.45-49, 1992.

A. El-barbary, R. A. Altschuler, and J. Schacht, Glutathione S-transferases in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization, Hearing research, vol.71, pp.80-90, 1993.

N. El-kechai, F. Agnely, E. Mamelle, Y. Nguyen, E. Ferrary et al., Recent advances in local drug delivery to the inner ear, Int J Pharm, vol.494, pp.83-101, 2015.

A. B. Elgoyhen, D. S. Johnson, J. Boulter, D. E. Vetter, and S. Heinemann, Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells, Cell, vol.79, pp.705-715, 1994.

A. B. Elgoyhen, D. E. Vetter, E. Katz, C. V. Rothlin, S. F. Heinemann et al., alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.3501-3506, 2001.

M. Endres, D. Biniszkiewicz, R. W. Sobol, C. Harms, M. Ahmadi et al., Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase, The Journal of Clinical Investigation, vol.113, p.1711, 2004.

C. Erostegui, C. H. Norris, and R. P. Bobbin, In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells, Hearing research, vol.74, pp.135-147, 1994.

M. G. Evans, Acetylcholine activates two currents in guinea-pig outer hair cells, The Journal of physiology, vol.491, pp.563-578, 1996.

M. Eybalin, Neurotransmitters and neuromodulators of the mammalian cochlea, Physiological reviews, vol.73, pp.309-373, 1993.

K. A. Fernandez, P. W. Jeffers, K. Lall, M. C. Liberman, and S. G. Kujawa, Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.35, pp.7509-7520, 2015.

A. M. Fichtinger-schepman, A. T. Oosterom, P. H. Lohman, and F. Berends, cisDiamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cisdiamminedichloroplatinum(II), Cancer Research, vol.47, p.3000, 1987.

E. Fielder, T. Von-zglinicki, J. , and D. , The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State, Journal of Alzheimer's disease : JAD, vol.60, pp.107-131, 2017.

P. G. Foiles, S. A. Akerkar, S. G. Carmella, M. Kagan, G. D. Stoner et al., Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers, Chemical research in toxicology, vol.4, pp.364-368, 1991.

P. Fortini, C. Ferretti, B. Pascucci, L. Narciso1, D. Pajalunga et al., DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity, Cell Death and Differentiation, vol.19, pp.1741-1749, 1741.

R. J. Fram, Cisplatin and platinum analogues: recent advances, Current opinion in oncology, vol.4, pp.1073-1079, 1992.

T. Frank, D. Khimich, A. Neef, and T. Moser, Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.4483-4488, 2009.

L. Frederico, T. Kunkel, B. Shaw, P. Froehlich, L. Collet et al., A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy, Biochemistry, vol.29, 1990.

P. A. Fuchs and B. W. Murrow, Cholinergic inhibition of short (outer) hair cells of the chick's cochlea, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.12, pp.800-809, 1992.

M. Fumagalli, F. Rossiello, C. Mondello, and F. Di-fagagna, Stable cellular senescence is associated with persistent DDR activation, PloS one, vol.9, p.110969, 2014.

A. C. Furman, S. G. Kujawa, and M. C. Liberman, Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates, Journal of neurophysiology, vol.110, pp.577-586, 2013.

E. R. Galimov, The Role of p66shc in Oxidative Stress and Apoptosis, Acta naturae, vol.2, pp.44-51, 2010.

G. A. Gates, N. N. Couropmitree, and R. H. Myers, Genetic associations in age-related hearing thresholds. Archives of otolaryngology--head & neck surgery 125, pp.654-659, 1999.

G. A. Gates and J. H. Mills, Presbycusis. Lancet, vol.366, pp.1111-1120, 2005.

R. A. Gatti, I. Berkel, E. Boder, G. Braedt, P. Charmley et al., Localization of an ataxia-telangiectasia gene to chromosome 11q22-23, Nature, vol.336, pp.577-580, 1988.

S. A. Gatz and L. Wiesmuller, p53 in recombination and repair, Cell Death Differ, vol.13, pp.1003-1016, 2006.

D. Gell, J. , and S. P. , Mapping of protein-protein interactions within the DNA-dependent protein kinase complex, Nucleic Acids Research, vol.27, p.3494, 1999.

D. C. Gent, J. H. Hoeijmakers, and R. Kanaar, Chromosomal stability and the DNA double-stranded break connection, Nature Reviews Genetics, vol.2, 0196.

E. Glowatzki and P. A. Fuchs, Transmitter release at the hair cell ribbon synapse, Nature neuroscience, vol.5, pp.147-154, 2002.

M. Goldberg, M. Stucki, J. Falck, D. D'amours, D. Rahman et al., MDC1 is required for the intra-S-phase DNA damage checkpoint, Nature, vol.421, pp.952-956, 2003.

J. Goodship, H. Gill, J. Carter, A. Jackson, M. Splitt et al., Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1-q24, American journal of human genetics, vol.67, pp.498-503, 2000.

T. M. Gottlieb, J. , and S. P. , The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, vol.72, p.131, 1993.

P. R. Graves, L. Yu, J. K. Schwarz, J. Gales, E. A. Sausville et al., , 2000.

, The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01, The Journal of biological chemistry, vol.275, pp.5600-5605

C. M. Green, H. Erdjument-bromage, P. Tempst, and N. F. Lowndes, A novel Rad24 checkpoint protein complex closely related to replication factor C, Current biology : CB, vol.10, pp.39-42, 2000.

J. D. Griffith, L. A. Lindsey-boltz, and A. Sancar, Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy, The Journal of biological chemistry, vol.277, pp.15233-15236, 2002.

J. Gruber, S. Schaffer, and B. Halliwell, The mitochondrial free radical theory of ageing--where do we stand?, Frontiers in bioscience : a journal and virtual library, vol.13, pp.6554-6579, 2008.

Y. Gu, K. J. Seidl, G. A. Rathbun, C. Zhu, J. P. Manis et al., Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice, Immunity, vol.7, p.653, 1997.

A. Guan, H. Gong, Y. Ye, J. Jia, G. Zhang et al., Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis. PloS one 8, e76529. Guirouilh-Barbat, Molecular Biology of the Cell, vol.19, p.3969, 2008.

X. Guo, M. D. Ward, J. B. Tiedebohl, Y. M. Oden, J. O. Nyalwidhe et al., Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity, The Journal of biological chemistry, vol.285, p.33348, 2010.

X. L. Guo, F. Hu, S. S. Zhang, Q. D. Zhao, C. Zong et al., Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy, Cancer Lett, vol.346, pp.278-284, 2014.

S. Gupta and K. Meek, The leucine rich region of DNA-PKcs contributes to its innate DNA affinity, Nucleic Acids Research, vol.33, p.6972, 2005.

O. Hammarsten, C. , and G. , DNA-dependent protein kinase: DNA binding and activation in the absence of Ku, Proceedings of the National Academy of Sciences of the United States of America 95, vol.48, pp.1091-1095, 1998.

L. Harhaji-trajkovic, U. Vilimanovich, T. Kravic-stevovic, V. Bumbasirevic, and V. Trajkovic, , 2009.

, AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells, J Cell Mol Med, vol.13, pp.3644-3654

J. W. Harper and S. J. Elledge, The DNA damage response: ten years after, Mol Cell, vol.28, pp.739-745, 2007.

J. T. Hartmann and H. P. Lipp, Toxicity of platinum compounds, Expert opinion on pharmacotherapy, vol.4, pp.889-901, 2003.

E. P. Helzner, J. A. Cauley, S. R. Pratt, S. R. Wisniewski, J. M. Zmuda et al., Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study, Journal of the American Geriatrics Society, vol.53, pp.2119-2127, 2005.

B. A. Henry, C. M. Mckay, H. J. Mcdermott, and G. M. Clark, The relationship between speech perception and electrode discrimination in cochlear implantees, The Journal of the Acoustical Society of America, vol.108, pp.1269-1280, 2000.

K. H. Herzog, M. J. Chong, M. Kapsetaki, J. I. Morgan, and P. J. Mckinnon, Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system, Science, vol.280, pp.1089-1091, 1998.

G. Hesse, , 2016.

S. E. Hind, R. Haines-bazrafshan, C. L. Benton, W. Brassington, B. Towle et al., , 2011.

, Prevalence of clinical referrals having hearing thresholds within normal limits, International journal of audiology, vol.50, pp.708-716

R. Hinojosa, L. C. Riggs, M. Strauss, and G. J. Matz, Temporal bone histopathology of cisplatin ototoxicity, The American journal of otology, vol.16, pp.731-740, 1995.

A. Hirao, Y. Kong, S. Matsuoka, A. Wakeham, J. Ruland et al., DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2, Trends in genetics : TIG, vol.287, pp.583-586, 1824.

A. Huet, C. Batrel, Y. Tang, G. Desmadryl, J. Wang et al., Sound coding in the auditory nerve of gerbils, Hearing research, vol.338, pp.32-39, 2016.

B. J. Hwang, J. M. Ford, P. C. Hanawalt, C. , and G. , Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair, Proceedings of the National Academy of Sciences of the United States of America, vol.96, pp.424-428, 1999.

M. Ichihashi, M. Ueda, A. Budiyanto, T. Bito, M. Oka et al., UV-induced skin damage, Toxicology, vol.189, pp.21-39, 2003.

N. P. Issa and A. J. Hudspeth, Clustering of Ca2+ channels and Ca(2+)-activated K+ channels at fluorescently labeled presynaptic active zones of hair cells, Proceedings of the National Academy of Sciences of the United States of America, vol.91, pp.7578-7582, 1994.

N. P. Issa and A. J. Hudspeth, The entry and clearance of Ca2+ at individual presynaptic active zones of hair cells from the bullfrog's sacculus, Proceedings of the National Academy of Sciences of the United States of America, vol.93, pp.9527-9532, 1996.

K. Iwabuchi, B. P. Basu, B. Kysela, T. Kurihara, M. Shibata et al., Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA, The Journal of biological chemistry, vol.278, pp.36487-36495, 2003.

T. Jacks, L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi et al., Tumor spectrum analysis in p53-mutant mice, Current biology : CB, vol.4, pp.1-7, 1994.

T. Jacks, L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi et al., Tumor spectrum analysis in p53-mutant mice, Current Biology, vol.4, p.1, 1994.

J. G. Jackson, V. Pant, Q. Li, L. L. Chang, A. Quintas-cardama et al., p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer, Cancer Cell, vol.21, pp.793-806, 2012.

S. Jager, C. Bucci, I. Tanida, T. Ueno, E. Kominami et al., Role for Rab7 in maturation of late autophagic vacuoles, J Cell Sci, vol.117, pp.4837-4848, 2004.

S. Jamesdaniel, D. Ding, M. H. Kermany, B. A. Davidson, P. R. Knight et al., Proteomic analysis of the balance between survival and cell death responses in cisplatin-mediated ototoxicity, Journal of proteome research, vol.7, pp.3516-3524, 2008.

C. Jhappan, H. C. Morse, R. D. Fleischmann, M. M. Gottesman, and G. Merlino, DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus, Nature genetics, vol.17, p.483, 1997.

H. Jia, F. Francois, J. Bourien, M. Eybalin, R. V. Lloyd et al., Prevention of trauma-induced cochlear fibrosis using intracochlear application of anti-inflammatory and antiproliferative drugs, Neuroscience, vol.316, pp.261-278, 2016.

M. Jiang, X. Yi, S. Hsu, C. Y. Wang, D. et al., Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity, Am J Physiol Renal Physiol, vol.287, pp.1140-1147, 2004.

S. Jin, Autophagy and tumor suppression, Autophagy, vol.53, pp.171-173, 2005.

A. C. Joerger, H. C. Ang, and A. R. Fersht, Structural basis for understanding oncogenic p53 mutations and designing rescue drugs, Proceedings of the National Academy of Sciences of the United States of America, vol.103, pp.15056-15061, 2006.

G. G. Jones, P. M. Reaper, A. R. Pettitt, and P. D. Sherrington, The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes, Oncogene, vol.23, 1911.

Y. Jung and S. J. Lippard, Multiple states of stalled T7 RNA polymerase at DNA lesions generated by platinum anticancer agents, The Journal of biological chemistry, vol.278, pp.52084-52092, 2003.

Z. Korwek, T. Sewastianik, A. Bielak-zmijewska, G. Mosieniak, O. Alster et al., Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells, DNA repair, vol.11, pp.864-873, 2012.

T. F. Kowalik, J. Degregori, J. K. Schwarz, and J. R. Nevins, E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis, Journal of Virology, vol.69, p.2491, 1995.

A. S. Kozlov, T. Risler, and A. J. Hudspeth, Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels, Nature neuroscience, vol.10, pp.87-92, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00961026

S. V. Kozlov, M. E. Graham, B. Jakob, F. Tobias, A. W. Kijas et al., Autophosphorylation and ATM activation: additional sites add to the complexity, The Journal of biological chemistry, vol.286, pp.9107-9119, 2011.

S. V. Kozlov, M. E. Graham, C. Peng, P. Chen, P. J. Robinson et al., Involvement of novel autophosphorylation sites in ATM activation, EMBO J, vol.25, pp.3504-3514, 2006.

P. Krauss, K. Tziridis, C. Metzner, A. Schilling, U. Hoppe et al., Stochastic Resonance Controlled Upregulation of Internal Noise after Hearing Loss as a Putative Cause of Tinnitus-Related Neuronal Hyperactivity, Frontiers in neuroscience, vol.10, p.597, 2016.

K. J. Krishnan, A. K. Reeve, D. C. Samuels, P. F. Chinnery, J. K. Blackwood et al., What causes mitochondrial DNA deletions in human cells?, Nature genetics, vol.40, pp.275-279, 2008.

M. Kruhlak, E. E. Crouch, M. Orlov, C. Montaño, S. A. Gorski et al., The ATM repair pathway inhibits RN chromosome breaks, Nature, vol.447, p.730, 2007.

S. G. Kujawa, T. J. Glattke, M. Fallon, and R. P. Bobbin, Contralateral sound suppresses distortion product otoacoustic emissions through cholinergic mechanisms, Hearing research, vol.68, pp.97-106, 1993.

S. G. Kujawa, T. J. Glattke, M. Fallon, and R. P. Bobbin, A nicotinic-like receptor mediates suppression of distortion product otoacoustic emissions by contralateral sound, Hearing research, vol.74, pp.122-134, 1994.

S. G. Kujawa and M. C. Liberman, Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.26, pp.2115-2123, 2006.

S. G. Kujawa and M. C. Liberman, Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.29, pp.14077-14085, 2009.

A. Kumagai and W. G. Dunphy, Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts, Molecular cell, vol.6, p.839, 2000.

I. Kuraoka, C. Bender, A. Romieu, J. Cadet, R. D. Wood et al., Effects of Endogenous DNA Base Lesions on Transcription Elongation by Mammalian RNA Polymerase II Implications for Transcription-Coupled DNA Repair and Transcriptional Mutagenesis, Proceedings of the National Academy of Sciences of the United States of America, vol.97, 2000.

A. ;. Kuzminov, J. Wang, L. Simonneau, J. L. Puel, and M. Lenoir, Single-strand interruptions in replicating chromosomes cause double-strand breaks, Proceedings of the National Academy of Sciences of the United States of America 98, 8241. Ladrech, vol.85, pp.1970-1979, 2001.

N. D. Lakin, B. C. Hann, J. , and S. P. , The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53, Oncogene, vol.18, p.3989, 1999.

A. Lal, Y. Pan, F. Navarro, D. M. Dykxhoorn, L. Moreau et al., miR-24-mediated down-regulation of H2AX suppresses DNA repair in terminally differentiated blood cells, Nature structural & molecular biology, vol.16, p.492, 2009.

A. Lal, Y. Pan, F. Navarro, D. M. Dykxhoorn, L. Moreau et al., miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells, Nature structural & molecular biology, vol.16, pp.492-498, 2009.

M. Laos, T. Anttonen, A. Kirjavainen, T. Hallstrom, M. Laiho et al., DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells, Aging, vol.6, pp.496-510, 2014.

G. Laurell and B. Engstrom, The combined effect of cisplatin and furosemide on hearing function in guinea pigs, Hearing research, vol.38, pp.19-26, 1989.

K. H. Lauritzen, O. Moldestad, L. Eide, H. Carlsen, G. Nesse et al., Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior, Molecular and Cellular Biology, vol.30, p.1357, 2010.

J. Lautermann, J. Mclaren, and J. Schacht, Glutathione protection against gentamicin ototoxicity depends on nutritional status, Hearing research, vol.86, pp.15-24, 1995.

J. E. Lee, T. Nakagawa, T. S. Kim, T. Endo, A. Shiga et al., Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment, Acta oto-laryngologica, vol.124, pp.1131-1135, 2004.

J. H. Lee, A. A. Goodarzi, P. A. Jeggo, and T. T. Paull, 53BP1 promotes ATM activity through direct interactions with the MRN complex, EMBO J, vol.29, pp.574-585, 2010.

M. P. Lee, J. D. Ravenel, R. J. Hu, L. R. Lustig, G. Tomaselli et al., Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice, The Journal of clinical investigation, vol.106, pp.1447-1455, 2000.

T. Lee, J. Park, S. Leem, and T. Kang, Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair, Oncogene, vol.539, 2012.

Y. Lee and P. J. Mckinnon, ATM dependent apoptosis in the nervous system, Apoptosis, vol.5, pp.523-529, 2000.

S. P. Lees-miller, Y. Chen, A. , and C. W. , Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen, Molecular and Cellular Biology, vol.10, p.6472, 1990.

M. Lethbridge-cejku, J. S. Schiller, and L. Bernadel, Summary health statistics for U.S. adults: National Health Interview Survey, 2002. Vital and health statistics Series 10, Data from the National Health Survey, pp.1-151, 2004.

V. A. Letts, A. Valenzuela, C. Dunbar, Q. Y. Zheng, K. R. Johnson et al., A new spontaneous mouse mutation in the Kcne1 gene, Mammalian genome : official journal of the International Mammalian Genome Society, vol.11, pp.831-835, 2000.

J. I. Leu, .. Dumont, P. Hafey, M. Murphy, M. E. et al., Mitochondrial p53 activates Bak and causes disruption of a BakMcl1 complex, Nature Cell Biology, vol.6, p.443, 2004.

A. J. Levine, The p53 tumor suppressor gene and gene product, Princess Takamatsu, vol.20, pp.221-230, 1989.

N. Lévy, M. Oehlmann, F. Delalande, H. P. Nasheuer, A. V. Dorsselaer et al., XRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may coordinate DNA repair and replication during S phase, Nucleic Acids Research, vol.37, p.3177, 2009.

J. Li and D. F. Stern, DNA Damage Regulates Chk2 Association with Chromatin, The Journal of biological chemistry, vol.280, p.37948, 2005.

J. Li and D. F. Stern, Regulation of CHK2 by DNA-dependent Protein Kinase, The Journal of biological chemistry, vol.280, p.12041, 2005.

X. Li and J. L. Manley, Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability, Cell, vol.122, p.365, 2005.

Z. Li, P. R. Musich, M. A. Serrano, Z. Dong, and Y. Zou, XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase, PLoS One, vol.6, pp.1239-1241, 1982.

M. C. Liberman, J. Gao, D. Z. He, X. Wu, S. Jia et al., Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier, Nature, vol.419, p.300, 2002.

F. Lin, Y. Chen, J. Li, and R. N. Wang, , 2000.

B. Hua-xi-yi-ke-da-xue-xue, Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, vol.31, pp.21-23

S. J. Lin and C. M. Chuong, Toward the isolation and culture of melanocyte stem cells, The Journal of investigative dermatology, vol.131, pp.2341-2343, 2011.

W. Lin, F. Lin, and J. R. Nevins, Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation, Genes & Development, vol.15, p.1833, 2001.

A. J. Lincoln, D. Wickramasinghe, P. Stein, R. M. Schultz, M. E. Palko et al., Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation, Nature genetics, vol.30, pp.446-449, 2002.

C. Liu, E. Glowatzki, and P. A. Fuchs, Unmyelinated type II afferent neurons report cochlear damage, Proceedings of the National Academy of Sciences of the United States of America, vol.112, pp.14723-14727, 2015.

P. Liu, B. Xu, T. A. Cavalieri, and C. E. Hock, Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats, Shock, vol.26, pp.608-614, 2006.

R. Liu, I. Y. Liu, X. Bi, R. F. Thompson, S. R. Doctrow et al., Reversal of agerelated learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics, Proceedings of the National Academy of Sciences of the United States of America, vol.100, pp.8526-8531, 2003.

S. Liu, S. O. Opiyo, K. Manthey, J. G. Glanzer, A. K. Ashley et al., Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress, Nucleic Acids Res, vol.40, pp.10780-10794, 2012.

A. Long, S. Mitchell, D. Kashanin, V. Williams, A. P. Mello et al., , 2005.

, The "multiple hormone deficiency" theory of aging: is human senescence caused mainly by multiple hormone deficiencies?, Annals of the New York Academy of Sciences, vol.1057, p.448

M. P. Longhese, M. Foiani, M. Muzi-falconi, G. Lucchini, and P. Plevani, DNA damage checkpoint in budding yeast, EMBO J, vol.17, pp.5525-5528, 1998.

Z. Lou, K. Minter-dykhouse, S. Franco, M. Gostissa, M. A. Rivera et al., MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals, Molecular cell, vol.21, p.187, 2006.

Z. Lou, K. Minter-dykhouse, S. Franco, M. Gostissa, M. A. Rivera et al., MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals, Mol Cell, vol.21, pp.187-200, 2006.

Z. Lou, K. Minter-dykhouse, X. Wu, C. , and J. , MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways, Nature, vol.421, pp.957-961, 2003.

W. K. Low, S. T. Toh, J. Wee, S. M. Fook-chong, and D. Y. Wang, Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.24, pp.1904-1909, 2006.

C. Lu, F. Zhu, Y. Y. Cho, F. Tang, T. Zykova et al., Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3, Mol Cell, vol.23, pp.121-132, 2006.

C. Lukas, J. Bartkova, L. Latella, J. Falck, N. Mailand et al., DNA Damage-activated Kinase Chk2 Is Independent of Proliferation or Differentiation Yet Correlates with Tissue Biology, Cancer Research, vol.61, p.4990, 2001.

C. Lukas, J. Falck, J. Bartkova, J. Bartek, L. et al., Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage, Nat Cell Biol, vol.5, pp.255-260, 2003.

C. Lukas, J. Falck, J. Bartkova, J. Bartek, L. et al., Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage, Nature Cell Biology, vol.5, p.255, 2003.

C. Lukas, F. Melander, M. Stucki, J. Falck, S. Bekker-jensen et al., Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention, EMBO J, vol.23, pp.2674-2683, 2004.

K. Luo, J. Yuan, and Z. Lou, Oligomerization of MDC1 protein is important for proper DNA damage response, The Journal of biological chemistry, vol.286, p.28192, 2011.

C. X. Ma, J. W. Janetka, and H. Piwnica-worms, Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics, Trends Mol Med, vol.17, pp.88-96, 2011.

Y. Ma, U. Pannicke, H. Lu, D. Niewolik, K. Schwarz et al., The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis, The Journal of biological chemistry, vol.280, p.33839, 2005.

C. A. Macdougall, T. S. Byun, C. Van, M. C. Yee, and K. A. Cimprich, The structural determinants of checkpoint activation, Genes & development, vol.21, pp.898-903, 2007.

S. F. Maison, J. C. Adams, and M. C. Liberman, Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization, The Journal of comparative neurology, vol.455, pp.406-416, 2003.

M. C. Maiuri, L. Galluzzi, E. Morselli, O. Kepp, S. A. Malik et al., Autophagy regulation by p53, Current opinion in cell biology, vol.22, pp.181-185, 2010.

J. Majka, A. Niedziela-majka, and P. M. Burgers, The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint, Mol Cell, vol.24, pp.891-901, 2006.

I. A. Manke, D. M. Lowery, A. Nguyen, Y. , and M. B. , BRCT repeats as phosphopeptide-binding modules involved in protein targeting, Science, vol.302, pp.636-639, 2003.

A. K. Mantha, B. Sarkar, and G. Tell, A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases, Mitochondrion S1567-7249, pp.272-00279, 2013.

E. Marangoni, A. Vincent-salomon, N. Auger, A. Degeorges, F. Assayag et al., A new model of patient tumor-derived breast cancer xenografts for preclinical assays, Clin Cancer Res, vol.13, pp.3989-3998, 2007.

M. C. Marazita, M. F. Ogara, S. V. Sonzogni, M. Marti, N. J. Dusetti et al., CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response, PloS one, vol.7, p.35638, 2012.

N. D. Marchenko, S. Wolff, S. Erster, K. Becker, and U. M. Moll, Monoubiquitylation promotes mitochondrial p53 translocation, The EMBO journal, vol.26, p.923, 2007.

R. Marcotte, C. Lacelle, W. , and E. , Senescent fibroblasts resist apoptosis by downregulating caspase-3, Mechanisms of ageing and development, vol.125, pp.777-783, 2004.

A. Markaryan, E. G. Nelson, and R. Hinojosa, Quantification of the mitochondrial DNA common deletion in presbycusis, The Laryngoscope, vol.119, pp.1184-1189, 2009.

A. Markaryan, E. G. Nelson, and R. Hinojosa, Major arc mitochondrial DNA deletions in cytochrome c oxidase-deficient human cochlear spiral ganglion cells, Acta oto-laryngologica, vol.130, pp.780-787, 2010.

S. Marklund, Spectrophotometric study of spontaneous disproportionation of superoxide anion radical and sensitive direct assay for superoxide dismutase, The Journal of biological chemistry, vol.251, pp.7504-7507, 1976.

S. Marklund and G. Marklund, Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur J Biochem, vol.47, pp.469-474, 1974.

L. J. Marnett, Lipid peroxidation-DNA damage by malondialdehyde, Mutation research, vol.424, p.83, 1999.

L. J. Marnett and J. P. Plastaras, Endogenous DNA damage and mutation, Trends in genetics : TIG, vol.17, pp.214-221, 2001.

B. Martin-castillo, E. Lopez-bonet, M. Buxo, J. Dorca, F. Tuca-rodriguez et al., Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant basal-HER2 subtype of breast cancer, Oncotarget, vol.6, pp.7104-7122, 2015.

A. Matsubara, Y. Kawabata, Y. Takumi, S. Usami, H. Shinkawa et al., Quantitative immunogold cytochemistry reveals sources of glutamate release in inner ear ischemia, Acta oto-laryngologica Supplementum, vol.539, pp.48-51, 1998.

R. Maya, M. Balass, S. Kim, D. Shkedy, J. M. Leal et al., ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage, Genes & Development, vol.15, p.1067, 2001.

C. J. Mcnees, L. A. Conlan, N. Tenis, and J. Heierhorst, ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage, EMBO J, vol.24, pp.2447-2457, 2005.

K. Meek, S. P. Lees-miller, M. Modesti, R. Melchionna, X. Chen et al., N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku, Nucleic Acids Research, vol.40, p.762, 2000.

J. Melo and D. Toczyski, A unified view of the DNA-damage checkpoint, Current opinion in cell biology, vol.14, pp.237-245, 2002.

J. A. Melo, J. Cohen, and D. P. Toczyski, Two checkpoint complexes are independently recruited to sites of DNA damage in vivo, Genes & development, vol.15, pp.2809-2821, 2001.

J. Menardo, Y. Tang, S. Ladrech, M. Lenoir, F. Casas et al., Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea, Antioxidants & redox signaling, vol.16, pp.263-274, 2012.

S. Menini, L. Amadio, G. Oddi, C. Ricci, C. Pesce et al., Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress, Diabetes, vol.55, pp.1642-1650, 2006.

C. Meric and L. Collet, Visual attention and evoked otoacoustic emissions: a slight but real effect, International journal of psychophysiology : official journal of the International Organization of Psychophysiology, vol.12, pp.233-235, 1992.

M. Metzler, DNA adducts of medicinal drugs: some selected examples, Journal of cancer research and clinical oncology, vol.112, p.210, 1986.

A. Meulle, B. Salles, D. Daviaud, P. Valet, and C. Muller, Positive Regulation of DNA Double Strand Break Repair Activity during Differentiation of Long Life Span Cells: The Example of Adipogenesis, PLoS One, vol.3, p.3345, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00409180

A. C. Meyer, T. Frank, D. Khimich, G. Hoch, D. Riedel et al., Tuning of synapse number, structure and function in the cochlea, Nature neuroscience, vol.12, pp.444-453, 2009.

L. T. Mikalsen, H. P. Dhakal, O. S. Bruland, B. Naume, E. Borgen et al., The clinical impact of mean vessel size and solidity in breast carcinoma patients, PloS one, vol.8, p.75954, 2013.

K. Minter-dykhouse, I. Ward, M. S. Huen, J. Chen, and Z. Lou, Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis, J Cell Biol, vol.181, pp.727-735, 2008.

D. Mohrle, K. Ni, K. Varakina, D. Bing, S. C. Lee et al., Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain, Neurobiology of aging, vol.44, pp.173-184, 2016.

P. Moller and H. Wallin, Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product, Mutat Res, vol.410, pp.271-290, 1998.

D. A. Mordes, G. G. Glick, R. Zhao, C. , and D. , TopBP1 activates ATR through ATRIP and a PIKK regulatory domain, Genes & development, vol.22, pp.1478-1489, 2008.

N. Mori, M. Sakagami, K. Fukazawa, and T. Matsunaga, An immunohistochemical and electrophysiological study on Isk protein in the stria vascularis of the guinea pig, European archives of oto-rhinolaryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies, vol.250, pp.186-189, 1993.

E. Morselli, E. Tasdemir, M. C. Maiuri, L. Galluzzi, O. Kepp et al., Mutant p53 protein localized in the cytoplasm inhibits autophagy, Cell Cycle, vol.7, pp.3056-3061, 2008.

T. Moser and D. Beutner, Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse, Proceedings of the National Academy of Sciences of the United States of America, vol.97, pp.883-888, 2000.

M. Muller, K. Von-hunerbein, S. Hoidis, and J. W. Smolders, A physiological place-frequency map of the cochlea in the CBA/J mouse, Hearing research, vol.202, pp.63-73, 2005.

S. Murillo-cuesta, J. Contreras, E. Zurita, R. Cediel, M. Cantero et al., , 2010.

, Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice, Pigment cell & melanoma research, vol.23, pp.72-83

T. Naiki, T. Shimomura, T. Kondo, K. Matsumoto, and K. Sugimoto, Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae, Molecular and cellular biology, vol.20, pp.5888-5896, 2000.

A. J. Nakamura, V. A. Rao, Y. Pommier, W. M. Bonner, A. J. Nakamura et al., The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks, Cell Cycle, vol.9, pp.389-397, 2010.

K. Nakano and K. H. Vousden, PUMA, a novel proapoptotic gene, is induced by p53, Mol Cell, vol.7, pp.683-694, 2001.

J. A. Neal, V. Dang, P. Douglas, M. S. Wold, S. P. Lees-miller et al., Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation, Molecular and Cellular Biology, vol.31, p.1719, 2011.

J. Neef, A. Gehrt, A. V. Bulankina, A. C. Meyer, D. Riedel et al., , 2009.

, The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.29, pp.10730-10740

N. Neyroud, F. Tesson, I. Denjoy, M. Leibovici, C. Donger et al., A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and LangeNielsen cardioauditory syndrome, Nature genetics, vol.15, pp.186-189, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02330097

H. B. Ngo, J. T. Kaiser, C. , D. C. Noda, A. Ning et al., The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nature structural & molecular biology 18, 1290, Experimental cell research, vol.211, pp.90-98, 1994.

D. M. Noll, T. M. Mason, and P. S. Miller, Formation and Repair of Interstrand Cross-Links in DNA, Chemical Reviews, vol.106, p.277, 2006.

R. Nouvian, D. Beutner, T. D. Parsons, and T. Moser, Structure and function of the hair cell ribbon synapse, The Journal of membrane biology, vol.209, pp.153-165, 2006.

M. O'driscoll, V. L. Ruiz-perez, C. G. Woods, P. A. Jeggo, and J. A. Goodship, A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome, Nature genetics, vol.33, pp.497-501, 2003.

M. Ober and S. J. Lippard, A 1,2-d(GpG) Cisplatin Intrastrand Cross-Link Influences the Rotational and Translational Setting of DNA in Nucleosomes, Journal of the American Chemical Society, vol.130, p.2851, 2008.

E. Oda, R. Ohki, H. Murasawa, J. Nemoto, T. Shibue et al., Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis, Science, vol.288, pp.1053-1058, 2000.

H. Offer, N. Erez, I. Zurer, X. Tang, M. Milyavsky et al., The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA, Carcinogenesis, vol.23, pp.1025-1032, 2002.

G. S. Oh, H. J. Kim, J. H. Choi, A. Shen, C. H. Kim et al., Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice, Journal of immunology, vol.186, pp.1140-1150, 2011.

D. Oliver, N. Klocker, J. Schuck, T. Baukrowitz, J. P. Ruppersberg et al., Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells, Neuron, vol.26, pp.595-601, 2000.

N. Pabla, S. Huang, Q. Mi, R. Daniel, Z. Dong et al., ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis, The Journal of biological chemistry, vol.283, pp.6572-6583, 2008.

T. Pankotai, A. S. Hoffbeck, C. Boumendil, and E. Soutoglou, DNA damage response in the absence of DNA lesions continued, Cell Cycle, vol.8, pp.4025-4026, 2009.

E. R. Parrilla-castellar, S. J. Arlander, and L. Karnitz, Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex, DNA repair, vol.3, pp.1009-1014, 2004.

T. D. Parsons, D. Lenzi, W. Almers, and W. M. Roberts, Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: capacitance measurements in saccular hair cells, Neuron, vol.13, pp.875-883, 1994.

A. G. Paulovich, C. D. Armour, and L. H. Hartwell, The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage, Genetics, vol.150, pp.75-93, 1998.

Y. Pereg, D. Shkedy, P. D. Graaf, E. Meulmeester, M. Edelson-averbukh et al., Phosphorylation of Hdmx mediates its Hdm2-and ATM-dependent degradation in response to DNA damage, Proceedings of the National Academy of Sciences of the United States of America, vol.102, p.5056, 2005.

F. Perrone, P. Bossi, B. Cortelazzi, L. Locati, P. Quattrone et al., TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.28, pp.761-766, 2010.

J. H. Petrini and T. H. Stracker, The cellular response to DNA double-strand breaks: defining the sensors and mediators, Trends Cell Biol, vol.13, pp.458-462, 2003.

P. Pichierri and F. Rosselli, The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways, EMBO J, vol.23, pp.1178-1187, 2004.

M. Piechota, P. Sunderland, A. Wysocka, M. Nalberczak, M. A. Sliwinska et al., Is senescence-associated beta-galactosidase a marker of neuronal senescence, Oncotarget, vol.7, pp.81099-81109, 2016.

J. Platzer, J. Engel, A. Schrott-fischer, K. Stephan, S. Bova et al., , 2000.

, Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels, Cell, vol.102, pp.89-97

J. L. Podratz, A. M. Knight, L. E. Ta, N. P. Staff, J. M. Gass et al., Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons, Neurobiol Dis, vol.41, pp.661-668, 2011.

K. Polyak, I. Haviv, and I. G. Campbell, Co-evolution of tumor cells and their microenvironment, Trends in genetics : TIG, vol.25, pp.30-38, 2009.

T. V. Pospelova, Z. N. Demidenko, E. I. Bukreeva, V. A. Pospelov, A. V. Gudkov et al., Pseudo-DNA damage response in senescent cells, Cell Cycle, vol.8, pp.4112-4118, 2009.

S. Pospisilova, C. Siligan, J. Ban, G. Jug, and H. Kovar, Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y, Mol Cancer Res, vol.2, pp.296-304, 2004.

J. L. Puel, Chemical synaptic transmission in the cochlea, Progress in neurobiology, vol.47, pp.449-476, 1995.

J. L. Puel, R. P. Bobbin, F. , and M. , An ipsilateral cochlear efferent loop protects the cochlea during intense sound exposure, Hearing research, vol.37, pp.65-69, 1988.

J. L. Puel and G. Rebillard, Effect of contralateral sound stimulation on the distortion product 2F1-F2: evidence that the medial efferent system is involved, The Journal of the Acoustical Society of America, vol.87, pp.1630-1635, 1990.

M. R. Puumalainen, D. Lessel, P. Ruthemann, N. Kaczmarek, K. Bachmann et al., Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity, Nature communications, vol.5, p.3695, 2014.

J. Raber, M. J. Davis, T. Pfankuch, R. Rosenthal, S. R. Doctrow et al., Mitigating effect of EUK-207 on radiation-induced cognitive impairments, Behavioural brain research, vol.320, pp.457-463, 2017.

C. A. Rabik and M. E. Dolan, Molecular mechanisms of resistance and toxicity associated with platinating agents, Cancer Treat Rev, vol.33, pp.9-23, 2007.

K. S. Rao, Genomic Damage and Its Repair in Young and Aging Brain, Molecular Neurobiology, vol.7, pp.1637-1650, 1993.

I. Rappold, K. Iwabuchi, T. Date, C. , and J. , Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways, J Cell Biol, vol.153, pp.613-620, 2001.

I. Rappold, K. Iwabuchi, T. Date, C. , and J. , Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA DamageSignaling Pathways, The Journal of cell biology, vol.153, p.613, 2001.

C. Redon, D. Pilch, E. Rogakou, O. Sedelnikova, K. Newrock et al., Histone H2A variants H2AX and H2AZ. Current opinion in genetics & development, vol.12, pp.162-169, 2002.

G. Reifenberger, T. Weber, R. G. Weber, M. Wolter, A. Brandis et al., Chordoid glioma of the third ventricle: immunohistochemical and molecular genetic characterization of a novel tumor entity, Brain pathology, vol.9, pp.617-626, 1999.

E. Riballo, M. Kühne, N. Rief, A. Doherty, G. C. Smith et al., A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and -H2AX Foci, Molecular Cell, vol.16, p.715, 2004.

W. M. Roberts, R. A. Jacobs, and A. J. Hudspeth, Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.10, pp.3664-3684, 1990.

D. Robertson, Functional significance of dendritic swelling after loud sounds in the guinea pig cochlea, Hearing research, vol.9, pp.263-278, 1983.

D. Robertson, Horseradish peroxidase injection of physiologically characterized afferent and efferent neurones in the guinea pig spiral ganglion, Hearing research, vol.15, pp.113-121, 1984.

S. J. Robles and G. R. Adami, Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts, Oncogene, vol.16, pp.1113-1123, 1998.

E. P. Rogakou, C. Boon, C. Redon, and W. M. Bonner, Megabase chromatin domains involved in DNA double-strand breaks in vivo, J Cell Biol, vol.146, pp.905-916, 1999.

E. P. Rogakou, D. R. Pilch, A. H. Orr, V. S. Ivanova, and W. M. Bonner, DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139, The Journal of biological chemistry, vol.273, pp.5858-5868, 1998.

I. B. Roninson, E. V. Broude, C. , and B. D. , If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, vol.4, pp.303-313, 2001.

R. A. Rosenthal, B. Fish, R. P. Hill, K. D. Huffman, Z. Lazarova et al., Salen Mn complexes mitigate radiation injury in normal tissues, Anticancer Agents Med Chem, vol.11, pp.359-372, 2011.

J. Ruel, R. P. Bobbin, D. Vidal, R. Pujol, and J. L. Puel, The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea, Neuropharmacology, vol.39, pp.1959-1973, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00267756

J. Ruel, C. Chen, R. Pujol, R. P. Bobbin, and J. L. Puel, AMPA-preferring glutamate receptors in cochlear physiology of adult guinea-pig, The Journal of physiology, vol.518, pp.667-680, 1999.
URL : https://hal.archives-ouvertes.fr/inserm-00267753

S. J. Ryu, Y. S. Oh, and S. C. Park, Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts, Cell Death Differ, vol.14, pp.1020-1028, 2007.

Y. Saka and M. Yanagida, Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+, Cell, vol.74, pp.383-393, 1993.

M. Sakagami, K. Fukazawa, T. Matsunaga, H. Fujita, N. Mori et al., Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation, Hearing research, vol.56, pp.168-172, 1991.

L. Schneider, M. Fumagalli, and F. Di-fagagna, Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency, Cell Death Differ, vol.19, pp.582-591, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00686078

L. Schneider, M. Fumagalli, and F. D. Fagagna, Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency, Presbycusis. The Laryngoscope, vol.19, pp.402-419, 1955.
URL : https://hal.archives-ouvertes.fr/hal-00686078

H. F. Schuknecht, Further Observations on the Pathology of Presbycusis, Archives of otolaryngology, vol.80, pp.369-382, 1964.

H. F. Schuknecht and M. R. Gacek, Cochlear pathology in presbycusis. The Annals of otology, rhinology, and laryngology, vol.102, pp.1-16, 1993.

B. A. Schulte and R. A. Schmiedt, Lateral wall Na,K-ATPase and endocochlear potentials decline with age in quiet-reared gerbils, Hearing research, vol.61, pp.35-46, 1992.

L. B. Schultz, N. H. Chehab, A. Malikzay, and T. D. Halazonetis, p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks, J Cell Biol, vol.151, pp.1381-1390, 2000.

J. T. Sczepanski, A. C. Jacobs, B. V. Houten, and M. M. Greenberg, Double Strand Break Formation During Nucleotide Excision Repair of a DNA Interstrand Cross-link, Biochemistry, vol.48, p.7565, 2010.

C. Sebastian and R. Mostoslavsky, SIRT3 in calorie restriction: can you hear me now?, Cell, vol.143, pp.667-668, 2010.

O. A. Sedelnikova, E. P. Rogakou, I. G. Panyutin, and W. M. Bonner, Quantitative detection of, 2002.

, IdU-induced DNA double-strand breaks with gamma-H2AX antibody, Radiation research, vol.158, pp.486-492

A. Seluanov, V. Gorbunova, A. Falcovitz, A. Sigal, M. Milyavsky et al., Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53, Molecular and cellular biology, vol.21, pp.1552-1564, 2001.

S. Sengupta and C. C. Harris, p53: traffic cop at the crossroads of DNA repair and recombination, Nat Rev Mol Cell Biol, vol.6, pp.44-55, 2005.

S. Shieh, J. Ahn, K. Tamai, Y. Taya, and C. Prives, The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites, Genes & Development, vol.14, p.289, 2000.

S. Shieh, M. Ikeda, Y. Taya, and C. Prives, DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2, Cell, vol.91, p.325, 1997.

Y. Shiloh, ATM and related protein kinases: safeguarding genome integrity, Nat Rev Cancer, vol.3, pp.155-168, 2003.

H. Shimokata, A. , and F. , , 2008.

, Nihon Ronen Igakkai zasshi Japanese journal of geriatrics, vol.45, pp.563-572

T. Shinozaki, A. Nota, Y. Taya, and K. Okamoto, Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export, Oncogene, vol.22, p.8870, 2003.

Y. Shiomi, A. Shinozaki, D. Nakada, K. Sugimoto, J. Usukura et al., Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC, Genes to cells : devoted to molecular & cellular mechanisms, vol.7, pp.861-868, 2002.

N. Shrivastav, D. Li, M. Essigmann, and J. , Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation, Carcinogenesis, vol.31, p.59, 2010.

N. Shtraizent, H. Matsui, A. Polotskaia, and J. Bargonetti, Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient, Int J Environ Res Public Health, vol.13, p.13010022, 2016.

Z. H. Siddik, Cisplatin: mode of cytotoxic action and molecular basis of resistance, Oncogene, vol.22, pp.7265-7279, 2003.

M. O. Sikpi, Y. Wang, and S. M. Mallya, Defective modulation of double-strand break repair in ataxia telangiectasia cells by gamma radiation, Radiation research, vol.150, pp.627-635, 1998.

J. Smith, L. M. Tho, N. Xu, and D. A. Gillespie, The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer, Adv Cancer Res, vol.108, pp.73-112, 2010.

S. Someya, J. Xu, K. Kondo, D. Ding, R. J. Salvi et al., Age-related hearing loss in C57BL/6J mice is mediated by Bakdependent mitochondrial apoptosis, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.19432-19437, 2009.

S. Someya, T. Yamasoba, R. Weindruch, T. A. Prolla, and M. Tanokura, Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis, Neurobiology of aging, vol.28, pp.1613-1622, 2007.

S. Someya, W. Yu, W. C. Hallows, J. Xu, J. M. Vann et al., Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction, Cell, vol.143, pp.802-812, 2010.

O. Sordet, C. E. Redon, J. Guirouilh-barbat, S. Smith, S. Solier et al., Ataxia telangiectasia mutated activation by transcription-and topoisomerase Iinduced DNA double-strand breaks, EMBO reports, vol.10, p.887, 2009.

O. Sordet, C. E. Redon, J. Guirouilh-barbat, S. Smith, S. Solier et al., Ataxia telangiectasia mutated activation by transcription-and topoisomerase Iinduced DNA double-strand breaks, EMBO Rep, vol.10, pp.887-893, 2009.

T. Soussi, C. Ishioka, M. Claustres, and C. Béroud, Locus-specific mutation databases: pitfalls and good practice based on the p53 experience, Nature reviews Cancer, vol.6, p.83, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00018573

T. Soussi and K. G. Wiman, Shaping genetic alterations in human cancer: the p53 mutation paradigm, Cancer Cell, vol.12, pp.303-312, 2007.

N. C. Souza-pinto, D. M. Wilson, T. V. Stevnsner, and V. A. Bohr, Mitochondrial DNA, base excision repair and neurodegeneration, DNA Repair (Amst), vol.7, p.1098, 2008.

A. Spector, Oxidative stress-induced cataract: mechanism of action, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.9, pp.1173-1182, 1995.

H. Spoendlin, Innervation patterns in the organ of corti of the cat, Acta oto-laryngologica, vol.67, pp.239-254, 1969.

H. Spoendlin, Innervation densities of the cochlea, Acta oto-laryngologica, vol.73, pp.235-248, 1972.

H. Spoendlin and J. P. Brun, Relation of structural damage to exposure time and intensity in acoustic trauma, Acta oto-laryngologica, vol.75, pp.220-226, 1973.

M. Spoor, A. P. Nagtegaal, Y. Ridwan, N. Z. Borgesius, B. Van-alphen et al., Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse, Mechanisms of ageing and development, vol.133, pp.59-67, 2012.

J. A. Sprowl, C. S. Lancaster, N. Pabla, E. Hermann, A. M. Kosloske et al., Cisplatin-induced renal injury is independently mediated by OCT2 and p53, Clin Cancer Res, vol.20, pp.4026-4035, 2014.

N. Srivastava, S. Gochhait, P. De-boer, and R. N. Bamezai, Role of H2AX in DNA damage response and human cancers, Mutat Res, vol.681, pp.180-188, 2009.

C. Stevens, L. Smith, and N. B. Thangue, Chk2 activates E2F-1 in response to DNA damage, Nature Cell Biology, vol.5, p.401, 2003.

G. S. Stewart, B. Wang, C. R. Bignell, A. M. Taylor, and S. J. Elledge, MDC1 is a mediator of the mammalian DNA damage checkpoint, Nature, vol.421, pp.961-966, 2003.

T. Stiff, M. O'driscoll, N. Rief, K. Iwabuchi, M. Lobrich et al., Mismatch repairdependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase, Genes & development, vol.64, pp.1331-1344, 2004.

S. Sugiura, Y. Uchida, T. Nakashima, F. Ando, and H. Shimokata, The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elderly, Acta oto-laryngologica, vol.130, pp.487-492, 2010.

X. Sui, W. Han, and H. Pan, p53-induced autophagy and senescence, Oncotarget, vol.6, pp.11723-11724, 2015.

F. W. Summerfield, A. L. Tappel, Y. Sun, Y. Xu, K. Roy et al., Detection and measurement by high-performance liquid chromatography of malondialdehyde crosslinks in DNA, Molecular and cellular biology, vol.143, pp.8502-8509, 1984.

F. W. Sunderman, . Jr, A. Marzouk, S. M. Hopfer, O. Zaharia et al., Increased lipid peroxidation in tissues of nickel chloride-treated rats, Ann Clin Lab Sci, vol.15, pp.229-236, 1985.

R. J. Sweet, J. M. Price, and K. R. Henry, Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA/J mouse, Audiology : official organ of the International Society of Audiology, vol.27, pp.305-312, 1988.

H. Takai, K. Naka, Y. Okada, M. Watanabe, N. Harada et al., Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription, The EMBO journal, vol.21, p.5195, 2002.

Y. Takeishi, E. Ohashi, K. Ogawa, H. Masai, C. Obuse et al., Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1, Genes to cells : devoted to molecular & cellular mechanisms, vol.15, pp.761-771, 2010.

R. A. Tange and V. D. Vuzevski, Changes in the stria vascularis of the guinea pig due to cis-platinum, Archives of oto-rhino-laryngology, vol.239, pp.41-47, 1984.

E. Tavanai and G. Mohammadkhani, Role of antioxidants in prevention of age-related hearing loss: a review of literature, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies, vol.274, pp.1821-1834, 2017.

F. Teyssier, J. O. Bay, C. Dionet, and P. Verrelle, Bulletin du cancer, vol.86, pp.345-357, 1999.

T. Tezil and H. Basaga, Modulation of Cell Death in Age-Related Diseases, Curr Pharm Des, 2013.

J. P. Thomas, J. Lautermann, B. Liedert, F. Seiler, and J. Thomale, High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity, Molecular pharmacology, vol.70, pp.23-29, 2006.

A. Tinel and J. Tschopp, The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress, Science, vol.304, pp.843-846, 2004.

N. Tsukasaki, C. A. Whitworth, and L. P. Rybak, Acute changes in cochlear potentials due to cisplatin, Hearing research, vol.149, pp.189-198, 2000.

T. Tucker and R. Fettiplace, Confocal imaging of calcium microdomains and calcium extrusion in turtle hair cells, Neuron, vol.15, pp.1323-1335, 1995.

M. J. Tunstall, J. E. Gale, and J. F. Ashmore, Action of salicylate on membrane capacitance of outer hair cells from the guinea-pig cochlea, The Journal of Physiology, vol.485, p.739, 1995.

N. Turner, A. Tutt, and A. Ashworth, Hallmarks of 'BRCAness' in sporadic cancers, Nat Rev Cancer, vol.4, pp.814-819, 2004.

Y. Uchida, S. Sugiura, F. Ando, T. Nakashima, and H. Shimokata, Molecular genetic epidemiology of age-related hearing impairment, Auris, nasus, larynx, vol.38, pp.657-665, 2011.

Y. Uchida, S. Sugiura, T. Nakashima, F. Ando, and H. Shimokata, Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese, The Laryngoscope, vol.119, pp.938-943, 2009.

K. Uto, D. Inoue, K. Shimuta, N. Nakajo, and N. Sagata, Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism, EMBO J, vol.23, pp.3386-3396, 2004.

T. Uziel, Y. Lerenthal, L. Moyal, Y. Andegeko, L. Mittelman et al., Requirement of the MRN complex for ATM activation by DNA damage, EMBO J, vol.22, pp.5612-5621, 2003.

M. W. Van-ruijven, J. C. De-groot, F. Hendriksen, and G. F. Smoorenburg, Immunohistochemical detection of platinated DNA in the cochlea of cisplatin-treated guinea pigs, Hearing research, vol.203, pp.112-121, 2005.

P. B. Vermeulen, G. Gasparini, S. B. Fox, C. Colpaert, L. P. Marson et al., Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours, European journal of cancer, vol.38, pp.1564-1579, 2002.

D. E. Vetter, J. R. Mann, P. Wangemann, J. Liu, K. J. Mclaughlin et al., Inner ear defects induced by null mutation of the isk gene, Neuron, vol.17, pp.1251-1264, 1996.

L. M. Viana, M. Seyyedi, C. C. Brewer, C. Zalewski, J. J. Digiovanna et al., Histopathology of the inner ear in patients with xeroderma pigmentosum and neurologic degeneration, Otol Neurotol, vol.34, pp.1230-1236, 2013.

A. Villunger, E. M. Michalak, L. Coultas, F. Mullauer, G. Bock et al., p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa, Science, vol.302, pp.1036-1038, 2003.

B. Vogelstein, D. Lane, and A. J. Levine, Surfing the p53 network, Nature, vol.408, p.307, 2000.

V. Voitkun and A. Zhitkovich, Analysis of DNA-protein crosslinking activity of malondialdehyde in vitro, Mutation research, vol.424, pp.779-783, 1956.

G. Von-bekesy, Travelling waves as frequency analysers in the cochlea, Nature, vol.225, pp.1207-1209, 1970.

S. M. Vos, E. M. Tretter, B. H. Schmidt, and J. M. Berger, All tangled up: how cells direct, manage and exploit topoisomerase function, Nature reviews Molecular cell biology, vol.12, p.827, 2011.

B. Wang, S. Matsuoka, P. B. Carpenter, and S. J. Elledge, 53BP1, a mediator of the DNA damage checkpoint, Science, vol.298, pp.1435-1438, 2002.

D. Wang and S. J. Lippard, Cellular processing of platinum anticancer drugs, Nature reviews Drug discovery, vol.4, pp.307-320, 2005.

E. Wang, Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved, Cancer research, vol.55, pp.2284-2292, 1995.

J. Wang, C. L. Clauson, P. D. Robbins, L. J. Niedernhofer, W. et al., The oxidative DNA lesions 8,5¢-cyclopurines accumulate with aging in a tissue-specific manner, Aging Cell, vol.11, p.714, 2012.

J. Wang, S. Ladrech, R. Pujol, P. Brabet, T. R. Van-de-water et al., Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss, Cancer research, vol.64, pp.9217-9224, 2004.

J. Wang, R. V. Lloyd-faulconbridge, A. Fetoni, M. J. Guitton, R. Pujol et al., Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig, Neuropharmacology, vol.45, pp.380-393, 2003.

J. Wang, J. Ruel, S. Ladrech, C. Bonny, T. R. Van-de-water et al., Inhibition of the c-Jun Nterminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals, Molecular pharmacology, vol.71, pp.654-666, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00145399

J. Wang, T. R. Van-de-water, C. Bonny, F. De-ribaupierre, J. L. Puel et al., A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, pp.8596-8607, 2003.

I. M. Ward, C. , and J. , Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress, The Journal of biological chemistry, vol.276, pp.47759-47762, 2001.

I. M. Ward, K. Minn, J. V. Deursen, C. , J. Ward et al., Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX, The Journal of biological chemistry, vol.23, pp.19579-19582, 2003.

I. M. Ward, K. Minn, J. Van-deursen, C. , and J. , p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice, Molecular and cellular biology, vol.23, pp.2556-2563, 2003.

C. J. Weisz, M. Lehar, H. Hiel, E. Glowatzki, and P. A. Fuchs, Synaptic transfer from outer hair cells to type II afferent fibers in the rat cochlea, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.32, pp.9528-9536, 2012.

E. White, Autophagy and p53. Cold Spring Harbor perspectives in medicine 6, 2016.

D. R. Williams, K. Lee, J. Shi, D. J. Chen, and P. L. Stewart, Cryo-EM structure of the DNAdependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding, Structure, vol.16, p.468, 2008.

D. M. Wilson and V. A. Bohr, The mechanics of base excision repair, and its relationship to aging and disease, DNA Repair (Amst), vol.6, p.544, 2007.

D. Woods and J. J. Turchi, Chemotherapy induced DNA damage response: convergence of drugs and pathways, Cancer Biol Ther, vol.14, pp.379-389, 2013.

Z. Wu, Y. Shi, R. S. Tibbetts, and S. Miyamoto, Molecular Linkage Between the Kinase ATM and NF-Response to Genotoxic Stimuli, Science, vol.311, p.1141, 2006.

A. G. Yakovlev, S. Di-giovanni, G. Wang, W. Liu, B. Stoica et al., BOK and NOXA are essential mediators of p53-dependent apoptosis, The Journal of biological chemistry, vol.279, pp.28367-28374, 2004.

K. Yamane, X. Wu, C. , and J. , A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival, Molecular and cellular biology, vol.22, pp.555-566, 2002.

T. Yamasoba, F. R. Lin, S. Someya, A. Kashio, T. Sakamoto et al., Current concepts in agerelated hearing loss: epidemiology and mechanistic pathways, Hearing research, vol.303, pp.30-38, 2013.

T. Yamasoba, A. L. Nuttall, C. Harris, Y. Raphael, and J. M. Miller, Role of glutathione in protection against noise-induced hearing loss, Brain research, vol.784, pp.82-90, 1998.

A. Yancey, M. S. Harris, A. Egbelakin, J. Gilbert, D. B. Pisoni et al., Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients, Pediatric blood & cancer, vol.59, pp.144-148, 2012.

S. Yang, C. Kuo, J. E. Bisi, and M. K. Kim, PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2, Nature Cell Biology, vol.4, p.865, 2002.

H. Yasuda, K. Kamide, S. Takiuchi, T. Matayoshi, H. Hanada et al., Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension, Journal of human hypertension, vol.21, pp.883-892, 2007.

Y. Ying and B. J. Padanilam, Regulation of necrotic cell death: p53, PARP1 and cyclophilin Doverlapping pathways of regulated necrosis?, Cell Mol Life Sci, vol.73, pp.2309-2324, 2016.

J. L. Yu, B. L. Coomber, and R. S. Kerbel, A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance, Differentiation, vol.70, pp.599-609, 2002.

X. Yu, C. C. Chini, M. He, G. Mer, C. et al., The BRCT domain is a phospho-protein binding domain, Science, vol.302, pp.639-642, 2003.

Y. Yu, B. L. Mahaney, K. Yano, R. Ye, S. Fang et al., , 2008.

, DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks, DNA Repair (Amst), vol.7, p.1680

W. A. Yuhas and P. A. Fuchs, Apamin-sensitive, small-conductance, calcium-activated potassium channels mediate cholinergic inhibition of chick auditory hair cells, Journal of comparative physiology A, Sensory, neural, and behavioral physiology, vol.185, pp.455-462, 1999.

D. Zenisek, V. Davila, L. Wan, A. , and W. , Imaging calcium entry sites and ribbon structures in two presynaptic cells, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, pp.2538-2548, 2003.

H. Zhang, H. Wang, B. Lai, C. Zhang, Y. et al., , 2003.

, Zhongguo Fei Ai Za Zhi, vol.6, pp.172-175

L. Zhang, Q. Li, L. T. Wolff, G. E. Antonio, D. K. Yeung et al., Changes of brain activity in the aged SAMP mouse, Biogerontology, vol.8, pp.81-88, 2007.

M. Zhang, W. Liu, D. Ding, and R. Salvi, Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis, Neuroscience, vol.120, pp.191-205, 2003.

H. Zhao and J. Santos-sacchi, Auditory collusion and a coupled couple of outer hair cells, Nature, vol.399, p.359, 1999.

H. Zhao and H. Piwnica-worms, ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1, Molecular and Cellular Biology, vol.21, p.4129, 2001.

H. Zhao, J. L. Watkins, and H. Piwnica-worms, Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.14795-14800, 2002.

J. Zheng, W. Shen, D. Z. He, K. B. Long, L. D. Madison et al., Prestin is the motor protein of cochlear outer hair cells, Nature, vol.405, p.149, 2000.

Y. Zheng, Y. Liu, J. Ge, X. Wang, L. Liu et al., Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression, Mol Vis, vol.16, pp.1467-1474, 2010.

Y. Zhong, Y. J. Hu, B. Chen, W. Peng, Y. Sun et al., Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging, The FEBS journal, vol.278, pp.2500-2510, 2011.

J. Zhou, J. Ahn, S. H. Wilson, and C. Prives, A role for p53 in base excision repair, EMBO J, vol.20, pp.914-923, 2001.

Z. Zhoua, C. Bruhna, Z. Wang, C. Zhu, M. A. Bogue et al., Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates, Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway, vol.11, 1996.

L. Zou and S. J. Elledge, Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes, Science, vol.300, pp.1542-1548, 2003.

, The salaries of Nesrine Benkafadar and Julien Menardo were supported by the Fondation de l'Avenir and the French Ministry of Research and Technology, respectively. The manuscript has been revised by an independent scien-. JW performed SEM evaluations and JB carried out quantification analysis, l'Avenir (Et2-675) INSERM (ENV201508) and the Fondation Gueules Cassées

W. H. Ang, M. Myint, and S. J. Lippard, Transcription inhibition by platinum-DNA cross-links in live mammalian cells, J Am Chem Soc, vol.132, pp.7429-7435, 2010.

M. Anniko and A. Sobin, Cisplatin: evaluation of its ototoxic potential, Am J Otolaryngol, vol.7, pp.276-293, 1986.

J. Bar, N. Moskovits, and M. Oren, Involvement of stromal p53 in tumorstroma interactions, Semin Cell Dev Biol, vol.21, pp.47-54, 2010.

C. H. Bassing, K. F. Chua, J. Sekiguchi, H. Suh, S. R. Whitlow et al., Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX, Proc Natl Acad Sci, vol.99, pp.8173-8178, 2002.

P. Bertheau, E. Turpin, D. S. Rickman, M. Espie, A. De-reynies et al., Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen, PLoS Med, vol.4, p.90, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00700961

W. M. Bonner, C. E. Redon, J. S. Dickey, A. J. Nakamura, O. A. Sedelnikova et al., GammaH2AX and cancer, Nat Rev Cancer, vol.8, pp.957-967, 2008.

A. Bozzato, V. Bozzato, A. Kadah, B. Schick, and B. , A novel multipurpose modular mini-endoscope for otology, Eur Arch Otorhinolaryngol, vol.271, pp.3341-3348, 2014.

T. Browder, C. E. Butterfield, B. M. Kraling, B. Shi, B. Marshall et al., Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer, Cancer Res, vol.60, pp.1878-1886, 2000.

F. Bunz, P. M. Hwang, C. Torrance, T. Waldman, Y. Zhang et al., Disruption of p53 in human cancer cells alters the responses to therapeutic agents, J Clin Invest, vol.104, pp.263-269, 1999.

L. G. Burdelya, E. A. Komarova, J. E. Hill, T. Browder, N. D. Tararova et al., Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice, Cancer Res, vol.66, pp.9356-9361, 2006.

Y. Cao and D. J. Klionsky, Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein, Cell Res, vol.17, pp.839-849, 2007.

A. Celeste, S. Petersen, P. J. Romanienko, O. Fernandez-capetillo, H. T. Chen et al., Genomic instability in mice lacking histone H2AX, Science, vol.296, pp.922-927, 2002.

H. Chaachouay, P. Ohneseit, M. Toulany, R. Kehlbach, G. Multhoff et al., Autophagy contributes to resistance of tumor cells to ionizing radiation, Radiother Oncol, vol.99, pp.287-292, 2011.

M. J. Chong, M. R. Murray, E. C. Gosink, H. R. Russell, A. Srinivasan et al., Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system, Proc Natl Acad Sci, vol.97, pp.889-894, 2000.

A. Ciccia and S. J. Elledge, The DNA damage response: making it safe to play with knives, Mol Cell, vol.40, pp.179-204, 2010.

D. Micco, R. Cicalese, A. Fumagalli, M. Dobreva, M. Verrecchia et al., di fibroblasts undergoing replicative senescence and following spontaneous immortalization, Cell Cycle, vol.7, pp.3601-3606

N. El-kechai, F. Agnely, E. Mamelle, Y. Nguyen, E. Ferrary et al., Recent advances in local drug delivery to the inner ear, Int J Pharm, vol.494, pp.83-101, 2015.

R. J. Fram, Cisplatin and platinum analogues: recent advances, Curr Opin Oncol, vol.4, pp.1073-1079, 1992.

A. Guan, H. Gong, Y. Ye, J. Jia, G. Zhang et al., Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis, PLoS ONE, vol.8, p.76529, 2013.

X. L. Guo, F. Hu, S. S. Zhang, Q. D. Zhao, C. Zong et al., Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy, 2014.

, Cancer Lett, vol.346, pp.278-284

L. Harhaji-trajkovic, U. Vilimanovich, T. Kravic-stevovic, V. Bumbasirevic, and V. Trajkovic, AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells, J Cell Mol Med, vol.13, pp.3644-3654, 2009.

J. T. Hartmann and H. P. Lipp, Toxicity of platinum compounds, Expert Opin Pharmacother, vol.4, pp.889-901, 2003.

B. A. Henry, C. M. Mckay, H. J. Mcdermott, and G. M. Clark, The relationship between speech perception and electrode discrimination in cochlear implantees, J Acoust Soc Am, vol.108, pp.1269-1280, 2000.

T. Jacks, R. L. Williams, B. O. Schmitt, E. M. Halachmi, S. Bronson et al., Tumor spectrum analysis in p53-mutant mice, Curr Biol, vol.4, pp.1-7, 1994.

J. G. Jackson, V. Pant, Q. Li, L. L. Chang, A. Quintas-cardama et al., -mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer, Cancer Cell, vol.21, pp.793-806, 2012.

S. Jager, C. Bucci, I. Tanida, T. Ueno, E. Kominami et al., Role for Rab7 in maturation of late autophagic vacuoles, J Cell Sci, vol.117, pp.4837-4848, 2004.

H. Jia, F. Francois, J. Bourien, M. Eybalin, R. V. Lloyd et al., Prevention of trauma-induced cochlear fibrosis using intracochlear application of anti-inflammatory and antiproliferative drugs, Neuroscience, vol.316, pp.261-278, 2016.

M. Jiang, X. Yi, S. Hsu, C. Y. Wang, and Z. Dong, Role of p53 in cisplatininduced tubular cell apoptosis: dependence on p53 transcriptional activity, 2004.

, Am J Physiol Renal Physiol, vol.287, pp.1140-1147

Y. Jung and S. J. Lippard, Nature of full-length HMGB1 binding to cisplatinmodified DNA, Biochemistry, vol.42, pp.2664-2671, 2003.

F. Klemm and J. A. Joyce, Microenvironmental regulation of therapeutic response in cancer, Trends Cell Biol, vol.25, pp.198-213, 2015.

P. A. Knobel, I. N. Kotov, E. Felley-bosco, R. A. Stahel, and T. M. Marti, Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells, Neoplasia, vol.13, pp.961-970, 2011.

E. A. Komarova, R. V. Kondratov, K. Wang, K. Christov, T. V. Golovkina et al., Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice, Oncogene, vol.23, pp.3265-3271, 2004.

S. Ladrech, J. Wang, L. Simonneau, J. L. Puel, and M. Lenoir, Macrophage contribution to the response of the rat organ of Corti to amikacin, J Neurosci Res, vol.85, pp.1970-1979, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00145381

T. Langer, A. Zehnhoff-dinnesen, A. Radtke, S. Meitert, J. Zolk et al., Understanding platinum-induced ototoxicity, Trends Pharmacol Sci, vol.34, pp.458-469, 2013.

Y. Lee and P. J. Mckinnon, ATM dependent apoptosis in the nervous system, Apoptosis, vol.5, pp.523-529, 2000.

P. Liu, B. Xu, T. A. Cavalieri, and C. E. Hock, Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats, Shock, vol.26, pp.608-614, 2006.

C. X. Ma, J. W. Janetka, and H. Piwnica-worms, Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics, Trends Mol Med, vol.17, pp.88-96, 2011.

E. Marangoni, A. Vincent-salomon, N. Auger, and A. Degeorges,

P. Cremoux, L. De-plater, C. Guyader, D. Pinieux, G. Judde et al., A new model of patient tumor-derived breast cancer xenografts for preclinical assays, Clin Cancer Res, vol.13, pp.3989-3998, 2007.

M. C. Marazita, M. F. Ogara, S. V. Sonzogni, M. Marti, N. J. Dusetti et al., CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response, PLoS ONE, vol.7, p.35638, 2012.

B. Martin-castillo, E. Lopez-bonet, M. Buxo, J. Dorca, F. Tuca-rodriguez et al., Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumabresistant basal-HER2 subtype of breast cancer, Oncotarget, vol.6, pp.7104-7122, 2015.

L. T. Mikalsen, H. P. Dhakal, O. S. Bruland, B. Naume, E. Borgen et al., The clinical impact of mean vessel size and solidity in breast carcinoma patients, PLoS ONE, vol.8, p.75954, 2013.

E. Morselli, E. Tasdemir, M. C. Maiuri, L. Galluzzi, O. Kepp et al., Mutant p53 protein localized in the cytoplasm inhibits autophagy, Cell Cycle, vol.7, pp.3056-3061, 2008.

M. Muller, K. Von-hunerbein, S. Hoidis, and J. W. Smolders, A physiological placefrequency map of the cochlea in the CBA/J mouse, Hear Res, vol.202, pp.63-73, 2005.

H. Offer, N. Erez, I. Zurer, X. Tang, M. Milyavsky et al., The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA, Carcinogenesis, vol.23, pp.1025-1032, 2002.

G. S. Oh, H. J. Kim, J. H. Choi, A. Shen, C. H. Kim et al., Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice, J Immunol, vol.186, pp.1140-1150, 2011.

N. Pabla, S. Huang, Q. S. Mi, R. Daniel, and Z. Dong, ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin, 2008.

, J Biol Chem, vol.283, pp.6572-6583

F. Perrone, P. Bossi, B. Cortelazzi, L. Locati, P. Quattrone et al., TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma, J Clin Oncol, vol.28, pp.761-766, 2010.

J. L. Podratz, A. M. Knight, L. E. Ta, N. P. Staff, J. M. Gass et al., Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons, Neurobiol Dis, vol.41, pp.661-668, 2011.

K. Polyak, I. Haviv, and I. G. Campbell, Co-evolution of tumor cells and their microenvironment, Trends Genet, vol.25, pp.30-38, 2009.

S. Pospisilova, C. Siligan, J. Ban, G. Jug, and H. Kovar, Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y, Mol Cancer Res, vol.2, pp.296-304, 2004.

C. A. Rabik and M. E. Dolan, Molecular mechanisms of resistance and toxicity associated with platinating agents, Cancer Treat Rev, vol.33, pp.9-23, 2007.

E. Riballo, M. Kuhne, N. Rief, A. Doherty, G. C. Smith et al., A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci, Mol Cell, vol.16, pp.715-724, 2004.

E. P. Rogakou, D. R. Pilch, A. H. Orr, V. S. Ivanova, and W. M. Bonner, DNA doublestranded breaks induce histone H2AX phosphorylation on serine 139, J Biol Chem, vol.273, pp.5858-5868, 1998.

L. B. Schultz, N. H. Chehab, A. Malikzay, and T. D. Halazonetis, binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks, J Cell Biol, vol.151, pp.1381-1390, 2000.

, The Authors EMBO Molecular Medicine, vol.9, issue.1, 2016.

, Nesrine Benkafadar et al PFT-a prevents cisplatin ototoxicity EMBO Molecular Medicine

Y. Shiloh, The ATM-mediated DNA-damage response: taking shape, Trends Biochem Sci, vol.31, pp.402-410, 2006.

N. Shtraizent, H. Matsui, A. Polotskaia, and J. Bargonetti, Hot spot mutation in TP53 (R248Q) causes oncogenic gain-of-function phenotypes in a breast cancer cell line derived from an African American patient, Int J Environ Res Public Health, vol.13, p.22, 2016.

Z. H. Siddik, Cisplatin: mode of cytotoxic action and molecular basis of resistance, Oncogene, vol.22, pp.7265-7279, 2003.

J. Smith, L. M. Tho, N. Xu, and D. A. Gillespie, The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer, Adv Cancer Res, vol.108, pp.73-112, 2010.

T. Soussi and K. G. Wiman, Shaping genetic alterations in human cancer: the p53 mutation paradigm, Cancer Cell, vol.12, pp.303-312, 2007.

J. A. Sprowl, C. S. Lancaster, N. Pabla, E. Hermann, A. M. Kosloske et al., Cisplatin-induced renal injury is independently mediated by OCT2 and p53, Clin Cancer Res, vol.20, pp.4026-4035, 2014.

N. Tsukasaki, C. A. Whitworth, and L. P. Rybak, Acute changes in cochlear potentials due to cisplatin, Hear Res, vol.149, pp.189-198, 2000.

P. B. Vermeulen, G. Gasparini, S. B. Fox, C. Colpaert, L. P. Marson et al., Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours, Eur J Cancer, vol.38, pp.1564-1579, 2002.

J. Wang, L. Faulconbridge, R. V. Fetoni, A. Guitton, M. J. Pujol et al., Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig, Neuropharmacology, vol.45, pp.380-393, 2003.

J. Wang, T. R. Van-de-water, C. Bonny, F. De-ribaupierre, J. L. Puel et al., , 2003.

, A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss, J Neurosci, vol.23, pp.8596-8607

J. Wang, S. Ladrech, R. Pujol, P. Brabet, T. R. Van-de-water et al., Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss, Cancer Res, vol.64, pp.9217-9224, 2004.

D. Wang and S. J. Lippard, Cellular processing of platinum anticancer drugs, Nat Rev Drug Discov, vol.4, pp.307-320, 2005.

D. Woods and J. J. Turchi, Chemotherapy induced DNA damage response: convergence of drugs and pathways, Cancer Biol Ther, vol.14, pp.379-389, 2013.

J. L. Yu, B. L. Coomber, and R. S. Kerbel, A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance, Differentiation, vol.70, pp.599-609, 2002.

M. Zhang, W. Liu, D. Ding, and R. Salvi, Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis, Neuroscience, vol.120, pp.191-205, 2003.

H. Zhao, J. L. Watkins, and H. Piwnica-worms, Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiationinduced S and G2 checkpoints, Proc Natl Acad Sci, vol.99, pp.14795-14800, 2002.

T. Soussi and K. G. Wiman, Shaping genetic alterations in human cancer: the p53 mutation Paradigm, Cancer Cell, vol.12, pp.303-312, 2007.

Y. Shetzer, H. Solomon, G. Koifman, A. Molchadsky, and S. Horesh, The paradigm of mutant p53-expressing cancer stem cells and drug resistance, Carcinogenesis, vol.35, pp.1196-208, 2014.

A. V. Gudkov and E. A. Komarova, The role of p53 in determining sensitivity to radiotherapy, Nat Rev Cancer, vol.3, pp.117-129, 2003.

P. G. Komarov, E. A. Komarova, R. V. Kondratov, K. Christov-tselkov, and J. S. Coon, A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy, Science, vol.285, pp.1733-1737, 1999.

A. V. Gudkov and E. A. Komarova, Prospective therapeutic applications of p53 inhibitors, Biochem Biophys Res Commun, vol.331, pp.726-736, 2005.

E. A. Komarova and A. V. Gudkov, Chemoprotection from p53-dependent apoptosis: A potential Clinical applications of the p53 inhibitors, Biochem Pharmacol, vol.62, pp.657-67, 2001.

M. R. Junttila and G. I. Evan, -A Jack of all trades but master of none, Nat Rev Cancer, vol.9, pp.821-829, 2009.

A. V. Gudkov and E. A. Komarova, against doxorubicin-induced apoptosis and acute cardiotoxicity in mice, Am J Physiol Heart Circ Physiol, vol.2, pp.933-939, 2010.

M. Jiang, X. Yi, S. Hsu, C. Y. Wang, and Z. Dong, Role of p53 in cisplatin-induced tubular cell apoptosis: Dependence on p53 transcriptional activity, Am J Physiol Renal Physiol, vol.287, pp.1140-1147, 2004.

, protects cochlear and vestibular hair cells from cisplatin-induced apoptosis, Neuroscience, vol.120, pp.191-205

A. J. Merritt, C. S. Potten, C. J. Kemp, J. A. Hickman, and A. Balmain, The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of, 2004.

N. Benkafadar, J. Menardo, J. Bourien, R. Nouvian, and F. François, Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01427877

C. S. Ha, J. E. Michalek, R. Elledge, K. R. Kelly, and S. Ganapathy, p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study, Mol Oncol, vol.10, pp.148-56, 2016.

R. M. Kelly, E. M. Goren, P. A. Taylor, S. N. Mueller, and H. E. Stefanski, Shortterm inhibition of p53 combined with keratinocyte growth factor Improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation, Blood, vol.115, pp.1088-1097, 2010.

M. A. Christophorou, I. Ringshausen, A. J. Finch, L. B. Swigart, and G. I. Evan, The pathological response to DNA damage does not contribute to p53-mediated tumour suppression, Nature, vol.443, pp.214-217, 2006.

L. Bassi, M. Carloni, E. Fonti, P. De-la-peña, N. Meschini et al., etoposide (VP16) in human lymphoblastoid cells treated in vitro, Mutat Res, vol.499, pp.163-176, 2002.

K. Krukowski, C. H. Nijboer, X. Huo, A. Kavelaars, and C. J. Heijnen, Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor 19. resistant cancer, Cancer Res, vol.60, pp.1878-1886, 2015.

L. G. Burdelya, E. A. Komarova, J. E. Hill, T. Browder, and N. D. Tararova, ) treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice, Cancer Res, vol.66, pp.9356-9361, 2006.

X. L. Guo, F. Hu, S. S. Zhang, Q. D. Zhao, and C. Zong, Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy, Cancer Lett, vol.346, pp.278-84, 2014.

L. Harhaji-trajkovic, U. Vilimanovich, T. Kravic-stevovic, V. Bumbasirevic, and V. Trajkovic, AMPK-mediated autophagy inhibits apoptosis in cisplatintreated tumour cells, J Cell Mol Med, vol.13, pp.3644-3654, 2009.

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