Nano-objets photo-activés pour le ciblage cellulaire et l’hyperthermie

Abstract : Plasmonic nanoparticles possessinteresting properties thanks to the localizedsurface plasmon resonance. In addition totheir high photothermal conversion efficiency,the heat release confinement can bemodulated by the type of light source used(pulsed or continuous laser). These propertiesmake the plasmonic nanoparticles a potentialsolution for cancer therapy by hyperthermia.In order to develop such a biomedicalapplication, it is necessary to optimize theabsorption of light energy and the targeting ofnanoparticles on the tumor considered.In this thesis, the influence of the photogeneratedhot electrons on the absorption ofultrashort laser pulses by nanoparticles is firststudied. Then, a work carried out withchemists, biologists and physicians for theapplication of gold nanoparticles irradiated byultrashort laser pulses to cancer therapy isdescribed. Finally, we present a preliminarystudy on the photoluminescence of plasmonicnanoparticles, the origin of which is stillcontroversial, by applying a model accountingfor the non-thermal nature of the hot electrondistribution.
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Submitted on : Thursday, February 28, 2019 - 10:13:13 AM
Last modification on : Thursday, April 11, 2019 - 8:04:08 AM
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Xue Hou. Nano-objets photo-activés pour le ciblage cellulaire et l’hyperthermie. Optique / photonique. Université Paris-Saclay, 2019. Français. ⟨NNT : 2019SACLC011⟩. ⟨tel-02051858⟩

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