, Corresponding author J. Gallego: INSERM, U676, Hôpital Robert Debré, p.75019, 2012.
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, arbitrary unit; pFRG, parafacial respiratory group; 5-HIAA, 5-hydroxyindoleacetic acid; HVD, hypoxic ventilatory decline; IS, irregularity score
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, RRG, respiratory rhythm generator
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rose circles), 1000 (red circles) and 2000 (black circles) µM of LSP5-2157. All points represent mean ± S.E. values calculated from seven animals. Note almost no effect of LSP52157 on CM and SP. By contrast, LSP5-2157 caused a drastic reduction in CAP amplitude and an increase in N1 latency. E: Dose-response curves obtained with LSP5-2157. The dose-responses were fitted to a curve using a non-linear least-square logistic equation. The IC50 value, Am J Hum Genet, vol.73, issue.5, pp.1082-1091, 2003. ,
, SAMP8-EE et SAMR1 valeur de p = 0.0004, comparaison SAMP8-NE et SAMR1 valeur de p =0.08)
, Ces différences disparaissent à 9 mois pour la latence (test de Fisher, comparaison des groupes SAMP8-EE et SAMP8-NE valeur de p = 0.28, comparaison SAMP8-EE et SAMR1 valeur de p = 0.59, comparaison SAMP8-NE et SAMR1 valeur de p =0.12), le temps d'immobilité (test de Fisher, comparaison des groupes SAMP8-EE et SAMP8-NE valeur de p = 0.16, comparaison SAMP8-EE et SAMR1 valeur de p = 0.9, comparaison SAMP8NE et SAMR1 valeur de p = 0.12) et le nombre de périodes d'immobilité
, SAMP8-EE et SAMR1 valeur de p = 0.62, comparaison SAMP8-NE et SAMR1 valeur de p =, vol.14, p.0
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