, Loi relative aux droits des malades et à la qualité du système de santé, 2002.

, Loi créant de nouveaux droits en faveur des malades et des personnes en fin de vie, 2016.

, Plan Cancer, 2003.

G. Dworkin, The Theory and Practice of Autonomy, vol.192, 1988.

P. Ricoeur, Soi-même comme un autre

T. L. Beauchamp and J. F. Childress, Les principes de l'éthique biomédicale. Les Belles Lettres, vol.645, 2008.

E. Kant, Fondements de la métaphysique des moeurs. Presses Électroniques de France, vol.110, 2013.

P. L. Coz, Petit traité de la décision médicale: un nouveau cheminement au service des patients. Editions du Seuil, vol.195, 2007.

. Acharnement-thérapeutique, Le Larousse, 2016.

, Avis sur Fin de vie, arrêt de vie, euthanasie. Comité National Consultatif d'Ethique, Jan. Report, p.63, 2000.

L. J. Schneiderman, N. S. Jecker, and A. R. Jonsen, Medical futility: its meaning and ethical implications, Ann Intern Med, vol.112, issue.12, pp.949-54, 1990.

F. Goldwasser, La relation médecin-malade en cancérologie de la théorie à la pratique. Paris: JBH santé, 2010.

M. Orgerie, Rôle de la Réunion de Concertation Pluridisciplinaire, 2007.

C. J. Sweeney, Y. H. Chen, M. Carducci, G. Liu, D. F. Jarrard et al., Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer, N Engl J Med, vol.373, pp.737-783, 2015.

N. D. James, M. R. Sydes, N. W. Clarke, M. D. Mason, D. P. Dearnaley et al., Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial, Lancet Lond Engl, vol.387, pp.1163-77, 2016.

I. F. Tannock, R. De-wit, W. R. Berry, J. Horti, A. Pluzanska et al., Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer, N Engl J Med, vol.351, pp.1502-1514, 2004.

C. J. Ryan, M. R. Smith, J. S. De-bono, A. Molina, C. J. Logothetis et al., Abiraterone in metastatic prostate cancer without previous chemotherapy, N Engl J Med, vol.368, pp.138-186, 2013.

E. Rajpert-de-meyts, K. A. Mcglynn, K. Okamoto, M. Jewett, and C. Bokemeyer, Testicular germ cell tumours, Lancet Lond Engl, vol.387, pp.1762-74, 2016.

R. Arriagada, B. Bergman, A. Dunant, L. Chevalier, T. Pignon et al., Cisplatinbased adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer, N Engl J Med, vol.350, issue.4, pp.351-60, 2004.

G. Chvetzoff, Enjeux éthiques des décisions d'arrêt de chimiothérapie, 2010.

S. M. Swain, J. Baselga, S. Kim, J. Ro, V. Semiglazov et al., Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer, N Engl J Med, vol.372, issue.8, pp.724-758, 2015.

O. Huillard, Place de la chimiothérapie dans le traitement des cancers prostatiques : pratiques actuelles et perspectives. Réflex En Médecine Oncol, p.68, 2015.

O. Huillard, Principales utilisations cliniques des nouvelles immunothérapies, principaux essais de phase III. Réflex En Médecine Oncol, Juin, vol.74, 2016.

M. J. Moore, D. Goldstein, J. Hamm, A. Figer, J. R. Hecht et al., Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group, J Clin Oncol Off J Am Soc Clin Oncol, vol.25, issue.15, pp.1960-1966, 2007.

F. A. Shepherd, R. Pereira, J. Ciuleanu, T. Tan, E. H. Hirsh et al., Erlotinib in previously treated non-small-cell lung cancer, N Engl J Med, vol.353, pp.123-155, 2005.

R. Rosell, E. Carcereny, R. Gervais, A. Vergnenegre, B. Massuti et al., Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial, Lancet Oncol, vol.13, issue.3, pp.239-285, 2012.

S. Dolbeault, S. Dauchy, A. Brédart, and S. M. Consoli, La Psycho-oncologie, vol.276

M. Ruszniewski, Face à la maladie grave: patients, familles, soignants. Dunod, 2004.

I. J. Higginson, I. Finlay, D. M. Goodwin, A. M. Cook, K. Hood et al., Do hospital-based palliative teams improve care for patients or families at the end of life?, J Pain Symptom Manage, vol.23, issue.2, pp.96-106, 2002.

I. J. Higginson, I. G. Finlay, D. M. Goodwin, K. Hood, A. Edwards et al., Is there evidence that palliative care teams alter end-of-life experiences of patients and their caregivers?, J Pain Symptom Manage, vol.25, issue.2, pp.150-68, 2003.

K. Wentlandt, M. K. Krzyzanowska, N. Swami, G. M. Rodin, L. W. Le et al., Referral practices of oncologists to specialized palliative care, J Clin Oncol, vol.30, pp.4380-4386, 2012.

D. Hui, A. Elsayem, M. De-la-cruz, A. Berger, D. S. Zhukovsky et al., Availability and integration of palliative care at US cancer centers, JAMA, vol.303, issue.11, pp.1054-61, 2010.

, Loi visant à garantir le droit à l'accès aux soins palliatifs, pp.99-477, 1999.

C. C. Earle, E. R. Park, B. Lai, J. C. Weeks, J. Z. Ayanian et al., Identifying potential indicators of the quality of end-of-life cancer care from administrative data, J Clin Oncol, vol.21, pp.1133-1141, 2003.

C. C. Earle, B. A. Neville, M. B. Landrum, J. Z. Ayanian, S. D. Block et al., Trends in the aggressiveness of cancer care near the end of life, J Clin Oncol, vol.22, pp.315-336, 2004.

C. C. Earle, M. B. Landrum, J. M. Souza, B. A. Neville, J. C. Weeks et al., Aggressiveness of cancer care near the end of life: is it a quality-of-care issue?, J Clin Oncol, vol.26, pp.3860-3866, 2008.

C. C. Earle, B. A. Neville, M. B. Landrum, J. M. Souza, J. C. Weeks et al., Evaluating claims-based indicators of the intensity of end-of-life cancer care, Int J Qual Health Care, vol.17, pp.505-514, 2005.

E. J. Emanuel, Y. Young-xu, N. G. Levinsky, G. Gazelle, O. Saynina et al., Chemotherapy use among Medicare beneficiaries at the end of life, Ann Intern Med, vol.138, pp.639-682, 2003.

U. Nappa, O. Lindqvist, B. H. Rasmussen, and B. Axelsson, Palliative chemotherapy during the last month of life, Ann Oncol Off J Eur Soc Med Oncol ESMO, vol.22, pp.2375-80, 2011.

O. 'brien, M. E. Borthwick, A. Rigg, A. Leary, A. Assersohn et al., Mortality within 30 days of chemotherapy: a clinical governance benchmarking issue for oncology patients, Br J Cancer, vol.95, pp.1632-1638, 2006.

F. Andreis, A. Rizzi, L. Rota, F. Meriggi, M. Mazzocchi et al., Chemotherapy use at the end of life. A retrospective single centre experience analysis, Tumori, vol.97, pp.30-34, 2011.

S. Braga, A. Miranda, R. Fonseca, J. L. Passos-coelho, A. Fernandes et al., The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis, Psychooncology, vol.16, pp.863-871, 2007.

J. F. Goncalves and C. Goyanes, Use of chemotherapy at the end of life in a Portuguese oncology center, Support Care Cancer, vol.16, pp.321-328, 2008.

B. Keam, D. Y. Oh, S. H. Lee, D. W. Kim, M. R. Kim et al., Aggressiveness of cancer-care near the end-of-life in Korea, Jpn J Clin Oncol, vol.38, pp.381-387, 2008.

S. Kao, J. Shafiq, J. Vardy, and D. Adams, Use of chemotherapy at end of life in oncology patients, Ann Oncol Off J Eur Soc Med Oncol ESMO, vol.20, pp.1555-1564, 2009.

L. E. Schnipper, T. J. Smith, D. Raghavan, D. W. Blayney, P. A. Ganz et al., American Society of Clinical Oncology identifies five key opportunities to improve care and reduce costs: the top five list for oncology, J Clin Oncol, vol.30, pp.1715-1739, 2012.

A. A. Wright and I. T. Katz, Letting go of the rope-aggressive treatment, hospice care, and open access, N Engl J Med, vol.357, pp.324-331, 2007.

N. L. Keating, M. B. Landrum, S. O. Rogers, S. K. Baum, B. A. Virnig et al., Physician factors associated with discussions about end-of-life care, Cancer, vol.116, pp.998-1006, 2010.

P. R. Helft, Necessary collusion: prognostic communication with advanced cancer patients, J Clin Oncol, vol.23, pp.3146-50, 2005.

H. A. Huskamp, N. L. Keating, J. L. Malin, A. M. Zaslavsky, J. C. Weeks et al., Discussions with physicians about hospice among patients with metastatic lung cancer, Arch Intern Med, vol.169, pp.954-62, 2009.

A. A. Wright, B. Zhang, N. L. Keating, J. C. Weeks, and H. G. Prigerson, Associations between palliative chemotherapy and adult cancer patients' end of life care and place of death: prospective cohort study, BMJ, vol.348, p.1219, 2014.

J. S. Temel, J. A. Greer, A. Muzikansky, E. R. Gallagher, S. Admane et al., Early palliative care for patients with metastatic non-small-cell lung cancer, N Engl J Med, vol.363, pp.733-775, 2010.

J. S. Temel, J. A. Greer, S. Admane, E. R. Gallagher, V. A. Jackson et al., Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care, J Clin Oncol, vol.29, pp.2319-2345, 2011.

J. A. Greer, W. F. Pirl, V. A. Jackson, A. Muzikansky, I. T. Lennes et al., Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer, J Clin Oncol, vol.30, pp.394-400, 2012.

J. C. Weeks, E. F. Cook, O. Day, S. J. Peterson, L. M. Wenger et al., Relationship between cancer patients' predictions of prognosis and their treatment preferences, JAMA, vol.279, pp.1709-1723, 1998.

J. C. Weeks, P. J. Catalano, A. Cronin, M. D. Finkelman, J. W. Mack et al., Patients' expectations about effects of chemotherapy for advanced cancer, N Engl J Med, vol.367, pp.1616-1641, 2012.

J. W. Mack, A. Cronin, N. L. Keating, N. Taback, H. A. Huskamp et al., Associations between end-of-life discussion characteristics and care received near death: a prospective cohort study, J Clin Oncol, vol.30, pp.4387-95, 2012.

A. A. Wright, B. Zhang, A. Ray, J. W. Mack, E. Trice et al., Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment, JAMA, vol.300, pp.1665-73, 2008.

B. Zhang, A. A. Wright, H. A. Huskamp, M. E. Nilsson, M. L. Maciejewski et al., Health care costs in the last week of life: associations with end-of-life conversations, Arch Intern Med, vol.169, pp.480-488, 2009.

A. L. Back, R. M. Arnold, W. F. Baile, J. A. Tulsky, and K. Fryer-edwards, Approaching difficult communication tasks in oncology, CA Cancer J Clin, vol.55, pp.164-77, 2005.

M. Jefford and M. H. Tattersall, Informing and involving cancer patients in their own care, Lancet Oncol, vol.3, pp.629-666, 2002.

P. Vinant and . Du-pronostic-en-cancérologie, Fin de vie, éthique et société. ERES, 2012.

A. L. Back, R. M. Arnold, and T. E. Quill, Hope for the best, and prepare for the worst, Ann Intern Med, vol.138, issue.5, pp.439-482, 2003.

S. Audrey, J. Abel, J. M. Blazeby, S. Falk, and R. Campbell, What oncologists tell patients about survival benefits of palliative chemotherapy and implications for informed consent: qualitative study, BMJ, vol.337, p.752, 2008.

A. Dimoska, P. N. Butow, E. Dent, B. Arnold, R. F. Brown et al., An examination of the initial cancer consultation of medical and radiation oncologists using the Cancode interaction analysis system, Br J Cancer, vol.98, pp.1508-1522, 2008.

C. G. Koedoot, F. J. Oort, R. J. De-haan, P. J. Bakker, A. De-graeff et al., The content and amount of information given by medical oncologists when telling patients with advanced cancer what their treatment options are. palliative chemotherapy and watchful-waiting, Eur J Cancer, vol.40, pp.225-260, 2004.

G. Silvestri, R. Pritchard, and H. G. Welch, Preferences for chemotherapy in patients with advanced nonsmall cell lung cancer: descriptive study based on scripted interviews, BMJ, vol.317, pp.771-776, 1998.

T. R. Fried, E. H. Bradley, V. R. Towle, and H. Allore, Understanding the treatment preferences of seriously ill patients, N Engl J Med, vol.346, pp.1061-1067, 2002.

O. Huillard, F. Goldwasser, and L. Morin, Aggressiveness of care at the end of life in patients with localized and advanced bladder cancer, vol.34, p.10029, 2016.

D. F. Bajorin, P. M. Dodd, M. Mazumdar, M. Fazzari, J. A. Mccaffrey et al., Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy, J Clin Oncol Off J Am Soc Clin Oncol, vol.17, issue.10, pp.3173-81, 1999.

, Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration, Eur Urol, vol.48, issue.2, pp.205-211, 2005.

C. Wu, T. Hsu, C. Chang, C. Lee, C. Huang et al., Chemotherapy Affects Aggressiveness of End-of-Life Care, The Oncologist, vol.21, issue.6, pp.771-778, 2016.

F. Goldwasser, P. Vinant, O. Huillard, and L. Morin, Goals and aggressiveness of care in metastatic lung cancer, vol.34, p.10026, 2016.

P. Vinant, I. Rousseau, O. Huillard, F. Goldwasser, M. Guillard et al., Respecting patient's end of life wishes: feasibility study of an information on surrogate and advance directives, Bull Cancer, vol.102, issue.3, pp.234-278, 2015.

J. Léonetti, Rapport d'information fait au nom de la mission d'évaluation de la loi n° 2005-370 du 22 avril 2005, relative aux droits des malades et à la fin de vie, Assemblée Nationale, p.1287, 2008.

D. Sicard, Commission de réflexion sur la fin de vie en France. Penser solidairement la fin de vie. Rapport à François Hollande, 2012.

S. Pennec, A. Monnier, S. Pontone, and A. R. , End-of-life medical decisions in France: a death certificate follow-up survey 5 years after the 2005 act of parliament on patients' rights and end of life, BMC Palliat Care, vol.11, p.25, 2012.

L. A. Dow, R. K. Matsuyama, V. Ramakrishnan, L. Kuhn, E. B. Lamont et al., Paradoxes in advance care planning: the complex relationship of oncology patients, their physicians, and advance medical directives, J Clin Oncol, vol.28, pp.299-304, 2010.

A. J. Mitchell, M. Chan, H. Bhatti, M. Halton, L. Grassi et al., Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies, Lancet Oncol, vol.12, issue.2, pp.160-74, 2011.

R. G. Hagerty, P. N. Butow, P. A. Ellis, E. A. Lobb, S. Pendlebury et al., Cancer patient preferences for communication of prognosis in the metastatic setting, J Clin Oncol Off J Am Soc Clin Oncol, vol.22, issue.9, pp.1721-1751, 2004.

E. Azoulay, F. Pochard, N. Kentish-barnes, S. Chevret, J. Aboab et al., Risk of post-traumatic stress symptoms in family members of intensive care unit patients, Am J Respir Crit Care Med, vol.171, issue.9, pp.987-94, 2005.

R. A. Stein, L. Sharpe, M. L. Bell, F. M. Boyle, S. M. Dunn et al., Randomized controlled trial of a structured intervention to facilitate end-of-life decision making in patients with advanced cancer, J Clin Oncol Off J Am Soc Clin Oncol, vol.31, issue.27, pp.3403-3413, 2013.

J. A. Tulsky, Beyond advance directives: importance of communication skills at the end of life, JAMA, vol.294, issue.3, pp.359-65, 2005.

E. B. Lamont and M. Siegler, Paradoxes in cancer patients' advance care planning, J Palliat Med, vol.3, pp.27-35, 2000.

M. Maltoni, E. Scarpi, C. Pittureri, F. Martini, L. Montanari et al., Prospective comparison of prognostic scores in palliative care cancer populations, The Oncologist, vol.17, issue.3, pp.446-54, 2012.

M. H. Levy, M. D. Adolph, A. Back, S. Block, S. N. Codada et al., Palliative care. J Natl Compr Cancer Netw JNCCN, vol.10, pp.1284-309, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01969482

M. J. Silveira, S. Kim, and K. M. Langa, Advance directives and outcomes of surrogate decision making before death, N Engl J Med, vol.362, issue.13, pp.1211-1219, 2010.

N. Michael, C. O'callaghan, J. Clayton, A. Pollard, N. Stepanov et al., Understanding how cancer patients actualise, relinquish, and reject advance care planning: implications for practice. Support Care Cancer Off J Multinatl Assoc Support Care Cancer, vol.21, pp.2195-205, 2013.

O. Huillard, Collecting Living Wills and Preferences Regarding End of Life: Feasibility in Patients with Non Curable Cancer, Palliat Med, pp.385-452, 2012.

O. Huillard, P. Vinant, I. Colombet, V. Montheil, M. Y. Guillard et al., End-of-life discussions with noncurable lung cancer patients: A patients' and oncologists' qualitative study, vol.32, p.151, 2014.

J. Yoong, E. R. Park, J. A. Greer, V. A. Jackson, E. R. Gallagher et al., Early palliative care in advanced lung cancer: a qualitative study, JAMA Intern Med, vol.173, issue.4, pp.283-90, 2013.
DOI : 10.1001/jamainternmed.2013.1874

URL : https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/1566605/iiq120100_283_290.pdf

P. K. Maciejewski and H. G. Prigerson, Emotional numbness modifies the effect of end-of-life discussions on end-of-life care, J Pain Symptom Manage, vol.45, issue.5, pp.841-848, 2013.

A. C. Enzinger, B. Zhang, D. Schrag, and H. G. Prigerson, Outcomes of Prognostic Disclosure: Associations With Prognostic Understanding, Distress, and Relationship With Physician Among Patients With Advanced Cancer, J Clin Oncol Off J Am Soc Clin Oncol, vol.33, issue.32, pp.3809-3825, 2015.

J. M. Clayton, P. N. Butow, M. H. Tattersall, R. J. Devine, J. M. Simpson et al., Randomized controlled trial of a prompt list to help advanced cancer patients and their caregivers to ask questions about prognosis and end-of-life care, J Clin Oncol, vol.25, pp.715-738, 2007.

J. R. Curtis, A. L. Back, D. W. Ford, L. Downey, S. E. Shannon et al., Effect of communication skills training for residents and nurse practitioners on quality of communication with patients with serious illness: a randomized trial, JAMA, vol.310, issue.21, pp.2271-81, 2013.

E. Bruera and D. Hui, Integrating supportive and palliative care in the trajectory of cancer: establishing goals and models of care, J Clin Oncol Off J Am Soc Clin Oncol, vol.28, issue.25, pp.4013-4020, 2010.

D. Hui, Y. J. Kim, J. C. Park, Y. Zhang, F. Strasser et al., Integration of oncology and palliative care: a systematic review, Oncologist, vol.20, pp.77-83, 2015.

O. Huillard, I. Colombet, V. Montheil, F. Weiler, P. Boudou-rouquette et al., Integration of Oncology and Palliative Care, a Forgotten Indicator: Shared Decision-Making. The Oncologist, vol.20, p.26, 2015.
DOI : 10.1634/theoncologist.2015-0131

URL : http://theoncologist.alphamedpress.org/content/20/9/e26.full.pdf

I. Colombet, V. Montheil, J. P. Durand, F. Gillaizeau, R. Niarra et al., Effect of integrated palliative care on the quality of end-of-life care: retrospective analysis of 521 cancer patients, BMJ Support Palliat Care, vol.2, pp.239-286, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01295713

D. Hui, E. Bruera, and . In-reply, The Oncologist, vol.20, issue.9, p.27, 2015.

L. Martin, L. Birdsell, N. Macdonald, T. Reiman, M. T. Clandinin et al., Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index, J Clin Oncol, vol.31, pp.1539-1586, 2013.

C. M. Prado, J. R. Lieffers, L. J. Mccargar, T. Reiman, M. B. Sawyer et al., Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study, Lancet Oncol, vol.9, pp.629-664, 2008.

A. Young, O. Chapman, C. Connor, C. Poole, P. Rose et al., Thrombosis and cancer, Nat Rev Clin Oncol, vol.9, pp.437-486, 2012.

N. M. Kuderer, T. L. Ortel, and C. W. Francis, Impact of venous thromboembolism and anticoagulation on cancer and cancer survival, J Clin Oncol, vol.27, pp.4902-4913, 2009.
DOI : 10.1200/jco.2009.22.4584

URL : http://europepmc.org/articles/pmc2799059?pdf=render

A. Tauber, Patient autonomy and the ethics of responsibility, 2005.

H. Rosa, Aliénation et accélération. Vers une théorie critique de la modernité tardive. La déouverte / Poche, 2014.

S. Freud, . L'inquiétante, and . Étrangeté,

A. Lalande, Vocabulaire technique et critique de la philosophie. Presses Universitaires de France, 1968.

, Annexe Annexe, vol.1