Optimisation de la conception de bioprocédés : vers une approche intégrée biologie de synthèse et conduite du procédé

Abstract : The design of efficient strains forthe production of compounds of interest offerstremendous potentials that remain insufficientlyexploited due to the lack of link between theoptimization stages of strain design and that ofbioprocess control.This thesis proposes a description of bioprocessesthat fully integrates the internal functioningof micro-organisms involved in the productionof compounds of interest. This descriptionallows the strain and process to be optimizedsimultaneously to maximize the productionof a compound of interest while respecting theconstraints attached to these two stages.First, a new bioprocess modelling class is developedat the interface between intracellular resourceallocation models and macroscopic modelscommonly used in bioprocess control. In asecond stage, constraints linked to the biologicalimplementation of the control strategy are integratedinto the problem. This provides a morerealistic genome engineering design. Finally, thelast part of the thesis shows that the methodologypresented so far on an aggregate model canbe extended to detailed representations of thebehaviour of micro-organisms.
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Guillaume Jeanne. Optimisation de la conception de bioprocédés : vers une approche intégrée biologie de synthèse et conduite du procédé. Autre [cs.OH]. Université Paris-Saclay, 2018. Français. ⟨NNT : 2018SACLC064⟩. ⟨tel-02015607⟩

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