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M. Lai,

, China Medical University

, China Medical University Hospital

, Academia Sinica

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U. Inserm, International Research Center in Infectiology (CIRI)

, Novira Pharmaceuticals

, Hospices Civils de Lyon (HCL)

, Viremia, antigenemia, and intra-liver virologic parameters in HBV-infected FRG mice. (A and B) Viremia and antigenemia (HBeAg and HBsAg) was monitored every week for 9 weeks after HBV, pp.10-18

, vge/mouse for panels A; 5.10e7 vge/mouse for panels B) infection by qPCR and ELISA. (C) Intra-liver total

, HBV DNA and cccDNA levels were obtained by qPCR and cccDNA specific qPCR {Werle, 2004.

, Immunohistostaining was performed on paraffin embedded mouse liver samples with anti-HBc (Dako) and human-specific anti-FAH (Cliniscience) antibodies. Representative picture of immune-staining in mock-and

. Bissig, which were chronically infected with HBV. In mice showing persistent infection and high levels of HBV DNA and viral proteins in the serum and liver (Figure S5A and S5C, i.e. mice 396, 399, and 420 versus mock infected, 2010.

, 10 mM EDTA, 1% SDS and protease inhibitor cocktail (Complete EDTA-free tablets, Roche)) chromatin (100 ?l) was diluted 10-fold in RIPA buffer, PBS 1X then scrapped and lysed in 500?l of lysis buffer per 10 7 cells (50 mM Tris HCl pH8

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, Je tenais tout d'abord à remercier les membres de mon jury d'avoir accepté de lire mon manuscrit et d'avoir apporté leur critique constructive à mes travaux de thèse, Merci aux Dr. Kremsdorf, Dr. Neuveut et Dr. Lupberger. Merci au Pr. Baumert. Merci à vous, Pr. Bernet, qui m'avez donné le goût de la recherche et avez accepté la présidence de mon jury

M. Au and P. , Zoulim de m'avoir acceuilli au sein de son laboratoire

M. and T. David, qui a toujours su être là malgré un emploi du temps plus que chargé ! Merci pour les discussions scientifiques, les digressions