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Development of new types of mechanocatalytic systems

Abstract : The fascinating process by which mechanical signals are transformed into biochemical reactions in Nature is called mechanotransduction. The goal of my PhD was to mimic Nature by elaborating new types of mechanocatalytic materials, i.e materials able to modulate a catalytic activity when mechanically stimulated. We first aimed at understanding the impact of stretching on the structural properties of polyelectrolyte multilayers films, polymeric matrices often used for the design of smart biomaterials. Within the framework of a new strategy essentially relying on mechanically induced conformational changes, we then developed stretchable polymeric matrices based on poly(ethylene glycol)s. We more particularly designed new types of covalent coatings, called nanogels. We showed that these architectures were buildable on stretchable silicone and that they could be functionalized with different types of biomacromolecules; thus opening new biomimetic routes.
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Submitted on : Friday, February 1, 2019 - 12:24:40 PM
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Sarah Zahouani. Development of new types of mechanocatalytic systems. Material chemistry. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAE037⟩. ⟨tel-02003608⟩

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