N. A. Abumrad, M. R. El-maghrabi, E. Z. Amri, E. Lopez, and P. A. Grimaldi, Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36, J Biol Chem, vol.268, issue.24, pp.17665-17668, 1993.

?. Adeva-andany, M. M. , N. Perez-felpete, C. Fernandez-fernandez, C. Donapetrygarcia et al., Liver glucose metabolism in humans, Biosci Rep, vol.36, issue.6, 2016.

E. Ahlqvist, T. S. Ahluwalia, and L. Groop, Genetics of type 2 diabetes, Clin Chem, vol.57, issue.2, pp.241-254, 2011.

H. Ajouz, D. Mukherji, and A. Shamseddine, Secondary bile acids: an underrecognized cause of colon cancer, World J Surg Oncol, vol.12, p.164, 2014.

M. C. ?-althage, E. L. Ford, S. Wang, P. Tso, K. S. Polonsky et al., Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet, J Biol Chem, vol.283, issue.26, pp.18365-18376, 2008.

S. W. Altmann, H. R. Davis, L. J. Zhu, X. Yao, L. M. Hoos et al., Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption, Science, vol.303, issue.5661, pp.1201-1204, 2004.

F. Ameer, L. Scandiuzzi, S. Hasnain, H. Kalbacher, and N. Zaidi, De novo lipogenesis in health and disease, Metabolism, vol.63, issue.7, pp.895-902, 2014.

K. Aoki, Y. Tamai, S. Horiike, M. Oshima, and M. M. Taketo, Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716, 2003.

, Cdx2+/-compound mutant mice, Nat Genet, vol.35, issue.4, pp.323-330

?. Araya-secchi, R. , B. L. Neel, and M. Sotomayor, An elastic element in the protocadherin-15 tip link of the inner ear, Nat Commun, vol.7, p.13458, 2016.

T. Asano, H. Katagiri, K. Tsukuda, J. L. Lin, H. Ishihara et al., Upregulation of GLUT2 mRNA by glucose, mannose, and fructose in isolated rat hepatocytes, Diabetes, vol.41, issue.1, pp.22-25, 1992.

F. M. Ashcroft and P. Rorsman, Diabetes mellitus and the beta cell: the last ten years, Cell, vol.148, issue.6, pp.1160-1171, 2012.

F. Authier, B. I. Posner, and J. J. Bergeron, Insulin-degrading enzyme, Clin Invest Med, vol.19, issue.3, pp.149-160, 1996.

G. H. Ballantyne, Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions, Obes Surg, vol.16, issue.5, pp.651-658, 2006.

F. Baraille, S. Ayari, V. Carriere, C. Osinski, K. Garbin et al., Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4gamma: A Critical Role for Enteroendocrine Cell Lineage, Diabetes, vol.64, issue.8, pp.2744-2756, 2015.

A. Barthel and D. Schmoll, Novel concepts in insulin regulation of hepatic gluconeogenesis, Am J Physiol Endocrinol Metab, vol.285, issue.4, pp.685-692, 2003.

H. E. Bays, R. B. Goldberg, K. E. Truitt, and M. R. Jones, Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects, Arch Intern Med, vol.168, issue.18, pp.1975-1983, 2008.

L. P. Bechmann, R. A. Hannivoort, G. Gerken, G. S. Hotamisligil, M. Trauner et al., The interaction of hepatic lipid and glucose metabolism in liver diseases, J Hepatol, vol.56, issue.4, pp.952-964, 2012.

U. Beisiegel, Lipoprotein metabolism, Eur Heart J, vol.19, 1998.

K. E. Berge, H. Tian, G. A. Graf, L. Yu, N. V. Grishin et al., Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters, Science, vol.290, issue.5497, pp.1771-1775, 2000.

G. Berx and F. Van-roy, The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression, Breast Cancer Res, vol.3, issue.5, pp.289-293, 2001.

M. Birbilis, G. Moschonis, V. Mougios, Y. Manios, and G. , Obesity in adolescence is associated with perinatal risk factors, parental BMI and sociodemographic characteristics, Healthy Growth Study, vol.67, issue.1, pp.115-121, 2013.

R. Blomhoff and K. Wake, Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis, FASEB J, vol.5, issue.3, pp.271-277, 1991.

C. Bonhomme, E. Duluc, K. Martin, M. P. Chawengsaksophak, M. Chenard et al., The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development, Gut, vol.52, issue.10, pp.1465-1471, 2003.

C. L. Bos, S. H. Diks, J. C. Hardwick, K. V. Walburg, M. P. Peppelenbosch et al., Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity, Carcinogenesis, vol.27, issue.12, pp.2371-2382, 2006.

C. Bouchard, Gene-environment interactions in the etiology of obesity: defining the fundamentals, Obesity (Silver Spring), vol.16, pp.5-10, 2008.

M. O. Boylan, L. I. Jepeal, L. A. Jarboe, and M. M. Wolfe, Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene in a mouse neuroendocrine tumor cell line, J Biol Chem, vol.272, issue.28, pp.17438-17443, 1997.

M. S. Brown and J. L. Goldstein, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, vol.89, issue.3, pp.331-340, 1997.

N. L. Bucher, Regeneration of Mammalian Liver, Int Rev Cytol, vol.15, pp.245-300, 1963.

M. Bujko, P. Kober, M. Statkiewicz, M. Mikula, M. Ligaj et al., Epigenetic-Mediated Downregulation of muProtocadherin in Colorectal Tumours, Gastroenterol Res Pract, p.317093, 2015.

R. Burcelin, M. Eddouks, J. Kande, R. Assan, and J. Girard, Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats, Biochem J, vol.288, pp.675-679, 1992.

S. Butalia, G. G. Kaplan, B. Khokhar, and D. M. Rabi, Environmental Risk Factors and Type 1 Diabetes: Past, Present, and Future, Can J Diabetes, vol.40, issue.6, pp.586-593, 2016.

B. Cariou, K. Van-harmelen, D. Duran-sandoval, T. H. Van-dijk, A. Grefhorst et al.,

S. Abdelkarim, G. Caron, J. C. Torpier, F. J. Fruchart, F. Gonzalez et al.,

. Staels, The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice, J Biol Chem, vol.281, issue.16, pp.11039-11049, 2006.

K. L. Cepek, S. K. Shaw, C. M. Parker, G. J. Russell, J. S. Morrow et al., Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin, Nature, vol.372, issue.6502, pp.190-193, 1994.

R. Chandra and R. A. Liddle, Curr Opin Endocrinol Diabetes Obes, vol.14, issue.1, pp.63-67, 2007.

F. Chen, L. Ma, P. A. Dawson, C. J. Sinal, E. Sehayek et al., Liver receptor homologue-1 mediates species-and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter, J Biol Chem, vol.278, issue.22, pp.19909-19916, 2003.

L. Chen, B. Tuo, and H. Dong, Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters, Nutrients, vol.8, issue.1, 2016.

X. R. Cheng, W. X. Zhou, and Y. X. Zhang, The family of calsyntenins: learning and memory related genes, Sheng Li Ke Xue Jin Zhan, vol.37, issue.3, pp.205-210, 2006.

J. Y. Chiang, Bile acids: regulation of synthesis, J Lipid Res, vol.50, issue.10, pp.1955-1966, 2009.

Y. T. Chiang, W. Ip, and T. Jin, The role of the Wnt signaling pathway in incretin hormone production and function, Front Physiol, vol.3, p.273, 2012.

C. A. Chu, Y. Fujimoto, K. Igawa, J. Grimsby, J. F. Grippo et al., Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats, Am J Physiol Gastrointest Liver Physiol, vol.286, issue.4, pp.627-634, 2004.

S. Cipriani, A. Mencarelli, G. Palladino, and S. Fiorucci, FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats, J Lipid Res, vol.51, issue.4, pp.771-784, 2010.

T. Claudel, B. Staels, and F. Kuipers, The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism, Arterioscler Thromb Vasc Biol, vol.25, issue.10, pp.2020-2030, 2005.

H. C. Clevers and C. L. Bevins, Paneth cells: maestros of the small intestinal crypts, Annu Rev Physiol, vol.75, pp.289-311, 2013.

R. Conti, E. Mannucci, P. Pessotto, E. Tassoni, P. Carminati et al., Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis, Diabetes, vol.60, issue.2, pp.644-651, 2011.

D. L. Cook, M. Ikeuchi, and W. Y. Fujimoto, Lowering of pHi inhibits Ca2+activated K+ channels in pancreatic B-cells, Nature, vol.311, issue.5983, pp.269-271, 1984.

S. W. Crawley, D. A. Shifrin, N. E. Grega-larson, R. E. Mcconnell, and A. E. ,

S. Benesh, Y. Mao, Q. Y. Zheng, K. T. Zheng, B. A. Nam et al.,

. Tyska, Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion, Cell, vol.157, issue.2, pp.433-446, 2014.

?. Cuesta-munoz, A. L. , T. Tuomi, N. Cobo-vuilleumier, H. Koskela et al.,

. Matschinsky, Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY), Diabetes Care, vol.33, issue.2, pp.290-292, 2010.

S. ?-daemen, M. Kutmon, and C. T. Evelo, A pathway approach to investigate the function and regulation of SREBPs, Genes Nutr, vol.8, issue.3, pp.289-300, 2013.

S. Danielzik, K. Langnase, M. Mast, C. Spethmann, and M. J. Muller, Impact of parental BMI on the manifestation of overweight 5-7 year old children, Eur J Nutr, vol.41, issue.3, pp.132-138, 2002.

S. Dash, C. Xiao, C. Morgantini, and G. F. Lewis, New Insights into the Regulation of Chylomicron Production, Annu Rev Nutr, vol.35, pp.265-294, 2015.

Z. Dastani, M. F. Hivert, N. Timpson, J. R. Perry, X. Yuan et al.,

I. M. Henneman, J. R. Heid, L. P. Kizer, C. Lyytikainen, T. Fuchsberger et al.,

J. S. Kanoni, H. W. Pankow, Y. Uh, A. Wu, L. J. Bidulescu et al.,

M. Greenwood, J. Ladouceur, A. K. Grimsby, C. T. Manning, J. Liu et al.,

P. Mooser, K. A. Vollenweider, J. Kapur, N. J. Chambers, C. Wareham et al.,

B. M. Winkler, R. P. Psaty, J. Tracy, I. Brody, J. Chen et al.,

D. M. Pramstaller, B. Evans, N. St-pourcain, A. R. Sattar, S. Wood et al.,

J. M. Carlson, S. Egan, D. Bohringer, L. Van-heemst, K. Kedenko et al.,

B. M. Nuotio, T. Loo, M. Harris, A. Garcia, M. Kanaya et al.,

P. Wichmann, E. Deloukas, D. J. Katsareli, B. B. Couper, M. Duncan et al.,

G. Wilson, S. Musani, X. Guo, T. Johnson, R. Semple et al.,

S. Allison, S. G. Redline, K. L. Buxbaum, I. Mohlke, C. M. Meulenbelt et al.,

A. Ferrucci, M. Jula, O. Perola, J. C. Raitakari, V. Florez et al.,

M. Frayling, A. A. Hicks, T. Lehtimaki, G. D. Smith, D. S. Siscovick et al.,

F. Voight, L. J. Scott, V. Steinthorsdottir, C. Dina, R. P. Welch et al.,

N. P. Bumpstead, G. Burtt, P. S. Charpentier, M. Chines, G. Cornelis et al.,

K. S. Doney, A. L. Elliott, M. R. Elliott, C. S. Erdos, C. S. Fox et al.,

C. Hassanali, B. Herder, A. U. Isomaa, P. R. Jackson, T. Johnson et al.,

A. Kao, P. Kong, J. Kraft, T. Kuusisto, M. Lauritzen et al.,

K. R. Nilsson, F. Owen, A. K. Payne, C. Petersen, C. Platou et al.,

R. Sampson, B. M. Saxena, P. Shields, G. Shrader, T. Sigurdsson et al.,

H. M. Strassburger, Q. Stringham, A. J. Sun, B. Swift, J. Thorand et al.,

M. N. Walters, C. Weedon, J. Wijmenga, R. N. Witteman, S. Bergman et al.,

A. L. Collins, U. Gloyn, T. Gyllensten, W. A. Hansen, G. A. Hide et al.,

D. J. Hofman, K. Hunter, M. Hveem, A. D. Laakso, C. N. Morris et al.,

L. D. Sijbrands, J. Stein, A. Tuomilehto, M. Uitterlinden, R. M. Walker et al.,

R. Abecasis, B. O. Boehm, H. Campbell, M. J. Daly, A. T. Hattersley et al.,

L. Barroso, R. Groop, U. Sladek, J. F. Thorsteinsdottir, T. Wilson et al.,

M. Van-duijn, K. Stefansson, D. Altshuler, M. Boehnke, M. I. Mccarthy et al.,

A. Luan, S. A. Elliott, R. M. Mccarroll, F. Roccasecca, P. Pattou et al.,

P. Ariyurek, J. P. Barter, Y. Beilby, S. Ben-shlomo, M. Bergmann et al.,

K. Bonnefond, Y. Borch-johnsen, E. Bottcher, S. J. Brunner, Y. D. Bumpstead et al.,

M. O. Galan, J. Goodarzi, S. Graessler, R. Grundy, G. Gwilliam et al.,

X. Hammond, A. L. Han, C. Hartikainen, S. C. Hayward, S. Heath et al.,

A. D. Hillman, J. Hingorani, J. Hui, M. Hung, J. Kaakinen et al.,

O. L. Lawlor, C. Bacquer, Y. Lecoeur, R. Li, M. Mahley et al.,

S. Mitchell, S. Mukherjee, M. J. Naitza, M. Neville, R. Orru et al.,

D. Pattaro, J. F. Pearson, N. L. Peden, A. F. Pedersen, I. Pfeiffer et al.,

F. Ripatti, O. Rivadeneira, A. Rolandsson, M. Sandbaek, S. Sandhu et al.,

P. Sayer, U. Scheet, S. J. Seedorf, B. Sharp, G. Shields et al.,

S. H. Watkins, G. Wild, J. C. Willemsen, J. W. Witteman, D. Yarnell et al.,

G. Zethelius, J. H. Zhai, M. C. Zhao, D. Zillikens, G. Consortium et al.,

C. Global, I. B. Borecki, P. Meneton, P. K. Magnusson, D. M. Nathan et al.,

K. Williams, S. R. Silander, P. Bornstein, J. Schwarz, F. Spranger et al.,

C. Shuldiner, M. Cooper, L. Serrano-rios, L. J. Lind, F. B. Palmer et al.,

S. Franks, M. Ebrahim, W. H. Marmot, P. P. Kao, A. F. Pramstaller et al.,

A. Stumvoll, C. Hamsten, T. A. Procardis, T. T. Buchanan, J. I. Valle et al.,

D. I. Penninx, A. Boomsma, A. Cao, D. Scuteri, M. Schlessinger et al.,

D. I. Pirruccello, C. T. Chasman, S. W. Johansen, G. M. Fouchier, and M. Peloso,

S. L. Barbalic, J. C. Ricketts, M. F. Bis, M. Feitosa, O. Orho-melander et al.,

M. Li, Y. S. Li, M. J. Cho, Y. J. Go, J. Y. Kim et al.,

D. C. Ong, L. A. Croteau-chonka, J. D. Lange, A. Smith, W. Ziegler et al.,

J. B. Zee, J. R. Whitfield, I. Thompson, T. D. Surakka, J. H. Spector et al.,

D. Mcardle, N. G. Masson, F. Martin, G. Marroni, R. Lucas et al.,

L. J. Lettre, E. G. Launer, R. Lakatta, K. O. Laaksonen, I. R. Kyvik et al.,

L. M. Khaw, A. Kaplan, A. C. Johansson, W. Janssens, G. K. Igl et al.,

A. S. Hengstenberg, N. D. Havulinna, T. B. Hastie, T. Harris, A. S. Haritunians et al.,

S. Dominiczak, P. Demissie, U. Deloukas, G. De-faire, Y. D. Crawford et al.,

S. M. Caulfield, T. L. Boekholdt, T. Assimes, M. Quertermous, and T. Y. Seielstad,

E. S. Wong, A. B. Tai, C. W. Feranil, H. A. Kuzawa, S. B. Taylor et al.,

V. Holm, R. M. Gudnason, J. M. Krauss, P. B. Ordovas, J. S. Munroe et al.,

R. A. Tall, J. J. Hegele, E. E. Kastelein, D. P. Schadt, M. P. Strachan et al.,

H. Samani, L. A. Schunkert, M. S. Cupples, P. M. Sandhu, D. J. Ridker et al.,

. Kathiresan, Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals, PLoS Genet, vol.8, issue.3, p.1002607, 2012.

P. A. Dawson, M. L. Hubbert, and A. Rao, Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism, Biochim Biophys Acta, vol.1801, issue.9, pp.994-1004, 2010.

P. A. Dawson and S. J. Karpen, Bile acids reach out to the spinal cord: new insights to the pathogenesis of itch and analgesia in cholestatic liver disease, Hepatology, vol.59, issue.4, pp.1638-1641, 2014.

P. A. Dawson, T. Lan, and A. Rao, Bile acid transporters, J Lipid Res, vol.50, issue.12, pp.2340-2357, 2009.

?. De-aguiar, T. Q. Vallim, E. J. Tarling, and P. A. Edwards, Pleiotropic roles of bile acids in metabolism, Cell Metab, vol.17, issue.5, pp.657-669, 2013.

C. F. ?-deacon, M. A. Nauck, J. Meier, K. Hucking, and J. J. Holst, Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide, J Clin Endocrinol Metab, vol.85, issue.10, pp.3575-3581, 2000.

J. M. Dietschy, Theoretical considerations of what regulates low-densitylipoprotein and high-density-lipoprotein cholesterol, Am J Clin Nutr, vol.65, issue.5, pp.1581-1589, 1997.

K. L. Donnelly, C. I. Smith, S. J. Schwarzenberg, J. Jessurun, M. D. Boldt et al., Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease, J Clin Invest, vol.115, issue.5, pp.1343-1351, 2005.

J. K. ?-dowman, J. W. Tomlinson, and P. N. Newsome, Pathogenesis of nonalcoholic fatty liver disease, QJM, vol.103, issue.2, pp.71-83, 2010.

W. C. Duane and N. B. Javitt, 27-hydroxycholesterol: production rates in normal human subjects, J Lipid Res, vol.40, issue.7, pp.1194-1199, 1999.

R. L. Dusek and L. D. Attardi, Desmosomes: new perpetrators in tumour suppression, Nat Rev Cancer, vol.11, issue.5, pp.317-323, 2011.

L. Eshkind, Q. Tian, A. Schmidt, W. W. Franke, R. Windoffer et al., Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells, Eur J Cell Biol, vol.81, issue.11, pp.592-598, 2002.

A. F. Fleisch, R. O. Wright, and A. A. Baccarelli, Environmental epigenetics: a role in endocrine disease?, J Mol Endocrinol, vol.49, issue.2, pp.61-67, 2012.

J. N. Freund, J. M. Duluc, I. Reimund, C. Gross, and . Domon-dell, Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities, World J Gastroenterol, vol.21, issue.5, pp.1436-1443, 2015.

V. Frochot, M. Alqub, A. L. Cattin, V. Carriere, A. Houllier et al.,

. Lacorte, The transcription factor HNF-4alpha: a key factor of the intestinal uptake of fatty acids in mouse, Am J Physiol Gastrointest Liver Physiol, vol.302, issue.11, pp.1253-1263, 2012.

J. C. Fruchart, Insulin-resistance and lipoprotein abnormalities, Diabete Metab, vol.17, issue.1, pp.244-248, 1991.

N. Gao, P. White, and K. H. Kaestner, Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2, Dev Cell, vol.16, issue.4, pp.588-599, 2009.

?. Garcia-martinez, J. M. , A. Chocarro-calvo, C. M. Moya, and C. Garcia-jimenez, WNT/beta-catenin increases the production of incretins by entero-endocrine cells, Diabetologia, vol.52, issue.9, pp.1913-1924, 2009.

A. Garg and S. M. Grundy, Cholestyramine therapy for dyslipidemia in noninsulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial, Ann Intern Med, vol.121, issue.6, pp.416-422, 1994.

D. R. Garrod, A. J. Merritt, and Z. Nie, Desmosomal cadherins, Curr Opin Cell Biol, vol.14, issue.5, pp.537-545, 2002.

F. Ge, S. Zhou, C. Hu, H. T. Lobdell, and P. D. Berk, Insulin-and leptinregulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice, Am J Physiol Gastrointest Liver Physiol, vol.299, issue.4, pp.855-866, 2010.

L. Ge, J. Wang, W. Qi, H. H. Miao, J. Cao et al., The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1, Cell Metab, vol.7, issue.6, pp.508-519, 2008.

R. E. Gimeno, D. J. Hirsch, S. Punreddy, Y. Sun, A. M. Ortegon et al., Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality, J Biol Chem, vol.278, issue.49, pp.49512-49516, 2003.

A. H. Gold, The effect of diabetes and insulin on liver glycogen synthetase activation, J Biol Chem, vol.245, issue.4, pp.903-905, 1970.

M. Goldberg, C. Peshkovsky, A. Shifteh, and Q. Al-awqati, muProtocadherin, a novel developmentally regulated protocadherin with mucin-like domains, J Biol Chem, vol.275, issue.32, pp.24622-24629, 2000.

M. Goldberg, M. Wei, B. Tycko, I. Falikovich, and D. Warburton, , 2002.

, Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys, Am J Physiol Renal Physiol, vol.283, issue.3, pp.454-463

?. Gonzalez-pons, M. , and M. Cruz-correa, Colorectal Cancer Biomarkers: Where Are We Now?, Biomed Res Int, p.149014, 2015.

V. Gorboulev, A. Schurmann, V. Vallon, H. Kipp, A. Jaschke et al.,

D. Balen, R. Breljak, H. E. Rexhepaj, F. M. Parker, F. Gribble et al.,

I. Wiese, M. Sabolic, H. Sendtner, and . Koepsell, Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucosedependent incretin secretion, Diabetes, vol.61, issue.1, pp.187-196, 2012.

C. J. Gottardi, E. Wong, and B. M. Gumbiner, E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner, J Cell Biol, vol.153, issue.5, pp.1049-1060, 2001.

A. Gougelet, C. Torre, P. Veber, C. Sartor, L. Bachelot et al., T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice, Hepatology, vol.59, issue.6, pp.2344-2357, 2014.

J. W. Grisham, A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3, Cancer Res, vol.22, pp.842-849, 1962.

A. R. Gunawardene, B. M. Corfe, and C. A. Staton, Classification and functions of enteroendocrine cells of the lower gastrointestinal tract, Int J Exp Pathol, vol.92, issue.4, pp.219-231, 2011.

H. Gylling, Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia, Int J Clin Pract, vol.58, issue.9, pp.859-866, 2004.

V. Hainer, A. Stunkard, M. Kunesova, J. Parizkova, V. Stich et al., A twin study of weight loss and metabolic efficiency, Int J Obes Relat Metab Disord, vol.25, issue.4, pp.533-537, 2001.

S. Hameed, W. S. Dhillo, and S. R. Bloom, Gut hormones and appetite control, Oral Dis, vol.15, issue.1, pp.18-26, 2009.

T. Hansotia, A. Maida, G. Flock, Y. Yamada, K. Tsukiyama et al., Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure, J Clin Invest, vol.117, issue.1, pp.143-152, 2007.

M. Hatzfeld, C. Haffner, K. Schulze, and U. Vinzens, The function of plakophilin 1 in desmosome assembly and actin filament organization, J Cell Biol, vol.149, issue.1, pp.209-222, 2000.

J. M. Hazlehurst, C. Woods, T. Marjot, J. F. Cobbold, and J. W. Tomlinson, Non-alcoholic fatty liver disease and diabetes, Metabolism, vol.65, issue.8, pp.1096-1108, 2016.

J. C. Henquin, D. Dufrane, J. Kerr-conte, and M. Nenquin, Dynamics of glucose-induced insulin secretion in normal human islets, Am J Physiol Endocrinol Metab, vol.309, issue.7, pp.640-650, 2015.

I. Hinkel, E. Duluc, D. Martin, J. N. Guenot, I. Freund et al., Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and betacatenin activity in colon cancer cells, Gastroenterology, vol.142, issue.4, pp.875-885, 2012.

D. J. Huels, R. A. Ridgway, S. Radulescu, M. Leushacke, A. D. Campbell et al.,

N. Soderberg, A. Barker, L. Watson, A. R. Larue, O. J. Clarke et al., , 2015.

, E-cadherin can limit the transforming properties of activating beta-catenin mutations, EMBO J, vol.34, issue.18, pp.2321-2333

P. Hulpiau, I. S. Gul, and F. Van-roy, New insights into the evolution of metazoan cadherins and catenins, Prog Mol Biol Transl Sci, vol.116, pp.71-94, 2013.

, ? International Agency For Research On Cancer, 2014.

, ? International Federation of Diabetes, 2015.

H. Ireland, C. Houghton, L. Howard, and D. J. Winton, Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine, Dev Dyn, vol.233, issue.4, pp.1332-1336, 2005.

D. B. Ivanov, M. P. Philippova, and V. A. Tkachuk, Structure and functions of classical cadherins, Biochemistry (Mosc), vol.66, issue.10, pp.1174-1186, 2001.

L. I. Jepeal, M. O. Boylan, and M. M. Wolfe, GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage, Mol Cell Endocrinol, vol.287, issue.1-2, pp.20-29, 2008.

L. I. Jepeal, M. O. Boylan, and M. M. Wolfe, Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine tumor cell line, Regul Pept, vol.113, issue.1-3, pp.139-147, 2003.

L. I. Jepeal, Y. Fujitani, M. O. Boylan, C. N. Wilson, C. V. Wright et al., Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1, Endocrinology, vol.146, issue.1, pp.383-391, 2005.

D. Kanamaluru, Z. Xiao, S. Fang, S. E. Choi, D. H. Kim et al.,

. Kemper, Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner, Mol Cell Biol, vol.31, issue.7, pp.1540-1550, 2011.

P. Karagianni and I. Talianidis, Transcription factor networks regulating hepatic fatty acid metabolism, Biochim Biophys Acta, vol.1851, issue.1, pp.2-8, 2015.

G. L. Kellett, E. Brot-laroche, O. J. Mace, and A. Leturque, Sugar absorption in the intestine: the role of GLUT2, Annu Rev Nutr, vol.28, pp.35-54, 2008.

T. J. Kieffer, C. H. Mcintosh, and R. A. Pederson, Degradation of glucosedependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV, Endocrinology, vol.136, issue.8, pp.3585-3596, 1995.

J. J. Kim and W. I. Khan, Goblet cells and mucins: role in innate defense in enteric infections, Pathogens, vol.2, issue.1, pp.55-70, 2013.

Y. C. Kim, S. Byun, Y. Zhang, S. Seok, B. Kemper et al., Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2, Genome Biol, vol.16, p.268, 2015.

A. Kitamoto, T. Kitamoto, T. Nakamura, T. Matsuo, Y. Nakata et al.,

K. Chayama, K. Hamaguchi, T. Yamada, S. Hanafusa, T. Oikawa et al., CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass, J Atheroscler Thromb, vol.23, issue.3, pp.309-319, 2016.

A. Kljuic, H. Bazzi, J. P. Sundberg, A. Martinez-mir, R. O'shaughnessy et al.,

M. Mahoney, X. Levy, W. Montagutelli, V. M. Ahmad, D. Aita et al.,

V. T. Panteleyev, A. M. Nguyen, and . Christiano, Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris, Cell, vol.113, issue.2, pp.249-260, 2003.

B. C. Knowles, V. G. Weis, S. Yu, J. T. Roland, J. A. Williams et al., Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes, J Cell Sci, vol.128, issue.8, pp.1617-1626, 2015.

B. Kong, L. Wang, J. Y. Chiang, Y. Zhang, C. D. Klaassen et al., Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice, Hepatology, vol.56, issue.3, pp.1034-1043, 2012.

A. Kourtidis, R. Lu, L. J. Pence, and P. Z. Anastasiadis, A central role for cadherin signaling in cancer, Exp Cell Res, 2017.

R. E. Kuhre, J. J. Holst, and C. Kappe, The regulation of function, growth and survival of GLP-1-producing L-cells, Clin Sci (Lond), vol.130, issue.2, pp.79-91, 2016.

D. P. Kumar, A. Asgharpour, F. Mirshahi, S. H. Park, S. Liu et al., Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet alpha Cells to Promote Glucose Homeostasis, J Biol Chem, vol.291, issue.13, pp.6626-6640, 2016.

D. P. Kumar, S. Rajagopal, S. Mahavadi, F. Mirshahi, J. R. Grider et al., Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic beta cells, Biochem Biophys Res Commun, vol.427, issue.3, pp.600-605, 2012.

F. Lammert and T. Sauerbruch, Mechanisms of disease: the genetic epidemiology of gallbladder stones, Nat Clin Pract Gastroenterol Hepatol, vol.2, issue.9, pp.423-433, 2005.

J. L. Leahy, Pathogenesis of type 2 diabetes mellitus, Arch Med Res, vol.36, issue.3, pp.197-209, 2005.

F. Y. Lee, H. Lee, M. L. Hubbert, P. A. Edwards, and Y. Zhang, FXR, a multipurpose nuclear receptor, Trends Biochem Sci, vol.31, issue.10, pp.572-580, 2006.

J. T. Lewis, B. Dayanandan, J. F. Habener, and T. J. Kieffer, Glucosedependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist, Endocrinology, vol.141, issue.10, pp.3710-3716, 2000.

T. Li, E. Owsley, M. Matozel, P. Hsu, C. M. Novak et al., , 2010.

, Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents highfat diet-induced obesity and insulin resistance in mice, Hepatology, vol.52, issue.2, pp.678-690

B. Liaset, Q. Hao, H. Jorgensen, P. Hallenborg, Z. Y. Du et al.,

E. J. Ofjord, M. Lock, L. Espe, L. Froyland, K. Madsen et al., , 2011.

, Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome, J Biol Chem, vol.286, issue.32, pp.28382-28395

Y. Liu, Y. Wang, Y. Zhang, Y. Miao, Y. Zhao et al., Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer, Lung Cancer, vol.63, issue.3, pp.375-382, 2009.

L. Losi, S. Parenti, F. Ferrarini, F. Rivasi, M. Gavioli et al.,

. Grande, Down-regulation of mu-protocadherin expression is a common event in colorectal carcinogenesis, Hum Pathol, vol.42, issue.7, pp.960-971, 2011.

H. Ma and M. E. Patti, Bile acids, obesity, and the metabolic syndrome, Best Pract Res Clin Gastroenterol, vol.28, issue.4, pp.573-583, 2014.

K. Ma, P. K. Saha, L. Chan, and D. D. Moore, Farnesoid X receptor is essential for normal glucose homeostasis, J Clin Invest, vol.116, issue.4, pp.1102-1109, 2006.

L. Ma, M. Juttner, G. A. Kullak-ublick, and J. J. Eloranta, Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2, Am J Physiol Gastrointest Liver Physiol, vol.302, issue.1, pp.123-133, 2012.

M. Makishima, A. Y. Okamoto, J. J. Repa, H. Tu, R. M. Learned et al., Identification of a nuclear receptor for bile acids, Science, vol.284, issue.5418, pp.1362-1365, 1999.

L. Marisa, A. De-reynies, A. Duval, J. Selves, M. P. Gaub et al.,

R. Etienne-grimaldi, D. Schiappa, M. Guenot, S. Ayadi, M. Kirzin et al.,

D. Flejou, A. Benchimol, A. Berger, E. Lagarde, F. Pencreach et al.,

S. Parc, G. Olschwang, P. Milano, V. Laurent-puig, and . Boige, Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value, PLoS Med, vol.10, issue.5, p.1001453, 2013.

I. Marmol, C. Sanchez-de-diego, A. Pradilla-dieste, E. Cerrada, and M. J. Rodriguez-yoldi, Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer, Int J Mol Sci, vol.18, issue.1, 2017.

H. U. Marschall and C. Einarsson, Gallstone disease, J Intern Med, vol.261, issue.6, pp.529-542, 2007.

E. Marshman, C. Booth, and C. S. Potten, The intestinal epithelial stem cell, Bioessays, vol.24, issue.1, pp.91-98, 2002.

?. Massey-harroche and D. , Epithelial cell polarity as reflected in enterocytes, Microsc Res Tech, vol.49, issue.4, pp.353-362, 2000.

D. Masuda, K. Hirano, H. Oku, J. C. Sandoval, R. Kawase et al., Chylomicron remnants are increased in the postprandial state in CD36 deficiency, J Lipid Res, vol.50, issue.5, pp.999-1011, 2009.

R. Mazzolini, H. Dopeso, S. Mateo-lozano, W. Chang, P. Rodrigues et al.,

J. Armengol, S. Tabernero, M. Ramon-y-cajal, J. Kloor, J. M. Gebert et al.,

J. Schwartz, L. A. Aaltonen, M. S. Mooseker, and D. Arango, Brush border myosin Ia has tumor suppressor activity in the intestine, Proc Natl Acad Sci U S A, vol.109, issue.5, pp.1530-1535, 2012.

R. E. Mcconnell, A. E. Benesh, S. Mao, D. L. Tabb, and M. J. Tyska, , 2011.

, Proteomic analysis of the enterocyte brush border, Am J Physiol Gastrointest Liver Physiol, vol.300, issue.5, pp.914-926

R. M. Mcdevitt, S. J. Bott, M. Harding, W. A. Coward, L. J. Bluck et al.,

. Prentice, De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women, Am J Clin Nutr, vol.74, issue.6, pp.737-746, 2001.

A. Misra and S. Bhardwaj, Obesity and the metabolic syndrome in developing countries: focus on South Asians, Nestle Nutr Inst Workshop Ser, vol.78, pp.133-140, 2014.

K. Miyawaki, Y. Yamada, H. Yano, H. Niwa, N. Ban et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice, Proc Natl Acad Sci U S A, vol.96, issue.26, pp.14843-14847, 1999.

S. Modica, M. Cariello, A. Morgano, I. Gross, M. C. Vegliante et al.,

J. N. Salvatore, C. Freund, A. Sabba, and . Moschetta, Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudalrelated homeobox 2 (CDX2), J Biol Chem, vol.289, issue.41, pp.28421-28432, 2014.

L. Montorsi, S. Parenti, L. Losi, F. Ferrarini, C. Gemelli et al., , 2016.

, Expression of mu-protocadherin is negatively regulated by the activation of the betacatenin signaling pathway in normal and cancer colorectal enterocytes, Cell Death Dis, vol.7, p.2263

D. E. Moulton, W. Crandall, R. Lakhani, and M. E. Lowe, Expression of a novel cadherin in the mouse and human intestine, Pediatr Res, vol.55, issue.6, pp.927-934, 2004.

B. Nagar, M. Overduin, M. Ikura, and J. M. Rini, Structural basis of calciuminduced E-cadherin rigidification and dimerization, Nature, vol.380, issue.6572, pp.360-364, 1996.

A. M. Nauli, F. Nassir, S. Zheng, Q. Yang, C. M. Lo et al., CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine, Gastroenterology, vol.131, issue.4, pp.1197-1207, 2006.

W. J. Nelson, Regulation of cell-cell adhesion by the cadherin-catenin complex, Biochem Soc Trans, vol.36, issue.2, pp.149-155, 2008.

R. Nesher and E. Cerasi, Modeling phasic insulin release: immediate and time-dependent effects of glucose, Diabetes, vol.51, pp.53-59, 2002.

D. S. Ng, Diabetic dyslipidemia: from evolving pathophysiological insight to emerging therapeutic targets, Can J Diabetes, vol.37, issue.5, pp.319-326, 2013.

M. Ng, T. Fleming, M. Robinson, B. Thomson, N. Graetz et al.,

S. Mullany, C. Biryukov, S. F. Abbafati, J. P. Abera, N. M. Abraham et al.,

W. Guzman, P. Ammar, A. Anwari, S. Banerjee, S. Barquera et al.,

J. Bhutta, N. Blore, I. C. Cabral, J. C. Nonato, R. Chang et al.,

D. Dharmaratne, E. L. Ding, A. M. Durrani, A. Esteghamati, F. Farzadfar et al.,

G. J. Hafezi-nejad, H. C. Hankey, R. Harewood, S. Havmoeller, L. Hay et al.,

J. B. Jeffreys, E. K. Jonas, S. E. Kabagambe, A. P. Khalifa, Y. S. Kengne et al.,

H. Khang, D. Kim, R. W. Kimokoti, J. M. Kinge, Y. Kokubo et al.,

M. Lai, Y. Leinsalu, X. Li, S. Liang, G. Liu et al.,

T. Nisar, S. O. Ohkubo, A. Oti, D. Pedroza, N. Prabhakaran et al.,

S. G. Seo, K. Sepanlou, R. Shibuya, I. Shiri, G. M. Shiue et al.,

N. J. Skirbekk, L. Stapelberg, B. L. Sturua, M. Sykes, B. X. Tobias et al.,

H. Trasande, S. Toyoshima, T. J. Van-de-vijver, J. L. Vasankari, and G. Veerman,

V. V. Velasquez-melendez, S. E. Vlassov, T. Vollset, C. Vos, X. Wang et al.,

A. Weiderpass, J. L. Werdecker, Y. C. Wright, H. Yang, J. Yatsuya et al., Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study, Lancet, vol.384, issue.9945, pp.766-781, 2013.

M. Nicolaou, E. J. Andress, J. K. Zolnerciks, P. H. Dixon, C. Williamson et al.,

. Linton, Canalicular ABC transporters and liver disease, J Pathol, vol.226, issue.2, pp.300-315, 2012.

I. Niot, H. Poirier, T. T. Tran, and P. Besnard, Intestinal absorption of longchain fatty acids: evidence and uncertainties, Prog Lipid Res, vol.48, issue.2, pp.101-115, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01916996

, ? North American Association of Central Cancer Registries, 2012.

A. Nose, K. Tsuji, and M. Takeichi, Localization of specificity determining sites in cadherin cell adhesion molecules, Cell, vol.61, issue.1, pp.147-155, 1990.

M. Okawa, K. Fujii, K. Ohbuchi, M. Okumoto, K. Aragane et al., Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion, Biochem Biophys Res Commun, vol.390, issue.3, pp.377-381, 2009.

?. Openstax-college, Anatomy & Physiology. OpenStax-CNX, 2016.

R. Ose, T. Yanagawa, S. Ikeda, O. Ohara, and H. Koga, PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling, Mol Oncol, vol.3, issue.1, pp.54-66, 2009.

X. ?-pan and M. M. Hussain, Gut triglyceride production, Biochim Biophys Acta, vol.1821, issue.5, pp.727-735, 2012.

S. Parenti, F. Ferrarini, R. Zini, M. Montanari, L. Losi et al.,

. Grande, Mesalazine inhibits the beta-catenin signalling pathway acting through the upregulation of mu-protocadherin gene in colo-rectal cancer cells, Aliment Pharmacol Ther, vol.31, issue.1, pp.108-119, 2010.

H. E. Parker, A. M. Habib, G. J. Rogers, F. M. Gribble, and F. Reimann, Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells, Diabetologia, vol.52, issue.2, pp.289-298, 2009.

D. J. Parks, S. G. Blanchard, R. K. Bledsoe, G. Chandra, T. G. Consler et al.,

. Lehmann, Bile acids: natural ligands for an orphan nuclear receptor, Science, vol.284, issue.5418, pp.1365-1368, 1999.

M. Peakman, Immunological pathways to beta-cell damage in Type 1 diabetes, Diabet Med, vol.30, issue.2, pp.147-154, 2013.

J. Pedersen, R. K. Ugleholdt, S. M. Jorgensen, J. A. Windelov, K. V. Grunddal et al.,

E. M. Schwartz, S. S. Fuchtbauer, P. J. Poulsen, J. J. Holst, and . Holst, Glucose metabolism is altered after loss of L cells and alpha-cells but not influenced by loss of K cells, Am J Physiol Endocrinol Metab, vol.304, issue.1, pp.60-73, 2013.

G. M. Petersen, J. Slack, and Y. Nakamura, Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage, Gastroenterology, vol.100, issue.6, pp.1658-1664, 1991.

M. Philippova, M. B. Joshi, E. Kyriakakis, D. Pfaff, P. Erne et al., , 2009.

, A guide and guard: the many faces of T-cadherin, Cell Signal, vol.21, issue.7, pp.1035-1044

I. Pineda-torra, T. Claudel, C. Duval, V. Kosykh, J. C. Fruchart et al., Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor, Mol Endocrinol, vol.17, issue.2, pp.259-272, 2003.

H. Pinheiro, R. Bordeira-carrico, S. Seixas, J. Carvalho, J. Senz et al., Allelespecific CDH1 downregulation and hereditary diffuse gastric cancer, Hum Mol Genet, vol.19, issue.5, pp.943-952, 2010.

M. J. Potthoff, J. Boney-montoya, M. Choi, T. He, N. E. Sunny et al., FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway, Cell Metab, vol.13, issue.6, pp.729-738, 2011.

M. J. Potthoff, S. A. Kliewer, and D. J. Mangelsdorf, Endocrine fibroblast growth factors 15/19 and 21: from feast to famine, Genes Dev, vol.26, issue.4, pp.312-324, 2012.

F. Preitner, M. Ibberson, I. Franklin, C. Binnert, M. Pende et al., Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors, J Clin Invest, vol.113, issue.4, pp.635-645, 2004.

D. Raddatz and G. Ramadori, Carbohydrate metabolism and the liver: actual aspects from physiology and disease, Z Gastroenterol, vol.45, issue.1, pp.51-62, 2007.

V. I. Reshetnyak, Physiological and molecular biochemical mechanisms of bile formation, World J Gastroenterol, vol.19, issue.42, pp.7341-7360, 2013.

T. Reya and H. Clevers, Wnt signalling in stem cells and cancer, Nature, vol.434, issue.7035, pp.843-850, 2005.

D. L. Rimm, E. R. Koslov, P. Kebriaei, C. D. Cianci, and J. S. Morrow, Alpha 1(E)-catenin is an actin-binding and-bundling protein mediating the attachment of Factin to the membrane adhesion complex, Proc Natl Acad Sci U S A, vol.92, pp.8813-8817, 1995.

G. A. Rutter, T. J. Pullen, D. J. Hodson, and A. Martinez-sanchez, Pancreatic beta-cell identity, glucose sensing and the control of insulin secretion, Biochem J, vol.466, issue.2, pp.203-218, 2015.

A. K. ?-san-roman, B. E. Aronson, S. D. Krasinski, R. A. Shivdasani, and M. P. Verzi, Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2, J Biol Chem, vol.290, issue.3, pp.1850-1860, 2015.

A. T. Sane, D. Sinnett, E. Delvin, M. Bendayan, V. Marcil et al., Localization and role of NPC1L1 in cholesterol absorption in human intestine, J Lipid Res, vol.47, issue.10, pp.2112-2120, 2006.

L. Santiago, G. Daniels, D. Wang, F. M. Deng, and P. Lee, Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment, Am J Cancer Res, vol.7, issue.6, pp.1389-1406, 2017.

D. Sauvaget, V. Chauffeton, D. Citadelle, F. P. Chatelet, C. Cywiner-golenzer et al., , 2002.

, Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms, J Biol Chem, vol.277, issue.37, pp.34540-34548

M. Sawa, M. Masuda, and T. Yamada, Targeting the Wnt signaling pathway in colorectal cancer, Expert Opin Ther Targets, vol.20, issue.4, pp.419-429, 2016.

F. G. Schaap, Role of fibroblast growth factor 19 in the control of glucose homeostasis, Curr Opin Clin Nutr Metab Care, vol.15, issue.4, pp.386-391, 2012.

J. Schleicher, C. Tokarski, E. Marbach, M. Matz-soja, S. Zellmer et al.,

. Schuster, Zonation of hepatic fatty acid metabolism-The diversity of its regulation and the benefit of modeling, Biochim Biophys Acta, vol.1851, issue.5, pp.641-656, 2015.

M. Schwarz, E. G. Lund, K. D. Setchell, H. J. Kayden, J. E. Zerwekh et al., Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alphahydroxylase, J Biol Chem, vol.271, issue.30, pp.18024-18031, 1996.

M. Schwarz, D. W. Russell, J. M. Dietschy, and S. D. Turley, Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding, J Lipid Res, vol.42, issue.10, pp.1594-1603, 2001.

S. Seok, D. Kanamaluru, Z. Xiao, D. Ryerson, S. E. Choi et al., Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Czeta is critical for epigenomic regulation of liver metabolic genes, J Biol Chem, vol.288, issue.32, pp.23252-23263, 2013.

M. T. Shanahan, I. M. Carroll, and A. S. Gulati, Critical design aspects involved in the study of Paneth cells and the intestinal microbiota, Gut Microbes, vol.5, issue.2, pp.208-214, 2014.

P. Sharma and H. Mcneill, Fat and Dachsous cadherins, Prog Mol Biol Transl Sci, vol.116, pp.215-235, 2013.

J. Shim, C. L. Moulson, E. P. Newberry, M. H. Lin, Y. Xie et al., Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice, J Lipid Res, vol.50, issue.3, pp.491-500, 2009.

A. Shimotoyodome, D. Fukuoka, J. Suzuki, Y. Fujii, T. Mizuno et al., Coingestion of acylglycerols differentially affects glucose-induced insulin secretion via glucose-dependent insulinotropic polypeptide in C57BL/6J mice, Endocrinology, vol.150, issue.5, pp.2118-2126, 2009.

?. Shirazi-beechey, S. P. , A. W. Moran, D. J. Batchelor, K. Daly et al., Glucose sensing and signalling; regulation of intestinal glucose transport, Proc Nutr Soc, vol.70, issue.2, pp.185-193, 2011.

R. L. Silverstein and M. Febbraio, CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior, Sci Signal, vol.2, issue.72, p.3, 2009.

C. J. Sinal, M. Tohkin, M. Miyata, J. M. Ward, G. Lambert et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis, Cell, vol.102, issue.6, pp.731-744, 2000.

A. Sing, Y. Tsatskis, L. Fabian, I. Hester, R. Rosenfeld et al.,

. Mcneill, The atypical cadherin fat directly regulates mitochondrial function and metabolic state, Cell, vol.158, issue.6, pp.1293-1308, 2014.

R. Singh, S. Kaushik, Y. Wang, Y. Xiang, I. Novak et al., Autophagy regulates lipid metabolism, Nature, vol.458, issue.7242, pp.1131-1135, 2009.

W. Stremmel, L. Pohl, A. Ring, and T. Herrmann, A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids, Lipids, vol.36, issue.9, pp.981-989, 2001.

K. Sugawara, T. Shibasaki, A. Mizoguchi, T. Saito, and S. Seino, Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis, Genes Cells, vol.14, issue.4, pp.445-456, 2009.

S. Sykes, L. M. Morgan, J. English, and V. Marks, Evidence for preferential stimulation of gastric inhibitory polypeptide secretion in the rat by actively transported carbohydrates and their analogues, J Endocrinol, vol.85, issue.2, pp.201-207, 1980.

K. Takagi, R. Legrand, A. Asakawa, H. Amitani, M. Francois et al., Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans, Nat Commun, vol.4, p.2685, 2013.

C. Thomas, A. Gioiello, L. Noriega, A. Strehle, J. Oury et al., TGR5-mediated bile acid sensing controls glucose homeostasis, Cell Metab, vol.10, issue.3, pp.167-177, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00420823

P. M. Titchenell, M. A. Lazar, and M. J. Birnbaum, Unraveling the Regulation of Hepatic Metabolism by Insulin, Trends Endocrinol Metab, vol.28, issue.7, pp.497-505, 2017.

M. S. Trabelsi, M. Daoudi, J. Prawitt, S. Ducastel, V. Touche et al.,

V. Baud, N. Spinelli, S. Hennuyer, K. Caron, R. Bantubungi et al.,

P. Marchetti, F. Lefebvre, F. M. Backhed, K. Gribble, F. Schoonjans et al.,

B. Tailleux, S. Staels, and . Lestavel, Farnesoid X receptor inhibits glucagonlike peptide-1 production by enteroendocrine L cells, Nat Commun, vol.6, p.7629, 2015.

T. M. Tuohy, K. G. Rowe, G. P. Mineau, R. Pimentel, R. W. Burt et al., Risk of colorectal cancer and adenomas in the families of patients with adenomas: a population-based study in Utah, Cancer, vol.120, issue.1, pp.35-42, 2014.

?. Van-roy and F. , Beyond E-cadherin: roles of other cadherin superfamily members in cancer, Nat Rev Cancer, vol.14, issue.2, pp.121-134, 2014.

?. Varela-calvino, R. , G. Sgarbi, S. Arif, and M. Peakman, T-Cell reactivity to the P2C nonstructural protein of a diabetogenic strain of coxsackievirus B4, Virology, vol.274, issue.1, pp.56-64, 2000.

E. J. Verspohl, Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors, Pharmacol Ther, vol.124, issue.1, pp.113-138, 2009.

M. P. Verzi, H. Shin, L. L. Ho, X. S. Liu, and R. A. Shivdasani, Essential and redundant functions of Caudal family proteins in activating adult intestinal genes, Mol Cell Biol, 2011.

H. H. Wang, N. H. Afdhal, S. J. Gendler, and D. Q. Wang, Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/-mice, Am J Physiol Gastrointest Liver Physiol, vol.287, issue.3, pp.547-554, 2004.

Y. Wang, C. Montrose-rafizadeh, L. Adams, M. Raygada, O. Nadiv et al., GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells, Mol Cell Endocrinol, vol.116, issue.1, pp.81-87, 1996.

M. Watanabe, Y. Horai, S. M. Houten, K. Morimoto, T. Sugizaki et al., , 2011.

, Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure, J Biol Chem, vol.286, issue.30, pp.26913-26920

M. Watanabe, S. M. Houten, L. Wang, A. Moschetta, D. J. Mangelsdorf et al.,

D. D. Heyman, J. Moore, and . Auwerx, Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c, J Clin Invest, vol.113, issue.10, pp.1408-1418, 2004.

R. T. Watson and J. E. Pessin, Intracellular organization of insulin signaling and GLUT4 translocation, Recent Prog Horm Res, vol.56, pp.175-193, 2001.

M. F. White, The insulin signalling system and the IRS proteins, Diabetologia, vol.40, pp.2-17, 1997.

B. M. Wice, S. Wang, D. L. Crimmins, K. A. Diggs-andrews, M. C. Althage et al.,

H. Ford, M. Tran, T. A. Ohlendorf, Q. Griest, S. J. Wang et al., Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism, J Biol Chem, vol.285, issue.26, pp.19842-19853, 2010.

E. J. Williams, J. Furness, F. S. Walsh, P. Doherty-;-n-, C. et al., Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, Neuron, vol.13, issue.3, pp.583-594, 1994.

G. M. Williams and M. J. Iatropoulos, Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity, Toxicol Pathol, vol.30, issue.1, pp.41-53, 2002.

J. M. Winter, A. H. Ting, F. Vilardell, E. Gallmeier, S. B. Baylin et al., Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer, Clin Cancer Res, vol.14, issue.2, 2008.

L. Y. Yang and A. Kuksis, Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols, J Lipid Res, vol.32, issue.7, pp.1173-1186, 1991.

C. R. Yellaturu, X. Deng, L. M. Cagen, H. G. Wilcox, C. M. Mansbach et al., Insulin enhances posttranslational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles, J Biol Chem, vol.284, issue.12, pp.7518-7532, 2009.

C. R. Yellaturu, X. Deng, E. A. Park, R. Raghow, and M. B. Elam, Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex, J Biol Chem, vol.284, pp.31726-31734, 2009.

C. L. ?-yen, M. L. Cheong, C. Grueter, P. Zhou, J. Moriwaki et al., Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding, Nat Med, vol.15, issue.4, pp.442-446, 2009.

L. Yu, J. Li-hawkins, R. E. Hammer, K. E. Berge, J. D. Horton et al., Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol, J Clin Invest, vol.110, issue.5, pp.671-680, 2002.

Y. Zhang, F. Y. Lee, G. Barrera, H. Lee, C. Vales et al., Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice, Proc Natl Acad Sci U S A, vol.103, issue.4, pp.1006-1011, 2006.

I. Publications, N. Platet, I. Hinkel, L. Richert, D. Murdamoothoo et al., The tumor suppressor CDX2 opposes prometastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton, Cancer Letters, vol.386, pp.57-64, 2017.

?. Baranger, M. Beck, M. Moufok-sadoun, A. Bersuder, E. Hinkel et al., And Gross I. The Atypical Cadherin MUCDHL antagonizes colon cancer and inhibits ß-Catenin signaling through multiple mechanisms

?. Moufok-sadoun, A. Baranger, M. , L. May, C. et al., Brush border Cadherin MUCDHL controls the digestive metabolism. En preparation. * contribution équivalente II, Liste des communications

M. Georg, M. Elisabeth, . Laetitia, . Freund-jean-noël, and . Gross-isabelle, Implication de la cadhérine atypique Mucdhl dans la tumorigenèse colique

, Communication orale, 28 et 29 avril 2016-4èmes Journées Scientifiques de la FMTS

?. Ahlam, *. Baranger-mathilde, *. Beck-marine, . Georg, M. Martin-elisabeth et al.,