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Les complexes Ni-bis (dithiolène) pour des applications en science des matériaux et en biotechnologies

Abstract : The photothermal properties in the near Infrared (NIR) of neutral nickel-bis(dithiolene) complexes were used in materials science and for the first time in biotechnology. Hydrophilic and hydrophobic neutral Ni-bis(dithiolene) complexes were developped and for the first time, their photothermal effect under NIR laser irradiation was quantified. Thanks to this remarkable property and their high stability under irradiaton, it has been demonstrated that these complexes could find applications to photothermal therapy, controlled drug delivery but also in the developpement of stimuli responsive nanomaterials. Indeed, this photothermal effect, under NIR laser irradiation, allow to destroy malignant cells, increase the permeability of polymeric nanoparticles or liposomes containing active ingredients and disintegrate métallogels based on Ni-bis(dithiolene) cores. Finally, we showed that the [Ni(R2-timdt)2]0 complexes having higher phothothermal activity are very promising new candidates for these applications.
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Kenny Mebrouk. Les complexes Ni-bis (dithiolène) pour des applications en science des matériaux et en biotechnologies. Matériaux. Université Rennes 1, 2016. Français. ⟨NNT : 2016REN1S126⟩. ⟨tel-02003529⟩

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