-. Did, DiD-Cl (1 eq., 8 mg, 0.0081 mmol) and sodium tetrakis

H. Nmr,

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, H, m) 7.56-7.61 (10 H, m) 8.42 (2 H, t, J=12.97 Hz). 19 F NMR, p.376

. Mhz, F, s). 11 B NMR (128 MHz, acetone-d6) ? ppm5.85 (1 B, s). 13 C NMR (126 MHz, acetone-d6) ? ppm 13.47 (s), 22.45 (s), 26.56 (s), 26.92 (s), 27.23 (s), 29.04 (s), 29.14 (s), 29.19 (s), vol.29, p.47

, 23 (s), 111.08 (s), 119.22 (s), 121.51 (s), 122.33 (s), 122.83 (s), 123.81 (s), 125.06 (s), 125.29 (dd), 126.11 (s), 128.59 (s), vol.29

F. Nmr-;-f,-d and . Hz, 376 MHz, acetonitrile-d3) ? ppm-136, vol.53

B. Nmr,

, HRMS

B. Nmr, 128 MHz, acetonitrile-d3), p.144

;. Hz and D. Hz,

, MS

R. ,

F. Nmr-;-f, 376 MHz, acetonitrile-d3) ? ppm-133.66 (2 F, s),-163, vol.89, p.19

;. Hz and . Hz, , vol.26

B. Nmr, 128 MHz, acetonitrile-d3) ? ppm-16, vol.70

, HRMS

R. ,

F. Nmr, 376 MHz, acetonitrile-d3) ? ppm-63.21 (1 F, s)

B. Nmr, 128 MHz, acetonitrile-d3) ? ppm-6, vol.66

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, 4A) and an attempt was made to form ion pairs of the corresponding barbiturates with R18 dye. From the first set of tested barbiturates (compounds 1, 2 and BarC6) only BarC6 could form stable ion pairs with R18, most likely due to additional electron-withdrawing effect of pentafluorophenyl ring. Quantum yields tests have shown, that BarC6 can decrease ACQ of R18 inside PLGA nanoparticles (Fig. 4B), but less efficiently than F5-TPB or F9-Al, Therefore, a series of barbiturates was synthesized (Fig

, Therefore, much bulkier barbituric derivative, BarPh2, was synthesized (Fig. 4A), its ion pair with R18 was successfully formed, and the quantum yield of 50 mM-loaded PLGA NPs has reached ~52% (Fig. 4B)

, A) Scheme of synthesis of the target barbiturates. (B) Quantum yield of NPs

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