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Modélisation de l'interaction entre l'hémodynamique hépatique et la régénération hépatique dans l'étude de l'insuffisance hépatique post hépatectomie

Abstract : Liver regeneration after liver resection does not occur in the same way in different conditions. A major determining factor of the regeneration could be the hemodynamic environment of the regenerating liver.The aim of our work was to study the relationship between liver regeneration and hemodynamic parameters, based mainly on experimental models of liver resection in large animals. We studied regeneration as CT scan volume, histopathology, hepatocyte proliferation and vessel neoformation inside the liver parenchyma, up to 3D reconstruction of the liver lobule.Our results show important relationships between liver hemodynamics and liver regeneration and let imagine the possibility to modulate hemodynamic parameters in order to modify liver regeneration.
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Submitted on : Friday, February 1, 2019 - 11:36:49 AM
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Petru Bucur. Modélisation de l'interaction entre l'hémodynamique hépatique et la régénération hépatique dans l'étude de l'insuffisance hépatique post hépatectomie. Médecine humaine et pathologie. Université Paris Saclay (COmUE), 2017. Français. ⟨NNT : 2017SACLS016⟩. ⟨tel-02003340⟩

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