. , Mécanisme proposé pour la formation du composé (273), Schéma, vol.47

. , Formation de cycles à 7 atomes, vol.48

. , Schéma, vol.49

, Formation du cycle à 7 chaînon des dérivées du 8-BrGCV et du 8-BrPCV, vol.50, p.114

. , Formation des 5',8-cyclopurines dans l'ADN et structures chimiques des stéréoisomères des nucléosides dans lesquels ces lésions sont formées, vol.51

. , Formation du radical en C5' et cyclisation intramoléculaire des 8bromonucléosides, vol.52

. , Synthèse des 5',8-cyclo-2'-deoxyadénosine [271], Schéma, vol.53

, Cyclisation des radicaux C5'-guanosynil via les, vol.54

.. .. ,

. , Formation des cyclonucléosides par voie radicalaire chimique, Schéma, vol.55

. , Schéma de synthèse proposé pour accéder aux cyclonucléosides recherchés, vol.56

. , Réaction photo-amorcée utilisée pour la cyclisation du 8-BrGCV, Schéma, vol.57

. , Schéma de synthèse pour accéder au cyclonucléoside (288), Schéma, vol.58

. , Protection du 8-BrGCV et du 8-BrPCV par TBDMS, Schéma, vol.59

. , Réaction de cyclisation par l'AIBN/Bu 3 SnH et produits formés.* Détermination du taux de conversion réalisée par RMN, Schéma, vol.60

. , Schéma, vol.61

. , Synthèse du composé 256, vol.62

. , Synthèses complémentaires pour accéder à des analogues, vol.63

P. .. , Schéma 64 Synthèse des composés cycliques à 7 chaînons à partir du GCV, p.138

. , Réactions réalisée pour accéder au composé 288a, vol.65

. , Synthèses réalisées pour accéder aux composés cycliques des dérives GCV et PCV. *Détermination du taux de conversion réalisée par RMN, Schéma, vol.66

A. Lustig and A. J. Levine, One hundred years of virology, Journal of Virology, vol.66, issue.8, pp.4629-4631, 1992.

M. Zaitlin, The discovery of the causal agent of the tobacco mosaic disease. Discoveries in Plant Biology, vol.1, pp.105-110, 1998.

P. Forterre, M. Krupovic, and D. Prangishvili, Cellular domains and viral lineages, Trends in Microbiology, vol.22, issue.10, pp.554-558, 2014.
URL : https://hal.archives-ouvertes.fr/pasteur-01977393

P. Forterre and D. Prangishvili, The major role of viruses in cellular evolution: facts and hypotheses. Current Opinion in Virology, pp.558-565, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00881056

P. Forterre, Why Are There So Many Diverse Replication Machineries, Journal of Molecular Biology, vol.425, issue.23, pp.4714-4726, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00932191

P. Forterre, The virocell concept and environmental microbiology, The ISME Journal-Nature, vol.7, issue.2, pp.233-236, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00784628

P. Forterre, The great virus comeback, Biologie Aujourd'hui, vol.207, issue.3, pp.153-68, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00932229

P. Forterre, Defining life: the virus viewpoint, Orig Life Evol Biosph, vol.40, issue.2, pp.151-60, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00506367

P. Forterre and D. Prangishvili, The origin of viruses, Research in Microbiology, vol.160, issue.7, pp.466-472, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01443846

D. Raoult and P. Forterre, Redefining viruses: lessons from Mimivirus, Nature Reviews Microbiology, vol.6, issue.4, pp.315-319, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00297223

P. Forterre, The origin of viruses and their possible roles in major evolutionary transitions, Virus Research, vol.117, issue.1, pp.5-16, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00068013

F. Patrick, Virocell Concept, The, in eLS, 2001.

A. Davison, The order Herpesvirales. Archives of Virology, vol.154, pp.171-177, 2009.

L. Aurelian, Herpes Simplex Viruses: General Features, Encyclopedia of Virology, pp.383-397, 2008.

D. J. Mcgeoch, The genomes of the human herpesviruses: contents, relationships, and evolution. Annual Review of Microbiology, vol.43, pp.235-65, 1989.

D. J. Mcgeoch, F. J. Rixon, and A. J. Davison, Topics in herpesvirus genomics and evolution, Virus Research, vol.117, issue.1, pp.90-104, 2006.

H. Muehlbach, Dominant-negative proteins in herpesviruses-from assigning gene function to intracellular immunization. Viruses, vol.1, pp.420-440, 2009.

A. S. Olia, Three-dimensional structure of a viral genome-delivery portal vertex, Nature Structural & Molecular Biology, vol.18, issue.5, pp.597-603, 2011.

J. C. Brown and W. W. Newcomb, Herpesvirus capsid assembly: insights from structural analysis. Current Opinion in Virology, vol.1, pp.142-149, 2011.

R. Germi, Three-dimensional structure of the Epstein-Barr virus capsid, Journal of General Virology, vol.93, issue.8, pp.1769-1773, 2012.

B. J. Kelly, Functional roles of the tegument proteins of herpes simplex virus type 1. Virus Research, vol.145, pp.173-186, 2009.

H. Guo, Role of tegument proteins in herpesvirus assembly and egress, Protein Cell, vol.1, issue.11, pp.987-98, 2010.

T. C. Mettenleiter, B. G. Klupp, and H. Granzow, Herpesvirus assembly: a tale of two membranes, Current Opinion in Microbiology, vol.9, issue.4, pp.423-429, 2006.

F. A. Rey, Molecular gymnastics at the herpesvirus surface, EMBO reports, vol.7, issue.10, pp.1000-1005, 2006.

J. Bosse, Herpes-virus capsid dynamics in living cells, 2011.

P. Boehmer and A. Nimonkar, Herpes Virus Replication. IUBMB Life, vol.55, issue.1, pp.13-22, 2003.

D. M. Coen and P. A. Schaffer, Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets, Nature reviews. Drug discovery, vol.2, issue.4, pp.278-88, 2003.

S. A. Connolly, Fusing structure and function: a structural view of the herpesvirus entry machinery, Nature Reviews Microbiology, vol.9, issue.5, pp.369-381, 2011.

R. J. Whitley and B. Roizman, Herpes simplex virus infections. The Lancet, vol.357, pp.1513-1518, 2001.

R. J. Eisenberg, Herpesvirus fusion and entry: a story with many characters, Viruses, vol.4, pp.800-832, 2012.

S. J. Molesworth, Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells, Journal of Virology, vol.74, issue.14, pp.6324-6356, 2000.

L. Wu, C. M. Borza, and L. M. Hutt-fletcher, Mutations of Epstein-Barr Virus gH That Are Differentially Able To Support Fusion with B Cells or Epithelial Cells, Journal of Virology, vol.79, issue.17, pp.10923-10930, 2005.

L. Wu and L. M. Hutt-fletcher, Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion. Virology, vol.363, pp.148-155, 2007.

C. Krummenacher, Entry of herpesviruses into cells: the Enigma variations, Viral Entry into Host Cells), pp.178-195, 2013.

T. C. Mettenleiter, The way out: what we know and do not know about herpesvirus nuclear egress, Cellular Microbiology, vol.15, issue.2, pp.170-178, 2013.

G. Cardone, Procapsid Assembly, Maturation, Nuclear Exit: Dynamic Steps in the Production of Infectious Herpesvirions, Viral Molecular Machines, pp.423-439, 2012.

K. Radtke, Plus-and Minus-End Directed Microtubule Motors Bind Simultaneously to Herpes Simplex Virus Capsids Using Different Inner Tegument Structures, PLoS Pathog, vol.6, issue.7, p.1000991, 2010.

R. J. Diefenbach, Transport and egress of herpes simplex virus in neurons, Reviews in Medical Virology, vol.18, issue.1, pp.35-51, 2008.

A. Wolfstein, The Inner Tegument Promotes Herpes Simplex Virus Capsid Motility Along Microtubules in vitro, Traffic, vol.7, issue.2, pp.227-237, 2006.

G. W. Luxton, Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins, Proceedings of the National Academy of Sciences of the United States of America, vol.102, pp.5832-5837, 2005.

K. Döhner, Function of Dynein and Dynactin in Herpes Simplex Virus Capsid Transport, Molecular Biology of the Cell, vol.13, issue.8, pp.2795-2809, 2002.

B. Sodeik, M. W. Ebersold, and A. Helenius, Microtubule-mediated Transport of Incoming Herpes Simplex Virus 1 Capsids to the Nucleus, The Journal of Cell Biology, vol.136, issue.5, pp.1007-1021, 1997.

F. Anderson, Targeting of Viral Capsids to Nuclear Pores in a Cell-Free Reconstitution System, Traffic, vol.15, issue.11, pp.1266-1281, 2014.

S. V. Zaichick, The Herpesvirus VP1/2 Protein Is an Effector of DyneinMediated Capsid Transport and Neuroinvasion. Cell host & microbe, vol.13, 2013.

D. Pasdeloup, Herpesvirus Tegument Protein pUL37 Interacts with Dystonin/BPAG1 To Promote Capsid Transport on Microtubules during Egress, Journal of Virology, vol.87, issue.5, pp.2857-2867, 2013.

L. Sage, V. , A. C. Mouland-;-c, and . Hoogenraad, Microtubule-based transport-basic mechanisms, traffic rules and role in neurological pathogenesis, Journal of Cell Science, vol.5, issue.8, pp.2319-2329, 2013.

I. Liashkovich, Nuclear delivery mechanism of herpes simplex virus type 1 genome, Journal of Molecular Recognition, vol.24, issue.3, pp.414-421, 2011.

R. B. Vallee, Dynein: An ancient motor protein involved in multiple modes of transport, Journal of Neurobiology, vol.58, issue.2, pp.189-200, 2004.

N. Huot, Relationship between the expression of LAT and RL2 gene during HSV-1 latency, 2012.
URL : https://hal.archives-ouvertes.fr/tel-00923161

P. L. Ward and B. Roizman, Herpes simplex genes: the blueprint of a succesful human pathogen, Trends in Genetics, vol.10, issue.8, pp.267-274, 1994.

L. J. Rosenthal, Replication of herpesviruses and latency, Canadian Journal of Microbiology, vol.25, issue.3, pp.239-244, 1979.

E. K. Flemington, Herpesvirus Lytic Replication and the Cell Cycle: Arresting New Developments, Journal of Virology, vol.75, issue.10, pp.4475-4481, 2001.

H. H. Balfour, Age-Specific Prevalence of Epstein-Barr Virus Infection Among Individuals Aged 6-19 Years in the United States and Factors Affecting Its Acquisition, Journal of Infectious Diseases, vol.208, issue.8, pp.1286-1293, 2013.

S. K. Sanghavi, D. T. Rowe, and C. R. Rinaldo, Cytomegalovirus, Varicella-Zoster virus, and Epstein-Barr virus, 2009.

B. P. Yawn and D. Gilden, The global epidemiology of herpes zoster, Neurology, vol.81, issue.10, pp.928-958, 2013.

E. T. Stoopler and M. S. Greenberg, Update on herpesvirus infections, Dent Clin North Am, vol.47, issue.3, pp.517-549, 2003.

F. Fan, Laboratory diagnosis of HSV and varicella zoster virus infections, Future Virology, vol.9, issue.8, pp.721-731, 2014.

N. Van-wagoner and E. Hook, III, Herpes Diagnostic Tests and Their Use, Current Infectious Disease Reports, vol.14, issue.2, pp.175-184, 2012.

H. Agut, Infections aiguës à herpèsvirus humain 6 (HHV-6) : quand et comment traiter ? Pathologie Biologie, vol.59, pp.108-112, 2011.

M. Csire and G. Mikala, Human herpesviruses in hematologic diseases, 2012.

W. H. Prusoff, Synthesis and biological activities of iododeoxyuridine, an analog of thymidine, Biochimica et Biophysica Acta, vol.32, pp.295-296, 1959.

V. Hodge and R. A. , Meeting report: 26th International Conference on Antiviral Research, vol.100, pp.276-285, 2013.

R. A. Hodge and H. J. Field, Antiviral agents for herpes simplex virus, Advances Pharmacol, issue.67, pp.1-38, 2013.

Y. Cheng, H. William, and . Prusoff, Father of Antiviral Chemotherapy, vol.9, p.1001190, 1920.

R. F. Schinazi and H. William, Prusoff dies at 90-a renaissance man that revolutionized the treatment of herpesviruses and HIV. Antiviral Chemistry and Chemotherapy, vol.21, pp.219-220, 2011.

M. Skore?ski and M. Sie?czyk, Anti-herpesvirus agents: a patent and literature review (2003 to present), Expert Opinion on Therapeutic Patents, vol.24, issue.8, pp.925-941, 2014.

S. H. James and M. N. Prichard, Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance. Current Opinion in Virology, vol.8, pp.54-61, 2014.

A. D. Vadlapudi, R. K. Vadlapatla, and A. K. Mitra, Update on emerging antivirals for the management of herpes simplex virus infections: a patenting perspective, Recent Pat. Anti-Infect. Drug Discovery, vol.8, issue.1, pp.55-67, 2013.

G. B. Elion, Selectivity of action of an antiherpetic agent, Proceedings of the National Academy of Sciences, vol.74, pp.5716-5720, 1977.

C. Heidelberger, D. G. Parsons, and D. C. Remy, Syntheses of 5-trifluoromethyluracil and 5-trifluoromethul-2'-deoxyuridine, Journal of Medicinal Chemistry, vol.7, pp.1-5, 1964.

C. S. Crumpacker, Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections, Antimicrobial Agents and Chemotherapy, vol.15, issue.5, pp.642-645, 1979.

G. B. Elion, The purine path to chemotherapy, Science, issue.4900, pp.41-48

R. J. Whitley and J. W. Gnann, Acyclovir: A Decade Later, New England Journal of Medicine, vol.327, issue.11, pp.782-789, 1992.

M. S. Hirsch and R. T. Schooley, Treatment of Herpesvirus Infections, New England Journal of Medicine, vol.309, issue.17, pp.1034-1039, 1983.

E. D. Clercq, Chapter 1 Looking Back in 2009 at the Dawning of Antiviral Therapy Now 50 Years Ago: An Historical Perspective, Advances in Virus Research, pp.1-53, 2009.

G. B. Elion, Acyclovir: Discovery, mechanism of action, and selectivity, Journal of Medical Virology, vol.41, issue.S1, pp.2-6, 1993.

E. De-clercq, Antiviral drugs in current clinical use, Journal of Clinical Virology, vol.30, issue.2, pp.115-133, 2004.

L. Brunton, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2007.

E. De-clercq, Strategies in the design of antiviral drugs, Nature Reviews Drug Discovery, vol.1, issue.1, pp.13-25, 2002.

H. H. Balfour, Antiviral Drugs, New England Journal of Medicine, vol.340, issue.16, pp.1255-1268, 1999.

D. M. Coen, Antiherpesviral DNA Polymerase Inhibitors, Antiviral Research, 2009.

E. De-clercq and H. J. Field, Antiviral prodrugs-the development of successful prodrug strategies for antiviral chemotherapy, British Journal of Pharmacology, vol.147, issue.1, pp.1-11, 2006.

R. R. Razonable, Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus, vol.86, pp.1009-1026, 2011.

E. De-clercq, Selective Anti-Herpesvirus Agents, Antiviral Chemistry and Chemotherapy, vol.23, issue.3, pp.93-101, 2013.

C. M. Evans, G. Kudesia, and M. Mckendrick, Management of herpesvirus infections, International Journal of Antimicrobial Agents, vol.42, issue.2, pp.119-128, 2013.

C. S. Crumpacker and . Ganciclovir, New England Journal of Medicine, vol.335, issue.10, pp.721-729, 1996.

S. K. Tyring, Valomaciclovir versus valacyclovir for the treatment of acute herpes zoster in immunocompetent adults: A randomized, double-blind, activecontrolled trial, Journal of Medical Virology, vol.84, issue.8, pp.1224-1232, 2012.

K. K. Biron, Antiviral drugs for cytomegalovirus diseases, Antiviral Research, vol.71, issue.2-3, pp.154-163, 2006.

H. J. Field and R. A. Hodge, Recent developments in anti-herpesvirus drugs, British Medical Bulletin, vol.106, issue.1, pp.213-249, 2013.

A. Loregian, Separation methods for acyclovir and related antiviral compounds, Journal of Chromatography B: Biomedical Sciences and Applications, vol.764, issue.1-2, pp.289-311, 2001.

T. H. Bacon, Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy, Clinical Microbiology Reviews, vol.16, issue.1, pp.114-128, 2003.

J. Piret and G. Boivin, Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management, Antimicrobial Agents and Chemotherapy, vol.55, issue.2, pp.459-472, 2011.

H. Kaufman, E. L. Martola, and D. , Use of 5-iodo-29-deoxyuridine (IDU) in treatment of herpes simplex keratitis, Archives of Ophthalmology, vol.68, pp.235-239, 1962.

E. De-clercq, Antiviral drugs: current state of the art, Journal of Clinical Virology, vol.22, issue.1, pp.73-89, 2001.

E. D. Clercq, Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster, Biochemical Pharmacology, vol.68, issue.12, pp.2301-2315, 2004.

E. De-clercq, E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective antiherpes agent, Proceedings of the National Academy of Sciences, vol.76, pp.2947-2951, 1979.

E. De-clercq, Antiviral Drug Development-Success and Failure: A Personal Perspective with a Japanese Connection, Antiviral Chemistry and Chemotherapy, vol.23, issue.2, pp.45-55, 2013.

E. De-clercq, A 40-Year Journey in Search of Selective Antiviral Chemotherapy*. Annual Review of Pharmacology and Toxicology, vol.51, pp.1-24, 2011.

E. D. Clercq, E)-5-(2-bromovinyl)-2?-deoxyuridine (BVDU, vol.25, pp.1-20, 2005.

H. S. Allaudeen, On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine, Proceedings of the National Academy of Sciences, vol.78, pp.2698-2702, 1981.

N. Abdel-haq, New antiviral agents, Indian Journal of Pediatrics, vol.73, issue.4, pp.313-334, 2006.

E. De-clercq, Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives, Medicinal Research Reviews, vol.29, issue.4, pp.611-645, 2009.

E. De-clercq, Antiviral drug discovery and development: Where chemistry meets with biomedicine, Antiviral Research, vol.67, issue.2, pp.56-75, 2005.

B. Öberg, Antiviral effects of phosphonoformate (pfa, foscarnet sodium)

, Pharmacology & Therapeutics, vol.40, issue.2, pp.213-285, 1989.

C. S. Crumpacker, Mechanism of action of foscarnet against viral polymerases, The American Journal of Medicine, vol.92, issue.2A, pp.3-7, 1992.

M. Martin, Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity, Antiviral Therapy, vol.15, issue.4, pp.487-494, 2010.

P. C. Maudgal, E. D. Clercq, and L. Missotten, Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections, Antiviral Research, vol.4, issue.5, pp.281-291, 1984.

J. Piret and G. Boivin, Antiviral drug resistance in herpesviruses other than cytomegalovirus, Reviews in Medical Virology, vol.24, issue.3, pp.186-218, 2014.

D. H. Katz, n-Docosanol: Broad Spectrum Anti-Viral Activity against Lipidenveloped Virusesa, Annals of the New York Academy of Sciences, vol.724, issue.1, pp.472-488, 1994.

D. T. Leung and S. L. Sacks, Docosanol: a topical antiviral for herpes labialis, Expert Opinion on Pharmacotherapy, vol.5, issue.12, pp.2567-2571, 2004.

L. E. Pope, The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process, Antiviral Research, vol.40, issue.1-2, pp.85-94, 1998.

N. S. Treister and S. Woo, Topical n-docosanol for management of recurrent herpes labialis, Expert Opinion on Pharmacotherapy, vol.11, issue.5, pp.853-860, 2010.

W. Roush, Antisense Aims for a Renaissance, Science, vol.276, issue.5316, pp.1192-1193, 1997.

R. S. Geary, S. P. Henry, and L. R. Grillone, Fomivirsen: Clinical pharmacology and potential drug interactions, Clin. Pharmacokinet, vol.41, issue.4, pp.255-260, 2002.

S. H. James, Helicase-Primase as a Target of New Therapies for Herpes Simplex Virus Infections, vol.97, pp.66-78, 2015.

J. Just, Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit ?7 by recombinant antibody technology. Free Radical Biology and Medicine, vol.89, pp.786-792, 2015.

N. B. Price and M. N. Prichard, Progress in the development of new therapies for herpesvirus infections. Current Opinion in Virology, vol.1, pp.548-554, 2011.

K. Y. Hostetler, Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art, Antiviral Research, vol.82, issue.2, pp.84-98, 2009.

D. M. Lowe, Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses, Antimicrobial Agents and Chemotherapy, vol.39, issue.8, pp.1802-1808, 1995.

G. Abele, Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture, Antimicrobial Agents and Chemotherapy, vol.31, issue.1, pp.76-80, 1987.

A. Akesson-johansson, Inhibition of human herpesvirus 6 replication by 9

, Antimicrobial Agents and Chemotherapy, vol.34, issue.12, pp.2417-2419, 1990.

R. J. Rybak, Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides, Antiviral Research, vol.43, issue.3, pp.175-188, 1999.

S. Zhou, Synthesis and Antiviral Activity of (Z)-and (E)-2,2[Bis(hydroxymethyl)cyclopropylidene]methylpurines and-pyrimidines: SecondGeneration Methylenecyclopropane Analogues of Nucleosides, Journal of Medicinal Chemistry, vol.47, issue.3, pp.566-575, 2004.

M. N. Prichard and E. R. Kern, The search for new therapies for human cytomegalovirus infections, Virus Research, vol.157, issue.2, pp.212-221, 2011.

E. D. Clercq, Highlights in Antiviral Drug Research: Antivirals at the Horizon, Medicinal Research Reviews, vol.33, issue.6, pp.1215-1248, 2013.
DOI : 10.1002/med.21256

E. De-clercq, A Cutting-Edge View on the Current State of Antiviral Drug Development, Medicinal Research Reviews, vol.33, issue.6, pp.1249-1277, 2013.

R. J. Rybak, In Vitro Activities of Methylenecyclopropane Analogues of Nucleosides and Their Phosphoralaninate Prodrugs against Cytomegalovirus and Other Herpesvirus Infections, Antimicrobial Agents and Chemotherapy, vol.44, issue.6, pp.1506-1511, 2000.

E. R. Kern, Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections, Antimicrob Agents Chemother, vol.48, issue.12, pp.4745-53, 2004.

N. L. Kushner, Efficacy of Methylenecyclopropane Analogs of Nucleosides Against Herpesvirus Replication In Vitro, Nucleosides, Nucleotides and Nucleic Acids, vol.22, issue.12, pp.2105-2119, 2003.

B. G. Gentry, Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir, Antimicrob. Agents Chemother, vol.54, issue.8, pp.3093-3098, 2010.
DOI : 10.1128/aac.00468-10
URL : https://aac.asm.org/content/54/8/3093.full.pdf

S. B. Mhaske, Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity, Bioorganic & Medicinal Chemistry, vol.17, issue.11, pp.3892-3899, 2009.
DOI : 10.1016/j.bmc.2009.04.020
URL : http://europepmc.org/articles/pmc2765055?pdf=render

L. Fader, Naphthyridinone derivatives as inhibitors of cytomegalovirus DNA polymerase, p.163, 2013.

K. K. Biron, Maribavir: A promising new antiherpes therapeutic agent, New Concepts of Antiviral Therapy, A. Holzenburg and E. Bogner, pp.309-336, 2006.
DOI : 10.1007/978-0-387-31047-3_11

D. G. Wolf, Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation, Proceedings of the National Academy of Sciences, vol.98, pp.1895-1900, 2001.

P. M. Krosky, M. Baek, and D. M. Coen, The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress, Journal of Virology, vol.77, issue.2, pp.905-914, 2003.

K. K. Biron, Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, pp.2365-2372, 2002.

M. N. Prichard, Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir, Reviews in Medical Virology, vol.19, issue.4, pp.215-244, 2009.

B. Chacko and G. T. John, Leflunomide for cytomegalovirus: bench to bedside, Transplant Infectious Disease, vol.14, issue.2, pp.111-120, 2012.
DOI : 10.1111/j.1399-3062.2011.00682.x

W. J. Waldman, Inhibition of Cytomegalovirus in vitro and in vivo by the Experimental Immunosuppressive Agent Leflunomide, Intervirology, vol.42, pp.412-418, 1999.

D. A. Knight, Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent Leflunomide 1, Transplantation, issue.1, p.71, 2001.

A. B. Marnett, Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor, Proceedings of the National Academy of Sciences of the United States of America, vol.101, pp.6870-6875, 2004.

A. M. Nomura, One Functional Switch Mediates Reversible and Irreversible Inactivation of a Herpesvirus Protease ?. Biochemistry, vol.45, pp.3572-3579, 2006.

A. Lazic, Substrate modulation of enzyme activity in the herpesvirus protease family, Journal of molecular biology, vol.373, issue.4, pp.913-936, 2007.

G. Kleymann, New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease, Nature medicine, vol.8, issue.4, pp.392-400, 2002.

J. J. Crute, Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease, Nature Medicine, vol.8, issue.4, pp.386-391, 2002.

K. Chono, ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2, The Journal of Antimicrobial Chemotherapy, vol.65, issue.8, pp.1733-1774, 2010.

S. Tyring, ASP2151 for the treatment of genital herpes: a randomized, doubleblind, placebo-and valacyclovir-controlled, dose-finding study, The Journal of Infectious Diseases, vol.205, issue.7, pp.1100-1110, 2012.

T. Goldner, H. Zimmermann, and P. Lischka, Phenotypic characterization of two naturally occurring human Cytomegalovirus sequence polymorphisms located in a distinct region of ORF UL56 known to be involved in in vitro resistance to letermovir, Antiviral Research, vol.116, pp.48-50, 2015.

T. Goldner, The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase, Journal of Virology, vol.85, pp.10884-10893, 1920.

M. Marschall, Vitro Evaluation of the Activities of the Novel Anticytomegalovirus Compound AIC246 (Letermovir) against Herpesviruses and Other Human Pathogenic Viruses, vol.56, pp.1135-1137, 2012.

D. R. Kaul, First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246, American Journal of Transplantation, vol.11, issue.5, pp.1079-84, 2011.

J. Reefschlaeger, Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action, Journal of Antimicrobial Chemotherapy, vol.48, issue.6, pp.757-767, 2001.

W. A. Bresnahan, Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication, Virology, vol.231, issue.2, pp.239-286, 1997.
DOI : 10.1006/viro.1997.8489
URL : https://doi.org/10.1006/viro.1997.8489

D. Bevec, Cellular kinases involved in cytomegalovirus infection and their inhibition, 2002.

S. Proesch, H. D. Volk, and D. Krueger, Proteaseome inhibitors for the treatment of herpesviridae infected individuals, 2004.

R. J. Visalli, Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication, Journal of virology, vol.77, issue.4, pp.2349-58, 2003.

J. D. Bloom, Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N?arylthiourea inhibitors of CMV, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.13, pp.3401-3406, 2004.

T. Borrmann, Structure-Activity Relationships of Adenine and Deazaadenine Derivatives as Ligands for Adenine Receptors, a New Purinergic Receptor Family, Journal of Medicinal Chemistry, vol.52, pp.5974-5989, 2009.

A. M. Nomura, One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease, Biochemistry, vol.45, issue.11, pp.3572-3581, 2006.

S. De-castro, 4-Benzyloxy-?-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus, Journal of Medicinal Chemistry, vol.52, issue.6, pp.1582-1591, 2009.

T. Wunberg, Substituted quinazolines as antiviral agents, especially against cytomegaloviruses, 2006.

J. D. Watson and F. H. Crick, Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid, Nature, vol.171, issue.4356, pp.737-745, 1953.

P. Merino and . Editor, Chemical Synthesis of Nucleoside Analogues, vol.895, 2013.

G. Keating, Ledipasvir/Sofosbuvir: A Review of Its Use in Chronic Hepatitis C. Drugs, vol.75, pp.675-685, 2015.

J. P. Horwitz, J. Chua, M. Noel, and N. V. , The Monomesylates of 1-(2'Deoxy-?-D-lyxofuranosyl)thymine1,2. The Journal of Organic Chemistry, vol.29, pp.2076-2078, 1964.

M. Yokoyama and A. Momotake, Synthesis and biological activity of aza nucleosides, Synthesis, issue.9, pp.1541-1554, 1999.

M. Yokoyama, The Properties of 4?-Thionucleosides, in Modified Nucleosides, pp.173-221, 2008.

G. Romeo, Chemical Synthesis of Heterocyclic?Sugar Nucleoside Analogues, Chemical Reviews, vol.110, issue.6, pp.3337-3370, 2010.

X. Zhu, The Latest Progress in the Synthesis of Carbocyclic Nucleosides, Nucleosides, Nucleotides and Nucleic Acids, vol.19, issue.3, pp.651-690, 2000.

J. Du, Use of 2?-Spirocyclic Ethers in HCV Nucleoside Design, Journal of Medicinal Chemistry, vol.57, issue.5, pp.1826-1835, 2014.

M. A. Shaban and A. Z. Nasr, The Chemistry of C-Nucleosides and Their Analogs I: C-Nucleosides of Hetero Monocyclic Bases, Advances in Heterocyclic Chemistry, pp.223-432, 1997.

E. Maougal, Synthesis of Conformationally Constrained Nucleoside Analogues, Chemical Synthesis of Nucleoside Analogues, pp.345-426, 2013.

A. Mieczkowski and L. A. Agrofoglio, Potential and perspectives of cyclonucleosides, Current Medicinal Chemistry, vol.17, issue.15, pp.1527-1549, 2010.

A. Mieczkowski, V. Roy, and L. A. Agrofoglio, Preparation of Cyclonucleosides, Chemical Reviews, vol.110, issue.4, pp.1828-1856, 2010.

C. Len, M. Mondon, and J. Lebreton, Synthesis of cyclonucleosides having a C-C bridge, Tetrahedron, vol.64, issue.32, pp.7453-7475, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02143957

Y. Yoshimura and H. Takahata, Recent Advances in Cyclonucleosides: CCyclonucleosides and Spore Photoproducts in Damaged DNA, Molecules, vol.17, issue.10, p.11630, 2012.

V. M. Clark, A. R. Todd, and J. Zussman, 655. Nucleotides. Part VIII. cycloNucleoside salts. A novel rearrangement of some toluene-p-sulphonylnucleosides, Journal of the Chemical Society, issue.0, pp.2952-2958

M. Ikehara, Purine 8-cyclonucleosides, Accounts of Chemical Research, vol.2, issue.2, pp.47-53, 1969.

R. J. Capon and N. S. Trotter, N3,5'-Cycloxanthosine, the First Natural Occurrence of a Cyclonucleoside, Journal of Natural Products, vol.68, issue.11, pp.1689-1691, 2005.

A. Hoshi, F. Kanzawa, and K. Kuretani, Antitumor activity of cyclocytidine in a variety of tumors, Gann, vol.63, issue.3, pp.353-60, 1972.

W. Nakahara and R. Tokuzen, Effect of 2,2'-O-cyclocytidine on transplanted lymphocytic sarcoma and reticulum cell sarcoma in mice, Gann, vol.63, issue.3, pp.379-81, 1972.

K. Palczewski, N. Kahn, and P. A. Hargrave, Nucleoside inhibitors of rhodopsin kinase, Biochemistry, vol.29, issue.26, pp.6276-82, 1990.

A. Hampton, P. J. Harper, and T. Sasaki, Substrate properties of cycloadenosines with adenosine aminohydrolase as evidence for the conformation of enzyme-bound adenosine, Biochemistry, vol.11, issue.25, pp.4736-4745, 1972.

M. Ikehara and T. Fukui, Nucleosides and nucleotides. LVIII. Deamination of adenosine analogs with calf intestine adenosine deaminase, Biochim. Biophys. Acta, vol.338, issue.2, pp.512-531, 1974.

M. Ikehara, Synthesis of Purine Cyclonucleoside Having a 8,2'-O-Anhydro Linkage, Journal of the American Chemical Society, vol.88, issue.13, pp.3165-3167, 1966.

E. J. Reist, Potential Anticancer Agents.1LI. Synthesis of 2-Amino-9-(5'-deoxy?-D-ribofuranosyl)-9-H-purine-6-thiol. The Journal of Organic Chemistry, vol.26, pp.1557-1562, 1961.

M. Ikehara and M. Kaneko, Synthesis of Purine Cyclonucleoside having 8, 3'-OAnhydro Linkage, Chemical & Pharmaceutical Bulletin, vol.15, issue.8, pp.1261-1262, 1967.

M. Ikehara and K. Muneyama, Nucleosides and nucleotides. XXXIV. Purine cyclonucleosides. 4. Synthesis of a cyclonucleoside having an O-cyclo linkage derived from guanosine. The Journal of Organic Chemistry, vol.32, pp.3039-3042, 1967.

M. Ikehara and M. Kaneko, Synthesis of Adenine Cyclonucleosides having 8, 2'-and 8, 3'O-Anhydro Linkages, Studies of Nucleosides and Nucleotides. XLII. Purine Cyclonucleosides, vol.18, pp.2401-2406, 1970.

M. Ikehara and S. Uesugi, Studies of nucleosides and nucleotides-LIII, Tetrahedron, vol.28, issue.14, pp.3687-3694, 1972.

T. A. Khwaja, R. Harris, and R. K. Robins, Synthesis of 9-?-Darabinofuranosyladenine-3?,5?-cyclic phosphate from adenosine-3?,5?-cyclic phosphate, Tetrahedron Letters, vol.13, issue.46, pp.4681-4684, 1972.

A. M. Mian, Synthesis and biological activity of 9-.beta.-Darabinofuranosyladenine cyclic 3',5'-phosphate and 9-.beta.-Darabinofuranosylguanine cyclic 3',5'-phosphate, Journal of Medicinal Chemistry, vol.17, issue.3, pp.259-263, 1974.

D. Wagner, J. P. Verheyden, and J. G. Moffatt, Preparation and Synthetic Utility of Some Organotin Derivatives of nucleosides. The Journal of Organic Chemistry, vol.39, pp.24-30, 1974.

M. Ikehara and T. Maruyama, Studies of nucleosides and nucleotides-LXV : Purine cyclonucleosides-26 a versatile method for the synthesis of purine O-cyclonucleosides. The first synthesis of 8,2?-anhydro-8-oxy 9-?-d-arabinofuranosylguanine, Tetrahedron, vol.31, pp.1369-1372, 1975.

M. Ikehara and M. Muraoka, Synthesis and Properties of O-Cyclonucleosides derived from Hypoxanthine, Mercaptopurine, Methylmer-captopurine and Purine, Chemical & Pharmaceutical Bulletin, vol.24, issue.4, pp.672-682, 1976.

M. Ikehara, H. Miki, and A. Hasegawa, Studies of Nucleosides and Nucleotides. LXXXIV. Purine Cyclonucleosides. XL. Cyclonucleosides derived from 5'Deoxyadenosine, Chemical & Pharmaceutical Bulletin, vol.27, issue.11, pp.2647-2652, 1979.

M. Muraoka, J. Iwahara, and M. Kaneko, Synthesis of 2, 6-Diamino-9-beta;-Darabinofuranosylpurine via Cyclonucleoside, Chemical & Pharmaceutical Bulletin, vol.34, issue.6, pp.2609-2613, 1986.

M. Ikehara and M. Kaneko, Studies of nucleosides and nucleotides-XLI : Purine cyclonucleosides-8 selective sulfonylation of 8-bromoadenosine derivatives and an alternate synthesis of 8,2?-and 8,3?-S-cyclonucleosides, Tetrahedron, vol.26, issue.18, pp.4251-4259, 1970.

M. Ikehara and S. Uesugi, Selective tosylation of adenosine 5?-monophosphate, Tetrahedron Letters, vol.11, issue.10, pp.713-716, 1970.

T. Ueda, Y. Nomoto, and A. Matsuda, Synthesis of 8-Alkyladenosines, 8, 2'-Anhydro8-hydroxymethyl-9-(beta;-D-arabinofuranosyl) adenine and Related Compounds (Nucleosides and Nucleotides. LVIII), Chemical & Pharmaceutical Bulletin, vol.33, issue.8, pp.3263-3270, 1985.

H. Urata, Synthesis and hybridization properties of l-oligodeoxynucleotide analogues fixed in a low anti glycosyl conformation, Organic & Biomolecular Chemistry, vol.2, issue.2, pp.183-189, 2004.

H. Urata, Racemic synthesis of carbocyclic purine nucleoside analogues with restricted glycosyl conformation, Journal of the Chemical Society, Perkin Transactions, vol.1, issue.13, pp.1833-1838, 1999.

M. Ikehara and M. Kaneko, A novel method for the synthesis of cyclonucleosides, Journal, vol.90, issue.2, pp.497-498, 1968.

K. L. Nagpal and M. M. Dhar, The use of a purine cyclonucleoside for the synthesis of a dinucleoside phosphate, Tetrahedron Letters, vol.9, issue.1, pp.47-49, 1968.

P. C. Srivastava, K. L. Nagpal, and M. M. Dhar, Synthesis of purine cyclonucleosides, Indian Journal of Chemistry, vol.7, issue.1, pp.1-2, 1969.

G. Butora, The elusive 8-fluoroadenosine: a simple non-enzymatic synthesis and characterization, Tetrahedron, vol.63, issue.18, pp.3782-3789, 2007.

T. Naka and M. Honjo, Synthesis of 8-Carbamoyl-and 8-Carboxyadenosine 3', 5'Cyclic Phosphates, Chemical & Pharmaceutical Bulletin, vol.24, issue.9, pp.2052-2056, 1976.

M. Yu, Copper-Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One-Step Synthesis of 5?-O,8-Cyclopurine Nucleosides. The Journal of Organic Chemistry, vol.80, pp.9446-9453, 2015.

C. Amiable and S. Pochet, Unprecedented formation of 8(R),5?-Ocycloribonucleosides through a triflation reaction of purine ribonucleosides, Tetrahedron, vol.71, issue.17, pp.2525-2529, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01968373

W. Schroeder and H. Hoeksema, A New Antibiotic, 6-amino-9-Dpsicofuranosylpurine, Journal of the American Chemical Society, vol.81, issue.7, pp.1767-1768, 1959.

S. G. Zavgorodny, A novel type of anhydronucleusides to model syn-conformers of natural nucleosides, Tetrahedron Letters, vol.22, issue.31, pp.3003-3006, 1981.

M. Ikehara, M. Kaneko, and Y. Nakahara, Synthesis and properties of an ?cyclonucleoside, Tetrahedron Letters, vol.9, issue.45, pp.4707-4710, 1968.

R. Zou, J. C. Drach, and L. B. Townsend, Design, Synthesis, and Antiviral Evaluation of 2-Chloro-5,6-dihalo-1-?-d-ribofuranosylbenzimidazoles as Potential Agents for Human Cytomegalovirus Infections, Journal of Medicinal Chemistry, vol.40, issue.5, pp.811-818, 1997.

M. Ikehara and H. Tada, Studies of Nucleosides and Nucleotides. XXIV.1 Purine Cyclonucleosides. I. 8,2'-Cyclonucleoside Derived from 2-Chloro-8-mercapto-9-?-Dxylofuranosyladenine2, Journal of the American Chemical Society, vol.87, issue.3, pp.606-610, 1965.

M. Ikehara and H. Tada, A New Type of "Cyclonucleoside" Derived from 2-Chloro-8mercapto-9-?-D-xylofuranosyladenine, Journal of the American Chemical Society, vol.85, issue.15, pp.2344-2345, 1963.

M. Ikehara and K. Muneyama, Nucleosides and nucleotides. XXXVI. Purine cyclonucleosides. 6. Formation of 8,5'-S-cyclonucleoside from guanosine. The Journal of Organic Chemistry, vol.32, pp.3042-3044, 1967.

M. Ikehara and H. Tada, Studies of Nucleosides and Nucleotides. XXXII. Purine Cyclonucleosides. 3. Synthesis of 2'-Deoxy-and 3'-Deoxyadenosine from Adenosine

, Chemical & Pharmaceutical Bulletin, vol.15, issue.1, pp.94-100, 1967.

A. Yamazaki, Synthesis of 2'-and 3'-Deoxyinosines, Chemical & Pharmaceutical Bulletin, vol.21, issue.5, pp.1143-1146, 1973.

M. Ikehara, M. Kaneko, and M. Sagai, Synthesis of 8,5'-anhydro-8mercaptoadenosine, Chemical & pharmaceutical bulletin, vol.16, issue.6, pp.1151-1154, 1968.

K. L. Nagpal, P. C. Srivastava, and M. M. Dhar, Synthesis of 8,5'-anhydro-8thioadenosine, Indian Journal of Chemistry, vol.9, issue.2, pp.183-187, 1971.

M. Ikehara, Y. Nakahara, and S. Yamada, Synthesis and Properties of Cyclonucleosides derived from 9-D-Xylofuranosyladenine, Chemical & Pharmaceutical Bulletin, vol.19, issue.3, pp.538-544, 1971.

A. Hampton, Nucleotides. II.1 A New Procedure for the Conversion of Ribonucleosides to 2',3'-O-Isopropylidene Derivatives2, Journal of the American Chemical Society, vol.83, issue.17, pp.3640-3645, 1961.

K. K. Ogilvie, Synthesis of 8,2?-Thioanhydroguanosine, Canadian Journal of Chemistry, vol.50, issue.7, pp.1100-1104, 1972.

M. Ikehara, T. Maruyama, and H. Miki, Studies of nucleosides and nucleotides. LXXII. Purine cyclonucleosides. 33. A new method for the synthesis of 8,2'-Scyclonucleosides, Journal of carbohydrates, vol.4, issue.6, pp.409-422, 1977.

M. Kaneko, B. Shimizu, and M. Ikehara, Synthesis and properties of 8,2?-Ncycloadenosines, Tetrahedron Letters, vol.12, issue.33, pp.3113-3116, 1971.

T. Sasaki, K. Minamoto, and H. Itoh, Convenient synthesis of some purine 8,5'-imino cyclonucleosides. The Journal of Organic Chemistry, vol.43, pp.2320-2325, 1978.

T. Sasaki, K. Minamoto, and H. Itoh, Studies directed toward synthesis of guanosine 8,5'-imino cyclonucleosides and derivatives-I, Tetrahedron, vol.36, issue.24, pp.3509-3515, 1980.

T. Sasaki, Long-bridge cyclonucleosides. 1. Synthesis and reactions of some purine 8, vol.2

, The Journal of Organic Chemistry, vol.46, issue.25, pp.5176-5181, 1981.

T. Sasaki, Long-bridged cyclonucleosides. 2. A synthetic study aimed at cyclization between the C8 and C3', of some purine nucleosides using a methylhydrazo bridge, The Journal of organic chemistry, vol.47, issue.23, pp.4465-70, 1982.

K. J. Divakar and C. B. Reese, The cyclization of 8-carboxamido-2[prime or minute]O-tosyladenosine. A new preparation of 9-[small beta]-D-arabinofuranosyladenine (ara-A), Journal of the Chemical Society, Chemical Communications, issue.24, pp.1191-1193, 1980.

J. Zemlicka and A. Holy, Preparation of N-dimethylaminomethylene derivatives as a new method of a selective substitution of nucleoside amino groups. Collection of Czechoslovak Chemical Communications, vol.32, pp.3159-68, 1967.

A. Holy, Studies on S-adenosyl-L-homocysteine hydrolase. VIII. Preparation of isomeric 3-aminopropylamino derivatives of 9-(RS)-(2,3-dihydroxypropyl)adenine. Collection of Czechoslovak Chemical Communications, vol.48, pp.1910-1931, 1983.

E. D. Clercq, Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines, Antiviral Research, vol.8, pp.261-272, 1987.

M. Hocek, Synthesis and antiviral activity of acyclic nucleotide analogs derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collection of Czechoslovak Chemical Communications, vol.61, pp.1525-1537, 1996.

Z. Janeba, Intramolecular cyclization of some acyclic nucleoside analogs. Collection of Czechoslovak Chemical Communications, vol.61, pp.442-457, 1996.

Z. Janeba, A. Holy, and M. Masojidkova, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one. Collection of Czechoslovak Chemical Communications, vol.65, pp.1126-1144, 2000.

K. Meszarosova, A. Holy, and M. Masojidkova, Synthesis of acyclic adenine 8,Nanhydronucleosides. Collection of Czechoslovak Chemical Communications, vol.65, pp.1109-1125, 2000.

Z. Janeba, A. Holy, and M. Masojidkova, Synthesis of 8-amino-and N-substituted 8aminoadenine derivatives of acyclic nucleoside and nucleotide analogs. Collection of Czechoslovak Chemical Communications, vol.66, pp.517-532, 2001.

P. Jansa, A novel and efficient one-pot synthesis of symmetrical diamide (bisamidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities, European Journal of Medicinal Chemistry, vol.46, issue.9, pp.3748-3754, 2011.

A. B. Reitz, Small-Molecule Immunostimulants. Synthesis and Activity of 7,8Disubstituted Guanosines and Structurally Related Compounds, Journal of Medicinal Chemistry, vol.37, issue.21, pp.3561-3578, 1994.

A. Matsuda, A new synthesis of 5'-deoxy-8,5'-cyclo-adenosine and-inosine: conformationally-fixed purine nucleosides (nucleosides and nucleotides. XVI), Nucleic Acids Research, vol.3, issue.12, pp.3349-3357, 1976.

A. Matsuda, M. Tezuka, and T. Ueda, Photochemical cyclisation of 2',3'-0isopropylidene-8-phenylthioadenosine to the 8,5'(R)-and 8,5'(S)-cycloadenosines (nucleosides and nucleotides-XVII), Tetrahedron, vol.34, issue.16, pp.2449-2452, 1978.

A. Romieu, Site-Specific Introduction of (5'S)-5',8-Cyclo-2'-deoxyadenosine into Oligodeoxyribonucleotides. The Journal of Organic Chemistry, vol.63, pp.5245-5249, 1998.

P. J. Brooks, The Oxidative DNA Lesion 8,5?-(S)-Cyclo-2?-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells, Journal of Biological Chemistry, vol.275, issue.29, pp.22355-22362, 2000.

H. Usui, A. Matsuda, and T. Ueda, Synthesis of 8, 2'-Methanoguanosine and 9(alpha;-D-Arabinofuranosyl)-8, 2'-methanoguanine (Nucleosides and Nucleotides, LXVII.). Chemical & Pharmaceutical Bulletin, vol.34, issue.5, pp.1961-1967, 1986.

H. Usui and T. Ueda, Synthesis of 2'-Deoxy-8, 2'-ethanoadenosine and 3'-Deoxy-8, 3'-ethanoadenosine : Nucleosides and Nucleotides, LXIV. Chemical & Pharmaceutical Bulletin, vol.34, issue.1, pp.15-23, 1986.

A. Matsuda and T. Ueda, Synthesis of 8, 6'-Cyclo-6'-deoxyhexofuranosyladenines : Adenosines Fixed in an Anti-conformation (Nucleosides and Nucleotides. LXVI)

, Chemical & Pharmaceutical Bulletin, vol.34, issue.4, pp.1573-1578, 1986.

H. Usui and T. Ueda, Synthesis of 8, 2'-Methano-and 8, 2'Ethanoadenosines(Nucleosides and Nucleotides. LXV), Chemical & Pharmaceutical Bulletin, vol.34, issue.4, pp.1518-1523, 1986.

A. Manetto, Independent Generation of C5'-Nucleosidyl Radicals in Thymidine and 2'-Deoxyguanosine. The Journal of Organic Chemistry, vol.72, pp.3659-3666, 2007.

L. B. Jimenez, The photochemistry of 8-bromo-2-deoxyadenosine. A direct entry to cyclopurine lesions, Photochemical & Photobiological Sciences, issue.3, pp.1042-1046, 2004.

C. Chatgilialoglu, M. Guerra, and Q. G. Mulazzani, Model Studies of DNA C5' Radicals. Selective Generation and Reactivity of 2'-Deoxyadenosin-5'-yl Radical, Journal of the American Chemical Society, vol.125, issue.13, pp.3839-3848, 2003.

R. Flyunt, Fate of the 2'-Deoxyadenosin-5'-yl Radical under Anaerobic Conditions, Journal of the American Chemical Society, vol.122, issue.17, pp.4225-4226, 2000.

M. Russo, Chemical Radiation Studies of 8-Bromo-2?-deoxyinosine and 8Bromoinosine in Aqueous Solutions, Chemistry-A European Journal, vol.12, issue.29, pp.7684-7693, 2006.

F. Boussicault, The Fate of C5' Radicals of Purine Nucleosides under Oxidative Conditions, J. Am. Chem. Soc, vol.130, issue.26, pp.8377-8385, 2008.

C. Chatgilialoglu, S)-and (5'R)-5',8-Cyclo-2'-deoxyguanosine: Mechanistic Insights on the 2'-Deoxyguanosin-5'-yl Radical Cyclization, Chem. Res. Toxicol, vol.20, issue.5, pp.1820-1824, 2007.

C. Chatgilialoglu, Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development, p.50379, 2013.

V. T. Perchyonok, Black light induced radical cyclization approach to cyclonucleosides: an independent approach. Letters in Organic Chemistry, vol.8, pp.337-340, 2011.

M. L. Navacchia, Radical Cyclization Approach to Cyclonucleosides, European Journal of Organic Chemistry, pp.4640-4648, 2005.

M. L. Navacchia, C. Chatgilialoglu, and P. C. Montevecchi, C5'-adenosinyl radical cyclization. A stereochemical investigation. The Journal of organic chemistry, vol.71, pp.4445-52, 2006.

M. A. Terzidis and C. Chatgilialoglu, Radical Cascade Protocol for the Synthesis of (5?S)-and (5?R)-5?,8-Cyclo-2?-deoxyguanosine Derivatives*, Australian Journal of Chemistry, vol.66, issue.3, pp.330-335, 2013.

H. Yueh, Synthesis and NMR Assignment of the Two Diastereomers of 8,6'Cyclo-2',6'-Dideoxyadenosine. Nucleosides, Nucleotides and Nucleic Acids, vol.32, pp.320-332, 2013.

G. C. Magnin, Synthesis of a C-8 Modified Adenosine Analogue as a Potential Mechanistic Probe for Ribonucleotide Reductases. Nucleosides and Nucleotides, vol.18, pp.611-612, 1999.

H. Yoshioka, Preparation of cyclonucleosides and their use as virucides, Sanyo Kokusaku Pulp K. K, p.6, 1992.

T. Ikeda and M. Morozumi, Preparation of 2'-deoxy-or 2',3'-dideoxypurine nucleosides from anhydromercaptoarabinofuranosylpurines, p.7, 1990.

A. Holy, Studies on S-adenosyl-L-homocysteine hydrolase. XVI. 9(Aminoalkyl)-8-hydroxyadenines: preparation, mechanism of formation, and use in affinity chromatography of S-adenosyl-L-homocysteine hydrolase, Collection of Czechoslovak Chemical Communications, vol.51, issue.2, pp.459-77, 1986.

E. Bang, A Self-Complementary Nucleoside: Synthesis, Solid-State Structure, and Fluorescence Behavior, Chemistry-An Asian Journal, vol.6, issue.8, pp.2048-2054, 2011.

A. Kannan and C. J. Burrows, Synthesis of N2-Alkyl-8-oxo-7,8-dihydro-2?deoxyguanosine Derivatives and Effects of These Modifications on RNA Duplex Stability. The Journal of Organic Chemistry, vol.76, pp.720-723, 2011.

S. Pautus, New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain, Journal of Medicinal Chemistry, vol.56, issue.21, pp.8915-8930, 2013.

C. Lambertucci, 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands, Bioorganic & Medicinal Chemistry, vol.17, issue.7, pp.2812-2822, 2009.

D. Limnios and C. G. Kokotos, 2-Trifluoroacetophenone: An Organocatalyst for an Environmentally Friendly Epoxidation of Alkenes. The Journal of Organic Chemistry, vol.2, pp.4270-4276, 2014.

P. A. Cruickshank and M. Fishman, Studies in alkylation. II. Reactions of epoxyalkyl bromides. The Journal of Organic Chemistry, vol.34, pp.4060-4065, 1969.

A. T. Larsen, E. M. May, and K. Auclair, Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4, Journal of the American Chemical Society, vol.133, pp.7853-7858, 1920.

H. Hussain, I. R. Green, and I. Ahmed, Journey Describing Applications of Oxone in Synthetic Chemistry, Chemical Reviews, vol.113, issue.5, pp.3329-3371, 2013.

F. Padilla, Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors, Journal of Medicinal Chemistry, vol.56, issue.4, pp.1677-1692, 2013.

X. Chu, Pyrrolo[1,2-c]imidazolone derivatives as inhibitors of MDM2-p53 interactions and their preparation and use for the treatment of cancer, p.43, 2012.

C. Chatgilialoglu, C. Ferreri, and M. A. Terzidis, Purine 5',8-cyclonucleoside lesions: chemistry and biology, Chemical Society Reviews, vol.40, issue.3, pp.1368-1382, 2011.

M. Russo, Chemical radiation studies of 8-bromo-2'-deoxyinosine and 8bromoinosine in aqueous solutions. Chemistry (Weinheim an der Bergstrasse, Germany), vol.12, pp.7684-93, 2006.

F. Boussicault, The Fate of C5' Radicals of Purine Nucleosides under Oxidative Conditions, Journal of the American Chemical Society, vol.130, issue.26, pp.8377-8385, 2008.

C. Chatgilialoglu, S)-and (5'R)-5',8-Cyclo-2'-deoxyguanosine: Mechanistic Insights on the 2'-Deoxyguanosin-5'-yl Radical Cyclization. Chemical Research in Toxicology, vol.20, pp.1820-1824, 2007.

C. Chatgilialoglu, New Insights into the Reaction Paths of Hydroxyl Radicals with 2'-Deoxyguanosine, Chemical Research in Toxicology, vol.24, issue.12, pp.2200-2206, 2011.

C. Chatgilialoglu, C. Caminal, and Q. G. Mulazzani, Radical-based alkylation of guanine derivatives in aqueous medium, Organic & Biomolecular Chemistry, vol.9, issue.9, pp.3494-3498, 2011.

C. Chatgilialoglu, C. Ferreri, and M. A. Terzidis, 8cyclonucleoside lesions: chemistry and biology, Chemical Society Reviews, vol.40, issue.3, pp.1368-1382, 2011.

C. Chatgilialoglu, Selective Generation and Reactivity of 5?-Adenosinyl and 2?Adenosinyl Radicals, Chemistry-A European Journal, vol.10, issue.5, pp.1249-1255, 2004.

M. Ioele, Chemical Radiation Studies of 8-Bromoguanosine in Aqueous Solutions, Journal of the American Chemical Society, vol.122, issue.9, pp.1900-1907, 2000.

H. Gao and A. K. Mitra, Regioselective synthesis of various prodrugs of ganciclovir, Tetrahedron Letters, vol.41, issue.8, pp.1131-1136, 2000.

K. Inoue, Indium(III) Chloride-Sodium Borohydride System: A Convenient Radical Reagent for an Alternative to Tributyltin Hydride System, Journal of the American Chemical Society, vol.124, issue.6, pp.906-907, 2002.

R. Bowman, W. , S. L. Krintel, and M. B. Schilling, Tributylgermanium hydride as a replacement for tributyltin hydride in radical reactions, Organic & Biomolecular Chemistry, vol.2, issue.4, pp.585-592, 2004.

N. Hayashi, I. Shibata, and A. Baba, Triethylsilane-Indium(III) Chloride System as a Radical Reagent, Organic Letters, vol.6, issue.26, pp.4981-4983, 2004.

D. Pavia, Introduction to Spectroscopy, 2008.

X. Zhu, H. J. Williams, and A. I. Scott, Aqueous Trichloroacetic Acid: Another Useful Reagent for Highly Selective 5?-Desilylation of Multisilylated Nucleosides, Synthetic Communications, vol.33, issue.12, pp.2011-2016, 2003.