T. Rapp, S. Andrieu, F. Chartier, W. Deberdt, C. Reed et al., Resource Use and Cost of Alzheimer's Disease in France: 18-Month Results from the GERAS Observational Study, 2017.

C. Handicap, Charte Européenne de l'aidant familial, 2009.

. Disponible,

S. H. Zarit, K. E. Reever, and J. Bach-peterson, Relatives of the impaired elderly: correlates of feelings of burden, The Gerontologist. déc, vol.20, issue.6, p.64955, 1980.

R. Schulz and S. R. Beach, Caregiving as a risk factor for mortality: the Caregiver Health Effects Study, JAMA. 15 déc, vol.282, issue.23, p.22159, 1999.
DOI : 10.1001/jama.282.23.2215
URL : https://jamanetwork.com/journals/jama/articlepdf/192209/joc91040.pdf

S. M. Mccurry, R. G. Logsdon, L. Teri, and M. V. Vitiello, Sleep disturbances in caregivers of persons with dementia: contributing factors and treatment implications, Sleep Med Rev. avr, vol.11, issue.2, pp.143-53, 2007.

K. J. Joling, H. Van-marwijk, A. E. Veldhuijzen, H. E. Van-der-horst, P. Scheltens et al., The two-year incidence of depression and anxiety disorders in spousal caregivers of persons with dementia: who is at the greatest risk?, Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. mars, vol.23, issue.3, p.293303, 2015.

P. Thomas, C. Hazif-thomas, V. Delagnes, P. Bonduelle, and J. Clément,

, Psychol Neuropsychiatr Vieil. sept, vol.3, issue.3, p.20720, 2005.

M. Navaie-waliser, P. H. Feldman, D. A. Gould, C. Levine, A. N. Kuerbis et al., When the caregiver needs care: the plight of vulnerable caregivers, Am J Public Health. mars, vol.92, issue.3, p.40913, 2002.

R. Von-känel, B. T. Mausbach, T. L. Patterson, J. E. Dimsdale, K. Aschbacher et al., Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to noncaregiving controls, Gerontology, vol.54, issue.3, p.1317, 2008.

W. S. Shaw, T. L. Patterson, M. G. Ziegler, J. E. Dimsdale, S. J. Semple et al., Accelerated risk of hypertensive blood pressure recordings among Alzheimer caregivers, J Psychosom Res. mars, vol.46, issue.3, p.21527, 1999.

J. K. Kiecolt-glaser, J. R. Dura, C. E. Speicher, O. J. Trask, and R. Glaser, Spousal caregivers of dementia victims: longitudinal changes in immunity and health, Psychosom Med. août, vol.53, issue.4, p.62, 1991.

K. Yaffe, P. Fox, R. Newcomer, L. Sands, K. Lindquist et al., Patient and caregiver characteristics and nursing home placement in patients with dementia, JAMA. 24 avr, vol.287, issue.16, p.20907, 2002.

H. Brodaty, C. Thomson, C. Thompson, and M. Fine, Why caregivers of people with dementia and memory loss don't use services, Int J Geriatr Psychiatry. juin, vol.20, issue.6, p.53746, 2005.

M. Pinquart and S. Sörensen, Helping caregivers of persons with dementia: which interventions work and how large are their effects?, Int Psychogeriatr. déc, vol.18, issue.4, 2006.

S. Sörensen, M. Pinquart, and P. Duberstein, How effective are interventions with caregivers? An updated meta-analysis, The Gerontologist. juin, vol.42, issue.3, p.35672, 2002.

G. J. Acton and J. Kang, Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis. Res Nurs Health, vol.24, p.34960, 2001.

H. Brodaty, A. Green, and A. Koschera, Meta-analysis of psychosocial interventions for caregivers of people with dementia, J Am Geriatr Soc. mai, vol.51, issue.5, p.65764, 2003.

A. Spijker, M. Vernooij-dassen, E. Vasse, E. Adang, H. Wollersheim et al., Effectiveness of nonpharmacological interventions in delaying the institutionalization of patients with dementia: a meta-analysis, J Am Geriatr Soc. juin, vol.56, issue.6, p.111628, 2008.

K. Mangerel, S. Armand-branger, and M. Rhalimi, Spécificités de la personne âgée et leurs conséquences sur la prise en charge médicamenteuse, J Pharm Clin. 1 sept, vol.30, issue.3, p.16773, 2011.

P. Krolak-salmon, L. Letrilliart, M. Ceccaldi, S. Andrieu, O. Guérin et al., Towards a national strategy on the diagnosis of neurocognitive disorders. A shared approach among the French National College of General Practitioners and specialists of neurocognitive disorders

, Presse Med. 26 déc, 2017.

L. Fratiglioni, L. J. Launer, K. Andersen, M. M. Breteler, J. R. Copeland et al., Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, issue.11, pp.10-15, 2000.

C. L. Satizabal, A. S. Beiser, V. Chouraki, G. Chêne, C. Dufouil et al., Incidence of Dementia over Three Decades in the Framingham Heart Study, N Engl J Med. 11 févr, vol.374, issue.6, p.52332, 2016.

T. Mura, J. Dartigues, and C. Berr, How many dementia cases in France and Europe? Alternative projections and scenarios 2010-2050, Eur J Neurol. févr, vol.17, issue.2, p.2529, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00426844

P. Scheltens, K. Blennow, M. Breteler, B. De-strooper, G. B. Frisoni et al., Alzheimer's disease, Lancet Lond Engl. 30 juill, vol.388, p.50517, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01723790

M. Crocq and J. Guelfi, DSM-5-Manuel diagnostique et statistique des troubles mentaux. Traduction française de l'American Psychiatric Association

, Improving healthcare for people living with dementia, 2016.

A. Lobo, L. J. Launer, L. Fratiglioni, K. Andersen, D. Carlo et al., Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, issue.11, pp.4-9, 2000.

H. Ramaroson, C. Helmer, P. Barberger-gateau, L. Letenneur, J. Dartigues et al., Prevalence of dementia and Alzheimer's disease among subjects aged 75 years or over: updated results of the PAQUID cohort, Rev Neurol (Paris). avr, vol.159, issue.4, p.40511, 2003.

F. Perez, C. Helmer, J. F. Dartigues, S. Auriacombe, and F. Tison, A 15-year population-based cohort study of the incidence of Parkinson's disease and dementia with Lewy bodies in an elderly French cohort, J Neurol Neurosurg Psychiatry. juill, vol.81, issue.7, p.7426, 2010.

G. Perera, L. Pedersen, A. D. Alexander, M. Arrighi, H. M. Avillach et al., Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource, Alzheimers Dement J Alzheimers Assoc, vol.14, issue.2, p.1309, 2017.

C. Helmer, L. Grasset, K. Pérès, and J. Dartigues, Evolution temporelle des démences: état des lieux en France et à l'international, Bull Épidémiologique Hebd, vol.2829, p.46773, 2016.

C. Derouesné,

, Geriatr Psychol Neuropsychiatr Vieil. déc, vol.11, issue.4, p.40315, 2013.

S. I. Finkel, Behavioral and psychological symptoms of dementia: a current focus for clinicians, researchers, and caregivers, J Clin Psychiatry, vol.62, p.36, 2001.

M. Benoit, P. Brocker, J. Clement, X. Cnockaert, P. Hinault et al., Behavioral and psychological symptoms in dementia: description and management, Rev Neurol, vol.161, issue.3, p.35766, 2005.

P. Thomas, S. Chantoin-merlet, C. Hazif-thomas, J. Belmin, B. Montagne et al., Complaints of informal caregivers providing home care for dementia patients: the Pixel study, Int J Geriatr Psychiatry, vol.17, issue.11, p.103447, 2002.

P. Thomas, P. Ingrand, F. Lalloue, C. Hazif-thomas, R. Billon et al., Reasons of informal caregivers for institutionalizing dementia patients previously living at home: the Pixel study, Int J Geriatr Psychiatry. févr, vol.19, issue.2, p.12735, 2004.

H. Amjad, D. L. Roth, Q. M. Samus, S. Yasar, and J. L. Wolff, Potentially Unsafe Activities and Living Conditions of Older Adults with Dementia, Fondation Plan Alzheimer. Alzheimer-Articles-Les Plan nationaux, vol.64, 2016.

. Disponible,

, Ministère de l'éducation nationale, de l'enseignement supérieur et de la recherche, Stratégie nationale de santé. Plan Maladies Neuro-Dégénératives, Ministère des affaires sociales, de la santé et des droits des femmes, 2014.

, Unité de soins, d'évaluation et de prise en charge Alzheimer. Livre Blanc, 2016.

P. Krolak-salmon, Pourquoi une éducation en santé pour les troubles cognitifs ?, Journée Régionale ETP PMND de l'Agence Régionale de, 2017.

J. Birks, Cholinesterase inhibitors for Alzheimer's disease, Cochrane Database Syst Rev. 25 janv, issue.1, p.5593, 2006.

J. S. Birks, G. Evans, and J. , Rivastigmine for Alzheimer's disease, Cochrane Database Syst Rev. 10 avr, issue.4, p.1191, 2015.

R. Howard, R. Mcshane, J. Lindesay, C. Ritchie, A. Baldwin et al., Donepezil and memantine for moderate-to-severe Alzheimer's disease, N Engl J Med. 8 mars, vol.366, issue.10, p.893903, 2012.

M. Knapp, D. King, R. Romeo, J. Adams, A. Baldwin et al., Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial), Int J Geriatr Psychiatry. déc, vol.32, issue.12, p.120516, 2017.

P. Dorenlot,

, Psychol Neuropsychiatr Vieil. juin, vol.4, issue.2, p.13544, 2006.

I. Abraha, J. M. Rimland, F. M. Trotta, G. Dell'aquila, C. et al., Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series, BMJ Open. 16 mars, vol.7, issue.3, p.12759, 2017.

A. Bahar-fuchs, C. L. Woods, and B. , Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer's or vascular type: a review, Alzheimers Res Ther, vol.5, issue.4, p.35, 2013.

J. C. Chung, C. K. Lai, P. M. Chung, and H. P. French, Snoezelen for dementia, Cochrane Database Syst Rev, issue.4, p.3152, 2002.

J. T. Van-der-steen, M. C. Van-soest-poortvliet, J. C. Van-der-wouden, M. S. Bruinsma, R. J. Scholten et al., Music-based therapeutic interventions for people with dementia, Cochrane Database Syst Rev, vol.02, p.3477, 2017.

, Code civil mars 27, 1803, p.205

, Code civil mars 27, 1803, p.206

R. Schulz and L. M. Martire, Family caregiving of persons with dementia: prevalence, health effects, and support strategies, Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. juin, vol.12, issue.3, p.2409, 2004.

, Association française des aidants. 8,3 millions d'entre nous accompagnent au quotidien un proche, en situation de maladie ou de handicap, quel que soit son âge

P. Thomas and N. Pharma, Etude PIXEL. L'entourage familial des patients de la maladie d'Alzheimer
URL : https://hal.archives-ouvertes.fr/hal-01800563

. Disponible,

S. Andrieu, L. Balardy, S. Gillette-guyonnet, H. Bocquet, C. Cantet et al., Burden experienced by informal caregivers assisting Alzheimer's patients in the REAL.FR study, Rev Med Interne. oct, vol.24, 2003.

J. Hoenig and M. W. Hamilton, Elderly psychiatric patients and the burden on the household, Psychiatr Neurol (Basel), vol.152, issue.5, p.28193, 1966.
DOI : 10.1159/000128253

J. Hoenig and M. W. Hamilton, The schizophrenic patient in the community and his effect on the household, Int J Soc Psychiatry, vol.12, issue.3, p.16576, 1966.

E. H. Thompson and W. Doll, The Burden of Families Coping with the Mentally III: An Invisible Crisis, Fam Relat, vol.31, issue.3, p.37988, 1982.

S. Platt, Measuring the burden of psychiatric illness on the family: an evaluation of some rating scales, Psychol Med. mai, vol.15, issue.2, p.38393, 1985.

D. Yu, S. Cheng, and J. Wang, Unravelling positive aspects of caregiving in dementia: An integrative review of research literature, Int J Nurs Stud, vol.79, p.126, 2017.

S. Cheng, E. Mak, R. Lau, N. Ng, and L. Lam, Voices of Alzheimer Caregivers on Positive Aspects of Caregiving, The Gerontologist, vol.56, issue.3, p.45160, 2016.

N. Kate, S. Grover, P. Kulhara, and R. Nehra, Scale for positive aspects of caregiving experience: development, reliability, and factor structure, East Asian Arch Psychiatry. juin, vol.22, issue.2, p.629, 2012.

S. Grover, R. Nehra, R. Malhotra, and K. N. , Positive Aspects of Caregiving Experience among Caregivers of Patients with Dementia. East Asian Arch Psychiatry, vol.27, p.718, 2017.

R. Hébert, G. Bravo, and D. Girouard, Fidélité de la traduction française de trois instruments d'évaluation des aidants naturels de malades déments. Rev Can Vieil, vol.12, p.32437, 1993.

S. Zarit, N. K. Orr, and J. M. Zarit, The Hidden Victims of Alzheimer's Disease: Families Under Stress, 1985.

J. F. Deeken, K. L. Taylor, P. Mangan, K. R. Yabroff, and J. M. Ingham, Care for the caregivers: a review of self-report instruments developed to measure the burden, needs, and quality of life of informal caregivers, J Pain Symptom Manage, vol.26, issue.4, p.92253, 2003.

M. Bédard, D. W. Molloy, L. Squire, S. Dubois, J. A. Lever et al., The Zarit Burden Interview: a new short version and screening version. The Gerontologist, vol.41, p.6527, 2001.

O. 'rourke, N. Tuokko, and H. A. , Psychometric properties of an abridged version of The Zarit Burden Interview within a representative Canadian caregiver sample, The Gerontologist. févr, vol.43, issue.1, p.1217, 2003.

Y. Arai, N. Tamiya, and E. Yano, The short version of the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI_8): its reliability and validity

, Nihon Ronen Igakkai Zasshi Jpn J Geriatr. sept, vol.40, issue.5, p.497503, 2003.

V. Revel, I. Haritchabalet, and C. Kervinio, Construction of a simplified scale for general medicine in detection of caregiver burden of a dependent elderly person

, Année Gérontologique, vol.16, p.1317, 2002.

Y. G. Bachner and N. O'rourke, Reliability generalization of responses by care providers to the Zarit Burden Interview. Aging Ment Health, vol.11, p.67885, 2007.

B. C. Robinson, Validation of a Caregiver Strain Index, J Gerontol. mai, vol.38, issue.3, p.3448, 1983.

S. J. Marwit and T. M. Meuser, Development and initial validation of an inventory to assess grief in caregivers of persons with Alzheimer's disease, The Gerontologist. déc, vol.42, issue.6, p.75165, 2002.

S. Diwan, G. W. Hougham, and G. A. Sachs, Strain experienced by caregivers of dementia patients receiving palliative care: findings from the Palliative Excellence in Alzheimer Care Efforts (PEACE) Program, J Palliat Med. déc, vol.7, issue.6, p.797807, 2004.

S. Hoskins, M. Coleman, and D. Mcneely, Stress in carers of individuals with dementia and Community Mental Health Teams: an uncontrolled evaluation study, J Adv Nurs. mai, vol.50, issue.3, p.32533, 2005.

L. E. Bradshaw, S. E. Goldberg, J. M. Schneider, and R. H. Harwood, Carers for older people with co-morbid cognitive impairment in general hospital: characteristics and psychological well-being, Int J Geriatr Psychiatry. juill, vol.28, issue.7, p.68190, 2013.

L. Roche-dclinpsy, K. Croot, C. Maccann, B. Cramer, and J. Diehl-schmid, The Role of Coping Strategies in Psychological Outcomes for Frontotemporal Dementia Caregivers, J Geriatr Psychiatry Neurol. sept, vol.28, issue.3, p.21828, 2015.

A. Richters, R. Melis, N. J. Van-exel, O. Rikkert, M. Van-der-marck et al., Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity, Alzheimers Res Ther. 4 avr, vol.9, issue.1, p.26, 2017.

B. Mahdavi, M. Fallahi-khoshknab, F. Mohammadi, M. A. Hosseini, and M. Haghi, Effects of Spiritual Group Therapy on Caregiver Strain in Home Caregivers of the Elderly with Alzheimer's Disease, Arch Psychiatr Nurs. juin, vol.31, issue.3, p.26973, 2017.

J. I. Kosberg and R. E. Cairl, The Cost of Care Index: a case management tool for screening informal care providers, The Gerontologist. juin, vol.26, issue.3, p.2738, 1986.

T. Mizoguchi, S. Iijima, N. Niino, and H. Orimo,

, Nihon Ronen Igakkai Zasshi Jpn J Geriatr. juin, vol.32, issue.6, p.4039, 1995.

K. M. Robinson, P. Adkisson, and S. Weinrich, Problem behaviour, caregiver reactions, and impact among caregivers of persons with Alzheimer's disease, J Adv Nurs, vol.36, issue.4, p.57382, 2001.

M. Novak and C. Guest, Application of a multidimensional caregiver burden inventory, The Gerontologist. déc, vol.29, issue.6, p.798803, 1989.

P. De-fazio, P. Ciambrone, G. Cerminara, E. Barbuto, A. Bruni et al., Depressive symptoms in caregivers of patients with dementia: demographic variables and burden, Clin Interv Aging, vol.10, p.108590, 2015.

C. Chang, J. Su, and C. Lin, Using the Affiliate Stigma Scale with caregivers of people with dementia: psychometric evaluation, Alzheimers Res Ther, vol.8, issue.1, p.45, 2016.

Ö. Küçükgüçlü, A. Söylemez, B. Yener, G. I??k, and A. T. , The effects of support groups on dementia caregivers: A mixed method study, Geriatr Nur, 2017.

Ö. Küçükgüçlü, B. A. Söylemez, G. Yener, C. D. Barutcu, and M. A. Akyol, Examining Factors Affecting Caregiver Burden: A Comparison of Frontotemporal Dementia and Alzheimer's Disease, Am J Alzheimers Dis Other Demen. juin, vol.32, issue.4, 2006.

X. Wang, Z. Sun, L. Xiong, M. Semrau, J. He et al., Reliability and validity of the international dementia alliance schedule for the assessment and staging of care in China, BMC Psychiatry, vol.17, issue.1, p.371, 2017.

M. Torrisi, D. Cola, M. C. Marra, A. , D. Luca et al., Neuropsychiatric symptoms in dementia may predict caregiver burden: a Sicilian exploratory study, Psychogeriatr Off J Jpn Psychogeriatr Soc. mars, vol.17, issue.2, p.1037, 2017.

J. Tan, N. Li, B. Cui, L. Wang, Y. Zhao et al., Characteristics of participants' and caregivers' influence on non-response in a cross-sectional study of dementia in an older population, Arch Gerontol Geriatr. févr, vol.62, p.14351, 2016.

A. Raggi, D. Tasca, S. Panerai, W. Neri, and R. Ferri, The burden of distress and related coping processes in family caregivers of patients with Alzheimer's disease living in the community, J Neurol Sci, vol.15, issue.12, p.7781, 2015.

A. Raccichini, L. Spazzafumo, S. Castellani, P. Civerchia, G. Pelliccioni et al., Living with mild to moderate Alzheimer patients increases the caregiver's burden at 6 months, Am J Alzheimers Dis Other Demen. août, vol.30, issue.5, p.4637, 2015.

H. Chen, M. Huang, Y. Yeh, W. Huang, and C. Chen, Effectiveness of coping strategies intervention on caregiver burden among caregivers of elderly patients with dementia, Psychogeriatr Off J Jpn Psychogeriatr Soc. mars, vol.15, issue.1, p.205, 2015.

M. P. Lawton, M. H. Kleban, M. Moss, M. Rovine, and A. Glicksman, Measuring caregiving appraisal, J Gerontol. mai, vol.44, issue.3, pp.61-71, 1989.

D. G. Harwood, W. W. Barker, R. L. Ownby, M. Bravo, H. Aguero et al., Predictors of positive and negative appraisal among Cuban American caregivers of Alzheimer's disease patients, Int J Geriatr Psychiatry. juin, vol.15, issue.6, p.4817, 2000.

J. M. Stolley, D. Reed, and K. C. Buckwalter, Caregiving appraisal and interventions based on the progressively lowered stress threshold model, Am J Alzheimers Dis Other Demen. avr, vol.17, issue.2, p.11020, 2002.

M. P. Lawton, D. Rajagopal, E. Brody, and M. H. Kleban, The dynamics of caregiving for a demented elder among black and white families, J Gerontol. juill, vol.47, issue.4, pp.156-164, 1992.

M. P. Lawton, M. Moss, M. H. Kleban, A. Glicksman, and M. Rovine, A two-factor model of caregiving appraisal and psychological well-being, J Gerontol. juill, vol.46, issue.4, pp.181-189, 1991.

P. P. Vitaliano, J. Russo, H. M. Young, J. Becker, and R. D. Maiuro, The screen for caregiver burden, The Gerontologist. févr, vol.31, issue.1, p.7683, 1991.

P. H. Vetter, S. Krauss, O. Steiner, P. Kropp, W. D. Möller et al., Vascular dementia versus dementia of Alzheimer's type: do they have differential effects on caregivers' burden?, J Gerontol B Psychol Sci Soc Sci. mars, vol.54, issue.2, pp.93-98, 1999.

K. B. Hirschman, J. A. Shea, S. X. Xie, and J. Karlawish, The development of a rapid screen for caregiver burden, J Am Geriatr Soc, vol.52, issue.10, p.17249, 2004.

I. M. Hajjar, M. Keown, P. Lewis, and A. Almor, Angiotensin converting enzyme inhibitors and cognitive and functional decline in patients with Alzheimer's disease: an observational study, Am J Alzheimers Dis Other Demen. mars, vol.23, issue.1, p.7783, 2008.

E. Lubart, R. Segal, M. Pankin, J. Madjar, and A. Leibovitz,

, Harefuah. août, vol.148, issue.8, p.572, 2009.

M. G. Guerra-silla, L. M. Gutiérrez-robledo, J. M. Villalpando-berumen, M. U. Pérez-zepeda, M. Montañaálvarez et al., Psychometric evaluation of a Spanish language version of the Screen for Caregiver Burden (SCB) in caregivers of patients with mixed, vascular and Alzheimer's dementia, J Clin Nurs. déc, vol.20, p.344351, 2011.

S. R. Ferrario, P. Vitaliano, A. M. Zotti, E. Galante, and R. Fornara, Alzheimer's disease: usefulness of the Family Strain Questionnaire and the Screen for Caregiver Burden in the study of caregivingrelated problems, Int J Geriatr Psychiatry. déc, vol.18, issue.12, p.11104, 2003.

C. W. Given, B. Given, M. Stommel, C. Collins, S. King et al., The caregiver reaction assessment (CRA) for caregivers to persons with chronic physical and mental impairments, Res Nurs Health. août, vol.15, issue.4, p.27183, 1992.

F. J. Meiland, J. A. Danse, J. F. Wendte, and N. S. Klazinga, Gunning-Schepers LJ. Caring for relatives with dementia-caregiver experiences of relatives of patients on the waiting list for admission to a psychogeriatric nursing home in The Netherlands, Scand J Public Health. juin, vol.29, issue.2, pp.113-134, 2001.

C. Persson, A. Wennman-larsen, K. Sundin, and P. Gustavsson, Assessing informal caregivers' experiences: a qualitative and psychometric evaluation of the Caregiver Reaction Assessment Scale, Eur J Cancer Care (Engl). mars, vol.17, issue.2, p.18999, 2008.

A. Stephan, H. Mayer, R. Guiteras, A. Meyer, and G. , Validity, reliability, and feasibility of the German version of the Caregiver Reaction Assessment scale (G-CRA): a validation study, Int Psychogeriatr, vol.25, issue.10, p.16218, 2013.

K. Ehrlich, A. Boström, M. Mazaheri, K. Heikkilä, and A. Emami, Family caregivers' assessments of caring for a relative with dementia: a comparison of urban and rural areas, Int J Older People Nurs. mars, vol.10, issue.1, p.2737, 2015.

M. C. Alvira, E. Risco, E. Cabrera, M. Farré, R. Hallberg et al., The association between positive-negative reactions of informal caregivers of people with dementia and health outcomes in eight European countries: a cross-sectional study, J Adv Nurs. juin, vol.71, issue.6, pp.1417-1451, 2015.

C. A. Macera, E. D. Eaker, R. J. Jannarone, D. R. Davis, and C. H. Stoskopf, A measure of perceived burden among caregivers, Eval Health Prof. juin, vol.16, issue.2, p.20511, 1993.

M. J. Vernooij-dassen, J. M. Persoon, and A. J. Felling, Predictors of sense of competence in caregivers of demented persons, Soc Sci Med, vol.43, issue.1, p.419, 1982.

M. Vernooij-dassen, X. Kurz, J. Scuvee-moreau, and A. Dresse, The measurement of sense of competence in caregivers of patients with dementia, Rev Epidemiol Sante Publique. avr, vol.51, issue.2, p.22735, 2003.

M. Laakkonen, H. Kautiainen, E. Hölttä, N. Savikko, R. S. Tilvis et al., Effects of SelfManagement Groups for People with Dementia and Their Spouses-Randomized Controlled Trial, J Am Geriatr Soc. avr, vol.64, issue.4, p.75260, 2016.

X. Kurz, J. Scuvee-moreau, M. Vernooij-dassen, and A. Dresse, Cognitive impairment, dementia and quality of life in patients and caregivers, Acta Neurol Belg. mars, vol.103, issue.1, p.2434, 2003.

A. Jansen, H. Van-hout, H. Van-marwijk, G. Nijpels, C. Gundy et al., Sense of competence questionnaire among informal caregivers of older adults with dementia symptoms: a psychometric evaluation, Clin Pract Epidemiol Ment Health CP EMH. 23 juill, vol.3, p.11, 2007.

M. Graff, M. Vernooij-dassen, M. Thijssen, J. Dekker, W. Hoefnagels et al., Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial, BMJ. 9 déc, vol.333, issue.7580, p.1196, 2006.
DOI : 10.1136/bmj.39001.688843.be
URL : https://www.bmj.com/content/333/7580/1196.full.pdf

J. De-rotrou, I. Cantegreil, V. Faucounau, E. Wenisch, C. Chausson et al., Do patients diagnosed with Alzheimer's disease benefit from a psycho-educational programme for family caregivers? A randomised controlled study, Int J Geriatr Psychiatry. août, vol.26, issue.8, p.83342, 2011.

E. J. Meeuwsen, P. German, R. Melis, E. M. Adang, G. A. Golüke-willemse et al., Costeffectiveness of post-diagnosis treatment in dementia coordinated by Multidisciplinary Memory Clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial, J Nutr Health Aging. mars, vol.13, issue.3, p.2428, 2009.

R. J. Montgomery, E. F. Borgatta, and M. L. Borgatta, Societal and Family Change in the Burden of Care. In: Who should care for the Elderly ? : an East-West value Divide, p.2752, 2000.

R. J. Montgomery, J. Gonyea, and N. Hooyman, Caregiving and the experience of subjective and objective burden, Fam Relat, vol.34, issue.1, p.1926, 1985.

N. Farley, L. Demers, and B. R. Swaine,

, Can J Aging Rev Can Vieil, vol.27, issue.2, p.18190, 2008.

L. J. Stone and J. A. Clements, The effects of nursing home placement on the perceived levels of caregiver burden, J Gerontol Soc Work. avr, vol.52, issue.3, p.193214, 2009.

C. O. Bailes, C. M. Kelley, and N. M. Parker, Caregiver burden and perceived health competence when caring for family members diagnosed with Alzheimer's disease and related dementia, J Am Assoc Nurse Pract, vol.28, issue.10, p.53440, 2016.

R. Hébert, G. Bravo, and P. M. Reliability, Validity and Reference Values of the Zarit Burden Interview for Assessing Informal Caregivers of Community-Dwelling Older Persons with Dementia, Can J Aging, vol.19, issue.4, p.494507, 2000.

C. Reed, M. Belger, G. Wimo, A. Argimon, J. M. Bruno et al., Caregiver Burden in Alzheimer's Disease: Differential Associations in Adult-Child and Spousal Caregivers in the GERAS Observational Study, Dement Geriatr Cogn Disord Extra. janv, vol.4, issue.1, p.5164, 2014.

R. W. Jones, J. Lebrec, K. Kahle-wrobleski, G. Dell'agnello, G. Bruno et al., Disease Progression in Mild Dementia due to Alzheimer Disease in an 18-Month Observational Study 217 (GERAS): The Impact on Costs and Caregiver Outcomes, Dement Geriatr Cogn Disord Extra. avr, vol.7, issue.1, p.87100, 2017.

C. A. Yeager, L. A. Hyer, B. Hobbs, and A. C. Coyne, Alzheimer's disease and vascular dementia: the complex relationship between diagnosis and caregiver burden, Issues Ment Health Nurs. juin, vol.31, issue.6, p.37684, 2010.
DOI : 10.3109/01612840903434589

N. Bergvall, P. Brinck, D. Eek, A. Gustavsson, A. Wimo et al., Relative importance of patient disease indicators on informal care and caregiver burden in Alzheimer's disease, Int Psychogeriatr. févr, vol.23, issue.1, p.7385, 2011.

H. Kim, M. Chang, K. Rose, and S. Kim, Predictors of caregiver burden in caregivers of individuals with dementia, J Adv Nurs. avr, vol.68, issue.4, p.84655, 2012.

S. Huang, M. Lee, Y. Liao, W. Wang, and T. Lai, Caregiver burden associated with behavioral and psychological symptoms of dementia (BPSD) in Taiwanese elderly, Arch Gerontol Geriatr. août, vol.55, issue.1, p.559, 2012.

I. Contador, B. Fernández-calvo, D. L. Palenzuela, S. Miguéis, and F. Ramos, Prediction of burden in family caregivers of patients with dementia: a perspective of optimism based on generalized expectancies of control, Aging Ment Health, vol.16, issue.6, p.67582, 2012.

R. Rosdinom, M. Zarina, M. S. Zanariah, M. Marhani, and W. Suzaily, Behavioural and psychological symptoms of dementia, cognitive impairment and caregiver burden in patients with dementia, Prev Med, vol.57, pp.67-69, 2013.

A. Slachevsky, M. Budinich, C. Miranda-castillo, J. Núñez-huasaf, J. R. Silva et al., The CUIDEME Study: determinants of burden in chilean primary caregivers of patients with dementia, J Alzheimers Dis, vol.35, issue.2, p.297306, 2013.

H. Brodaty, M. Woodward, K. Boundy, D. Ames, R. Balshaw et al., Prevalence and predictors of burden in caregivers of people with dementia, Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. août, vol.22, issue.8, p.75665, 2014.

J. L. Conde-sala, O. Turró-garriga, L. Calvó-perxas, J. Vilalta-franch, S. Lopez-pousa et al., Three-year trajectories of caregiver burden in Alzheimer's disease, J Alzheimers Dis, vol.42, issue.2, p.62333, 2014.

M. Kamiya, T. Sakurai, N. Ogama, Y. Maki, and K. Toba, Factors associated with increased caregivers' burden in several cognitive stages of Alzheimer's disease, Geriatr Gerontol Int. avr, vol.14, issue.2, p.4555, 2014.

H. S. Kang, W. Myung, D. L. Na, S. Y. Kim, J. Lee et al., Factors associated with caregiver burden in patients with Alzheimer's disease, Psychiatry Investig. avr, vol.11, issue.2, p.1529, 2014.

B. A. Springate and G. Tremont, Dimensions of caregiver burden in dementia: impact of demographic, mood, and care recipient variables, Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. mars, vol.22, issue.3, p.294300, 2014.

V. Dauphinot, F. Delphin-combe, C. Mouchoux, A. Dorey, A. Bathsavanis et al., Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: a cross-sectional study, J Alzheimers Dis JAD, vol.44, issue.3, p.90716, 2015.

H. Sakurai, H. Hanyu, H. Terayama, K. Fukuda, T. Iwamoto et al., Factors associated with the burden of caregivers of patients with dementia, Geriatr Gerontol Int. mars, vol.15, issue.3, p.5, 2015.

S. Lau, M. S. Chong, A. N. Chan, M. Chua, K. C. Lim et al., Looking Beyond the Unidimensional Total Score, Alzheimer Dis Assoc Disord. déc, vol.29, issue.4, p.33846, 2015.

Q. Lou, S. Liu, Y. R. Huo, M. Liu, S. Liu et al., Comprehensive analysis of patient and caregiver predictors for caregiver burden, anxiety and depression in Alzheimer's disease, J Clin Nurs. sept, vol.24, p.266878, 1718.

V. Dauphinot, A. Ravier, T. Novais, F. Delphin-combe, C. Moutet et al., Relationship Between Comorbidities in Patients With Cognitive Complaint and Caregiver Burden: A Cross-Sectional Study, J Am Med Dir Assoc. 1 mars, vol.17, issue.3, p.2327, 2016.
DOI : 10.1016/j.jamda.2015.10.011

V. Dauphinot, A. Ravier, T. Novais, F. Delphin-combe, C. Mouchoux et al., Risk Factors of Caregiver Burden Evolution, for Patients With Subjective Cognitive Decline or Neurocognitive Disorders: A Longitudinal Analysis, J Am Med Dir Assoc, vol.17, issue.11, p.103743, 2016.

S. H. Shim, H. S. Kang, J. H. Kim, and D. K. Kim, Factors Associated with Caregiver Burden in Dementia: 1Year Follow-Up Study, Psychiatry Investig. janv, vol.13, issue.1, p.439, 2016.

M. Sousa, R. L. Santos, O. Turró-garriga, R. Dias, M. Dourado et al., Factors associated with caregiver burden: comparative study between Brazilian and Spanish caregivers of patients with Alzheimer's disease (AD), Int Psychogeriatr, vol.28, issue.8, p.136374, 2016.
DOI : 10.1017/s1041610216000508

G. Onofrio, D. Sancarlo, C. Fernandez, F. Addante, D. Seripa et al., Frailty Level in Alzheimer's Disease Patients Predicts the Caregiver Burden Level, Morb Mortal, vol.6, p.1222, 2017.

B. S. Black, D. Johnston, P. V. Rabins, A. Morrison, C. Lyketsos et al., Unmet needs of community-residing persons with dementia and their informal caregivers: findings from the maximizing independence at home study, J Am Geriatr Soc. déc, vol.61, issue.12, p.208795, 2013.

M. Bevans and E. M. Sternberg, Caregiving burden, stress, and health effects among family caregivers of adult cancer patients, JAMA. 25 janv, vol.307, issue.4, p.398403, 2012.

A. Yesufu-udechuku, B. Harrison, E. Mayo-wilson, N. Young, P. Woodhams et al., Interventions to improve the experience of caring for people with severe mental illness: systematic review and meta-analysis, Br J Psychiatry J Ment Sci. avr, vol.206, issue.4, p.26874, 2015.

M. E. Charlson, P. Pompei, K. L. Ales, and C. R. Mackenzie, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, vol.40, issue.5, p.83, 1987.

J. Wancata, M. Krautgartner, J. Berner, R. Alexandrowicz, A. Unger et al., The Carers' Needs Assessment for Dementia (CNA-D): development, validity and reliability, Int Psychogeriatr. sept, vol.17, issue.3, p.393406, 2005.

H. G. Van-der-roest, F. Meiland, H. C. Comijs, E. Derksen, A. Jansen et al., What do community-dwelling people with dementia need? A survey of those who are known to care and welfare services, Int Psychogeriatr, vol.21, issue.5, p.94965, 2009.

D. Buono, M. Busato, R. Mazzetto, M. Paccagnella, B. Aleotti et al., Community care for patients with Alzheimer's disease and non-demented elderly people: use and satisfaction with services and unmet needs in family caregivers, Int J Geriatr Psychiatry, vol.14, issue.11, p.91524, 1999.

K. A. Ryan, A. Weldon, N. M. Huby, C. Persad, A. K. Bhaumik et al., Caregiver support service needs for patients with mild cognitive impairment and Alzheimer disease, Alzheimer Dis Assoc Disord. juin, vol.24, issue.2, p.1716, 2010.

T. A. Rosness, P. K. Haugen, M. Gausdal, L. Gjøra, and K. Engedal, Carers of patients with early-onset dementia, their burden and needs: a pilot study using a new questionnaire-care-EOD, Int J Geriatr Psychiatry, vol.27, issue.10, p.10956, 2012.

L. A. Jennings, D. B. Reuben, L. C. Evertson, K. S. Serrano, L. Ercoli et al., Unmet needs of caregivers of individuals referred to a dementia care program, J Am Geriatr Soc. févr, vol.63, issue.2, p.2829, 2015.

V. Steiner, L. L. Pierce, and D. Salvador, Information Needs of Family Caregivers of People With Dementia, Rehabil Nurs Off J Assoc Rehabil Nurses. juin, vol.41, issue.3, p.1629, 2016.

E. K. Eifert and J. Eddy, The Role of Needs Assessments in Enhancing Support Service Utilization by Family Caregivers of Persons with Alzheimer's Disease. Am J Health Stud, vol.27, pp.227-262, 2012.

R. Schmid, A. Eschen, B. Rüegger-frey, and M. Martin, Instruments for comprehensive needs assessment in individuals with cognitive complaints, mild cognitive impairment or dementia: a systematic review, Int J Geriatr Psychiatry. avr, vol.27, issue.4, p.32941, 2012.

K. J. Burnell, A. Selwood, T. Sullivan, G. M. Charlesworth, F. Poland et al., Involving service users in the development of the Support at Home: Interventions to Enhance Life in Dementia Carer Supporter Programme for family carers of people with dementia, Health Expect Int J Public Particip Health Care Health Policy. févr, vol.18, issue.1, p.95110, 2015.

T. Novais, V. Dauphinot, P. Krolak-salmon, and C. Mouchoux, How to explore the needs of informal caregivers of individuals with cognitive impairment in Alzheimer's disease or related diseases? A systematic review of quantitative and qualitative studies, BMC Geriatr. 17 avr, vol.17, issue.1, p.86, 2017.

A. Spinewine, K. E. Schmader, N. Barber, C. Hughes, K. L. Lapane et al., Appropriate prescribing in elderly people: how well can it be measured and optimised?, Lancet. 14 juill, vol.370, issue.9582, p.17384, 2007.

A. Spinewine, C. Swine, S. Dhillon, P. Lambert, J. B. Nachega et al., Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial, J Am Geriatr Soc. mai, vol.55, issue.5, p.65865, 2007.

D. P. Alldred, D. K. Raynor, C. Hughes, N. Barber, T. F. Chen et al., Interventions to optimise prescribing for older people in care homes, Cochrane Database Syst Rev, vol.2, p.9095, 2013.

B. Ludwig, Predicting the Future: Have you considered using the Delphi Methodology?, J Ext, vol.35, issue.5, 1997.

H. M. Hearnshaw, R. M. Harker, F. M. Cheater, R. H. Baker, and G. M. Grimshaw, Expert consensus on the desirable characteristics of review criteria for improvement of health care quality, Qual Health Care QHC. sept, vol.10, issue.3, p.1738, 2001.

M. Murphy, S. Hollinghurst, and C. Salisbury, Agreeing the content of a patient-reported outcome measure for primary care: a Delphi consensus study. Health Expect Int J Public Particip Health Care Health Policy, vol.20, p.33548, 2017.

, Life skills education for children and adolescents in schools, 1993.

. Disponible,

S. Nicchi and C. L. Scanff, Les stratégies de faire face, Bull Psychol, vol.475, issue.1, p.97100, 2005.

S. M. Mccurry, R. G. Logsdon, M. V. Vitiello, and L. Teri, Successful behavioral treatment for reported sleep problems in elderly caregivers of dementia patients: a controlled study, J Gerontol B Psychol Sci Soc Sci. mars, vol.53, issue.2, pp.122-129, 1998.

Y. Wu, V. Faucounau, J. De-rotrou, M. Riguet, and A. Rigaud,

, Psychol Neuropsychiatr Vieil. sept, vol.7, issue.3, p.18592, 2009.

D. D. Cooke, L. Mcnally, K. T. Mulligan, M. J. Harrison, and S. P. Newman, Psychosocial interventions for caregivers of people with dementia: a systematic review, Aging Ment Health. mai, vol.5, issue.2, p.35, 2001.

H. Pusey and D. Richards, A systematic review of the effectiveness of psychosocial interventions for carers of people with dementia, Aging Ment Health. mai, vol.5, issue.2, p.10719, 2001.

C. A. Thompson, K. Spilsbury, J. Hall, Y. Birks, C. Barnes et al., Systematic review of information and support interventions for caregivers of people with dementia, BMC Geriatr. 27 juill, vol.7, p.18, 2007.

D. Parker, S. Mills, and J. Abbey, Effectiveness of interventions that assist caregivers to support people with dementia living in the community: a systematic review, Int J Evid Based Healthc. juin, vol.6, issue.2, p.13772, 2008.

J. Olazarán, B. Reisberg, C. L. Cruz, I. Peña-casanova, J. et al., Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy, Dement Geriatr Cogn Disord, vol.30, issue.2, p.16178, 2010.

N. Beinart, J. Weinman, D. Wade, and R. Brady, Caregiver burden and psychoeducational interventions in Alzheimer's disease: a review, Dement Geriatr Cogn Disord Extra. janv, vol.2, issue.1, p.63848, 2012.

L. D. Van-mierlo, F. Meiland, H. G. Van-der-roest, and R. Dröes, Personalised caregiver support: effectiveness of psychosocial interventions in subgroups of caregivers of people with dementia, Int J Geriatr Psychiatry. janv, vol.27, issue.1, p.114, 2012.

N. Van't-leven, A. Prick, J. Groenewoud, P. Roelofs, D. Lange et al., Dyadic interventions for community-dwelling people with dementia and their family caregivers: A systematic review, Int Psychogeriatr, vol.25, issue.10, p.1581603, 2013.

L. Boots, M. E. Vugt, R. Van-knippenberg, G. Kempen, and F. Verhey, A systematic review of Internet-based supportive interventions for caregivers of patients with dementia, Int J Geriatr Psychiatry. avr, vol.29, issue.4, p.33144, 2014.

H. Nehen and D. M. Hermann, Supporting dementia patients and their caregivers in daily life challenges: review of physical, cognitive and psychosocial intervention studies, Eur J Neurol. févr, vol.22, issue.2, pp.19-20, 2015.

W. Tang and C. Chan, Effects of psychosocial interventions on self-efficacy of dementia caregivers: a literature review, Int J Geriatr Psychiatry, vol.31, issue.5, p.47593, 2016.

P. Thomas, Evaluation de l'aide aux aidants dans la maladie d'Alzheimer. Analyse de l'article: Helping caregivers of persons with dementia: which interventions work and how large are their effects ? Rev Gériatrie, vol.32, p.4713, 2007.

P. Maccourt, D. Allan, H. Khamisa, M. Krawczyk, . For-the et al., Supporting Caregivers through Service Provision: The Service Provider Resource Guide, 2011.

. Disponible,

D. Gallagher-thompson and D. W. Coon, Evidence-based psychological treatments for distress in family caregivers of older adults, Psychol Aging. mars, vol.22, issue.1, p.3751, 2007.

M. S. Mittelman, D. L. Roth, D. W. Coon, and W. E. Haley, Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer's disease, Am J Psychiatry. mai, vol.161, issue.5, p.8506, 2004.

S. Zarit and E. Femia, Behavioral and psychosocial interventions for family caregivers, Am J Nurs. sept, vol.108, issue.9, p.4753, 2008.

M. Herr, J. Robine, J. Pinot, J. Arvieu, and J. Ankri, Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people, Pharmacoepidemiol Drug Saf. 1 juin, vol.24, issue.6, p.63746, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02006072

L. Pasina, A. L. Brucato, C. Falcone, E. Cucchi, A. Bresciani et al., Medication nonadherence among elderly patients newly discharged and receiving polypharmacy, Drugs Aging. avr, vol.31, issue.4, p.2839, 2014.

N. Lechevallier-michel, M. Gautier-bertrand, A. Alpérovitch, C. Berr, J. Belmin et al., Frequency and risk factors of potentially inappropriate medication use in a community-dwelling elderly population: results from the 3C Study, Eur J Clin Pharmacol. janv, vol.60, issue.11, p.8139, 2005.

K. Tifratene, F. L. Duff, C. Pradier, J. Quetel, P. Lafay et al., Use of drug treatments for Alzheimer's disease in France: a study on a national level based on the National Alzheimer's Data Bank (Banque Nationale Alzheimer), Pharmacoepidemiol Drug Saf. sept, vol.21, issue.9, pp.1005-1017, 2012.

M. Pinquart and S. Sörensen, Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis, Psychol Aging. juin, vol.18, issue.2, p.25067, 2003.

E. C. Clipp and L. K. George, Psychotropic drug use among caregivers of patients with dementia, J Am Geriatr Soc. mars, vol.38, issue.3, p.22735, 1990.

E. F. Camargos, A. B. Souza, A. S. Nascimento, -. Morais, A. C. Silva et al., Use of psychotropic medications by caregivers of elderly patients with dementia: is this a sign of caregiver burden?, Arq Neuropsiquiatr. mars, vol.70, issue.3, p.16974, 2012.

D. Fliser, E. Franek, M. Joest, S. Block, E. Mutschler et al., Renal function in the elderly: impact of hypertension and cardiac function, Kidney Int. avr, vol.51, issue.4, p.1196204, 1997.

M. W. Bowie and P. W. Slattum, Pharmacodynamics in older adults: a review, Am J Geriatr Pharmacother. sept, vol.5, issue.3, p.263303, 2007.

G. Trifirò and E. Spina, Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems, Curr Drug Metab. sept, vol.12, issue.7, p.61120, 2011.

M. White, R. Roden, W. Minobe, M. F. Khan, P. Larrabee et al., Age-related changes in beta-adrenergic neuroeffector systems in the human heart, Circulation. sept, vol.90, issue.3, pp.1225-1263, 1994.

K. Turnheim, When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly, Exp Gerontol. août, vol.38, issue.8, p.84353, 2003.

W. S. Aronow, Treating hypertension in older adults: safety considerations, Drug Saf, vol.32, issue.2, p.1118, 2009.

A. J. Yarnall, A. A. Sayer, A. Clegg, K. Rockwood, S. Parker et al., New horizons in multimorbidity in older adults, Age Ageing, vol.46, issue.6, p.8828, 2017.

A. Marengoni, E. Strauss, D. Rizzuto, B. Winblad, and L. Fratiglioni, The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study, J Intern Med. févr, vol.265, issue.2, p.28895, 2009.

A. Marengoni, S. Angleman, R. Melis, F. Mangialasche, A. Karp et al., Aging with multimorbidity: a systematic review of the literature, Ageing Res Rev. sept, vol.10, issue.4, p.4309, 2011.

M. Fortin, G. Bravo, C. Hudon, L. Lapointe, J. Almirall et al., Relationship between multimorbidity and health-related quality of life of patients in primary care, Qual Life Res Int J Qual Life Asp Treat Care Rehabil. févr, vol.15, issue.1, p.8391, 2006.

Z. Tyack, K. Frakes, A. Barnett, P. Cornwell, S. Kuys et al., Predictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort study, Qual Life Res Int J Qual Life Asp Treat Care Rehabil, vol.25, issue.10, p.257992, 2016.

C. Salisbury, L. Johnson, S. Purdy, J. M. Valderas, and A. A. Montgomery, Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study, Br J Gen Pract J R Coll Gen Pract. janv, vol.61, issue.582, pp.12-21, 2011.

J. L. Wolff, B. Starfield, and G. Anderson, Prevalence, expenditures, and complications of multiple chronic conditions in the elderly, Arch Intern Med, vol.162, issue.20, p.226976, 2002.

R. Gijsen, N. Hoeymans, F. G. Schellevis, D. Ruwaard, W. A. Satariano et al., Causes and consequences of comorbidity: a review, J Clin Epidemiol. juill, vol.54, issue.7, p.66174, 2001.

B. P. Nunes, T. R. Flores, G. I. Mielke, E. Thumé, and L. A. Facchini, Multimorbidity and mortality in older adults: A systematic review and meta-analysis, Arch Gerontol Geriatr. déc, vol.67, p.1308, 2016.

R. Yancik, W. Ershler, W. Satariano, W. Hazzard, H. J. Cohen et al., Report of the national institute on aging task force on comorbidity, J Gerontol A Biol Sci Med Sci. mars, vol.62, issue.3, p.80, 2007.

, Multimorbidity: clinical assessment and management, 2016.

W. , A glossary of terms for community health care and services for older persons, Aging and Health Technical Report, 2004.

E. R. Hajjar, A. C. Cafiero, and J. T. Hanlon, Polypharmacy in elderly patients, Am J Geriatr Pharmacother. déc, vol.5, issue.4, p.34551, 2007.

K. K. Viktil, H. S. Blix, T. A. Moger, and A. Reikvam, Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems, Br J Clin Pharmacol. févr, vol.63, issue.2, p.18795, 2007.

T. S. Field, J. H. Gurwitz, J. Avorn, D. Mccormick, S. Jain et al., Risk factors for adverse drug events among nursing home residents, Arch Intern Med. 9 juill, vol.161, issue.13, p.162934, 2001.
DOI : 10.1001/archinte.161.13.1629
URL : https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/648554/ioi00375.pdf

T. S. Field, J. H. Gurwitz, L. R. Harrold, J. Rothschild, K. R. Debellis et al., Risk factors for adverse drug events among older adults in the ambulatory setting, J Am Geriatr Soc. août, vol.52, issue.8, p.134954, 2004.

S. C. Frazier, Health outcomes and polypharmacy in elderly individuals: an integrated literature review, J Gerontol Nurs. sept, vol.31, issue.9, p.411, 2005.

C. I. Neutel, S. Perry, and C. Maxwell, Medication use and risk of falls, Pharmacoepidemiol Drug Saf. mars, vol.11, issue.2, p.97104, 2002.

A. Calderón-larrañaga, B. Poblador-plou, F. González-rubio, L. A. Gimeno-feliu, J. M. Abad-díez et al., Multimorbidity, polypharmacy, referrals, and adverse drug events: are we doing things well?, Br J Gen Pract J R Coll Gen Pract. déc, vol.62, issue.605, pp.821-826, 2012.

O. 'mahony, D. Gallagher, and P. F. , Inappropriate prescribing in the older population: need for new criteria, Age Ageing. mars, vol.37, issue.2, p.13841, 2008.

S. E. Campbell, D. G. Seymour, W. R. Primrose, and A. Project, A systematic literature review of factors affecting outcome in older medical patients admitted to hospital, Age Ageing. mars, vol.33, issue.2, p.1105, 2004.

V. Sehgal, S. Bajwa, R. Sehgal, A. Bajaj, U. Khaira et al., Polypharmacy and potentially inappropriate medication use as the precipitating factor in readmissions to the hospital, J Fam Med Prim Care. avr, vol.2, issue.2, p.1949, 2013.

D. Garfinkel, Poly-de-prescribing to treat polypharmacy: efficacy and safety, Ther Adv Drug Saf. janv, vol.9, issue.1, p.2543, 2018.

M. Laroche, F. Bouthier, M. L. Charmes, and J. ,

, Rev Med Interne. juill, vol.30, issue.7, p.592601, 2009.

C. Cahir, T. Fahey, M. Teeling, C. Teljeur, J. Feely et al., Potentially inappropriate prescribing and cost outcomes for older people: a national population study, Br J Clin Pharmacol. mai, vol.69, issue.5, p.54352, 2010.

M. H. Beers, J. G. Ouslander, I. Rollingher, D. B. Reuben, J. Brooks et al., Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine, Arch Intern Med. sept, vol.151, issue.9, p.182532, 1991.

D. M. Fick, J. W. Cooper, W. E. Wade, J. L. Waller, J. R. Maclean et al., Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts, Arch Intern Med. 8 déc, vol.163, issue.22, p.271624, 2003.

M. H. Beers, Explicit criteria for determining potentially inappropriate medication use by the elderly. An update, Arch Intern Med. 28 juill, vol.157, issue.14, p.15316, 1997.

, American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults, American Geriatrics Society, vol.60, issue.4, p.61631, 2012.

, Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel, vol.63, p.222746, 2015.

P. Gallagher, C. Ryan, S. Byrne, J. Kennedy, D. O'mahony et al., Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation, Int J Clin Pharmacol Ther, vol.46, issue.2, p.7283, 2008.

O. 'mahony, D. , O. 'sullivan, D. Byrne, S. et al., STOPP/START criteria for potentially inappropriate prescribing in older people: version 2, Age Ageing. mars, vol.44, issue.2, p.2138, 2015.

A. Renom-guiteras, P. A. Thürmann, R. Miralles, R. Klaaßen-mielke, U. Thiem et al., Potentially inappropriate medication among people with dementia in eight European countries, Age Ageing. 1 janv, vol.47, issue.1, p.6874, 2018.

O. , Adherence to Long-Term Therapies-Evidence for Action, 2003.

L. De-decker, A. Gouraud, and G. Berrut,

, Geriatr Psychol Neuropsychiatr Vieil. mars, vol.9, issue.1, p.2938, 2011.

M. Van-eijken, S. Tsang, M. Wensing, P. Smet, and R. Grol, Interventions to improve medication compliance in older patients living in the community: a systematic review of the literature, Drugs Aging, vol.20, issue.3, p.22940, 2003.

D. Smith, J. Lovell, C. Weller, B. Kennedy, M. Winbolt et al., A systematic review of medication non-adherence in persons with dementia or cognitive impairment, PloS One, vol.12, issue.2, p.170651, 2017.

B. Garros, Conférence nationale de santé 1998, rapport du HCSP : Contribution du HCSP aux réflexions sur la lutte contre l'iatrogénie, 1998.

. Disponible,

, Comment améliorer la qualité et la sécurité des prescriptions de médicaments chez la personne âgée ?, HAS, 2014.

S. M. Patterson, C. Hughes, N. Kerse, C. R. Cardwell, and M. C. Bradley, Interventions to improve the appropriate use of polypharmacy for older people, Cochrane Database Syst Rev. 16 mai, issue.5, p.8165, 2012.

A. A. Mangoni, Predicting and detecting adverse drug reactions in old age: challenges and opportunities, Expert Opin Drug Metab Toxicol. mai, vol.8, issue.5, p.52730, 2012.
DOI : 10.1517/17425255.2012.665874
URL : https://www.tandfonline.com/doi/pdf/10.1517/17425255.2012.665874?needAccess=true

H. J. Hamilton, P. F. Gallagher, O. 'mahony, and D. , Inappropriate prescribing and adverse drug events in older people, BMC Geriatr. 28 janv, vol.9, p.5, 2009.
DOI : 10.1186/1471-2318-9-5
URL : https://doi.org/10.1186/1471-2318-9-5

C. M. Lindley, M. P. Tully, V. Paramsothy, and R. C. Tallis, Inappropriate medication is a major cause of adverse drug reactions in elderly patients, Age Ageing. juill, vol.21, issue.4, p.294300, 1992.

A. Corsonello, C. Pedone, and R. A. Incalzi, Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions, Curr Med Chem, vol.17, issue.6, p.57184, 2010.

W. T. Chang, S. R. Kowalski, W. Sorich, and C. P. Alderman, Medication regimen complexity and prevalence of potentially inappropriate medicines in older patients after hospitalisation, Int J Clin Pharm. août, vol.39, issue.4, p.86773, 2017.

. Cespharm, La maladie d'Alzheimer, 2013.

. Disponible,

, EXELON (rivastigmine), REMINYL (galantamine), anticholinestérasiques, EBIXA (mémantine), antagoniste non compétitif des récepteurs NMDA, 2016.

R. Howard, R. Mcshane, J. Lindesay, C. Ritchie, A. Baldwin et al., Donepezil and memantine for moderate-to-severe Alzheimer's disease, N Engl J Med. 8 mars, vol.366, issue.10, p.893903, 2012.
DOI : 10.1056/nejmoa1106668
URL : http://discovery.ucl.ac.uk/1366016/1/NEJMoa1106668.pdf

R. Jones, B. Sheehan, P. Phillips, E. Juszczak, J. Adams et al., DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease-a multicentre RCT, Trials. 24 juill, vol.10, p.57, 2009.

R. Howard, R. Mcshane, J. Lindesay, C. Ritchie, A. Baldwin et al., Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses, Lancet Neurol. déc, vol.14, issue.12, p.117181, 2015.

M. Knapp, D. King, R. Romeo, J. Adams, A. Baldwin et al., Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial), Int J Geriatr Psychiatry. déc, vol.32, issue.12, p.120516, 2017.

L. Rozzini, B. V. Chilovi, E. Bertoletti, M. Conti, I. Delrio et al., Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: a case control study, Am J Alzheimers Dis Other Demen. mars, vol.22, issue.1, p.427, 2007.

M. Rolinski, C. Fox, I. Maidment, and R. Mcshane, Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease, Cochrane Database Syst Rev. 14 mars, issue.3, p.6504, 2012.

H. Autorité-de-santé, Alzheimer et maladies apparentées: prise en charge des troubles du comportement perturbateur, 2009.

A. Jacquin-piques, G. Sacco, N. Tavassoli, O. Rouaud, Y. Bejot et al., Psychotropic Drug Prescription in Patients with Dementia: Nursing Home Residents Versus Patients Living at Home, J Alzheimers Dis, vol.49, issue.3, p.67180, 2016.

C. Mouchoux, P. Krolak-salmon, and . L'iatrogénie-cognitive, Rev Gériatrie, vol.42, p.21924, 2017.

N. Campbell, M. Boustani, T. Limbil, C. Ott, C. Fox et al., The cognitive impact of anticholinergics: a clinical review, Clin Interv Aging, vol.4, p.22533, 2009.

C. Fox, K. Richardson, I. D. Maidment, G. M. Savva, F. E. Matthews et al., Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study, J Am Geriatr Soc. août, vol.59, issue.8, p.147783, 2011.

C. Fox, T. Smith, I. Maidment, W. Chan, N. Bua et al., Effect of medications with anticholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review, Age Ageing. sept, vol.43, issue.5, p.60415, 2014.

A. Collamati, A. M. Martone, A. Poscia, V. Brandi, M. Celi et al., Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence, Aging Clin Exp Res. févr, vol.28, issue.1, p.2535, 2016.

S. Billioti-de-gage, B. Bégaud, F. Bazin, H. Verdoux, J. Dartigues et al., Benzodiazepine use and risk of dementia: prospective population based study, BMJ. 27 sept, vol.345, p.6231, 2012.

S. Billioti-de-gage, Y. Moride, T. Ducruet, T. Kurth, H. Verdoux et al., Benzodiazepine use and risk of Alzheimer's disease: case-control study, BMJ. 9 sept, vol.349, p.5205, 2014.

S. Paterniti, C. Dufouil, and A. Alpérovitch, Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study, J Clin Psychopharmacol. juin, vol.22, issue.3, pp.285-93, 2002.

S. L. Gray, M. L. Anderson, S. Dublin, J. T. Hanlon, R. Hubbard et al., Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study, JAMA Intern Med. mars, vol.175, issue.3, p.4017, 2015.

M. L. Ancelin, S. Artero, F. Portet, A. Dupuy, J. Touchon et al., Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study, BMJ. 25 févr, vol.332, issue.7539, p.4559, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00000025

R. M. Carnahan, B. C. Lund, P. J. Perry, B. G. Pollock, and K. R. Culp, The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity, J Clin Pharmacol. déc, vol.46, issue.12, p.14816, 2006.

E. Lowry, R. J. Woodman, R. L. Soiza, and A. A. Mangoni, Associations between the anticholinergic risk scale score and physical function: potential implications for adverse outcomes in older hospitalized patients, J Am Med Dir Assoc, vol.12, issue.8, p.56572, 2011.

J. L. Rudolph, M. J. Salow, M. C. Angelini, and R. E. Mcglinchey, The anticholinergic risk scale and anticholinergic adverse effects in older persons, Arch Intern Med. 10 mars, vol.168, issue.5, p.50813, 2008.

T. Linjakumpu, S. Hartikainen, T. Klaukka, H. Koponen, S. Kivelä et al., A model to classify the sedative load of drugs, Int J Geriatr Psychiatry. juin, vol.18, issue.6, p.5424, 2003.

D. Gnjidic, L. Couteur, D. G. Hilmer, S. N. Cumming, R. G. Blyth et al., Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study, Fundam Clin Pharmacol. févr, vol.28, issue.1, p.109, 2014.

P. Sloane, J. Ivey, M. Roth, M. Roederer, and C. S. Williams, Accounting for the sedative and analgesic effects of medication changes during patient participation in clinical research studies: measurement development and application to a sample of institutionalized geriatric patients, Contemp Clin Trials. mars, vol.29, issue.2, p.1408, 2008.

J. T. Hanlon, R. M. Boudreau, Y. F. Roumani, A. B. Newman, C. M. Ruby et al., Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study, J Gerontol A Biol Sci Med Sci. avr, vol.64, issue.4, p.4928, 2009.

R. M. Wright, Y. F. Roumani, R. Boudreau, A. B. Newman, C. M. Ruby et al., Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: findings from the Health, Aging And Body Composition Study, J Am Geriatr Soc. févr, vol.57, issue.2, p.24350, 2009.

S. N. Hilmer, D. E. Mager, E. M. Simonsick, Y. Cao, S. M. Ling et al., A drug burden index to define the functional burden of medications in older people, Arch Intern Med. 23 avr, vol.167, issue.8, p.7817, 2007.

K. Johnell, Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review, Curr Clin Pharmacol, vol.10, issue.3, p.17884, 2015.

H. Mehta, S. Sura, M. Raji, H. Holmes, Y. Kuo et al., Quality of pharmaceutical care in dementia patients, Innov Aging. 1 juill, vol.1, p.905905, 2017.

Z. K. Hudani and C. H. Rojas-fernandez, A scoping review on medication adherence in older patients with cognitive impairment or dementia, Res Soc Adm Pharm RSAP. déc, vol.12, issue.6, p.81529, 2016.

N. L. Campbell, M. A. Boustani, E. N. Skopelja, S. Gao, F. W. Unverzagt et al., Medication adherence in older adults with cognitive impairment: a systematic evidence-based review, Am J Geriatr Pharmacother. juin, vol.10, issue.3, p.16577, 2012.

P. Thomas, C. Hazif-thomas, M. Pareault, F. Vieban, and J. Clément,

, L'Encephale. avr, vol.36, issue.2, p.15965, 2010.

K. W. Piercy, E. B. Fauth, M. C. Norton, R. Pfister, C. D. Corcoran et al., Predictors of dementia caregiver depressive symptoms in a population: the Cache County dementia progression study, J Gerontol B Psychol Sci Soc Sci, vol.68, issue.6, p.9216, 2013.

D. L. Roth, L. Fredman, and W. E. Haley, Informal caregiving and its impact on health: a reappraisal from population-based studies, The Gerontologist. avr, vol.55, issue.2, p.30919, 2015.

J. M. Thorpe, C. T. Thorpe, K. A. Kennelty, W. F. Gellad, and R. Schulz, The impact of family caregivers on potentially inappropriate medication use in noninstitutionalized older adults with dementia, Am J Geriatr Pharmacother. août, vol.10, issue.4, p.23041, 2012.

R. Martín-garcía, G. Martín-avila, L. Rubia-marcos, M. D. Maroto-rodríguez, R. Ortega-angulo et al., Consumption of Drugs and Nonpharmacological Therapies in Caregivers of Patients with Alzheimer's Disease: A Case-Control Study in Madrid, Dement Geriatr Cogn Disord Extra. avr, vol.6, issue.1, p.6877, 2016.

L. C. Burton, J. T. Newsom, R. Schulz, C. H. Hirsch, and P. S. German, Preventive health behaviors among spousal caregivers, Prev Med. avr, vol.26, issue.2, p.1629, 1997.

X. Wang, K. M. Robinson, and H. K. Hardin, The Impact of Caregiving on Caregivers' Medication Adherence and Appointment Keeping, West J Nurs Res. déc, vol.37, issue.12, p.154862, 2015.

H. Autorité-de-santé, Alzheimer et maladies apparentées: suivi médical des aidants naturels. Recommandations de bonne pratique

. Disponible, HAS. Fiche action: maladie d'Alzheimer, accompagnement des aidants. Document pharmacien d'officine

T. Novais, C. Moutet, F. Delphin-combe, V. Dauphinot, C. Colin et al., PHARMAID study protocol: Randomized controlled trial to assess the impact of integrated pharmaceutical care at a psychosocial intervention on caregiver's burden in Alzheimer's disease or related diseases, Contemp Clin Trials. févr, vol.53, p.13742, 2017.

E. Rosa, G. Lussignoli, F. Sabbatini, A. Chiappa, D. Cesare et al., Needs of caregivers of the patients with dementia, Arch Gerontol Geriatr. août, vol.51, issue.1, p.548, 2010.

A. S. Efjestad, E. Molden, and A. R. Oksengård, Pharmacist-initiated management of antagonistic interactions between anticholinergic drugs and acetyl cholinesterase inhibitors in individuals with dementia, J Am Geriatr Soc. sept, vol.61, issue.9, p.16245, 2013.

H. Kersten, E. Molden, I. K. Tolo, E. Skovlund, K. Engedal et al., Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: a randomized controlled trial, J Gerontol A Biol Sci Med Sci. mars, vol.68, issue.3, p.2718, 2013.

M. Sakakibara, A. Igarashi, Y. Takase, H. Kamei, and T. Nabeshima, Effects of Prescription Drug Reduction on Quality of Life in Community-Dwelling Patients with Dementia, J Pharm Pharm Sci Publ Can Soc Pharm Sci Soc Can Sci Pharm, vol.18, issue.5, p.70512, 2015.

M. Gustafsson, M. Sjölander, B. Pfister, J. Jonsson, J. Schneede et al., Pharmacist participation in hospital ward teams and hospital readmission rates among people with dementia: a randomized controlled trial, Eur J Clin Pharmacol. juill, vol.73, issue.7, p.82735, 2017.

V. Dauphinot, E. Jean-bart, P. Krolak-salmon, and C. Mouchoux, A multi-center, randomized, controlled trial to assess the efficacy of optimization of drug prescribing in an elderly population, at 18 months of follow-up, in the evolution of functional autonomy: the OPTIM study protocol. BMC Geriatr, vol.17, p.195, 2017.

A. Child, A. Clarke, C. Fox, and I. Maidment, A pharmacy led program to review anti-psychotic prescribing for people with dementia, BMC Psychiatry. 25 sept, vol.12, p.155, 2012.
DOI : 10.1186/1471-244x-12-155
URL : https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/1471-244X-12-155

C. H. Rojas-fernandez, M. Eng, and A. Nd, Pharmacologic management by clinical pharmacists of behavioral and psychological symptoms of dementia in nursing home residents: results from a pilot study, Pharmacotherapy. févr, vol.23, issue.2, p.21721, 2003.

C. Smeets, M. Smalbrugge, D. L. Gerritsen, M. Nelissen-vrancken, R. B. Wetzels et al., Improving psychotropic drug prescription in nursing home patients with dementia: design of a cluster randomized controlled trial, BMC Psychiatry, vol.13, p.280, 2013.

I. D. Maidment, R. L. Shaw, K. Killick, S. Damery, A. Hilton et al., Improving the management of behaviour that challenges associated with dementia in care homes: protocol for pharmacy-health psychology intervention feasibility study, BMJ Open. 23 mars, vol.6, issue.3, p.10279, 2016.

K. Van-der-spek, R. Koopmans, M. Smalbrugge, M. Nelissen-vrancken, R. B. Wetzels et al., The effect of biannual medication reviews on the appropriateness of psychotropic drug use for neuropsychiatric symptoms in patients with dementia: a randomised controlled trial, Age Ageing. 8 févr, 2018.

R. Gillespie, J. Mullan, and L. Harrison, Managing medications: the role of informal caregivers of older adults and people living with dementia. A review of the literature, J Clin Nurs. déc, vol.23, p.3296308, 2014.

A. M. Paquin, M. Salow, and J. L. Rudolph, Pharmacist calls to older adults with cognitive difficulties after discharge in a Tertiary Veterans Administration Medical Center: a quality improvement program, J Am Geriatr Soc. mars, vol.63, issue.3, p.5717, 2015.

L. Oderda, C. Holman, B. Nichols, R. Rupper, B. Bair et al., Pharmacist-managed telephone clinic review of antidementia medication effectiveness, Consult Pharm J Am Soc Consult Pharm. avr, vol.26, issue.4, p.26473, 2011.

T. E. Sonnett, S. M. Setter, D. L. Weeks, and S. Borson, Point-of-care screening to identify cognitive impairment in older adults, J Am Pharm Assoc JAPhA. août, vol.52, issue.4, p.4927, 2012.

R. M. Breslow, Patient attitudes regarding pharmacist-administered memory screening in community pharmacies, J Am Pharm Assoc JAPhA. déc, vol.53, issue.6, p.64851, 2013.

N. M. Rickles, J. B. Skelton, J. Davis, and J. Hopson, Cognitive memory screening and referral program in community pharmacies in the United States, Int J Clin Pharm. avr, vol.36, issue.2, p.3607, 2014.

N. V. Cotelo, N. Rodríguez, J. Pérez, J. Iglesias, and M. R. Lago, Burden and associated pathologies in family caregivers of Alzheimer's disease patients in Spain, Pharm Pract. juin, vol.13, issue.2, p.521, 2015.

, Arrêté du 28 novembre 2016 relatif aux bonnes pratiques de dispensation des médicaments dans les pharmacies d'officine, les pharmacies mutualistes et les pharmacies de secours minières

. Disponible, ANNNEXES Vous sentir tiraillé entre les soins à votre parent et vos autres responsabilités

, Vous sentir embarrassé par les comportements de votre parent ? 5 Vous sentir en colère quand vous êtes en présence de votre parent ? 6 Sentir que votre parent nuit à vos relations avec d'autres membres de la famille ou des amis ?

, Avoir peur de ce que l'avenir réserve à votre parent ?

, Sentir que votre parent est dépendant de vous ?

, Sentir que votre santé s'est détériorée à cause de votre implication auprès de votre parent ? 11 Sentir que vous n'avez pas autant d'intimité que vous aimeriez à cause de votre parent ? 12 Sentir que votre vie sociale s'est détériorée du fait que vous prenez soin de votre parent ? 13 Vous sentir mal à l'aise de recevoir des amis à cause de votre parent ? 14 Sentir que votre parent semble s'attendre à ce que vous preniez soin de lui comme si vous étiez la seule personne sur qui il puisse compter ? 15 Sentir que vous n'avez pas assez d'argent

, Sentir que vous avez perdu le contrôle de votre vie depuis la maladie de votre parent ? 18 Souhaiter pouvoir laisser le soin de votre parent à quelqu'un d'autre ? 19 Sentir que vous ne savez pas trop quoi faire pour votre parent ? 20 Sentir que vous devriez en faire plus pour votre parent ? 21 Sentir que vous pourriez donner de meilleurs soins à votre parent ? 22 En fin de compte, à quelle fréquence vous arrive-t-il de sentir que les soins à votre parent sont une charge

, Le score total qui est la somme des scores obtenus à chacun de 22 items

, Avis favorable du Comité de Protection des Personnes pour l'étude PHARMAID

, Annexe 8. Avis favorable du Comité de Protection des Personnes pour l'étude