I. V. Méthode-de-criblage-Électrochimique and .. .. ,

V. .. Conclusions,

.. .. Chapitre,

I. , Expression et purification de la TK de E, vol.87

. , Dosage des protéines selon la méthode de Bradford

I. , Électrophorèse en conditions dénaturantes (SDS-PAGE)

. , 3.2. Mesure d'activité TK en présence d'alcool déshydrogénase

. , Préparation des plaques de criblages électrochimiques (PCE)

. , 2.2.b. Mesure de l'activité de la galactose oxydase de Dactylium dendroides (GAOx) par IPA

. , 3.b. Mesure de l'activité TK par oxydation de l'intermédiaire réactionnel, 106 ii) Mesure de la TK immobilisée dans les hydroxydes doubles lamellaires (HDL), p.106

. .. Criblage-de-la-chimiothèque-de-l'icbms,

V. E. ,

I. I. Détection-du-peroxyde-d'hydrogène and .. .. , 1.2. Optimisation de la détection de l'H2O2 par IPA

E. .. , 2.1. Optimisation de la détection de l'H2O2 par ECL

. , Autres méthodes permettant la détection de l'H2O2, Comparaison avec des systèmes ou des méthodes déjà existantes

I. Mesure-de-l'activité-gaox and E. .. ,

. , Comparaison avec une autre méthode : test colorimétrique

. Iv, Mesure de l'activité de la GAOx en présence d'un inhibiteur

V. Mesures and .. .. Le-système-bi-enzymatique, Activité de la GAOx@laponite en présence des substrats de la TK

. , Mesure de l'activité TK-GAOx par ECL

. , Chapitre IV : Identification d'inhibiteurs de la TK par oxydation d'un intermédiaire réactionnel

I. Mesure and . .. Ipa, Mesure de l'activité TK à l'aide d'électrode de carbone dopées au Bleu de Prusse .. 184 III.10. Reproductibilité sur la mesure d'activité

.. .. Iv.-criblage-d'inhibiteurs-de-la-transcétolase-d'e.coli, Validation de la preuve de concept avec des inhibiteurs connus de la TK

. , 3.2. Détermination des paramètres cinétiques en présence de I38-49

. , Détermination du mécanisme d'inhibition par résonnance magnétique nucléaire

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