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Biomatériaux fonctionnels à base de complexes de polyélectrolytes compactés de type chitosan/alginate : conception, caractérisation et premières évaluations biologiques

Abstract : Nowadays, many chronic diseases, such as cancer or osteoarthritis, still need new modalities of treatment. Natural biomaterials able to convey active substances represent a solution to this problematic. Lately, several research works have been conducted on a new type of biomaterial named Compact Polyelectrolyte Complexes (CoPEC). As part of this thesis, CoPEC have been prepared from two biosourced polyelectrolytes, chitosan and alginate, functionalized with β-cyclodextrin (βCD). Through an in vitro inflammation model, the non-cytotoxic βCD-chitosan/alginate CoPEC has displayed intrinsic anti-inflammatory properties. Moreover, this CoPEC has demonstrated a capacity to host and release piroxicam and prednisolone, two model hydrophobic active substances. Finally, a strategy to include hydrophilic active substances into the material has been implemented.Thus, the newly CoPEC is promising because it can exhibit an intrinsic anti-inflammatory effect as well as other therapeutic effects through the inclusion of active substances into the cyclodextrins.
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Alexandre Hardy. Biomatériaux fonctionnels à base de complexes de polyélectrolytes compactés de type chitosan/alginate : conception, caractérisation et premières évaluations biologiques. Autre. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF024⟩. ⟨tel-01996521⟩

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