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De l'imagerie cérébrale au recueil de données en vie quotidienne : vers une compréhension intégrée des liens entre fonctionnement cognitif, expériences émotionnelles, perception du temps et symptômes de la schizophrénie

Abstract : Schizophrenia is characterized by significant variability over time in symptoms and functioning. However, little information is available concerning the short-term variability of symptoms and their associated phenomena (cognitive functioning, emotional experiences, perception of time), and despite their importance for providing precise descriptions of this complex mental disorder. Traditional laboratory-based assessments are confronted with a number of methodological limitations that make it impossible to assess such variability. This doctoral thesis therefore aims at providing missing information concerning the short-term temporal links between cognitive functioning, emotional experience, and time perception relative to the manifestation of symptoms of schizophrenia and examines the cerebral correlates of these associations. To address this issue, an innovative approach was applied that combined Ecological Momentary Assessment (EMA) using mobile technologies with Magnetic Resonance Imaging (MRI) of the brain. The EMA methodology identified the roles of cognitive performance, emotional experience and time perception in the expression of symptoms of schizophrenia over short time intervals in the patient’s daily life. MRI revealed the anatomical and functional correlates of these relationships, confirming in particular the central role of fronto-temporo-cerebellar regions in this disorder. Taken together, this dual approach provides novel insights into the underlying mechanisms of symptom expression in individuals with schizophrenia.
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Maud Dupuy. De l'imagerie cérébrale au recueil de données en vie quotidienne : vers une compréhension intégrée des liens entre fonctionnement cognitif, expériences émotionnelles, perception du temps et symptômes de la schizophrénie. Psychologie. Université de Bordeaux, 2018. Français. ⟨NNT : 2018BORD0366⟩. ⟨tel-01994208⟩

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